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儿童原发性肾病综合征     
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  children ' s primary nephrotic syndrome
     Significance of C-myc Expression in Renal Tissue in Children's Primary Nephrotic Syndrome
     儿童原发性肾病综合征肾脏C-myc表达的意义
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     Objective To observe the correlation between the C-myc expression and pathologic lesions of kidney to explore the role of C-myc re-expression in children's primary nephrotic syndrome(CPNS).
     目的观察C-myc在儿童原发性肾病综合征不同肾脏病理的表达以及与肾病理损害的相关性,说明C-myc再表达在儿童原发性肾病综合征的作用。
短句来源
     Children's Primary nephrotic syndrome treated with PSS
     藻酸双酯钠治疗儿童原发性肾病综合征
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     Conclusion C-myc re-expression was involved in the pathogenesis of children's primary nephrotic syndrome, and may be related with the proliferation and regeneration of the impaired epithelial cells.
     结论C-myc再表达参与了儿童原发性肾病综合征的病理发生,可能与损伤上皮细胞的增殖与再生有关。
短句来源
     Research into the correlation factor between children's primary nephrotic syndrome and their parent.
     探讨儿童原发性肾病综合征与父母禀赋的相关性。
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  children with primary nephrotic syndrome
     Th1/Th2 imbalance in children with primary nephrotic syndrome
     儿童原发性肾病综合征与Th1/Th2细胞失衡
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     Expression and Clinical Significance of TGF-β_1 and VEGF in Children with Primary Nephrotic Syndrome
     TGF-β_1 VEGF在儿童原发性肾病综合征中的表达及其临床意义研究
短句来源
     Expression of 'TGF-β1 and VEGF and its clinical significance in children with primary nephrotic syndrome
     TGF-β1、VEGF在儿童原发性肾病综合征中的表达及其临床意义
短句来源
     Objectives To explore dynamic changes in immune function of lymphocytes in children with primary nephrotic syndrome(NS)and to clarify the clinical significance of the changes of soluble interleukin-2 receptor (sIL-2R) and T cell subsets,IL-1 ,IL-6, IL-8 in children with NS.
     目的 探讨儿童原发性肾病综合征 (NS)淋巴细胞免疫功能的动态变化和可溶性白介素 2受体(sIL 2R)、T细胞亚群、IL 1、IL 6及IL 8改变的临床意义。
短句来源
     Objective To examine the expression of angiopoietin-like protein(ANGPTL)3 in kidneys from children with primary nephrotic syndrome.
     目的研究血管生成素样蛋白3(angiopoietin-like 3 protein,ANGPTL3)在儿童原发性肾病综合征(PNS)患者肾组织中表达分布及其参与蛋白尿发生的机制。
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  children with nephrotic syndrome
     Effect of serum cytokines excreted by T helper cells of children with nephrotic syndrome on low dosage heparin calcium
     小剂量肝素钙对儿童原发性肾病综合征T辅助细胞因子的影响
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     Objective:To study the clinical significance of measuring T lymphocytes subsets in children with nephrotic syndrome(NS).
     目的 :探讨儿童原发性肾病综合征 (NS)T细胞亚群检测的临床意义。
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     Objective To discuss the risk factors for nosocomial infection in the children with nephrotic syndrome (NS) and their prevention.
     目的 探讨儿童原发性肾病综合征 (肾病 )医院感染的危险因素及其防治措施。
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  children with primary nephritic syndrome
     Angiotensin 1-converting enzyme gene polymorphism in children with primary nephritic syndrome.
     儿童原发性肾病综合征血管紧张素I转换酶基因多态性研究
短句来源
     Expressions and clinical significance of cell adhesion molecules CD44 and CD62p in children with primary nephritic syndrome
     细胞粘附分子CD44、CD62p在儿童原发性肾病综合征中的表达及临床意义
短句来源
     Objective To investigate the role of angiotensin 1-converting enzyme(ACE) gene polymorphism in children with primary nephritic syndrome(PNS).
     目的 探讨血管紧张素I转换酶 (ACE)基因多态性在儿童原发性肾病综合征 (PNS)中的作用。
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     Objective To detect the levels of fasting serum leptin and soluble leptin receptor (s-OBR) in children with primary nephritic syndrome (PNS), and to explore the effect of OBR gene expression on the levels of serum leptin and s-OBR.
     目的检测儿童原发性肾病综合征(PNS)血清瘦素(leptin)、可溶性瘦素受体(sOBR)滴度,探讨外周组织瘦素受体(OBR)mRNA表达强弱对血清sOBR、leptin状态的影响。
短句来源
     Objective The curative effect of TWH on children with primary nephritic syndrome.
     目的 为观察双倍剂量雷公藤多甙对儿童原发性肾病综合征的疗效。
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      children with primary nephrotic syndrome
    Fifty-five Arab children with primary nephrotic syndrome (PNS) were seen at two regional hospitals in Kuwait over a 5-year period.
          
    The study includes 150 children with primary nephrotic syndrome (NS), aged 16 months to 13 years with a median age of 5 years.
          
    We report the SCE of peripheral blood lymphocytes in children with primary nephrotic syndrome (NS) treated with chlorambucil.
          
    This retrospective case review of 43 children with primary nephrotic syndrome was designed to evaluate the relationship among renal ultrasound findings at presentation, subsequent corticosteroid responsiveness and histological diagnoses.
          
    We conclude that increased renal echogenicity at time of presentation is a possible indicator of corticosteroid resistance in children with primary nephrotic syndrome.
          
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      children with nephrotic syndrome
    In a pilot study 23 children with nephrotic syndrome were treated with cyclosporin A (Cs) for 6-45 months.
          
    The pharmacokinetic parameters of cyclosporine (CsA) were determined in 23 kidney transplant recipients and 19 children with nephrotic syndrome, after intravenous and oral administration.
          
    Forty-four percutaneous renal biopsies of 33 children with nephrotic syndrome were examined with light microscopy.
          
    Cortisone cataract in children with nephrotic syndrome
          
    The effect of prednisone therapy on serum levels of 25-hydroxyvitamin D [25(OH)D] and 24,25-dihydroxyvitamin D [24,25(OH)2D] was investigated in 16 children with nephrotic syndrome.
          
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    Objective The curative effect of TWH on children with primary nephritic syndrome. Methods The diseased children( n =46)were given TWH 2 mg/(kg·d)for 4 weeks and then half dose was maintained. Results During the treatment,35 children got entire remission(76.1%)and 9 improved,and the total effective rate was 97.5%.Of the 46 children,MCNS hit 11,MsPCN 27,MPGN 5 and MN 3, and their remission rates were 81.8%,81.5%,60.0%and 33.3%,respectively. Recurrence of the disease not showed during 3 month follow...

    Objective The curative effect of TWH on children with primary nephritic syndrome. Methods The diseased children( n =46)were given TWH 2 mg/(kg·d)for 4 weeks and then half dose was maintained. Results During the treatment,35 children got entire remission(76.1%)and 9 improved,and the total effective rate was 97.5%.Of the 46 children,MCNS hit 11,MsPCN 27,MPGN 5 and MN 3, and their remission rates were 81.8%,81.5%,60.0%and 33.3%,respectively. Recurrence of the disease not showed during 3 month follow up. Conclusion The curative effect of TWH is varied with the difference of renal pathology.The renal biopsy should be done for the steroid resistant patients with primary renal syndrome to get definite diagnosis.For MCNS,MsPGN and MPGN,the TWH can be used alone and can avoid side effects during the long term use of steroids.

    目的 为观察双倍剂量雷公藤多甙对儿童原发性肾病综合征的疗效。方法 对住院明确病理类型的46 例原发性肾病综合征患儿,用雷公藤多甙(2 mg/kg .d) 治疗4 周,随之减半量维持。结果 在治疗期间,35 例患儿获得缓解( 缓解率761 % ) ,9 例患儿改善,总有效率达957 % 。其中 M C N S(11 例) , Ms P G N(27 例) , M P G N(5 例) , M N(3 例) 的缓解率分别为818 % ,815 % ,600 % ,333 % 。随访3 个月内未见复发。结论 由于病理类型不同疗效相差较大,临床上对激素治疗无效或耐药的原发性肾病综合征者,应及时行肾活检以明确病理诊断,对病理类型为 M C N S、 Ms P G N 和 M P G N 者,可单用双倍剂量雷公藤多甙治疗,以避免长期服用激素的副作用,是治疗儿童原发性肾病综合征的有效方法之一。

    To find out the risk factors of hospital infection in childhood primary nephrotic syndrome(nephrosis) and prophylactico therapeutic measures, 190 cases of child patients hospitalized for nephrosis during the period lasting from 1991 to 1999 were collected. Then a retrospective analysis of the distribution of the various risk factors was made using the single factor analysis and the logistic multi factor regression model. The hospital infection rate was found to be 34.2%, with respiratory infection accounting...

    To find out the risk factors of hospital infection in childhood primary nephrotic syndrome(nephrosis) and prophylactico therapeutic measures, 190 cases of child patients hospitalized for nephrosis during the period lasting from 1991 to 1999 were collected. Then a retrospective analysis of the distribution of the various risk factors was made using the single factor analysis and the logistic multi factor regression model. The hospital infection rate was found to be 34.2%, with respiratory infection accounting for 69.7%. The single factor analysis indicated that the risk factors included quantity of urinary protein per kilogram of weight within 24 hours(urinary protein), length of stay, length of hormone usage, entities of antibiotics used and length of such usage. The multi factor analysis indicated that the risk factors included urinary protein, entities of antibiotics used and length of such usage. The authors present the view that strengthening the control of respiratory diseases, setting up clean wards, and ensuring the rational use of antibiotics are some of the key measures for reducing the rate of hospital infection. The quantity of urinary protein is a sensitive index of hospital infection in nephrosis. Once diagnosis of nephrosis has been confirmed, it is necessary to use ACH in full dose and for a complete course of treatment so as to reduce the loss of protein from the urine as soon as possible.

    为探讨儿童原发性肾病综合征 (肾病 )医院感染的危险因素及其防治措施 ,我们收集了1991~ 1999年肾病住院患儿 190例 ,采用单因素分析及Logistic多因素回归模型回顾性分析各危险因素的分布。发现医院感染率为 34 2 %,其中呼吸道感染占 6 9 7%。单因素分析危险因素为 2 4小时每公斤体重尿蛋白定量 (尿蛋白 )、住院时间、激素使用时间、抗生素使用种数及时间。多因素分析危险因素为尿蛋白、使用抗生素种数及时间。提出加强呼吸道疾病管理 ,建立洁净病房 ,合理使用抗生素是降低医院感染率的重要措施。尿蛋白定量是肾病医院感染的灵敏指标 ,肾病确诊后应足量足疗程使用肾上腺皮质激素 ,以尽快减少蛋白从尿中的丢失

    Objectives: To investgate the relationship between histological types in childhood primary nephrotic syndrome and effect of prednisone therapy. Methods: Four hundred and ten primary nephrotic syndrome patients whose pathological diognosis were established by renal biopsy in the past 16 years were analysed retrospectively in details.All patients were treated with prednisone for 8 weeks,the initial dosage were 2 mg/(kg·d) . Some laterespond patients prolonged the theray...

    Objectives: To investgate the relationship between histological types in childhood primary nephrotic syndrome and effect of prednisone therapy. Methods: Four hundred and ten primary nephrotic syndrome patients whose pathological diognosis were established by renal biopsy in the past 16 years were analysed retrospectively in details.All patients were treated with prednisone for 8 weeks,the initial dosage were 2 mg/(kg·d) . Some laterespond patients prolonged the theray for another 2 weeks, the dosage were reduced gradually after complete remmision,immunosupressive agents were added for partial remmision and no remmision patients. Results: In all 410 patients, 55 patients were minimal changes(MCNS) , 255 patients were mesangial proliferative glomerulonephritis(MsPGNS),28 patients were membranous nephropathy(MN) 29 patients were membranous proliferative glomerulonephritis(MPGN), 27 patients were focal segmental glomerulosclerosis( FSGS) , the percenage of complete response to prednisone were 91.5%,79.2%,24.1%,21.4% and 22.2% respectively. Some patients responded in prolonged therapy. Conclusions:① Renal biopasy must be done as soon as possible for childhood primary nephrotic syndrome;②To get better effect of therapy, prednisone should be used in full dosages with MCNS and MsPGN; ③Prolonged therapy of prednisone were important for MN,FSGS and MPGN patients.

    目的 :为了探讨儿童原发性肾病综合征病理类型与激素疗效之间的关系。 方法 :对 16年来经肾活检明确病理类型的 410例原发性肾病综合征患儿应用泼尼松治疗的疗效分析 ,初始剂量为 2 m g/( kg· d) ,最大量不超过6 0 mg/d,共用 8周 ,部分迟发敏感的患儿再延长 2周 ;如完全缓解则逐渐减量 ;如部分缓解或不缓解 ,则逐渐减量并加用免疫抑制剂。 结果 :410例中 ,微小病变 ( MCNS) 71例 ,系膜增生 ( Ms PGN) 2 5 5例 ,膜增殖 ( MPGN) 2 9例 ,膜性肾病 ( MN) 2 8例 ,局灶节段性肾小球硬化症 ( FSGS) 2 7例 ,对激素治疗完全效应者分别为 91.5 %、79.2 %、2 4.1%、2 1.4%和 2 2 .2 % ,后续治疗仍可取得部分疗效。 结论 :1对儿童原发性肾病综合征必须尽快明确病理类型 ;2病理类型为 MCNS和 Ms PGN者 ,宜正规、足量地使用泼尼松 ,以达到较好的治疗目的 ;3病理类型为 MN、FSGS和 MPGN者 ,亦宜足量应用 ,即使在足量应用期间疗效不高 ,在后续治疗中仍可取得一定的效果

     
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