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基本氨基酸
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  basic amino acid
     The association of a polymorphism in the paired basic amino acid cleaving enzyme 4 gene and hypertension
     偶合基本氨基酸裂解酶4基因多态性与高血压的相关性研究
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     NO is generated by the conversion of the basic amino acid, L - arginine to L - citrulline in a reaction catalysed by a family of isoenzymes arising from three different genes. They are eNOS , iNOS and bNOS.
     NO在体内由基本氨基酸L-精氨酸合成,L-精氨酸反应生成L-瓜氨酸和NO的过程由三种NO合酶催化(NOS),其中两个是少量基本存在的(eNOS和bNOS),一个为大量诱生型的(iNOS)。
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  “基本氨基酸”译为未确定词的双语例句
     The results showed that 27%(23/85) PZA-resistant isolates had pncA mutations which altered the primary amino acid sequence of pyrazinamidase.
     PZA耐药株有27%(23/85)发生了pncA基因突变,从而导致吡嗪酰胺酶基本氨基酸序列的改变,突变分布在pncA基因开读框架17-546位的核苷酸。
短句来源
     A Research of Amino Acid Order Based on Amino Acid Classification
     基于氨基酸分类的基本氨基酸秩序的研究
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     Aspartic acid is one of the twenty kinds of basic aminos which make up the protein, it has been used in biochemical reagents and clinical medicine .
     天冬氨酸是构成蛋白质的20种基本氨基酸之一,它在生化试剂和临床医学方面具有广泛的应用。
短句来源
     Objective To investigate the relationship between polymorphisms in the paired amino acid cleaving enzyme (PACE) 4 gene and hypertension.
     目的 研究高血压易感位点 2 (HYT2 )内人类偶合基本氨基酸裂解酶 4 (PACE4 )基因多态性与高血压的关系。
短句来源
     Methods Plasmid containing mutant p53 GFP was constructed by site directed mutagenesis by which 5 amino scid residues in the nuclear localization signal (NLS) were replaced by alanine to produce mutant p53KRKKK GFP.
     方法 由直接点突变的方法构建质粒 ,将决定p5 3 GFP核位置信号 (NLS)的两个部分 5个基本氨基酸 (赖氨酸和精氨酸 )单一替换为丙氨酸 ,构建了p5 3 NLS突变型p5 3KRKKK GFP ,并且经DNA序列确定。
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  相似匹配句对
     A Research of Amino Acid Order Based on Amino Acid Classification
     基于氨基酸分类的基本氨基酸秩序的研究
短句来源
     Amino acids are the primary units of proteins.
     氨基酸是生命系统中蛋白质的基本结构单位 .
短句来源
     CHEMICAL SYNTHESIS OF AMINO ACIDS
     氨基酸的化学合成
短句来源
     Biogeochemistry of Amino Acids
     《氨基酸生物地球化学》
短句来源
     (2)essential features;
     基本特征;
短句来源
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  basic amino acid
The structure of the basic amino acid cluster located within the HA cleavage site was identical in all isolates: QGERRRKKR.
      
The absence of Cys residues and a high content of basic amino acid residues are characteristic of their amino acid compositions.
      
The four peptides are: the dipeptide Ala-Phe, the acidic tripeptide Ala-Phe-Asp, the basic tripeptide His-Ala-Phe and the tetrapeptide His-Ala-Phe-Asp which contains both an acidic and a basic amino acid moieties.
      
The absence of a basic amino acid in position 50 suggests the rhesus sequence may be cleaved to yield GAP peptides different from the human placenta.
      
Since then, seven PCs have so far been discovered that cleave at the carboxy-terminal of a basic amino acid characterized by the consensus sequence Arg/Lys/His-X-X/Lys/Arg-Arg↓, where X denotes any amino acid other than Cys.
      
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Several methods(MOLE method, titration, Cl-electrode) were used to determine Cl-content. The best one was discussed in detail and proved to be suitable for amino acid mother liquor by acidizing pighair and extracting cystine, before and after desatination(simply named mother liquorⅠand Ⅱ), and also for amino acid powder crystallized from mother liquor Ⅱ

解释了蛋白氨基酸和非蛋白氨基酸,并着重论述了非蛋白氨基酸的生物合成及其生物学作用。非蛋白氨基酸的生物合成主要通过基本氨基酸合成后的修饰、代谢及消旋作用产生,其生物学作用主要表现在能合成其他含氮物质、储藏氮和运输氮、储能、组成细菌细胞壁、毒性作用及药物作用等方面。

Objective To investigate the relationship between polymorphisms in the paired amino acid cleaving enzyme (PACE) 4 gene and hypertension. Methods In this casecontrol study two independent populations were used to analyze the association between 7 single nucleotide polymorphisms (SNP) and hypertension. There were 163 cases and 125 controls in population 1 and 508 cases and 568 controls in population 2, respectively. 7 SNPs were genotyped and their associations with hypertension were assessed in population...

Objective To investigate the relationship between polymorphisms in the paired amino acid cleaving enzyme (PACE) 4 gene and hypertension. Methods In this casecontrol study two independent populations were used to analyze the association between 7 single nucleotide polymorphisms (SNP) and hypertension. There were 163 cases and 125 controls in population 1 and 508 cases and 568 controls in population 2, respectively. 7 SNPs were genotyped and their associations with hypertension were assessed in population 1, and evaluated again in population 2. Results SNP rs1871977 of PACE 4 gene was associated with hypertension in the two populations. Multivariate logistic regression analysis showed that compared to the CC genotype, the AA genotype was associated with a low risk of hypertension (in population 1, OR=0.2, 95% CI: 0.1-0.6; in population 2, OR=0.5, 95% CI:0.3-1.0). Multivariate linear regression analysis showed that compared to the CC genotype, the AA genotype was associated with a low diastolic blood pressure (in population 1, β=-14.9, SE=3.3; in population 2, β=-5.6, SE=2.3). Conclusions SNP rs1871977 of PACE 4 gene may be in linkage disequilibrium with a nearby functional mutation so that it seems to be a marker of hypertension susceptible gene mutation. The results of this study provided important clues for identifying mutation influencing blood pressure in this gene.

目的 研究高血压易感位点 2 (HYT2 )内人类偶合基本氨基酸裂解酶 4 (PACE4 )基因多态性与高血压的关系。方法 在两个相互独立的人群中 ,分别采用病例 对照的研究方法 ,研究PACE4基因内 7个单核苷酸多态性 (SNP)与高血压的相关性。第一个研究人群包括 1 6 3例病例及1 2 5名对照 ,第二个人群包括 5 0 8例病例及 5 6 8名对照。我们在第一个人群中对PACE4基因 7个SNP与高血压的关系进行初步检测 ,并在第二个人群中进行验证。结果 在两个研究人群中均发现 ,PACE4基因rs1 871 977A/C多态性与高血压具有相关性。多因素Logistic回归显示 ,与CC基因型相比 ,AA基因型可以使高血压的危险性降低 :在第一个人群中 ,OR =0 2 ,95 %CI :0 1 - 0 6 ;在第二个研究人群中 ,OR =0 5 ,95 %CI :0 3- 1 0。多因素线性回归显示 ,携带AA基因型个体舒张压明显低于携带CC基因型个体 :在第一个人群中 ,β =- 1 4 9,SE =3 3;在第二个人群中 ,β =- 5 6 ,SE=2 3。结论...

目的 研究高血压易感位点 2 (HYT2 )内人类偶合基本氨基酸裂解酶 4 (PACE4 )基因多态性与高血压的关系。方法 在两个相互独立的人群中 ,分别采用病例 对照的研究方法 ,研究PACE4基因内 7个单核苷酸多态性 (SNP)与高血压的相关性。第一个研究人群包括 1 6 3例病例及1 2 5名对照 ,第二个人群包括 5 0 8例病例及 5 6 8名对照。我们在第一个人群中对PACE4基因 7个SNP与高血压的关系进行初步检测 ,并在第二个人群中进行验证。结果 在两个研究人群中均发现 ,PACE4基因rs1 871 977A/C多态性与高血压具有相关性。多因素Logistic回归显示 ,与CC基因型相比 ,AA基因型可以使高血压的危险性降低 :在第一个人群中 ,OR =0 2 ,95 %CI :0 1 - 0 6 ;在第二个研究人群中 ,OR =0 5 ,95 %CI :0 3- 1 0。多因素线性回归显示 ,携带AA基因型个体舒张压明显低于携带CC基因型个体 :在第一个人群中 ,β =- 1 4 9,SE =3 3;在第二个人群中 ,β =- 5 6 ,SE=2 3。结论 PACE4基因rs1 871 977A/C多态性可能通过与其附近的某一功能基因突变发生了连锁不平衡而成为高血压易感基因突变的标记物。本研究为今后在这一基因内寻找影响血压的基因突变提供了重要的线索。

Objective To study the function of p53 nuclear import in murine double minute 2(MDM2) mediated ubiquitination and degradation. Methods Plasmid containing mutant p53 GFP was constructed by site directed mutagenesis by which 5 amino scid residues in the nuclear localization signal (NLS) were replaced by alanine to produce mutant p53KRKKK GFP. After being fused with pEGF Nuc(NLS containing SV40)to produce p53KRKKK NLS GFP,it was transfected into U20S cells. Localization, degradation and ubiquitination of p53...

Objective To study the function of p53 nuclear import in murine double minute 2(MDM2) mediated ubiquitination and degradation. Methods Plasmid containing mutant p53 GFP was constructed by site directed mutagenesis by which 5 amino scid residues in the nuclear localization signal (NLS) were replaced by alanine to produce mutant p53KRKKK GFP. After being fused with pEGF Nuc(NLS containing SV40)to produce p53KRKKK NLS GFP,it was transfected into U20S cells. Localization, degradation and ubiquitination of p53 and MDM2 proteins were assessed by fluorescent staining, Western blot and ubiquitination analysis in MDM2 or MDM2 NLS co transfected U20S cells. Results p53KRKKK GFP was located in cytoplasm, and was not degraded by either MDM2 or MDM2 NLS mutation, but could be ubiquitinated; p53KRKKK NLS GFP could be brought back to nucleus by SV 40 NLS, so could be both degraded and ubiquitinated by either MDM2 or MDM2 NLS; Wild type p53 and mutant NLS could be ubiquitinated by either wild type MDM2 or mutant NLS. Ubiquitination happened to be even more efficient in cytoplasm when p53KRKKK and MDM2 NLS co localization, but not degraded. Conclusion Nuclear import is required for p53 degradation mediated by MDM2, but not for ubiquitination. p53 can be efficiently ubiquitinated in cytoplasm.

目的 研究p5 3核输入功能在鼠双微体 2 (murinedoubleminute 2 ,MDM2 )调节的p5 3降解与泛素化中的作用。方法 由直接点突变的方法构建质粒 ,将决定p5 3 GFP核位置信号 (NLS)的两个部分 5个基本氨基酸 (赖氨酸和精氨酸 )单一替换为丙氨酸 ,构建了p5 3 NLS突变型p5 3KRKKK GFP ,并且经DNA序列确定。用DNA克隆技术将p5 3KRKKK与pEGF Nuc融合 ,构建了p5 3KRKKK NLS GFP ,然后分别转染U2OS细胞 ,在荧光显微镜下直接观察活细胞的蛋白表达部位 ;同时用间接免疫荧光染色、Westernblot和泛素化分析的方法 ,观察p5 3KRKKK与MDM2野生型或MDM2 NLS突变型共转染U2OS细胞时的蛋白表达部位、降解和泛素化现象。结果 p5 3KRKKK GFP蛋白表达完全在细胞浆 ,并且不能被野生型和NLS突变型的MDM2降解 ,但是可以被泛素化。p5 3KRKKK NLS GFP可以使p5 3蛋白表达重新回到细胞核 ,此时能被MDM2野生型和NLS突变型降解和泛素化。p5 3野生型和NLS突变型均可被...

目的 研究p5 3核输入功能在鼠双微体 2 (murinedoubleminute 2 ,MDM2 )调节的p5 3降解与泛素化中的作用。方法 由直接点突变的方法构建质粒 ,将决定p5 3 GFP核位置信号 (NLS)的两个部分 5个基本氨基酸 (赖氨酸和精氨酸 )单一替换为丙氨酸 ,构建了p5 3 NLS突变型p5 3KRKKK GFP ,并且经DNA序列确定。用DNA克隆技术将p5 3KRKKK与pEGF Nuc融合 ,构建了p5 3KRKKK NLS GFP ,然后分别转染U2OS细胞 ,在荧光显微镜下直接观察活细胞的蛋白表达部位 ;同时用间接免疫荧光染色、Westernblot和泛素化分析的方法 ,观察p5 3KRKKK与MDM2野生型或MDM2 NLS突变型共转染U2OS细胞时的蛋白表达部位、降解和泛素化现象。结果 p5 3KRKKK GFP蛋白表达完全在细胞浆 ,并且不能被野生型和NLS突变型的MDM2降解 ,但是可以被泛素化。p5 3KRKKK NLS GFP可以使p5 3蛋白表达重新回到细胞核 ,此时能被MDM2野生型和NLS突变型降解和泛素化。p5 3野生型和NLS突变型均可被MDM2野生型和NLS突变型泛素化 ,当p5 3KRKKK和MDM2 NLS同时表达在细胞浆时 ,p5 3蛋白出现了更高效率的泛素化 ,但不能被降解。结论 p5 3核输入对由MDM2调节的p5 3降解是必须的 ;MDM2调节的p5 3泛素化可以出现在细胞浆 ,而且效率更高。

 
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