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临床病理疗效
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  clinical pathological treatment effect
     Objective:To observe the clinical pathological treatment effect of Weikangfu Chongji on IM(Intestinal metaplasia of gastric mucosa)and ATP(Atypical proliferation)and to observe its operative mechanism.
     目的 :观察胃康复冲剂治疗胃粘膜肠化生 (IM)和不典型增生 (ATP)的临床病理疗效
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  相似匹配句对
     Pathological type of liposarcoma and its effects of clinical treatment
     脂肪肉瘤的病理类型与临床疗效
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     The result of preliminary clinical trial has been satisfactory.
     临床疗效满意.
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     The clinical and pathological effects were observed during the course.
     观察两组患者的临床病理疗效
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     (3)the clinical curative effect.
     (3)临床疗效
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     CLINICAL AND PATHOLOGICAL CHARACTER OF OLFACTORY NEUROBLASTOMA AND ANALYSIS OF THE TREATMENT EFFECT
     嗅神经母细胞瘤的临床病理特点及疗效分析
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Objective: To explore the therapeutic effect and mechanism of Weishu capsule (WSC) in treating precancerous lesions of chronic atrophic gastritis (CAG). Methods: Seventy five cases of precancerous lesions of CAG were distributed to two groups randomly, the treated group (45 patients) treated with WSC by taken orally and the control group (30 patients) treated with Weining granule (WNG) orally. The treatment course of both groups were 6 months. The clinical and pathological effects and the changes in scores...

Objective: To explore the therapeutic effect and mechanism of Weishu capsule (WSC) in treating precancerous lesions of chronic atrophic gastritis (CAG). Methods: Seventy five cases of precancerous lesions of CAG were distributed to two groups randomly, the treated group (45 patients) treated with WSC by taken orally and the control group (30 patients) treated with Weining granule (WNG) orally. The treatment course of both groups were 6 months. The clinical and pathological effects and the changes in scores of atrophy, intestinal metaplasia and its subgroups, dysplasia, carcinoembryonic antigen (CEA) and proliferating cell nuclear antigen (PCNA) expression were observed before and after treatment. Results: The total effective rate was 91% and the effective rate of atrophy, intestinal metaplasia, dysplasia in the treated group were 64%, 67% and 65% respectively, and the respective scores were lowered significantly after treatment. Compared with the control group, the difference between the two groups was statistically significant (P<0 01,P<0 05). Immunohistochemical test showed that WSC could inhibit the subgroups of intestinal metaplasia, CEA and PCNA expression significantly (P<0 01). Conclusion: WSC could significantly improve the clinical and pathological changes in the precancerous lesions of CAG. The mechanism might be related to the inducing and promoting effect of WSC on the differentiation and maturity of intestinal metaplasia cells and dysplasia cells. WSC could also inhibit and correct the abnormal proliferation of cells.

目的 :探讨胃舒胶囊对萎缩性胃炎癌前病变的治疗作用及机理。方法 :75例萎缩性胃炎癌前病变患者随机分为两组 ,治疗组 (45例 )给予胃舒胶囊口服 ,对照组 (3 0例 )给予胃宁冲剂冲服 ,疗程均为 6个月。观察两组患者临床、病理疗效 ,治疗前后萎缩、肠化、异型增生、肠化亚型和癌胚抗原 (CEA)、增殖细胞核抗原 (PCNA)表达积分值的变化。结果 :治疗组临床总有效率为 91 % ,对萎缩、肠化、异型增生的有效率分别为 64 %、67%、65 % ,并能降低其积分值 ,与对照组比较有显著性差异 (P <0 0 1 ,P <0 0 5 ) ;治疗前后免疫组化结果显示胃舒胶囊对肠化亚型和CEA、PCNA的表达也有明显的改善和阻抑作用 (P <0 0 1 )。结论 :胃舒胶囊对萎缩性胃炎癌前病变的临床症状及病理变化有显著改善作用 ,其机理可能与其诱导和促进肠化细胞、异型增生细胞的分化成熟 ,抑制和纠正细胞的异常增殖有关。

Objection: To observe the effect of Shenyi decoction in treating chronic atrophic gastritis and precancerous lesion. Methods: 75 patients with chronic atrophic gastritis were randomly divided into two groups, 45 cases in treatment group treated with Shenyi decoction and 30 cases in control group with ulcerlmin and domperidone, both for six months. The clinical and pathological curative effects and the changes of atrophy, intestinal metaplasia and heterohyperplastic before and after treatment were detected. Result:...

Objection: To observe the effect of Shenyi decoction in treating chronic atrophic gastritis and precancerous lesion. Methods: 75 patients with chronic atrophic gastritis were randomly divided into two groups, 45 cases in treatment group treated with Shenyi decoction and 30 cases in control group with ulcerlmin and domperidone, both for six months. The clinical and pathological curative effects and the changes of atrophy, intestinal metaplasia and heterohyperplastic before and after treatment were detected. Result: In the treatment group, the total effective rates were 91%, and the effective rates in atrophy, intestinal metapalasia and heterohyperplastic were 64%,67%and 65%respectively, which had a significantly differences with that of the control group(P<0.05). Conclusion: Shenyi decoction has an improvement in treating chronic gastritis and precancerous lesion, even hasn't obviously toxic and side effect.

目的 :观察参薏汤对慢性萎缩性胃炎及癌前病变的作用。方法 :将75例慢性萎缩性胃炎患者随机分为两组 ,治疗组45例给予参薏汤 ,对照组30例给予硫糖铝、吗叮啉治疗 ,疗程均为6个月。观察两组患者临床、病理疗效 ,治疗前后萎缩、肠化、异型增生等变化。结果 :治疗组临床总有效率为91 % ,对萎缩、肠化、异型增生的有效率分别为64 %、67 %、65% ,与对照组比较有显著性差异(P<0.05)。结论 :参薏汤对慢性萎缩性胃炎及癌前病变有改善作用 ,且无明显毒副作用。

Objective:To observe the clinical pathological treatment effect of Weikangfu Chongji on IM(Intestinal metaplasia of gastric mucosa)and ATP(Atypical proliferation)and to observe its operative mechanism.Methods:61 patients,of which the treatment group consists,were diagnosed by means of integrated traditional Chinese and western medicine and planning treatment according to diagnosis(PDCD).The amount of Weikangfu Chongji taken was adjusted according to different syndromes.54 patients,of which the control group...

Objective:To observe the clinical pathological treatment effect of Weikangfu Chongji on IM(Intestinal metaplasia of gastric mucosa)and ATP(Atypical proliferation)and to observe its operative mechanism.Methods:61 patients,of which the treatment group consists,were diagnosed by means of integrated traditional Chinese and western medicine and planning treatment according to diagnosis(PDCD).The amount of Weikangfu Chongji taken was adjusted according to different syndromes.54 patients,of which the control group consists,took Weisu chongji without considering PTCD.Besides,Gastroscopy was conducted both before and after the treatment.Mucosa was taken from antral region of stomach for pathological diagnosis,for IM classification through histochemical staning.Results:The symptomatic and pathological treatment effect of treatment group are markedly superior to those of the control group( P <0.05~0.001).Conclusion:Weikangfu Chongji can reverse IM and ATP and imporve clinical symptoms.

目的 :观察胃康复冲剂治疗胃粘膜肠化生 (IM)和不典型增生 (ATP)的临床病理疗效。 方法 :中西医证病结合 ,辨证施治 ,随证加减应用胃康复冲剂作为治疗组 (6 1例 ) ,不予辨证用胃苏冲剂作为对照组 (5 4例 )。治疗前后均作胃镜检查 ,取胃窦部粘膜作病理诊断、肠化生和不典型增生的病理分度 ,以及组织化学染色肠化生分型。 结果 :治疗组的症状疗效和病理疗效明显优于对照组 ,P <0 .0 5~ 0 .0 0 1。 结论 :胃康复冲剂能够在改善临床症状的同时逆转肠化生和不典型增生

 
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