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原发性免疫球蛋白a肾病
相关语句
  primary immunoglobulin a nephropathy
     Clinicopathological Study in 55 Children with Primary Immunoglobulin A Nephropathy
     原发性免疫球蛋白A肾病55例临床病理分析
短句来源
     Objective To explore the clinical manifestations,pathologic features,and prognosis of primary immunoglobulin A nephropathy(IgAN) in children.
     目的探讨儿童原发性免疫球蛋白A肾病(IgAN)的临床、病理特征及预后。
短句来源
  相似匹配句对
     Clinicopathological Study in 55 Children with Primary Immunoglobulin A Nephropathy
     原发性免疫球蛋白A肾病55例临床病理分析
短句来源
     Objective To explore the clinical manifestations,pathologic features,and prognosis of primary immunoglobulin A nephropathy(IgAN) in children.
     目的探讨儿童原发性免疫球蛋白A肾病(IgAN)的临床、病理特征及预后。
短句来源
     Relationship between primary nephrotic syndrome and immunoglobulin
     原发性肾病综合征与免疫球蛋白的关系研究
短句来源
     Clinical Manifestation and Pathologic Feature of Children′s Immunoglobulin A Nephropathy
     儿童免疫球蛋白A肾病临床与病理分析
短句来源
     The somatic chromosome number of A.
     A.
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Objective To explore the clinical manifestations,pathologic features,and prognosis of primary immunoglobulin A nephropathy(IgAN) in children.Methods The clinical manifestations and pathological findings of 55 children with primary IgAN were carefully studied and correlated.Thirty five boys and 20 girls aged from 2 to 16 years old were included in this study.They accounted for 10.5% in children undergoing renal biopsy in the same period.Results Nephrotic syndrome was the most common clinical manifestation(30.9%),followed...

Objective To explore the clinical manifestations,pathologic features,and prognosis of primary immunoglobulin A nephropathy(IgAN) in children.Methods The clinical manifestations and pathological findings of 55 children with primary IgAN were carefully studied and correlated.Thirty five boys and 20 girls aged from 2 to 16 years old were included in this study.They accounted for 10.5% in children undergoing renal biopsy in the same period.Results Nephrotic syndrome was the most common clinical manifestation(30.9%),followed by simple hematuria(25.5%),hematuria with proteinuria(23.6%),acute nephritic syndrome((18.2%)) and chronic nephritic syndrome(1.8%).Pathologically,grade Ⅲ was most frequent(61.8%),followed by grade Ⅳ((21.8%)),gradeⅡ(12.7%),and gradeⅠ(3.6%) was the least.The deposition of IgA+IgM+IgG(+C_3) in the glomeruli was most common(45.5%),followed by IgA+IgM(+C_3) deposition(30.9%),solo IgA deposition(21.8%) and full-house deposition((1.8%)).The severity of glomerular lesion significantly correlated with clinical manifestations through double trend analysis(χ~2=(6.012) P=0.014).Proteinuric patients showed more serious glomerular lesions than those with isolated hematuria.The immunofluorescence pattern also showed close relationship with clinical manifestation,as solo IgA deposition was most frequent in patients with isolated hematuria,while deposition of IgA+IgM+IgG(+C_3) was predominant in patients presented with nephrotic syndrome.Among 24 children followed-up for a mean duration of 39 months,only 1 isolated hematuric case still had hematuria,another cases,who originally presented with hematuria and proteinuria,showed that proteinuria attenuated but hematuria remained unchanged,other 22 patients remarkably ameliorated both in hematuria and proteinuria and only had a few erythrocytes and trace protein in urine.Conclusions The clinical characteristics of primary IgAN in children are somewhat correlated with pathological changes.The patients with nephrotic syndrome or nephritic syndrome are more likely to have serious pathological grades like grade Ⅲ and grade Ⅳ,while the glomerular lesions are slight in patients with isolated hematuria.

目的探讨儿童原发性免疫球蛋白A肾病(IgAN)的临床、病理特征及预后。方法对1996~2005年经肾活检确诊为原发性IgAN的患儿55例进行详尽的临床病理分析。本组男35例,女20例,发病年龄2~16岁,平均9岁,占同期肾活检的10.5%。结果临床表现为肾病综合征占30.9%、孤立性血尿占25.5%、血尿蛋白尿占23.6%、急性肾炎综合征占18.2%、慢性肾炎综合征占1.8%;病理分级以Ⅲ级多见(61.8%),其次为Ⅳ级(21.8%)和Ⅱ级(12.7%),Ⅰ级仅占3.6%;免疫病理分型IgA+IgM+IgG(+C3)型占45.5%,IgA+IgM(+C3)型30.9%,IgA单独沉积21.8%,满堂亮者1.8%。双向有序χ2检验表明临床表现的严重程度与病理分级间存在线性关联,伴蛋白尿者病理改变较重;且临床表现与免疫病理分型间也具有一定相关性,孤立性肉眼血尿患儿中,以IgA型较多见,而表现为肾病综合征患儿中,IgA+IgM+IgG(+C3)型最多见。对其中24例平均随访39个月,除1例孤立性血尿尿检无改变,1例血尿蛋白尿蛋白尿好转血尿无改善外,其他患儿均明显好转,仅有轻微血尿或微量蛋白尿。结论儿童原...

目的探讨儿童原发性免疫球蛋白A肾病(IgAN)的临床、病理特征及预后。方法对1996~2005年经肾活检确诊为原发性IgAN的患儿55例进行详尽的临床病理分析。本组男35例,女20例,发病年龄2~16岁,平均9岁,占同期肾活检的10.5%。结果临床表现为肾病综合征占30.9%、孤立性血尿占25.5%、血尿蛋白尿占23.6%、急性肾炎综合征占18.2%、慢性肾炎综合征占1.8%;病理分级以Ⅲ级多见(61.8%),其次为Ⅳ级(21.8%)和Ⅱ级(12.7%),Ⅰ级仅占3.6%;免疫病理分型IgA+IgM+IgG(+C3)型占45.5%,IgA+IgM(+C3)型30.9%,IgA单独沉积21.8%,满堂亮者1.8%。双向有序χ2检验表明临床表现的严重程度与病理分级间存在线性关联,伴蛋白尿者病理改变较重;且临床表现与免疫病理分型间也具有一定相关性,孤立性肉眼血尿患儿中,以IgA型较多见,而表现为肾病综合征患儿中,IgA+IgM+IgG(+C3)型最多见。对其中24例平均随访39个月,除1例孤立性血尿尿检无改变,1例血尿蛋白尿蛋白尿好转血尿无改善外,其他患儿均明显好转,仅有轻微血尿或微量蛋白尿。结论儿童原发性IgAN的临床表现与病理特征存在一定程度关联。临床表现为肾病综合征及肾炎综合征者病理改变较重,以Ⅲ、Ⅳ级为主,而孤立性血尿者病变较前者轻。

 
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