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大鼠心脏移植
相关语句
  rat cardiac allograft
     Experimental Studies on the Gene Treatiment of Rat Cardiac Allograft
     大鼠心脏移植基因治疗的实验研究
短句来源
     Synergistic effect of tripterium wilfordii hook f and cyclosporine A on heterotopic rat cardiac allograft survival
     雷公藤多甙及环孢素A在大鼠心脏移植中的协同作用
短句来源
     Combined use of vitamin D-derived drug and DBMC to induce tolerance on heterotopic rat cardiac allograft
     维生素D衍生物联合供者骨髓细胞输注诱导异基因大鼠心脏移植免疫耐受
短句来源
     Inhibitory effect of L-arginine on cardiac allograft vasculopathy in a rat cardiac allograft model
     左旋精氨酸对大鼠心脏移植模型移植物血管病变的抑制作用(英文)
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  “大鼠心脏移植”译为未确定词的双语例句
     Expression of Fas, FasL, Bcl-2 and Bax in acute cardiac allograft rejection in rats
     大鼠心脏移植中Fas、FasL、Bcl-2和Bax的表达及意义
短句来源
     Expression of Interleukin-10,-2 and TGF-β_1 in the Grafts of Rats during Acute Rejection of Heart Transplantation
     白细胞介素2、10和转化生长因子β_1在大鼠心脏移植急性排斥反应中的表达
短句来源
     Monitoring CD15s and CD44 in Peripheral Blood T Cell of Rat Heart Transplantation Rejection Model
     大鼠心脏移植排斥模型T淋巴细胞CD15s、CD44表达
短句来源
     The Study of Immune Tolerance by CD40-mAb Blockading CD40-CD40L Interaction in Guinea-pig to Rat Heart Transplantation
     阻断CD40/CD40L通路诱导豚鼠到大鼠心脏移植免疫耐受的研究
短句来源
     Induction of cardiac transplantation tolerance by CTLA4Ig adenovirus gene therapy in allogeneic rats
     CTLA4Ig腺病毒基因治疗诱导异基因大鼠心脏移植耐受
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  相似匹配句对
     Cardiac allograft and arteriosclerosis in rat
     大鼠心脏移植与动脉硬化
短句来源
     Improved technique of heterotopic heart transplantation model in rats
     大鼠腹腔心脏移植技术的改良
短句来源
     An improved method of abdominal heart transplantation in rats
     大鼠腹部心脏移植模型的改进
短句来源
     Modification of a rat heterotopic heart transplantation model
     大鼠异位心脏移植模型的改进
短句来源
     The Experiment and Development of Modified Model of Heterotopic Cardiac Transplantation in Rats
     大鼠异位心脏移植模型的制作
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  rat cardiac allograft
In the present communication, we report that SASP has an immunomodulatory capacity in an experimental rat cardiac allograft model.
      
The superior effect of the combination of FK 506 and deoxyspergualin on rat cardiac allograft survival
      
In this present study, the effects of FK 506 and 15-deoxyspergualin (DSG), with respect to dose, timing, and combination, were investigated in an ACI-to-LEW rat cardiac allograft model.
      
Enhancement of the immunosuppressive effect of cyclosporin A by ciprofloxacin in a rat cardiac allograft transplantation model
      
To obtain an in vivo application of these findings, graft survival was studied by performing rat cardiac allograft transplantations in the presence or absence of CyA.
      
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The effect of Rapamycin (RPM) as immunosuppressant was evaluated in heart allotransplantation in SD.Wistar rats of the three groups. Experimental group was give RPM, control groups included untreated group and Cyclosporine (CsA)-treated group. The results showed RPM was a potent immunosuppressive agent which was superior to CsA in therapeutic effects.RPM had a strong immunosuppressive effect and significantly prolonged allograft heart survival.RPM not only prevented a1lograft rejection, but also reversed the...

The effect of Rapamycin (RPM) as immunosuppressant was evaluated in heart allotransplantation in SD.Wistar rats of the three groups. Experimental group was give RPM, control groups included untreated group and Cyclosporine (CsA)-treated group. The results showed RPM was a potent immunosuppressive agent which was superior to CsA in therapeutic effects.RPM had a strong immunosuppressive effect and significantly prolonged allograft heart survival.RPM not only prevented a1lograft rejection, but also reversed the ongoing allograft rejection.PRM had a good syncrgism with CsA in trcating graft rcjcction.

为了探讨雷帕霉素(RPM)对SD、Wistar大鼠心脏移植的免疫抑制效果,将大鼠分为3组,实验组给RPM,对照组包括来治疗组及环抱素A(CsA)组。结果显示RPM为一强效免疫抑制剂,治疗效果优于CsA。RPM具有强大的免疫抑制效果,可显著延长心脏移植物的存活时间。RPM不仅预防移植物的排斥反应,而区可逆转发生的移植物排斥反应。RPM与CsA治疗排斥反应具有协同作用。

The mouse heart was transplanted into the neck of rat using the cuff technique described by Heron with a little modification. The graft accending aorta to the host common carotiel artery and the graft pulmonary artery to the host exteral jugular vein were performed. 22 times of formal transplantation were done with the successful rate being 86%. The mean survival time was 2 .10±0. 80 days. The method is easy, quick and reliable- The superficial cervical localigation of the transplant is easily observed. This...

The mouse heart was transplanted into the neck of rat using the cuff technique described by Heron with a little modification. The graft accending aorta to the host common carotiel artery and the graft pulmonary artery to the host exteral jugular vein were performed. 22 times of formal transplantation were done with the successful rate being 86%. The mean survival time was 2 .10±0. 80 days. The method is easy, quick and reliable- The superficial cervical localigation of the transplant is easily observed. This is a good model to observe the hyperacute rejection(HAR),to induce the translantation tolerance, and to screen the new immunosuppressive agents.

采用Heron袖套法进行异种(小鼠→大鼠)心脏移植,异位移植于颈部皮下,供体主动脉接受体颈内动脉,供体肺动脉接受体项外静脉,并对手术方法进行了部分改进。进行正式手术22次,成功率86%,移植后平均存活时间2.10±0.80天;该方法简单、迅速、可靠,移植于颈部易于观察,对于超急性排斥反应的观察以及免疫耐受的诱导,抗免疫排斥药物筛选是一位得推广的动物模型。

Cardiomyocytes of adult Wister rats and spleen cells of adult SD rats were separated,and the cardiomyocytes(2×10 6 ml -1 )as stimulate cells and spleen cells(1×10 7 ml -1 )as responsed cells were cultured in 96 culture plated.The model of acute rejection of cardiac transplantation of rats in vitro was set up.The model includes four groups,negative group(mixed culture of the cardiomyocytes and the spleen cells treated with mitomycin C),positive group(mixed culture of the cardiomyocytes and the spleen...

Cardiomyocytes of adult Wister rats and spleen cells of adult SD rats were separated,and the cardiomyocytes(2×10 6 ml -1 )as stimulate cells and spleen cells(1×10 7 ml -1 )as responsed cells were cultured in 96 culture plated.The model of acute rejection of cardiac transplantation of rats in vitro was set up.The model includes four groups,negative group(mixed culture of the cardiomyocytes and the spleen cells treated with mitomycin C),positive group(mixed culture of the cardiomyocytes and the spleen cells),drug control group(cyclosprione A(CSA)group,mixed culture of the cardiomyocytes,the spleen cells and CSA)and experiment group(mixed culture of the cardiomycytes and the spleen cells and HSP(human seminal plasma)).Observed with microscope and electromicroscop,the damages of cardiomyocytes of the all of groups,and blastgesis of the recipients spleen cells(responsed cells)induced by donors cardiomyocytes(stimulate cells)with 3H thymidine.The authors confirmed immunosuppression activity of CSA and HSP with the model in vitro and model in vivo of cardiac transplantation in rats.The results of in vitro and in vivo experments are identical.It is concluded that the model in vitro can immitate well acute rejection of cardiac allo graft in vivo.It is a good model in the study of the mechanism of acute rejection in heart transplantation.This model has advantage of convenience,dependence,etc.

分离成年Wistar大鼠心肌细胞(2×106ml-1)SD大鼠的脾细胞(1×107ml-1),前者做刺激细胞,后者做反应细胞,进行混合细胞培养,建立大鼠心脏移植后急性排异反应体外模型。该模型包括4组:①阴性对照组,心肌细胞与经丝裂霉素C处理的脾细胞共同培养。②阳性对照组,心肌细胞与脾细胞共同培养。③药物对照组,在阳性组基础上加入CSA(环孢霉素A10μg/ml)。④实验组,在阳性组基础上加入实验药物(HSP,人类精浆,10μg/ml)。应用光镜、电镜观察各组心肌细胞的受损情况和脾细胞转化为淋巴母细胞的数量,并用3H-TdR掺入法测定脾细胞的转化率,证实了CSA和HSP有相似的免疫抑制作用。用大鼠腹腔内心脏异位移植体外模型来重复验证CSA和HSP的免疫抑制作用,两者结果相同,从而证明了心肌细胞混合培养的体外模型不仅简便易行,可靠性强,而且为大规模地筛选免疫抑制剂提供了一种方便、廉价的实验工具。

 
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