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   型前胶原mrna 的翻译结果: 查询用时:0.018秒
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消化系统疾病
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型前胶原mrna
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  procollagen mrna
     The type Ⅰ,Ⅲprocollagen mRNA expression wasdecreased by 25μ mol/L luteolin, in which the type Ⅰ procollagen mRNA was reduced with statistical significance(x~2=6.850. P<0.0l ).
     25 μmol/L木犀草素使Ⅰ、Ⅲ型前胶原mRNA的表达降低,其中Ⅰ型前胶原基因表达降低具有统计学差异(x~2=6.850,P<0.01)。
短句来源
     Type Ⅰ procollagen mRNA expression and MDA contents were significantly decreased respectively (5.2±1.4 vs 3.8±1.1,P<0.05 and 12.7±2.6 vs 8.2±2.0mmol/g, P<0.05), however, the MMPs activities were not changed.
     同时观察到Lu使肝脏Ⅰ型前胶原mRNA表达降低(5.2±1.4 vs 3.8±1.1,P<0.05)和MDA含量显著减少(12.7±2.6 vs 8.2±2.0μmmol/g,P<0.05),但MMPs的活性没有改变。
短句来源
     ④There was no significant difference in the expressions of type Ⅲ procollagen mRNA between the control group and group A(P<0.05),while the expression of type Ⅲ procollagen mRNA in group B was significantly higher than that of the above two groups(P<0.05).
     ④Ⅲ型前胶原mRNA表达在正常对照组与A组之间无显著差异,B组显著高于前两组(P均<0.05);
短句来源
     IFN-γ 103-105 ng/ml and sandostatin 10-10-10-7 mol/L decreased collagen synthesis. IFN-γ 103 U/ml and sandostatin 10 -9 mol/L decreased the expression of types Ⅰ and Ⅲ procollagen mRNA.
     1 ng/ml的EGF及103ng/ml的IL-1可增加Ⅰ、Ⅲ型前胶原mRNA表达,而103U/ml的IFN-γ及10-9mol/L的SS-8肽可减少Ⅰ、Ⅲ型前胶原mRNA表达。
短句来源
     Aldo up-regulated expression of α1(1) procollagen mRNA, which was attenuated by U0126 and NAC.
     U0126和NAC可显著抑制Aldo诱导的α1-1型前胶原mRNA表达增强。
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  “型前胶原mrna”译为未确定词的双语例句
     TGF-β1 group and TGF-β1+IGF-I group were similar (0.47 vs 0.48, P=0.104).
     TGF-β1组与TGF-β1+IGF-I组Ⅱ型前胶原mRNA表达水平无明显差异(0.47 vs 0.48,P=0.104);
短句来源
     Radix salviae miltiorrhizae with the dose over 0.1 g/L could downregulate the mRNA level of Ⅰtype procollagen of FB significantly(t=3.247-6.324,P< 0.01).
     0.1g/L以上剂量组FB的Ⅰ型前胶原mRNA水平受到了显著影响,低于正常水平(t=3.247~6.324,P<0.01);
短句来源
     HSC was treated with 100 pmol/L TGF- β1 for 15 min-90 min, and type I pro-collagen mRNA level was assayed by Northern blot.
     100pmol/L TGF-β_1温育细胞15~90min,northern blot法检测细胞Ⅰ型前胶原mRNA的表达水平。
短句来源
     RT-PCR was performed to detect the expression of procollagen type Ⅰ mRNA.
     用RT-PCR方法检测Ⅰ型前胶原mRNA的表达。
短句来源
     The average level of Collagen type II mRNA measured by RT-PCR showed that TGF-β1 group was higher than IGF-I+BMP-2 group (0.48 vs 0.15, P<0.01).
     半定量RT-PCR检测转化细胞Ⅱ型前胶原mRNA水平显示:TGF-β1组Ⅱ型前胶原mRNA表达水平明显高于IGF-I+BMP-2组(0.48 vs 0.15,P<0.01);
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  相似匹配句对
     And the type I procollagen mRNA of keloid derived fibroblasts decreased significantly.
     其相应I前胶原mRNA量显著下降。
短句来源
     The expression of pre-collegen I were obviously than pre-collegen Ⅲ.
     Ⅰ前胶原mRNA表达高于Ⅲ
短句来源
     Study on Expression of Proa1, (I ) and Proa1(m ) mRNA by Human Lens Epithelial Cells
     人晶状体上皮细胞Ⅰ、Ⅲ前胶原mRNA的表达
短句来源
     (2)C shape;
     C ;
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     (3)D shape.
     D
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  procollagen mrna
Transforming growth factor-β receptors and procollagen mRNA accumulation were examined at age of 14 days through immunohistochemical methods andin situ hybridization.
      
Type I collagen was markedly increased, and transforming growth factor-β receptors and procollagen mRNA were decreased by retinoic acid in bronchial epithelial cells, alveolar epithelial cells and alveolar intersitium.
      
In contrast, bone sialoprotein mRNA expression was increased by FGF2, while α1(I) procollagen mRNA expression was not altered.
      
Analysis by RT-PCR showed that the expression level of type III procollagen mRNA in the frozen-thawed tendon was significantly higher than that in the sham-operated tendon at 6 and 12?weeks.
      
Collagen biosynthesis and type I and type III procollagen mRNA in lichen sclerosus et atrophicus
      
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NFαwhich was produced mainly by

TNFα系单核-巨噬细胞产生的细胞因子,具有明确促进纤维母细胞增殖的作用,但对胶原产生的影响文献报道不尽相同。本文研究并比较了重组TNFα对NIH/3T3细胞及大鼠肝贮脂细胞增殖,Ⅰ、Ⅲ型前胶原基因表达的影响,结果发现TNFα具有促进上述两种细胞增殖作用,且具剂量依赖性。原位杂交显示,在单个细胞水平,TNFα可抑制或降低Ⅰ、Ⅲ型前胶原mRNA水平的表达。本研究提示肝贮脂细胞与纤维母细胞类似,接受TNFα调控,TNFα在肝纤维化始动激活及调控中具重要作用。

Human Pro a_1(Ⅰ),Pro a_1(Ⅲ)collagens cDNA probes and RNA dot blot were em-ployed to determine the levels of collagen mRNA in the lung of silicotic rats treated bypolyvinylpyridine oxide(PVNO). The results showed that Pro a_1(Ⅰ) ,Pro a_1(Ⅲ) , mRNA Ievelsincreased significantly at 60 and 120 days after the rats were exposed to silica dust. The mRNAlevels went down at 1 and 3 months after PVNO treatmant. The results suggest that PVNO mayinhibit the gene expression of lung collagen in silicosis.

使用Proa_1(Ⅰ),Proa_1(Ⅲ)人胶原cDNA探针,采用cDNA-mRNA斑点杂交技术,观察了染石英尘2个月、4个月矽肺大鼠及克矽平(PVNO)治疗1个月、3个月后肺组织中Ⅰ型和Ⅲ型前胶原mRNA水平的改变情况。结果表明,矽肺组织中Ⅰ、Ⅲ型前胶原mRNA含量比正常肺组织明显增加(P<0.05);经克矽平治疗后两型胶原mRNA皆显著减少。我们认为矽肺病变中胶原蛋白的积聚是由石英粉尘引起胶原基因表达改变所致。药物PVNO能直接或间接地抑制胶原基因的转录,从而抑制矽肺病变时胶原蛋自的合成。

PURPOSE The study was carried to observe the effect of platelet-drived growth factor(PDGF) on the cellular proliferation and synthesis of procollagen of rat pulmonary fibroblasts (PFbs). METHODS PFbs were isolated and cultured with the modified Kumar's method. Using the MTT method, immunocytochemistry and in situ hybridization, we observed the effect of PDGF on the cellular proliferation and the synthesis of procollagen of rat PFbs. RESULTS The growth-stimulating effect on PFbs by PDGF was determined by MTT...

PURPOSE The study was carried to observe the effect of platelet-drived growth factor(PDGF) on the cellular proliferation and synthesis of procollagen of rat pulmonary fibroblasts (PFbs). METHODS PFbs were isolated and cultured with the modified Kumar's method. Using the MTT method, immunocytochemistry and in situ hybridization, we observed the effect of PDGF on the cellular proliferation and the synthesis of procollagen of rat PFbs. RESULTS The growth-stimulating effect on PFbs by PDGF was determined by MTT method, which was dose-depenent in 1~10 μg/L. After PDGF stimulation, it was found that the rough endoplasmic reticulum of cytoplasm was dramatically abundant and the spike of the cytoprocesses on cell surface increased and extended. When the PFbs had been incubated in PDGF-containing medium for 24 hours, the cytoplasm was full of granular positive signals of type Ⅰ, Ⅲ procollagen mRNA. After incubated for 48 hours, the PFbs were full of the brown-yellowish positive granules of type Ⅰ, type Ⅲ and type ⅴ procollagens in their cytoplasms. CONCLUSIONS The results show that PDGF could stimulated the proliferation of rat PFbs with a high rate anabolism and the active communications among the cells and extracellular matrix. And it is proved that PDGF is able to increase the synthesis of type Ⅰ,Ⅲ, ⅴ procollagen, resulting from the enhancement of expression of type Ⅰ,Ⅲ procollagen mRNA.

观察血小板源性生长因子(PDGF)对肺纤维母细胞增殖、胶原合成的影响。以改良Kumar法,分离培养了大鼠肺纤维母细胞,并采用MTT、免疫细胞化学、原位分子杂交等方法。结果:PDGF对肺纤维母细胞具有促增殖作用,其浓度在1~10μg/L之间呈剂量依赖性。PDGF作用下的纤维母细胞胞浆内线粒体和粗面内浆网明显增多,树状突起和棘状突起也较对照组增多,PDGF作用24h,肺纤继母细胞Ⅰ、Ⅲ型前胶原mRNA表达增强,作用48h胞浆内布满Ⅰ、Ⅲ、Ⅴ型前胶原蛋白,作用72h,大量前胶原则被分泌到细胞外基质中。结论:PDGF不仅可以促进大鼠肺纤维母细胞增殖、合成代谢旺盛和信息传递活跃,而且使其Ⅰ、Ⅲ、Ⅴ型前胶原合成增加。其调控机制之一是在转录水平上增强了前胶原mRNA表达的结果。

 
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