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型前胶原基因
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  procollagen gene
     Transfection optimization of α_1(I) procollagen gene antisense oligodeoxynucleotide to human hypertrophic scar fibroblasts
     α_1(I)型前胶原基因反义寡核苷酸转染人瘢痕成纤维细胞的条件优化
短句来源
     The effect of cytokines on promoter activity of 2(I)procollagen gene
     细胞因子对小鼠α2(I)型前胶原基因启动子活性影响的研究
短句来源
     Optimal transfection of human hypertrophic scar fibroblasts with alpha 1(Ⅰ ) procollagen gene antisense oligodeoxynucleotide
     人增生性瘢痕成纤维细胞最佳转染条件:α_1(I)型前胶原基因反义寡核苷酸转染的实验
短句来源
     Results: The study reveals that TNF inhibits promoter activity of mouse 2(I) procollagen gene, this inhibition effect is even stronger when TNF was used in combination with IFN or IFN.
     结果:TNFα抑制小鼠α2(I)型前胶原基因启动子活性,TNFα分别与IFNγ、IFNα联合应用能加强这种抑制作用。
短句来源
     Objective To optimize the transfection of α_1(I) procollagen gene antisense oligodeoxynucleotide to human hypertrophic scar fibroblasts.
     目的优化α1(I)型前胶原基因反义寡核苷酸(ASODN)转染人增生性瘢痕成纤维细胞的条件。
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  procollagen genes
     Cloning and Identification of the Gene Fragments of α 1(Ⅰ)and(Ⅲ) Procollagen Genes in the Hypertrophic Scar After Trauma
     创伤后增生性疤痕中α1(Ⅰ)及(Ⅲ)型前胶原基因片段的克隆及鉴定
短句来源
     Construction and in vitro Activity of Specific Dual-ribozymeAgainst α_1(Ⅰ) and (Ⅲ) Procollagen Genes
     针对Ⅰ型及Ⅲ型前胶原基因的二联核酶的构建及体外活性研究
短句来源
     Construction of specific ribozymes against second exon of α_1 Ⅰ and α_1 Ⅲ procollagen genes
     针对α_1 Ⅰ型及α_1 Ⅲ型前胶原基因第二外显子片段核酶的构建
短句来源
     Objective To construct two ribozyme genes (gⅠand gⅢ) by using PCR according to the requirement of ribozyme's domains and the nucleotide sequences of α_1Ⅰand Ⅲ procollagen genes.
     目的 构建出针对α1Ⅰ型及α1Ⅲ型前胶原基因第 2外显子 (Exon 2 )片段的核酶。
短句来源
     The aim of this study was to obtain the cloning and identification of the gene fragments of α1(Ⅰ)and(Ⅲ) procollagen genes. Methods In this study, separate three primers were designed and synthesized according to the nucleotide sequence of each of α1(Ⅰ)and(Ⅲ) procollagen genes.
     【方法】本研究根据α 1(Ⅰ )型及 (Ⅲ )型前胶原基因的核苷酸序列分别设计 3条引物 ,从瘢痕组织中经RT PCR分别扩增Ⅰ及Ⅲ型前胶原基因的第 2外显子 (Exon 2 )区域的基因片段 (ⅠF2 ,ⅢF2 ) ,克隆到T载体 (pGEM Tvector)。
短句来源
  “型前胶原基因”译为未确定词的双语例句
     Further, Vit E diminished the increased collagen content [(0.23±0.01) vs (0.60±0.11), P<0.05] and inhibited the increased α1 (I) procollagen mRNA expression [(0.28±0.01) vs (0.85±0.15), P<0.05] in the liver in model group.
     降低肝脏胶原含量[(0.23±0.01)vs(0.60±0.11),P<0.05]和α1(I)型前胶原基因表达[(0.28±0.01)vs(0.85±0.15),P<0.05].
短句来源
     The type Ⅰ,Ⅲprocollagen mRNA expression wasdecreased by 25μ mol/L luteolin, in which the type Ⅰ procollagen mRNA was reduced with statistical significance(x~2=6.850. P<0.0l ).
     25 μmol/L木犀草素使Ⅰ、Ⅲ型前胶原mRNA的表达降低,其中Ⅰ型前胶原基因表达降低具有统计学差异(x~2=6.850,P<0.01)。
短句来源
     The corresponding fluence level for significant down-regulation of mRNA expression of procollage III α_1 was 6 J/cm~2 and 7 J/cm~2(P<0.05).
     在能量密度为6,7 J/cm2时能抑制III型前胶原基因α1mRNA的表达(P<0.05),而对I型前胶原基因1α,2α的表达与对照无显著性差异.
短句来源
     L~(-1) could obviously inhibit gene expression of type I procollagen(p<0.05), but the effect was not obvious at the concentration of 50g.
     L~(-1)浓度的茅台酒能明显抑制Ⅰ型前胶原基因表达(P<0.05),而50g.
短句来源
     Methods: Cultured fibroblasts derived from hypertrophic scars (HS) or normal human skin were treated with pulsed Nd: YAG laser at various energy density levels (500 J/cm2, 1000 J/cm~2, 1 500 J/cm~2 and 2000 J/cm~2). 24 hours after laser irradiation, collagen production of the fibroblasts was measured by [~3H] probine incorporation.
     方法:以不同能量密度(500J/cm~2、1000 J/cm~2、1500 J/cm~2和2000 J/cm~2)Nd:YAG激光照射体外培养增生性瘢痕和正常成纤维细胞,照射后24h分别用~3H-脯氨酸掺入法和斑点杂交检测成纤维细胞胶原合成和Ⅰ型前胶原基因表达。
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  procollagen gene
No significant differences in type III procollagen gene expression were noted between Groups MH and MC or between Groups AH and AC.
      
Similarly, α1(I) procollagen gene transcripts were, in all instances, colocalized with vimentin in human liver.
      
Type-IV procollagen gene expression was mainly observed in mesenchymal cells localized in both HCCs and non-cancerous liver.
      
Non-radioactive multiplex-SSCP analysis: detection of a new type II procollagen gene (COL2A1) mutation
      
Two forms of type II collagen, IIA and IIB, are known to be produced by alternative splicing of the Α1 (II) procollagen gene.
      
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  procollagen genes
Spatiotemporal patterns of OASIS partly overlapped that of osteopontin, osteonectin, and α1 type?I procollagen genes.
      
Cancer cells or hepatocytes did not express any of these procollagen genes.
      
Osteogenesis imperfecta (OI) is a heritable osteoporotic bone disease, due to defects in either type I procollagen genes (COL1A1 or COL1A2), resulting in abnormal and/or reduced levels of type I procollagen and alterations in bone mineralization.
      
Transcriptional repression of type I procollagen genes during adipocyte differentiation.
      


NFαwhich was produced mainly by

TNFα系单核-巨噬细胞产生的细胞因子,具有明确促进纤维母细胞增殖的作用,但对胶原产生的影响文献报道不尽相同。本文研究并比较了重组TNFα对NIH/3T3细胞及大鼠肝贮脂细胞增殖,Ⅰ、Ⅲ型前胶原基因表达的影响,结果发现TNFα具有促进上述两种细胞增殖作用,且具剂量依赖性。原位杂交显示,在单个细胞水平,TNFα可抑制或降低Ⅰ、Ⅲ型前胶原mRNA水平的表达。本研究提示肝贮脂细胞与纤维母细胞类似,接受TNFα调控,TNFα在肝纤维化始动激活及调控中具重要作用。

Objective\ To study the dynamic changes of α1(Ⅰ),α1(Ⅲ)and αⅠ(Ⅳ)procollagen mRNA and collagen producing cells during CCl 4 induced SD rat liver fibrogenesis(20 weeks).Methods\ \ The investigations were performed using Northern ...

Objective\ To study the dynamic changes of α1(Ⅰ),α1(Ⅲ)and αⅠ(Ⅳ)procollagen mRNA and collagen producing cells during CCl 4 induced SD rat liver fibrogenesis(20 weeks).Methods\ \ The investigations were performed using Northern blot analysis,in situ hybridization and immunohistochemical techniques.Results\ The increased expression of α1(Ⅲ)procollagen mRNA during fibrogenesis

目的探讨肝纤维化过程中胶原生成细胞的来源以及Ⅰ、Ⅲ、Ⅳ型前胶原基因及其蛋白表达的演变规律。方法利用免疫组化及核酸分子杂交技术,对CCl4诱导SD大鼠肝纤维化不同阶段(20周内)α1(Ⅰ)、α1(Ⅲ)及α1(Ⅳ)前胶原mRNA的表达进行动态观察。结果(1)肝纤维化时α1(Ⅳ)前胶原mRNA早期即迅速升高,α1(Ⅲ)前胶原mRNA呈优势性表达,α1(I)前胶原mRNA含量的增加则较为缓慢;(2)肝纤维化早期,变性坏死区结蛋白阳性和α-平滑肌肌动蛋白阳性的Ito细胞及肌纤维母细胞表达α1(Ⅲ)、α1(Ⅳ)及α1(Ⅰ)前胶原mRNA。纤维化中、后期,三种前胶原mRNA表达主要见于间隔内纤维母细胞和肌纤维母细胞。结论二者构成肝纤维化时的主要胶原生成细胞。此外,窦内皮细胞也参与肝内Ⅳ型胶原的合成。

IM To clarify the cellular sources of collagen in liver fibrosis and compare the capacity of various liver cells in collagen synthesis. METHODS Collagenase and pronase E were used to digest the rat liver, and followed by nycodenz or metrizamide density gradient centrifugation, fat storing cells (FSC) and hepatocytes (HC) were isolated. 3Hproline incorparation was used to compare the collagen synthesis capacity of FSC and HC. Dot blot hybridization was used to observe the types Ⅰ,Ⅲ and Ⅳ precollagen gene...

IM To clarify the cellular sources of collagen in liver fibrosis and compare the capacity of various liver cells in collagen synthesis. METHODS Collagenase and pronase E were used to digest the rat liver, and followed by nycodenz or metrizamide density gradient centrifugation, fat storing cells (FSC) and hepatocytes (HC) were isolated. 3Hproline incorparation was used to compare the collagen synthesis capacity of FSC and HC. Dot blot hybridization was used to observe the types Ⅰ,Ⅲ and Ⅳ precollagen gene expressions. RESULTS The collagen amount synthsized by FSC was approximately two times as much as that by HC. The level of collagen gene expression in FSC was higher than that in HC(P<005). CONCLUSION FSC may play a leading role in the collagen synthesis of hepatic fibrosis, but the HC function can not be ignored.

目的为明确肝纤维化过程中细胞外基质(extracelularmatrix,ECM)的细胞来源以及贮脂细胞(fatstoringcel,FSC)和肝细胞(hepatocyte,HC)在肝纤维化胶原合成中的作用.方法用胶原酶和链霉蛋白酶E消化大鼠肝脏,结合密度梯度离心法分离培养大鼠HC和FSC,在此基础上,用3H脯氨酸掺入结合胶原酶消化法和斑点杂交法,观察HC和FSC胶原的合成及Ⅰ,Ⅲ,Ⅳ型前胶原基因的表达.结果发现体外培养的FSC合成胶原的能力较HC强,约为HC的两倍(P<005);FSC胶原基因表达的水平同样较HC高(P<005).结论FSC在ECM胶原合成中起主要作用,但HC的作用也不容忽视.

 
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