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   儿童肾病综合征 在 泌尿科学 分类中 的翻译结果: 查询用时:0.615秒
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  children with nephrotic syndrome
    FOLLOW UP SURVEY OF 244 CHILDREN WITH NEPHROTIC SYNDROME
    244例儿童肾病综合征临床病理与疗效的随访观察
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    Abnormalities of lipid metabolism in children with nephrotic syndrome
    儿童肾病综合征的血脂代谢异常
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    METHODOLOGY 244 children with nephrotic syndrome, who had been diagnosed with renal biopsy between Feb.1978 and Dec.1993, were followed up for an averaged time of 42.8 months after 6~18 months' steroid therapy. All patients were treated with standard prednisone therapy (1.5~2 mg/kg·d -1 for 8 weeks and then tail off ) or plus nitrogen mustard (in refractory cases) in combination with the traditional Chinese medicine.
    方法:对1978年2月~1993年12月经肾穿刺确诊病理类型的244例儿童肾病综合征进行随访,停用强的松2年1个月~8年6个月,平均42.8个月。
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    Objective To investigate the abnormalities of lipid metabolism in children with nephrotic syndrome(NS), and relationship between the abnormalities and clinical state and prognosis of NS.
    探讨儿童肾病综合征血脂代谢异常的特点及其与肾病临床状态和预后的关系。
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  infantile nephrotic syndrome
    Objective:To explore the relationship between tumor necrosis factorα(TNFα) and infantile nephrotic syndrome and to observe the effect of TCM WM therapy on TNFα level.
    目的:探讨肿瘤坏死因子α(TNFα)与儿童肾病综合征发病关系及中西医结合治疗对TNFα的影响。
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    complicated by infection at active stage 〔(4585±510)pmol/L〕was higher than that of no complicating infection 〔(3471±939)pmol/L〕,P<001.Conclusions:TNFα was contributed to pathologic damage process of infantile nephrotic syndrome.
    活动期伴感染者(45.85±5.10)pmol/L显著高于不伴感染者(34.71±9.39)pmol/L,P<0.01。 结论:TNFα参与了儿童肾病综合征的病理损伤过程;
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OBJECTIVE Long term prognosis of childhood with nephrotic syndrome has not been systematically studied in this country. In this study, 244 nephrotic children who were diagnosed with renal biopsy were followed up with respect to the renal pathology and therapy in these children. METHODOLOGY 244 children with nephrotic syndrome, who had been diagnosed with renal biopsy between Feb.1978 and Dec.1993, were followed up for an averaged time of 42.8 months after 6~18 months' steroid therapy. All patients were...

OBJECTIVE Long term prognosis of childhood with nephrotic syndrome has not been systematically studied in this country. In this study, 244 nephrotic children who were diagnosed with renal biopsy were followed up with respect to the renal pathology and therapy in these children. METHODOLOGY 244 children with nephrotic syndrome, who had been diagnosed with renal biopsy between Feb.1978 and Dec.1993, were followed up for an averaged time of 42.8 months after 6~18 months' steroid therapy. All patients were treated with standard prednisone therapy (1.5~2 mg/kg·d -1 for 8 weeks and then tail off ) or plus nitrogen mustard (in refractory cases) in combination with the traditional Chinese medicine. RESULTS Satisfactory results were observed in nephrotic children treated with the combination of steroids or mustard with the traditional Chines medicine, both in the short and long term therapy. At the end of prednisone treatment, 222 cases (91 %) were in completely remission, 17 cases (7 %) in partial remission and 5 cases (2 %) resistant. At the end of the follow up survey, 131 cases (53.7 %) were in clinical recovery, 80 cases (32.8 %) in completely remission, 19 cases (8.6 %) were in relapse, 7(2.9 %) in partial remission, 4 (1.6 %) resistant and 3 (1.2 %) worsen. The near term and long term results in simple type nephrotic syndrome were better than in nephritis type nephrotic syndrome ( P <0.05), the therapeutic effects was better in patients with mild mesangial proliferative glomerulonephritis than in patients with middle or severe mesangial proliferative glomerulonephritis ( P <0.05), while patients with membranous proliferative glomerulonephritis got worse. No statistical difference of effectiveness was found in membranous nephropathy and focal segmental glomerulosclerosis ( P <0.05). CONCLUSION This combined therapy was proved to be long term effective in most nephrotic children. Clinical patterns, histological types and damage digress were related both to the near term and the long term therapeutic effectiveness.

目的:观察儿童肾病综合征的临床病理与远期疗效。方法:对1978年2月~1993年12月经肾穿刺确诊病理类型的244例儿童肾病综合征进行随访,停用强的松2年1个月~8年6个月,平均42.8个月。结果:经强的松,氮芥和中药联合治疗近、远期疗效较好。停用强的松时完全缓解222例(91%),随访时基本治愈131例(53.7%),完全缓解80例(32.8%),共86.5%,复发19例(8.6%)(其中微小病变复发14.8%),部分缓解7例(2.9%),激素依赖4例(1.6%),恶化3例(1.2%)。结论:肾病综合征的远期疗效大多数良好,临床分型和病理类型及病变程度与疗效密切相关,单纯性肾病的近、远期疗效较肾炎性肾病好(P<0.05),中度系膜增生性肾炎,中度系膜增生性IgM肾病与轻度者相比疗效相差显著(P<0.05),膜增生性肾炎疗效较差,其它病理类型疗效差异不明显(P>0.05)。

Objective To investigate the abnormalities of lipid metabolism in children with nephrotic syndrome(NS), and relationship between the abnormalities and clinical state and prognosis of NS. Methods Fasting serum lipid profiles were investigated in 30 children with nephrotic syndrome before treatment, after 8 weeks of steroid therapy and 12 months after recovery. Ten children with acute glomerulonephritis(AGN) and 10 healthy children (aged 2 ̄12 years) were also studied as diseased and normal control groups. Results...

Objective To investigate the abnormalities of lipid metabolism in children with nephrotic syndrome(NS), and relationship between the abnormalities and clinical state and prognosis of NS. Methods Fasting serum lipid profiles were investigated in 30 children with nephrotic syndrome before treatment, after 8 weeks of steroid therapy and 12 months after recovery. Ten children with acute glomerulonephritis(AGN) and 10 healthy children (aged 2 ̄12 years) were also studied as diseased and normal control groups. Results The nephrotic children showed significantly increased levels of total serum cholesterol (TC), lowdensity lipoprotein cholesterol (LDLC), very lowdensity lipoprotein cholesterol (VLDLC), triglycerides (TG) and apolipoproteins A1 and B100 (apoA1 and apoB100), while their highdensity lipoprotein cholesterol (HDLC) level was not different from that of controls. The levels of LDLC and TC were inversely corelated with those of serum albumin. After treatment with prednisone for eight weeks and lowlipid diet, children with steroidsensitive NS had a significant elevation of HDLC and reduction of TC, LDLC, VLDLC, TG and apoB100, compared with pretreatment levels, though the values were still higher than control. The lipid levels were completely normal after six months. Children with partial response to steroid therapy had persistent elevation of LDLC and TC at 8 weeks and 12 months. Conclusions The abnormalities of lipid metabolism may persist for a long time in nephrotic children, and lead to an increased risk of glomerulosclerosis and atherosclerosis, and it is necessary to treat steroid partial response nephrotic children with lowering hyperlipemia agents.

探讨儿童肾病综合征血脂代谢异常的特点及其与肾病临床状态和预后的关系。方法对30例肾病综合征患儿血清脂类、脂蛋白及载脂蛋白水平追踪观察。结果肾病发作期以TC和LDL-C水平显著升高为主,其升高幅度与血清白蛋白浓度呈显著负相关(r=-0.55,P<0.05;r=-0.61,P<0.01),伴有VLDL-C、TG、apo-B100升高,LDL-C无明显变化。激素治疗8周后激素敏感型患儿HDL-C明显升高(P<0.01),其余脂类水平降低,6月后完全恢复正常;非激素敏感型患儿治疗8周后血脂各项指标与治疗前比较无显著差异,3/6例TC、HDL-C水平增高持续至1年后。结论肾病患儿脂类代谢异常可持续很长时间并增加肾小球硬化和动脉硬化的危险性,有必要给予非激素敏感型患儿降脂药物治疗

ffecting factors of hormone induced remission in nephrotic syndrome in 68 children were analyzed with multifactorial stepwise regression analysis. Results showed that total cholesterol in blood, age, platelet count in peripheral blood and white cell count are the major factors affecting NS. It is suggested that anticoagulant and antilipemic therapy and active control of infection on the basis of hormone therapy are helpful to promote NS remission. 

运用多因素逐步回归分析法,对68例儿童肾病综合征激素诱导缓解的影响因素进行分析。结果显示血总胆固醇、年龄、外周血血小板数和白细胞数是影响NS缓解的主要因素,提示在激素治疗的基础上给予抗凝、降脂治疗及积极控制感染有利于促进NS缓解。

 
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