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精神分裂症亚型
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  subtypes of schizophrenia
     Conclusion:There is an association between the DRD 3 Ser9Gly gene polymorphism and the subtypes of schizophrenia. No association exists between the Ser9Gly polymorphism and the efficacy of risperidone.
     结论DRD3受体基因第一外显子Ser9Gly多态性可能与精神分裂症亚型相关,而与患者对药物的反应不相关。
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  “精神分裂症亚型”译为未确定词的双语例句
     Association between polymorphism in the dopamine D_3 receptor gene and the sutypes of schizophrenia and efficacy of risperidone
     多巴胺D_3受体基因多态性与精神分裂症亚型及利培酮疗效相关性分析
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     Changes of subtypes and symptoms of schizophrenia over 20 years
     近20年来精神分裂症亚型及症状变迁
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     (3)There were no significant differences in the distributions between the positive symptom group or the negative symptom group and the healthy controls,neither between the positive group and the negative group( Z <1.96, P >0.05).
     (3)阳性症状和阴性症状两类精神分裂症亚型分别与健康对照组相比 ,或两个亚型间比较 ,同样在DAT1基因多态性分布上无差异 (Z值小于 1.96 ,P >0 .0 5 )。
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     It was found that there was no significant relationship between the subtype of shizophrenia and the distribution of blood groups(P >0. 05),no obvious difference from distributing frequence of normal blood group(P> 0. 05).
     结果,精神分裂症亚型与ABO的血型分布无明显关系(P>0.05),与正常群体血型分布频率也无明显差异(P>0.05)。
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     and it doesn′t have effect on schizophrenia genetic background.
     该多态性与精神分裂症亚型不存在相关性,对精神分裂症患者遗传背景也没有影响。
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     Changes of subtypes and symptoms of schizophrenia over 20 years
     近20年来精神分裂症亚型及症状变迁
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     A Mathematic model for subtyping schizophrenia 1.Establishment of the model
     精神分裂症亚型划分的数学模型一、数学模型的建立
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     Topic for Discussion :Psychiatry and diabetes
     精神分裂症和糖尿病
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     Rs by RT-PCR.
     Rs的亚型
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     Split of the Mind——Schizophrenia
     思维的分裂——精神分裂症
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  subtypes of schizophrenia
The different components of EE, suitably combined, may differentiate between the two subtypes of schizophrenia in terms of relapse rate.
      
Brain imaging methods that study the structure or function of the cortical and subcortical regions have also identified distinct patterns that distinguish schizophrenics from controls, and that may identify meaningful subtypes of schizophrenia.
      
Furthermore, the DSM-III program identified residual subtypes of schizophrenia in 23% of the diagnostic decisions.
      
It is suggested that late onset paranoid schizophrenia is different in many ways from other subtypes of schizophrenia beginning in adolescence.
      
Triplet repeats in clinical subtypes of schizophrenia: variation at the DRPLA (B37 CAG repeat) locus is not associated with peri
      
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Objective:To study changes of subtypes and symptoms in schizophrenic patients at different periods during1974-1994. Method: Schizophrenic patients who were admitted for the first time studied by random sampling in 1974,1984 and 1994 respectively. Results:The hebephrenic and catatonic subtypes of schizophrenia decreased,undifferentiated subtype increased,paranoid and simple subtypes showed no significant change.As for clinical symptoms,apathy,poverty of thought,abulia,feeling of being controlled,feeling of being...

Objective:To study changes of subtypes and symptoms in schizophrenic patients at different periods during1974-1994. Method: Schizophrenic patients who were admitted for the first time studied by random sampling in 1974,1984 and 1994 respectively. Results:The hebephrenic and catatonic subtypes of schizophrenia decreased,undifferentiated subtype increased,paranoid and simple subtypes showed no significant change.As for clinical symptoms,apathy,poverty of thought,abulia,feeling of being controlled,feeling of being revealed,delusion of non-consanguinity and delusion of grandeur increased;loosening of association,parathymie,bizarre behavior and impulsive behavior decreased.The study suggested that schizophrenic patients showed less classical clinical patterns in recent years.Discussion:In 1974,Morrison reported that of the subtypes of schizophrenia,hebephrenic and catatonic subtypes decreased year by year,whereas the paranoid subtype increased.Similar studies were rare in China.The study could be related to changes in different periods in this social inprovement and the raising of educational level.Since our schizophrenic patients were from the Han ethnicity of Xinjiang province,further studies are requied to find out if similar changes occur is patients of other ethnic backgrounds.

作者对1974、1984、1994三个年度内首次住院的精神分裂症病人进行了随机抽样调查,发现近年来精神分裂症亚型中青春型、紧张型明显减少,未定型增多。精神症状中情感淡漠、思维贫乏、意志缺乏、被控体验、被洞悉感、非血统妄想和夸大妄想等症状增多,思维破裂及散漫、情感倒错、离奇行为和冲动伤人等症状减少,表明近年来精神分裂症已趋于不典型化,并对其原因进行了探讨

Objective:To investigate the association between Val158Met polymorphism of catechol-O-methyltransferase(COMT)gene and schizophrenia in Chinese Han nationality. Method: The Val158Met polymorphism of COMT gene was tested in the Chinese Han's pedigrees where there were at least two schizophrenic affected-siblings according to the ICD-10 while both their parents are alive at the sample collection. Result: 1)The distributions of alleles or genotypes of COMT gene are not significantly different between the groups...

Objective:To investigate the association between Val158Met polymorphism of catechol-O-methyltransferase(COMT)gene and schizophrenia in Chinese Han nationality. Method: The Val158Met polymorphism of COMT gene was tested in the Chinese Han's pedigrees where there were at least two schizophrenic affected-siblings according to the ICD-10 while both their parents are alive at the sample collection. Result: 1)The distributions of alleles or genotypes of COMT gene are not significantly different between the groups of parents,unaffected -siblings and affected-siblings,between different sex and between the sub-types of schizophrenia.2)The transmission disequilibrium test does not show the transmission disequibrilium in affected-siblings,but in unaffected-siblings(P=0.014).3)There are significant relations between COMT genotypes and delusion,affective disorders,depersonalization,disorganized behaviors,thought form disorders and irritation. Conclusion: 1)The high activity Val158 allele of COMT itself ,or its adjacent genes,plays a role of protecting from schizophrenia.2)For these Chinese Han schizophrenia in this study,we can not assure the association between Val158Met polymorphism of COMT gene and schizophrenia.On the other hand,we can not exclude that the Val158Met polymorphism of COMT gene affect clinical symptoms in schizophrenia,or associate with subtype of schizophrenia.

目的 :探讨儿茶酚 -O -甲基转移酶 (COMT)第 15 8位密码子从缬氨酸到蛋氨酸的错义突变(Val15 8Met)多态性与精神分裂症的关系。方法 :在 42个至少包含 2名符合ICD -10精神分裂症诊断标准的患病同胞、父母存活的汉族家系中 ,对COMTVal15 8Met多态标记进行检测。结果 :1)COMT等位基因频度和基因型频度在父母组、非患病同胞组和患病同胞组之间无差异 ,在三组男女性别之间以及在精神分裂症不同亚型之间基因型频度和等位基因频度的分布也没有统计学意义的差异。 2 )传递不平衡性检验在患病同胞中无统计学差异 ,但发现有较多的高活性Val15 8COMT传递给非患病同胞 (P =0 0 14 )。 3)基因型与妄想、瓦解行为、思维形式障碍、情感障碍、人格解体和易激惹等临床特征相关。结论 :1)高活性COMTVal15 8等位基因或其附近与之连锁的其它基因对精神分裂症可能具有保护作用。 2 )对于本研究中的汉族精神分裂症来说 ,尚不能确定COMTVal15 8Met多态性与精神分裂症有关联 /连锁 ,但不能排除它在精神分裂症临床症状中的作用以及与精神分裂症亚型关联或连锁的...

目的 :探讨儿茶酚 -O -甲基转移酶 (COMT)第 15 8位密码子从缬氨酸到蛋氨酸的错义突变(Val15 8Met)多态性与精神分裂症的关系。方法 :在 42个至少包含 2名符合ICD -10精神分裂症诊断标准的患病同胞、父母存活的汉族家系中 ,对COMTVal15 8Met多态标记进行检测。结果 :1)COMT等位基因频度和基因型频度在父母组、非患病同胞组和患病同胞组之间无差异 ,在三组男女性别之间以及在精神分裂症不同亚型之间基因型频度和等位基因频度的分布也没有统计学意义的差异。 2 )传递不平衡性检验在患病同胞中无统计学差异 ,但发现有较多的高活性Val15 8COMT传递给非患病同胞 (P =0 0 14 )。 3)基因型与妄想、瓦解行为、思维形式障碍、情感障碍、人格解体和易激惹等临床特征相关。结论 :1)高活性COMTVal15 8等位基因或其附近与之连锁的其它基因对精神分裂症可能具有保护作用。 2 )对于本研究中的汉族精神分裂症来说 ,尚不能确定COMTVal15 8Met多态性与精神分裂症有关联 /连锁 ,但不能排除它在精神分裂症临床症状中的作用以及与精神分裂症亚型关联或连锁的可能性

Objective To investigate the relationship between the minisatallite polymorphism of the dopamine transporter gene(DAT1)and schizophrenia and its subtypes.Methods The association between the minisatallite polymorphism of the DAT1 gene and schizophrenia in Shanghai Han population was analyzed by the Amp FLP technique.Results (1)Five alleles of the DAT1 gene were found as follows:360bp,400bp,440bp,480bp and 520bp.The most common allele was 480bp.(2)There were no significant differences in the distributions...

Objective To investigate the relationship between the minisatallite polymorphism of the dopamine transporter gene(DAT1)and schizophrenia and its subtypes.Methods The association between the minisatallite polymorphism of the DAT1 gene and schizophrenia in Shanghai Han population was analyzed by the Amp FLP technique.Results (1)Five alleles of the DAT1 gene were found as follows:360bp,400bp,440bp,480bp and 520bp.The most common allele was 480bp.(2)There were no significant differences in the distributions of the alleles and the genotypes of the DAT1 gene between the schizophrenic patients and the healthy controls( Z <1.96, P >0.05).(3)There were no significant differences in the distributions between the positive symptom group or the negative symptom group and the healthy controls,neither between the positive group and the negative group( Z <1.96, P >0.05).Conclusion There isn’t significant association between the DAT1 gene and schizophrenia in Shanghai Han population.

探讨精神分裂症及其亚型与多巴胺转运体 (DAT1)基因间的关系。方法 采用Amp -FLP技术 ,对上海地区汉族人群中精神分裂症与DAT1基因小卫星多态性进行遗传关联分析。结果  (1)观察到DAT1基因中 5种等基因 (36 0bp、40 0bp、440bp、480bp、5 2 0bp) ,最常见是 480bp。 (2 )精神分裂症和健康对照组在DAT1的等位基因、基因型的分布上无显著性差异 (Z值小于 1.96 ,P >0 .0 5 )。 (3)阳性症状和阴性症状两类精神分裂症亚型分别与健康对照组相比 ,或两个亚型间比较 ,同样在DAT1基因多态性分布上无差异 (Z值小于 1.96 ,P >0 .0 5 )。结论 上海地区汉族人群中DAT1基因多态性与精神分裂症无遗传关联。

 
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