肾间质炎症 renal tubulointerstitial inflammation(1)   renal tubulointerstitial inflammation      Protective effects of rosiglitazone on renal tubulointerstitial inflammation and fibrosis in rats with unilateral ureteral obstruction      罗格列酮对单侧输尿管梗阻大鼠肾间质炎症及其纤维化的保护作用 短句来源   “肾间质炎症”译为未确定词的双语例句      (6) interstitial inflammatory cells infiltration(infl).      (6)肾间质炎症细胞浸润(infl); 短句来源      2 The degree of interstitial cellular infiltration in IgAN with HBAg positive group was significantly more serious compared with negative group. (P<0.05);      2 HBAg阳性组肾间质炎症程度明显高于阴性组(P<0.05); 短句来源      Conclusions:YSJZC can reduce lipid,improve renal function and pathology.      结论 :益肾降脂胶囊具有降低血脂、改善肾功能、减轻肾间质炎症、促进受损组织恢复功能 短句来源      Overexpression of Bcl-2 in renal tissues of LN might play an important role in the process of glomerular hypercellularity and interstitial infiltration of inflammatory cells.      Bcl-2高表达在LN肾小球细胞增殖及肾间质炎症细胞浸润过程中可能起重要作用。 短句来源      Objective To characterize the expression of surfactant protein A (SP-A) in normal and acute pyelonephritic rat kidneys and to study the correlation of infection and inflammation with SP-A expression.      目的探讨表面活性蛋白A(SP-A)在肾组织中的表达部位及其表达变化与肾组织感染、肾间质炎症间的关系。 短句来源 更多          相似匹配句对      (6) interstitial inflammatory cells infiltration(infl).      (6)肾间质炎症细胞浸润(infl); 短句来源      Progress of Iinflammatory Factors in Renal Tubulointerstitial Fibrosis      炎症因子在肾小管间质纤维化中的研究进展 短句来源      Hyperemia was found in the kidney mesenchyme.      肾间质血管充血。 短句来源      The development of renal interstitial fibrosis involves the following steps:firstly, renal injury and inflammation;      肾间质纤维化的发生有4个步骤:①损伤和炎症; 短句来源      Renal biopsy revealed acute tubular necrosis and renal interstitial inflammation.      肾脏病理为急性肾小管坏死,肾间质炎症细胞浸润。 短句来源 查询“肾间质炎症”译词为用户自定义的双语例句     我想查看译文中含有：的双语例句 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法，我们为您准备了出自英文原文的大量英语例句，供您参考。   renal tubulointerstitial inflammation ROS have been shown to play an important role in renal tubulointerstitial inflammation and fibrosis.        Tubulointerstitial nephritis (TIN) was established in Wistar rats by direct intrarenal inoculation of TH protein. Focal TIN has heen found in all rats of the TIN group, the pathologic picture is focal infiltration of monocytes and lymphocytes, only one rat of the control group shows slight inflammatory change. Expression of T lymphocyte phenotype from the peripheral blood found there were no significant difference in the percentage of CD + 4,CD + 8,CD + 8-CD + 25 ,CD + 8-Ia the ratio of CD 4/CD... Tubulointerstitial nephritis (TIN) was established in Wistar rats by direct intrarenal inoculation of TH protein. Focal TIN has heen found in all rats of the TIN group, the pathologic picture is focal infiltration of monocytes and lymphocytes, only one rat of the control group shows slight inflammatory change. Expression of T lymphocyte phenotype from the peripheral blood found there were no significant difference in the percentage of CD + 4,CD + 8,CD + 8-CD + 25 ,CD + 8-Ia the ratio of CD 4/CD 8 between the TIN group and the control group at the 7th day after intrarenal inoculation (P<0.05). But the expression of CD 4.CD 8/CD 25 ,CD 8-Ia and CD 4/CD 8 of the TIN group were higher than that of the control group at the 14th day,which indicate that the Tlymphocyte immune response has been happened. These results showed that the system of cellular immunity has been indeed activated in the pathogenetic mechanism of TIN induced by THP. It resulted in the damage of renal tissue. 采用Ｔａｍｍ－Ｈｏｒｓｆａｌ蛋白（ＴＨＰ）直接肾内注射建立大鼠的小管间质性肾炎（ＴＩＮ）模型，ＴＩＮ组９只动物均发生小管间质性组织病理损伤，局灶性单核、淋巴细胞炎症细胞浸润；对照组仅１只轻度炎症改变。外周血Ｔ淋巴细胞免疫表型分析，术后７ｄＴＩＮ组与对照组间ＣＤ＋４、ＣＤ＋８、ＣＤ＋８－ＣＤ＋２５、ＣＤ＋８－Ｉａ＋抗原的表达及ＣＤ４／ＣＤ８的比值均无显著性差异（Ｐ＞０．０５），而术后１４ｄ、ＴＩＮ组均见升高，与对照组比差异有显著性（Ｐ＜０．０５），表明ＴＩＮ组出现Ｔ淋巴细胞的免疫应答反应和活化性细胞毒Ｔ细胞明显增加，从而证实ＴＨＰ在致ＴＩＮ免疫发病机制中，确实存在免疫系统激活，导致肾间质炎症损伤 Objective:The curative effect of IL 1ra on lupus nephritis in NZB/WF 1 mice was studied.Methods:Twelve female NZB/WF 1 mice of 13 weeks (wight 30 g～35 g) were divided randomly into 2 groups.Each mouse in the treated group was intraperitoneally injected with IL 1ra once per 2 weeks for 3 times by dosage of 100 μg (0 1 ml) per time.While in the control group injected with 0 1 ml normal saline.All the mice were killed at the age of 9 months.The kidneys were dissected and fixed with 10% neutral formalin solution... Objective:The curative effect of IL 1ra on lupus nephritis in NZB/WF 1 mice was studied.Methods:Twelve female NZB/WF 1 mice of 13 weeks (wight 30 g～35 g) were divided randomly into 2 groups.Each mouse in the treated group was intraperitoneally injected with IL 1ra once per 2 weeks for 3 times by dosage of 100 μg (0 1 ml) per time.While in the control group injected with 0 1 ml normal saline.All the mice were killed at the age of 9 months.The kidneys were dissected and fixed with 10% neutral formalin solution and embedded in paraffin.The sections were stained with HE, PAS,PASM and Masson,and then observed under light microscope respectively.Results:The control group showed moderate and severe diffuse mesangial proliferative GN with multiple characterisitcs of pathological changes.The treated group showed mild mesangioproliferative GN with simple characterisitc of pathological change in glomeruli,and the degeneration in tubules of kidneys and the inflammation in matrix of kidneys were present permanently.Conclusion:IL 1ra can obviously relieve and improve the renal damage of lupus nephritis in NZB/WF 1 mice. 目的：探讨白细胞介素１（ＩＬ１）受体拮抗剂ＩＬ１ｒａ对ＮＺＢ／ＷＦ１小鼠狼疮肾炎的治疗作用。方法：同批１３周龄，体重３０ｇ～３５ｇＮＺＢ／ＷＦ１雌鼠１２只，随机分为二组，治疗组每只小鼠每次腹腔内注射ＩＬ１ｒａ１００μｇ（０１ｍｌ），每２周１次，共３次，对照组每只每次腹腔内注射生理盐水０１ｍｌ，９月龄时活杀，取肾脏、石蜡包埋制片，作ＨＥ、ＰＡＳ、ＰＡＳＭ及Ｍａｓｏｎ三色染色，光镜观察其病理形态学变化。结果：对照组，主要为中至重度弥漫性系膜增生性肾小球肾炎并伴有病变多样性特征，ＩＬ１ｒａ治疗组，表现为轻度系膜增生肾小球肾炎，肾小球病变较单一，但肾小管变性及肾间质炎症仍持续存在。结论：ＩＬ１ｒａ对狼疮肾炎有明显减轻和改善肾小球损害作用 Objective To investigate the characteristics of the infiltration of the inflammatory cells in the development of chronic interstitial nephritis.Methods PAN was injected subcutaneously to famale Wister rats to induce animal models of chronic intersitial nephritis.Proteinuria per 24 hours respectively in 0,3,5,8,and 12 weeks after the injection was measured.Kidneys in divided groups were taken out respectively,stained with HE and labeled the monoclonal antibodies such as CD4,CD8,MΦ,ICAM 1,CD11a,CD11b,CD18,HA,TCR(α,β),MHCⅡ... Objective To investigate the characteristics of the infiltration of the inflammatory cells in the development of chronic interstitial nephritis.Methods PAN was injected subcutaneously to famale Wister rats to induce animal models of chronic intersitial nephritis.Proteinuria per 24 hours respectively in 0,3,5,8,and 12 weeks after the injection was measured.Kidneys in divided groups were taken out respectively,stained with HE and labeled the monoclonal antibodies such as CD4,CD8,MΦ,ICAM 1,CD11a,CD11b,CD18,HA,TCR(α,β),MHCⅡ with the immunohistochemical ABC technique.Resuls From the 3rd week after injection,the proteinuria per 24 hours increased gradually in experimental group.There was a significant difference compared with the control group.The infiltration of the inflammatory cells was found in renal interstitium by HE staining.The CD4,TCR and ICAM 1 positive cells incrcased at the same time.In the 8th week,the proteinuria per 24 hours reached the peak level.The interstitial fibrosis and the tubular atrophy appeared.ICAM 1,TCR,CD44,HA,CD11a,CD11b,CD18 and MHC Ⅱ positive cells reached the peak level.In the 12th week,the expression of varieties of cytokines and the quantity of the protein tended to decrease.Conclusion The infiltration and proliferation of CD4 positive cells may initiate the expression of varieties of cytokines which plays a key role in the development of chronic interstitial nephritis. 目的　探讨慢性间质性肾炎发生发展中炎症细胞浸润与粘附因子表达的特点。方法　用雌性Ｗｉｓｔｅｒ 大鼠，皮下注射嘌呤霉素氨基核苷（ＰＡＮ） 建立慢性间质性肾炎动物模型。于注射后０ 、３ 、５ 、８、１２ 周分别检测２４ 小时尿蛋白定量，分批取出肾脏作ＨＥ染色，免疫组织化学ＡＢＣ法标记单克隆抗体ＣＤ４、ＣＤ８、ＭΦ、粘附分子１（ＩＣＡＭ１） 、ＣＤ１１ａ、ＣＤ１１ｂ、ＣＤ１８、ＣＤ４４ 、ＨＡ、ＴＣＲ（α，β）、ＭＨＣⅡ。结果　实验组第３ 周始２４ 小时尿蛋白量逐渐增加，与对照组比较有显著性差异，ＨＥ染色可见肾间质炎症细胞浸润，ＣＤ４ 阳性、ＴＣＲ阳性、ＩＣＡＭ１ 阳性细胞增多，第８ 周２４ 小时尿蛋白量达高峰，出现肾间质纤维化，肾小管萎缩、ＩＣＡＭ１、ＴＣＲ、ＣＤ４４、ＨＡ、ＣＤ１１ａ、ＣＤ１１ｂ、ＣＤ１８、ＭＨＣ Ⅱ阳性细胞数达高峰；第１２ 周，多种细胞因子表达及２４ 小时尿蛋白定量呈下降趋势。结论　ＣＤ４ 阳性细胞的浸润增殖，启动了多种细胞因子表达，在慢性间质肾炎发生发展中起重要作用。   << 更多相关文摘      相关查询 肾间质 肾间质损伤的 肾间质损伤 肾间质病变 肾间质容量 肾间质成纤维细胞 肾间质损害 肾间质疾病 肾小管间质 肾间质改变 肾间质结构 肾间质细胞

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