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晚期宫颈鳞癌
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  advanced squamous cervical carcinoma
     Pretreatment serum hemoglobin level as a predictive factor of response to neoadjuvant chemotherapy in patients with locally advanced squamous cervical carcinoma: A preliminary report
     治疗前血清血红蛋白水平作为预测局部晚期宫颈鳞癌对新辅助化疗的反应指标的初步报道
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  “晚期宫颈鳞癌”译为未确定词的双语例句
     Methods: Forty-nine patients with UCC were randomized into two groups: the radiotherapy (RT) group with 25 patients who were given simple external irradiation of the pelvic cavity and after-loading therapy and, the synchronal radiochemotherapy (CRT) group with 24 patients who were given 3 cycles of chemotherapy (DDP+5-FU) besides the RT.
     方法:49例局部晚期宫颈鳞癌患者随机分为两组:单纯放疗(RT)组25例接受盆腔外照射和后装治疗; 同步放化疗(CRT)组24例除接受放疗外,还接受3个周期的化疗(DDP+5-FU)。
短句来源
     Conclusions: There is a better remission rate in CRT of the UCC compared to the RT. An additive or synergistic anti-cancer effect might be the mechanism of CRT, which is realized by up-regulating Bax pathway for induction of tumor-cell apoptosis.
     结论:局部晚期宫颈鳞癌,CRT比RT有更好的缓解率,其机制可能是化疗和放疗有协同作用,通过上调Bax通路诱导了肿瘤细胞的凋亡。
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  相似匹配句对
     CHEMOTHERAPY IN RECURRENT AND ADVANCED CERVICAL CANCER
     晚期及复发宫颈的化疗
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     The Expressions of Cathepsin B and Its Significance in Squamous Carcinoma of Uterine Cervix
     组织蛋白酶B在宫颈组织中的表达
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     Squamous Cell Carcinoma of Gastric Cardia
     贲门
短句来源
     and squamous cell carcinoma was negative.
     阴性。
短句来源
     Expression of PTEN and P53 in Squamous Carcinoma of Cervix and Its Relationship with Occurrence and Development
     PTEN和P53在宫颈中的表达
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Thirty six patients, age range 21-75 years (median-45) years) with recurrent and advanced histologically proven squamous cell carcinoma of cervix were treated with chemotherapy using a combination of bleomycin, ifosfamide and tisplatinum (BIP) . Thirty two patients were evaluable for response. 90% patients achieved subjective response.Objective response were seen in 18/ 32 (56%) patients: complete-7 (21.8%) , partial-11 (34.3%) patients. Average relative dose intensity (ARDI) for all patients as calculated by...

Thirty six patients, age range 21-75 years (median-45) years) with recurrent and advanced histologically proven squamous cell carcinoma of cervix were treated with chemotherapy using a combination of bleomycin, ifosfamide and tisplatinum (BIP) . Thirty two patients were evaluable for response. 90% patients achieved subjective response.Objective response were seen in 18/ 32 (56%) patients: complete-7 (21.8%) , partial-11 (34.3%) patients. Average relative dose intensity (ARDI) for all patients as calculated by the method of Hryniuk ranged from0.4 to 0.80 (median 0.6). Further the received dose intensity (amount of drug actually received) for each patient was calculated by multiplying ARDI × duration of treatment in weeks. There was a favourable trend for achieving complete and partial responses in patients receiving higher amount of drug. Side effects to chemotherapy were mainly-nausea/ vomiting, alopecia, myelosuppression. and reversible encephalopathy and impaired renal functions. One patient died due to chemotherapy toxicity.These results indicate that BIP is an effective combination in recurrent cervical cancer with manageable associated toxicity.

目前化疗已普遍应用于复发及转移性宫颈鳞癌的治疗,但一般方案的缓解期较短且药物的毒性大。自1989年1月—1990年10月在全印度医学研究所附属肿瘤医院肿瘤内科和妇科采用BLM+IFO+DDP联合化疗方案治疗了36例经病理证实的复发及晚期宫颈鳞癌患者。32例病人可评价疗效,获得主观疗效的病人占90%,客观缓解率(56%)(18/32),其中CR(21.8%)(7/32),PR(34.3%)(11/32)。化疗的主要毒副作用为恶心呕吐、脱发、骨髓抑制,可逆性脑病及肾功能损害。除有一例病人死于化疗引起的毒副作用以外,绝大部分病人对化疗耐受良好。上述结果显示BIP方案是一个治疗复发及晚期宫颈鳞癌的有效方案,且副作用容易控制。

Objective: To investigate the molecular mechanism of cell death after radiotherapy or radiochemotherapy of locally advanced uterine cervix cancer (UCC) and to discuss the apoptosis and expression of Bax and Bcl-2 protein. Methods: Forty-nine patients with UCC were randomized into two groups: the radiotherapy (RT) group with 25 patients who were given simple external irradiation of the pelvic cavity and after-loading therapy and, the synchronal radiochemotherapy (CRT) group with 24 patients who were given 3 cycles...

Objective: To investigate the molecular mechanism of cell death after radiotherapy or radiochemotherapy of locally advanced uterine cervix cancer (UCC) and to discuss the apoptosis and expression of Bax and Bcl-2 protein. Methods: Forty-nine patients with UCC were randomized into two groups: the radiotherapy (RT) group with 25 patients who were given simple external irradiation of the pelvic cavity and after-loading therapy and, the synchronal radiochemotherapy (CRT) group with 24 patients who were given 3 cycles of chemotherapy (DDP+5-FU) besides the RT. Biopsy of the UCC was conducted before and during the treatment(group RT: after 10 Gy radiotherapy; group CRT: 10 Gy radiotherapy+{DDP+5-FU}×1 cycle). The samples obtained in the treatment were employed to determine apoptosis and the expression of Bax and Bcl-2 protein using TUNEL and immunohistochemical methods. Results: A complete response achieved 52% of the RT group and 79.2%ofCRT group, respectively (P=0.044). Before and during the treatment, the positive rates of apoptosis were increased, ranging from 24%to 60%(P=0.01) in the RT group and from 20.8% to 87.5% (P=0.000) in the CRT group, respectively. There was a significant difference between the two groups, especially during the treatment(P= 0.03). The positive rate of Bax protein was increased, too. They were 24% and 25%, before treatment, and 52% and 79.2%, after treatment, in the RT and CRT group, respectively, with a significant difference(P=0.021 and P=0.000). There was a significant correlation between the expression of Bax and apoptosis, after treatment in both groups(P=0.015,r=0.827 vs P=0.027,r=0.523). However, there was no change in the expression of Bcl-2 in the two groups (P>0.05). Conclusions: There is a better remission rate in CRT of the UCC compared to the RT. An additive or synergistic anti-cancer effect might be the mechanism of CRT, which is realized by up-regulating Bax pathway for induction of tumor-cell apoptosis.

目的:研究局部晚期宫颈鳞癌细胞对同步放化疗应答的分子机制,探讨凋亡及Bax、Bcl-2的表达。方法:49例局部晚期宫颈鳞癌患者随机分为两组:单纯放疗(RT)组25例接受盆腔外照射和后装治疗;同步放化疗(CRT)组24例除接受放疗外,还接受3个周期的化疗(DDP+5-FU)。在治疗前和治疗过程中(RT组:放疗10Gy后;CRT组:放疗10Gy+(DDP+5-FU)×1个周期)分别活检留取标本,用TUNEL法及免疫组化检测凋亡及Bax、Bcl-2的表达。结果:RT组和CRT组完全缓解率分别为52.0%和79.2.0%(P=0.044)。在治疗前和治疗过程中,RT组和CRT组凋亡阳性率均增加,分别由24%上升到60.0%(P=0.01)和20.8%增加到87.5%(P=0.000),差异显著;治疗中CRT组较RT组增加更加明显(P=0.03)。Bax的表达亦增加,分别由24.0%上升到52.0%(P=0.021)和25.0%增加到79.2%(P=0.000),差异显著;CRT组较RT组增加的更显著(P=0.044)。两组在治疗中,凋亡的阳性率和Bax的阳性表达密切相关,CRT组较RT组相关性...

目的:研究局部晚期宫颈鳞癌细胞对同步放化疗应答的分子机制,探讨凋亡及Bax、Bcl-2的表达。方法:49例局部晚期宫颈鳞癌患者随机分为两组:单纯放疗(RT)组25例接受盆腔外照射和后装治疗;同步放化疗(CRT)组24例除接受放疗外,还接受3个周期的化疗(DDP+5-FU)。在治疗前和治疗过程中(RT组:放疗10Gy后;CRT组:放疗10Gy+(DDP+5-FU)×1个周期)分别活检留取标本,用TUNEL法及免疫组化检测凋亡及Bax、Bcl-2的表达。结果:RT组和CRT组完全缓解率分别为52.0%和79.2.0%(P=0.044)。在治疗前和治疗过程中,RT组和CRT组凋亡阳性率均增加,分别由24%上升到60.0%(P=0.01)和20.8%增加到87.5%(P=0.000),差异显著;治疗中CRT组较RT组增加更加明显(P=0.03)。Bax的表达亦增加,分别由24.0%上升到52.0%(P=0.021)和25.0%增加到79.2%(P=0.000),差异显著;CRT组较RT组增加的更显著(P=0.044)。两组在治疗中,凋亡的阳性率和Bax的阳性表达密切相关,CRT组较RT组相关性更强(P=0.015,r=0.827:P=0.027,r=0.523),但两组Bcl-2的表达无变化(P>0.05)。结论:局部晚期宫颈鳞癌,CRT比RT有更好的缓解率,其机制可能是化疗和放疗有协同作用,通过上调Bax通路诱导了肿瘤细胞的凋亡。

 
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