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例反应性增生淋巴结
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  benign lymphoid hyperplasia
     Methods Tissue microarray and immunohistochemistry were used to detect the expression of McM7,p53 and Ki-67 in 175 cases of NHL and 9 benign lymphoid hyperplasia.
     方法应用组织芯片和免疫组化S-P法检测M cM7、p53和K i-67在9例反应性增生淋巴结、175例NHL组织中的表达。
短句来源
     Methods Immunohistochemistry was used to detect the expression of clusterin on lymphoma tissue microarrays, which included 18 Hodgkin’s lymphoma(HL),175 non-Hodgkin’s lymphoma(NHL)and 8 benign lymphoid hyperplasia.
     方法应用组织芯片和免疫组化技术检测clusterin在8例反应性增生淋巴结、175例非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)及18例霍奇金淋巴瘤(Hodgkin’s lymphoma,HL)组织中的表达情况。
短句来源
  “例反应性增生淋巴结”译为未确定词的双语例句
     MethodsThe expressions of P27 kip1 , cyclin D3 and index Ki-67 was detected in 100 NHL and 20 reactive lymph nodes by immunohistochemical technique.
     方法采用免疫组织化学方法检测100例NHL患者病理标本及20例反应性增生淋巴结标本中P27kip1、cyclin D3及细胞增殖指标Ki-67的表达。
短句来源
     Methods The expressions of STAT3 and antiapoptotic gene protein—bcl 2 protein were detected by SP immunohistochemical techniques in 40 cases of HL with various subtypes and 13 reactive hyperplasia(RH) of lymph nodes.
     【方法】采用SP免疫组织化学方法检测了40 例不同亚型HL 之RS/H 细胞及13 例反应性增生淋巴结(RH) 的STAT3 和抗凋亡基因蛋白bcl2 的表达。
短句来源
     Methods The expression of CD8, EBV-LMP-1, Fas/Fas-L was detected by SP immunohistochemical staining in 40 cases of HNL and 10 cases of reactive hyperplastic lymphadenopathy.
     方法应用免疫组化SP法检测40例HNL和10例反应性增生淋巴结组织中的CD8、EB病毒编码的隐伏膜蛋白(EBV-LMP-1)、Fas、Fas-L蛋白的表达状况。
短句来源
     Polymerase chain reaction (PCR) and immunohistochemical staining method were used to detect the t (14; 18) and the over expression of Bcl-2 protein in 24 and 64 cases of Hodgkin's disease respectively, and PCR also was used to detect the translocation in 10 cases of reactive lymphoid hyperplasia as contrast.
     利用PCR技术检测了24例何杰金病例中的t(14;18),又利用免疫组织化学方法检测了64例何杰金病例中Bcl-2蛋白的表达,并利用上述两种方法对10例反应性增生淋巴结进行了对照检测,结果30%何杰金病例为t(14;18)阳性,同时在2例有明显滤泡增生的反应性增生淋巴结中也检出了这种易位。
短句来源
     Methods Expression of Pho-P38 and Ki67 antigen was studied in aggressive by immunohis-tochemistry B-NHL (n=20),indolent B-NHL (n=20),and reactive lymph node hyperplasia (n=10) .
     方法采用免疫组织化学方法(S-P法),检测20例B细胞侵袭性淋巴瘤、20例惰性淋巴瘤、10例反应性增生淋巴结组织中Pho-P38、Ki67的表达。
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  相似匹配句对
     A retrospective study of lymphonode reactive hyperplasia
     淋巴结反应性增生临床研究
短句来源
     In 10 cases of reactive hyperplasia of lymph node tissue,protein P53 was negative.
     10淋巴结反应性增生P53蛋白均为阴性。
短句来源
     The retrospective study of reactive hyperplasia of lymph node (RHLN)
     淋巴结反应性增生(假性淋巴瘤)的临床观察
     One case report of Castleman disease of the lung
     肺巨淋巴结增生1
短句来源
     Reactive nodular hyperplasia:a case report
     反应性结节性增生1
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  benign lymphoid hyperplasia
A case is reported of benign lymphoid hyperplasia in the stomach and proximal duodenum in a 12-year-old girl.
      
The average Cho/Cr ratio in the metastatic lymph nodes was significantly higher (mean: 4.8, range: 3.3-5.6) than that for benign lymphoid hyperplasia (mean: 2.2, range: 1.0-3.0).
      
Four cases of benign lymphoid hyperplasia (BLH) of the duodenal bulb are reported.
      
Benign lymphoid hyperplasia manifesting as a cecal mass: Report of a case
      
We have presented an unusual case of benign lymphoid hyperplasia, which manifested as a cecal deformity in a 15-year-old boy.
      
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In order to study the association between Epstein Barr virus(EBV) and non Hodgkin's Lymphoma(NHL), PCR, in situ hybridization(ISH) and LSAB inmmunohistochemical technique were applied to detect EBV BNLF 1 fragement and its expression product latent membrane protein(LMP 1) in 32 cases of NHL and 33 cases of reactive hyperplastic lymph nodes(RHLN). Results showed that the detection rate of BNLF 1 fragment by PCR was 53% in 32 cases of NHL, significantly higher than that of RHLN group 27%(P<0.05). 5 cases...

In order to study the association between Epstein Barr virus(EBV) and non Hodgkin's Lymphoma(NHL), PCR, in situ hybridization(ISH) and LSAB inmmunohistochemical technique were applied to detect EBV BNLF 1 fragement and its expression product latent membrane protein(LMP 1) in 32 cases of NHL and 33 cases of reactive hyperplastic lymph nodes(RHLN). Results showed that the detection rate of BNLF 1 fragment by PCR was 53% in 32 cases of NHL, significantly higher than that of RHLN group 27%(P<0.05). 5 cases of T cell lymphoma were all PCR positive. 5 of the 17 PCR positive cases were ISH positive. LMP 1, expression product of BNLF 1 gene, was demonstrated only in two cases of this group of NHL. Our results suggested that EBV infection existed in more than one half cases of this group of NHL and might be significant in the pathogenesis and development of lymphoma.

为研究EB病毒与非霍奇金淋巴瘤(NHL)的关系,采用PCR、原位杂交、LSAB(labelingstreptavidivinbiotin)免疫组化技术,检测32例NHL和33例反应性增生淋巴结中的EBVBNLF1基因片段及其表达产物潜伏膜蛋白(LMP1)。NHL中EBVBNLF1PCR扩增阳性率为53%,明显高于反应性增生淋巴结组27%(P<0.05),其中5例T细胞淋巴瘤全部阳性。17例PCR阳性的NHL中5例原位杂交阳性。LMP1检测仅2例阳性。结果表明本组病例半数以上NHL中有EBV感染,可能与肿瘤的发生发展有一定关系。

Polymerase chain reaction (PCR) and immunohistochemical staining method were used to detect the t (14; 18) and the over expression of Bcl-2 protein in 24 and 64 cases of Hodgkin's disease respectively, and PCR also was used to detect the translocation in 10 cases of reactive lymphoid hyperplasia as contrast. The results showed that t(14; 18) was present in 30% of Hodgkin's disease and that this translocation was also present in two cases of the reactive lymphoid hyperplasia. It is concluded that the expression...

Polymerase chain reaction (PCR) and immunohistochemical staining method were used to detect the t (14; 18) and the over expression of Bcl-2 protein in 24 and 64 cases of Hodgkin's disease respectively, and PCR also was used to detect the translocation in 10 cases of reactive lymphoid hyperplasia as contrast. The results showed that t(14; 18) was present in 30% of Hodgkin's disease and that this translocation was also present in two cases of the reactive lymphoid hyperplasia. It is concluded that the expression of Bcl-2 protein is not specific for the t(14;18) chromosomal translocation, and suggested that the t (14; 18) translocation also occur in non-malignant tissue and not, on its own, lead to malignancy.

利用PCR技术检测了24例何杰金病例中的t(14;18),又利用免疫组织化学方法检测了64例何杰金病例中Bcl-2蛋白的表达,并利用上述两种方法对10例反应性增生淋巴结进行了对照检测,结果30%何杰金病例为t(14;18)阳性,同时在2例有明显滤泡增生的反应性增生淋巴结中也检出了这种易位。因此不能确定何杰金病例中的t(14;18)是否来源于肿瘤细胞。此外发现在仅使用mbr引物的条件下,t(14;18)与Bcl-2蛋白高表达之间并无相互对应的关系。

Objective To investigate the regulation of activated signal transducer and activator of transcription 3 (STAT3) on the expression of bcl 2 protein in Hodgkin′s lymphoma(HL). Methods The expressions of STAT3 and antiapoptotic gene protein—bcl 2 protein were detected by SP immunohistochemical techniques in 40 cases of HL with various subtypes and 13 reactive hyperplasia(RH) of lymph nodes. Results Both of STAT3 and bcl 2 protein were overexpressed in RS/H cells of HL(positive rates were 65% and 67.5%...

Objective To investigate the regulation of activated signal transducer and activator of transcription 3 (STAT3) on the expression of bcl 2 protein in Hodgkin′s lymphoma(HL). Methods The expressions of STAT3 and antiapoptotic gene protein—bcl 2 protein were detected by SP immunohistochemical techniques in 40 cases of HL with various subtypes and 13 reactive hyperplasia(RH) of lymph nodes. Results Both of STAT3 and bcl 2 protein were overexpressed in RS/H cells of HL(positive rates were 65% and 67.5% respectively),a significantly positive correlation existed between their positive rates (P<0.05). Conclusions The activation of STAT3 may induce the overexpression of anti apoptotic gene bcl 2,leading to persistent proliferation of RS/H cells.Therefore, it may play an important role in malignant transformation and progression of RS/H cells in HL.

【目的】探讨霍奇金淋巴瘤(HL) 细胞信号转导物与转录激活剂3(STAT3) 的活化对bcl2 蛋白表达的调控作用。【方法】采用SP免疫组织化学方法检测了40 例不同亚型HL 之RS/H 细胞及13 例反应性增生淋巴结(RH) 的STAT3 和抗凋亡基因蛋白bcl2 的表达。【结果】STAT3 及bcl2 蛋白在HL 不同亚型的RS/H 细胞中均呈过度表达( 阳性率分别为65 % 和67 .5 % ) ,且两者的阳性率呈明显的正相关( P < 0 .05) 。【结论】STAT3 的活化可能通过介导抗凋亡基因bcl2 的过度表达而使RS/H 细胞呈持续性增殖,并在HL 之RS/H 细胞恶性转化及演进中起重要作用。

 
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