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阿尔茨海默病大鼠
相关语句
  rats with alzheimer ' s disease
    Effect of Jiannao Yizhi decoction on learning memory and oxidative stress in rats with Alzheimer's disease
    健脑益智汤对阿尔茨海默病大鼠学习记忆和氧化应激的影响
短句来源
    Effect of Yuanzhi on Learning and memory and AchE Activity of Model Rats with Alzheimer's disease
    中药远志对阿尔茨海默病大鼠模型学习记忆和胆碱酯酶活性的影响
短句来源
    Effect of Shudihuang,Gouqi,Shouwu and Wuweizi on Intracerebral Free Radical Injury of Model Rats with Alzheimer's Disease
    熟地、枸杞、首乌与五味子对实验性阿尔茨海默病大鼠模型脑自由基损伤的比较研究
短句来源
    Effects of Yizhikoufuye on apoptosis in different cerebral regions of rats with Alzheimer's disease
    益智口服液对阿尔茨海默病大鼠不同脑区细胞凋亡的影响
短句来源
    Objective:To observe the effect of Congnao decoction on acetylcholinesterase (AChE) activity of model rats with Alzheimer's disease.
    目的:探讨聪脑汤对实验性阿尔茨海默病大鼠模型学习记忆能力的影响及作用机制。
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  “阿尔茨海默病大鼠”译为未确定词的双语例句
    Treatment for AD Rats with Lingcao Oral Liquid and Its Mechanism
    灵草液对阿尔茨海默病大鼠的治疗作用及其机制研究
短句来源
    Establishment of Analogous Oxidative Damaged Alzheimer′s Disease Rat Model and Effect of Tiaoxin Recipe on It
    氧化损伤类阿尔茨海默病大鼠模型的建立及调心方的作用
短句来源
    Effects of Extracts of Ginkgo Biloba Leaves on Learning and Memory in Alzheimer’s Disease Rats
    银杏叶提取物对雌性阿尔茨海默病大鼠学习记忆能力影响
短句来源
    EFFECTS OF GANODERMA LUCIDUM POLYSACCHARIDES ON ANTIOXIDANT ABILITY AND MODALITY IN THE HIPPOCAMPUS OF AD RATS
    灵芝多糖对阿尔茨海默病大鼠海马组织形态学及抗氧化能力的影响
短句来源
    Effect of Congnao Decoction on Activity of Dopaminergic Neuro-transmitter in Rat Dementia Model
    聪脑汤对实验性阿尔茨海默病大鼠单胺类神经递质的影响
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Objective: To investigate the effects of ginkgo biloba leaves extracts on learning of Alzheimer’s disease (AD) model rats. Methods: A D model rats were built with administration of Dgalactose and aluminum chlorid e. Ginkgo biloba extracts of differect concentration were respectively instilled into the stomach of AD model rats. Ytype maze test was used to study the chan ge of learning, memory and recognition ability. Results: Learni ng and recognition ability in the experimental group was significantly better...

Objective: To investigate the effects of ginkgo biloba leaves extracts on learning of Alzheimer’s disease (AD) model rats. Methods: A D model rats were built with administration of Dgalactose and aluminum chlorid e. Ginkgo biloba extracts of differect concentration were respectively instilled into the stomach of AD model rats. Ytype maze test was used to study the chan ge of learning, memory and recognition ability. Results: Learni ng and recognition ability in the experimental group was significantly better th an that in the control group(P<0.01). Conclusion: Ginkgo biloba extracts can improve learning and memory ability in AD model rats.

目的:研究银杏叶提取物对雌性阿尔茨海默病(AD)大鼠学习记忆能力的影响。方法:以D-半乳糖和三氯化铝建立老年痴呆动物模型,用不同浓度的银杏叶提取物分别灌胃AD大鼠,利用Y-型迷宫进行被动回避反应和辨别性学习能力的测试,观察AD大鼠学习记忆能力及辨别性学习能力的改变。结果:实验组大鼠学习能力和记忆保持率均显著优于模型对照组(P<0.01)。结论:银杏叶提取物能有效改善阿尔茨海默病大鼠的学习和记忆能力。

BACKGROUND:Chinese herb, bushen yizhi formula protects at certain extent learning and memory in rat model of Alzheimer disease. The drug serum in this formula can alleviate neurotoxic reaction of nerve tumor cell NG 108-15 to beta-amyloid protein. In order to understand further the mechanism and compatibility of the formula, it is necessary to carry on the study on the broken formulas.OBJECTIVE:To study the effect of drug serum in subgroups of broken bushen yizhi formulas on growth and differentiation of cell...

BACKGROUND:Chinese herb, bushen yizhi formula protects at certain extent learning and memory in rat model of Alzheimer disease. The drug serum in this formula can alleviate neurotoxic reaction of nerve tumor cell NG 108-15 to beta-amyloid protein. In order to understand further the mechanism and compatibility of the formula, it is necessary to carry on the study on the broken formulas.OBJECTIVE:To study the effect of drug serum in subgroups of broken bushen yizhi formulas on growth and differentiation of cell model of Alzheimer disease and probe into the compatibility rule of bushen yizhi formula in view of serum pharmacology.DESIGN: Randomized controlled experiment.SETTING: DME Center of Clinical Pharmacological Institute Affiliated to Guangzhou University of Traditional Chinese Medicine.PARTICIPANTS:The experiment was performed in DME Center of Clinical Pharmacological Institute Affiliated to Guangzhou University of Traditional Chinese Medicine from January to August 2003, in which, 40 healthy male SD rats of 3 months old were employed and NG108-15 cell line was frozen-preserved.METHODS:①Preparation of drug serum: Forty SD rats were randomized into the control, original formula group (No.1 group) [shechuanzi (Cnidium monnieri (L.) Cuss), gouqizi (Lycium barbarum L.), renshen (Panax ginseng C.A.Mey.), heshouwu (Polygonum multiflorum Thunb.), danpi (Paeonia Suf-fruticisa Andr.) and bingpian (Borneolum)], kidney replenishment group (No.2 group) [shechuanzi (Cnidium monnieri (L.) Cuss), gouqizi (Lycium barbarum L.), etc.], group for benefiting qi and nourishing blood (No.3 group) [renshen (Panaz ginseng C.A.Mey), zhishouwu (Polygonum multiflorum Thunb.), etc.] and group with bingpian (Borneolum) removed (No.4 group) [Panax ginseng C.A.Mey.], heshouwu (Polygonum multiflorum Thunb.) and danpi (Paeonia Suffruticisa Andr.)], 8 rats in each group. The concentrated Chinese herbal solutions of every group were applied at 10 μL/g (equal to 6 g/kg of raw herbs) for gastric infusion successively,continuously for 1 month. In the control, the physical saline solution of equal dosage was used for infusion. Two hours after the last gastric infusion in rats of each group, the blood was collected from heart after anesthesia and the serum was separated for preparation.②Cell proliferation, culture and differentiation: NG108-15 cell cultured in vitro was divided into 6 groups. In the control and model group, normal rat serum was contained in proliferated culture solution. In the rest 4 groups, the drug serum of No.1 group and 3 sub-groups was contained.Simultaneously, beta-amyloid protein 25-35 in each hole was prepared to the terminal concentration 5 μmol/L (except in the control) and the culture went on for 48 hours.MAIN OUTCOME MEASURES:MTT method was used to determine proliferated number and survival rate of cells. Simultaneously, the ratio of neurite cells to total cell count and average length of neurit were determined.RESULTS: ① Cell proliferation: A value in model group was lower significantly than the control (0.520±0.022, 0.665±0.037, P < 0.01), and that in every drug serum group was higher than model group, of which, the result in No. 4 group was the most significant (0.636±0.035, P < 0.01). ② Survival rate of differentiated cells: That in model group was lower significantly than the control (58.4%, 100%) and that in every drug serum group was higher than model group, of which, the result in No.4 group was the most significant (75.8%, P < 0.01). ③ Ratio of differentiated neurite cells to total cell count: That in model group was lower significantly than the control [(42.95±11.42)%, (58.75±12.84)%, P < 0.01] and that in every drug serum group was higher than model group, of which, the result in No.4 group was the most significant [(58.20±8.40)%, P < 0.01]. ④ Average length of neurite: That in model group was shorter significantly than the control [(356.0 ±109.0), (493.8±133.0) μm, P < 0.01] and that in every drug serum group was longer than model group, of which, the result in No.4 group was the most significant [(486.8±79.2) μm, P < 0.01].CONCLUSION: The drug serum in all of bushen yizhi formula and every subgroup inhibits at certain extent the injury of beta-amyloid protein 25-35 to NG108-15 cell, but the results of each group are various. The protection of drug serum to the cell in every group is in the sequence from strong to weak as group with bingpian removed > original formula group > kidney replenishment group > group for benefiting qi and nourishing blood. It is to expect a further study on the efficacy of group with bingpian removed.

背景:中药补肾益智方对阿尔茨海默病大鼠模型学习记忆能力有一定的保护作用,该方含药血清也能减轻神经瘤细胞NG108-15细胞对β淀粉样蛋白的神经毒性反应,为了进一步了解该方的作用机制及其配伍规律,需对该方进行拆方研究。目的:研究补肾益智方拆方亚组的含药血清对阿尔茨海默病细胞模型生长、分化等方面的影响,从血清药理学的角度探讨该方的配伍规律。设计:随机对照实验。单位:广州中医药大学临床药理研究所DME中心。对象:实验于2003-01/08在广州中医药大学临床药理研究所DME中心实验室进行。实验对象为3月龄SD雄性健康大鼠40只和冻存的NG108-15细胞株。方法:①制备药物血清:将40只SD大鼠随机分为对照组、原方组(蛇床子、枸杞子、人参、何首乌、丹皮、冰片)、补肾组(蛇床子、枸杞等)、益气养血组(人参、制首乌等)、去冰片组(蛇床子、枸杞子、人参、何首乌、丹皮),每组8只。将各组中药浓缩液按按10μL/g(相当于生药6g/kg)分别进行灌胃,连续1个月,对照组灌等量生量盐水。各组大鼠最后1次灌胃2h,麻醉后心脏采血,分离血清备用。②细胞增殖、培养及分化:将体外培养的NG108-15细胞分为6组,对照组、...

背景:中药补肾益智方对阿尔茨海默病大鼠模型学习记忆能力有一定的保护作用,该方含药血清也能减轻神经瘤细胞NG108-15细胞对β淀粉样蛋白的神经毒性反应,为了进一步了解该方的作用机制及其配伍规律,需对该方进行拆方研究。目的:研究补肾益智方拆方亚组的含药血清对阿尔茨海默病细胞模型生长、分化等方面的影响,从血清药理学的角度探讨该方的配伍规律。设计:随机对照实验。单位:广州中医药大学临床药理研究所DME中心。对象:实验于2003-01/08在广州中医药大学临床药理研究所DME中心实验室进行。实验对象为3月龄SD雄性健康大鼠40只和冻存的NG108-15细胞株。方法:①制备药物血清:将40只SD大鼠随机分为对照组、原方组(蛇床子、枸杞子、人参、何首乌、丹皮、冰片)、补肾组(蛇床子、枸杞等)、益气养血组(人参、制首乌等)、去冰片组(蛇床子、枸杞子、人参、何首乌、丹皮),每组8只。将各组中药浓缩液按按10μL/g(相当于生药6g/kg)分别进行灌胃,连续1个月,对照组灌等量生量盐水。各组大鼠最后1次灌胃2h,麻醉后心脏采血,分离血清备用。②细胞增殖、培养及分化:将体外培养的NG108-15细胞分为6组,对照组、模型组孔中的增殖培养液含正常大鼠血清,其余4组分别为原方组及3个亚组的大鼠含药血清;同时每个孔加淀粉样β蛋白25~35至终浓度5umol/L(对照组除外),继续培养48h。主要观察指标:用MTT法测定细胞增殖数和存活率;同时检测分化突起细胞占总细胞数的比率及突起平均长度。结果:①细胞增殖情况:模型组A值显著低于对照组(0.520±0.022,0.665±0.037,P<0.01),各含药血清组A值均高于模型组,但以去冰片组效果最显著(0.636±0.035,P<0.01)。②分化细胞存活率:模型组显著低于对照组(58.4%,100%),各含药血清组均高于模型组,但以去冰片组效果最显著(75.8%,P<0.01)。③分化突起细胞占总细胞数的比率:模型组显著低于对照组犤(42.95±11.42)%,(58.75±12.84)%,P<0.01犦,各含药血清组均高于模型组,但以去冰片组效果最显著犤(58.20±8.40)%,P<0.01犦。④突起平均长度:模型组显著低于对照组犤(356.0±109.0),(493.8±133.0)μm,P<0.01犦,各含药血清组均高于模型组,但以去冰片组效果最显著犤(486.8±79.2)μm,P<0.01犦。结论:补肾益智方及各亚组含药血清都能在一定程度上抑制淀粉样β蛋白25-35对NG108-15细胞的损伤作用,但各组情况有所不同。各组含药血清对细胞的保护作用由强至弱依次是去冰片组>原方组>补肾组>益气养血组。故方中冰片的功效有待进一步研究。

Objective:To observe the effect of Congnao decoction on acetylcholinesterase (AChE) activity of model rats with Alzheimer's disease. Methods:60 male SD rats were randomized into normal group, sham operation control group, model group, Congnao decoction treatment group 1 (lower dosage), group 2 (medium dosage) and group 3 (high dosage ). Basal forebrain-injured rat was used as model of Alzheimer's disease, water maze was applied in six groups. The activity of AchE in brain was detected. Results:Compared with...

Objective:To observe the effect of Congnao decoction on acetylcholinesterase (AChE) activity of model rats with Alzheimer's disease. Methods:60 male SD rats were randomized into normal group, sham operation control group, model group, Congnao decoction treatment group 1 (lower dosage), group 2 (medium dosage) and group 3 (high dosage ). Basal forebrain-injured rat was used as model of Alzheimer's disease, water maze was applied in six groups. The activity of AchE in brain was detected. Results:Compared with normal group and sham operation control group, the swimming time and the error number of model group were obviously increased, the level of AchE in brain was also increased significantly. The swimming time and error number of three treatment groups were shortened, the levels of AchE in brain were decreased compared with model group. Conclusion:Congnao decoction could improve the ability of learning and memory, decrease cerebral AchE activity of model rat, exerting a positive effect on treatment of cognitive dysfunction.

目的:探讨聪脑汤对实验性阿尔茨海默病大鼠模型学习记忆能力的影响及作用机制。方法:60只大鼠随机分为正常组,假手术组,模型组,聪脑汤大中小剂量组。采用D-半乳糖合并鹅膏覃氨酸损毁大脑基底核神经元的方法复制模型。各组动物以通道式水迷宫游出时间和错误次数为学习记忆评价指标,水迷宫试验结束后各组测定脑组织胆碱酯酶活性。结果:模型组动物游出时间和错误次数显著高于正常组和假手术组,胆碱酯酶活性也明显增高。聪脑汤大中小剂量组游出时间和错误次数均显著低于模型组,胆碱酯酶活性也明显低于模型组。结论:聪脑汤能改善模型大鼠的学习记忆功能,其作用机制与有效降低胆碱酯酶活性有关。

 
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