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   mmp鄄2 的翻译结果: 查询用时:0.023秒
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mmp鄄
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  mmp-2
     The positive expression rate of COX-2 was 46%,which had no correlation with lymph metastasis and differentiation degree,and was positively correlated with the expression of MMP-2 and MMP-9 protein(P=0.010 and 0.018).
     COX鄄2蛋白在舌鳞癌组织中的阳性率为46%,其表达与淋巴结转移及分化程度无关,但与MMP鄄2和MMP鄄9蛋白的表达均呈正相关(P=0.010和0.018)。
短句来源
     The positive expression rates of MMP-2 and MMP-9 were 83% and 81% respectively,which correlated with lymph metastasis positively(P=0.006 and 0.033)and had no correlation with differentiation degree.
     [结果]MMP鄄2和MMP鄄9蛋白在舌鳞癌组织中的阳性率分别为83%和81%,它们的表达与淋巴结转移均呈正相关(P为0.006和0.033),与分化程度无关;
短句来源
     In 42 cases of lung cancer,MVD was 18.33~67.67(43.56±10.29). MVD in MMP-2 positively stained group (47.06±10.30) was significantly higher than that in negatively stained group(37.88±7.53)(P=0.004).
     42例肺癌组织中的MVD为18.33~67.67(43.56±10.29),MMP鄄2阳性组MVD为47.06±10.30,明显高于阴性组的37.88±7.53(P=0.004)。
短句来源
     Results: The expression levels of E1AF and MMP-7 in the colorectal tissue with lymphatic metastasis were significantly higher than those in the colorectal tissue without lymphatic metastasis (P<0.05), but the difference of MMP-2 expression level was not significant (P>0.05).
     结果:大肠癌患者淋巴结转移组E1AF和MMP鄄7的表达水平均显著高于淋巴结无转移组(P<0.05),MMP鄄2的表达水平在两组间无统计学意义(P>0.05);
短句来源
     Methods: Twenty-eight colorectal cancer specimens were studied by RT-PCR to detect the mRNA expressions of E1AF, MMP-2 and MMP-7, and then statistical analysis was performed.
     方法:采用RT鄄PCR方法测定28例大肠癌患者肿瘤组织中E1AF、MMP鄄2和MMP鄄7的表达水平,进行统计分析。
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  “mmp鄄2”译为未确定词的双语例句
     The expressions of MMP-2,-9 and COX-2 were detected in 59 cases of tongue squamous cell carcinoma by immunohistochemistry.
     [方法]应用免疫组织化学的方法检测59例舌鳞癌组织中MMP鄄2、MMP鄄9和COX鄄2蛋白的表达。
短句来源
     Univariate survival analyses indicated that the expression of MMP2 was associated with overall survival (Log-rank test,P<0.05).
     淋巴结转移组MMP鄄2表达明显高于无淋巴结转移组穴P<0.05雪;
短句来源
     OBJECTIVE: TO INVESTIGATE THE PROTEIN EXPRESSION AND EFFECT OF MATRIX METALLOPROTEINASES-2 IN PATIENTS WITH CRESCENT GLOMERULONEPHRITIS.
     目的探讨MMP鄄2(matrixmetalloproteinases鄄2)在新月体肾小球肾炎中的表达和作用。
短句来源
     Methods: Cells with a density of 1.5×105/ml were cultured for 48 hours and then treated with IGF-II at different concentrations for additional 18 hours.
     方法:以IGF鄄II处理卵巢癌细胞AO、3AO,用明胶酶谱法和RT鄄PCR法检测MMP鄄2蛋白的分泌以及基因表达。
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  相似匹配句对
     These suggest that MDM2 may play a specific role in the occurrence of gastric tumor.
     ·2·
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     2) R.
     2 ) R.
短句来源
     In addition, the expression of MMP-1,-9were correlated negatively with the changes of mechanical function during myocardial ischemia-reperfusion.
     MMP-2没有表达;
短句来源
     The sporopollen includes Osmundacidites sp., Deltoidospora sp., Leiotriletes sp., Punctatisporites sp., Ilexpollenites sp., Quercoidites sp., Caryapollenites sp., Betulaceoipollenites sp., Sporopollis?
     ,Betulaceoipollenitessp. ,Sporopollis?
短句来源
     Conclusion: MMP-1 and MMP-3 may have important role in triggering pulmonary vascular remodeling and take part in the whole process.
     结论:MMP1和MM
短句来源
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  mmp-2
Four closely related lines of RSV-transformed Syrian hamster fibroblasts differing drastically in their spontaneous metastatic capacity were investigated for the surface expression of integrins, in vitro invasion, and production of MMP-2 collagenase.
      
Substrate stimulation of the signal function of the collagen-specific integrins increases the production of MMP-2 by the metastatically active fibroblasts.
      
Inhibition of the signal activity of the integrins by RGD-containing pentapeptide or by genistein reduces markedly in vitro invasion in Matrigel and MMP-2 production.
      
Expression of matrix metalloproteinase (MMP-2) and extracellular matrix metalloproteinases inducer (EMMPRIN) in benign and advan
      
Extracellular matrix metalloproteinases inducer (EMMPRIN) stimulates synthesis of gelatinase A (MMP-2) in peritoneal fibroblasts.
      
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Objective:To evaluate the significance of Syndecan1and MMP1expression in gastric cancer.Methods:The expression of Syndecan1and MMP1were measured in tissues of gastric cancer(82cases),dysplasia(18cases)and normal gastric mucosa(36cases),by using streptavidinperoxidase immunohistochemistry.Results:All the cases of normal gastric mucosa(36/36,100%)expressed Syndecan1,the positive rate of Syndecan1expression was83.33%(15/18)in dysplastic mucosa and57.32(47/82)in carcinomatous tissue.Of the normal gastric mucosa,5.56%(2/36)expressed...

Objective:To evaluate the significance of Syndecan1and MMP1expression in gastric cancer.Methods:The expression of Syndecan1and MMP1were measured in tissues of gastric cancer(82cases),dysplasia(18cases)and normal gastric mucosa(36cases),by using streptavidinperoxidase immunohistochemistry.Results:All the cases of normal gastric mucosa(36/36,100%)expressed Syndecan1,the positive rate of Syndecan1expression was83.33%(15/18)in dysplastic mucosa and57.32(47/82)in carcinomatous tissue.Of the normal gastric mucosa,5.56%(2/36)expressed MMP1,whereas the positive rate was88.89%(16/18)and98.78%(81/82)in dysplastic and carcinomatous tissues respectively.Statistical analysis showed that there existed a significant difference of Syndecan1and MMP1expression between normal or dysplastic mucosa and cancerous tissue(P<0.01).The staining intensity of Syndecan1and MMP1bore a close relation with the pattern of tumor infiltration,the depth of tumor invasion,the lymphnode metastasis,the venous and lymphatic invasion of the carcinoma.Conclusions:Determination of Syndecan1and MMP1might be of value in the early detection as well as in the prognostication of gastric cancer.

目的:探讨Syndecan鄄1和MMP鄄1在胃癌组织中的表达及意义。方法:应用SP免疫组化染色技术,检测82例胃癌、18例异型增生及36例正常胃黏膜组织中Syndecan鄄1和MMP鄄1的表达。结果:胃癌组织Syndecan鄄1表达阳性率为57.32%(47/82),胃异型增生组织为83.33%(15/18),正常胃黏膜组织均呈Syndecan鄄1阳性表达。胃癌组织的Syndecan鄄1表达与正常胃黏膜上皮、胃异型增生组织中的表达相比差异显著(P<0.01)。胃癌组织的MMP鄄1表达阳性率为98.78%(81/82),其中强阳性表达占45例(54.88%);胃异型增生组织MMP鄄1阳性率为88.89%(16/18),无强阳性表达;正常胃黏膜组织MMP鄄1表达阳性率为5.56%(2/36)。胃癌组织的MMP鄄1表达与正常胃黏膜上皮、胃异型增生组织中的表达相比差异显著(P<0.01)。Syndecan鄄1表达的减弱、MMP鄄1表达的增强与胃癌的淋巴结转移、静脉侵犯、淋巴管侵犯、浸润深度、TNM分期显著相关(P<0.05)。Synd...

目的:探讨Syndecan鄄1和MMP鄄1在胃癌组织中的表达及意义。方法:应用SP免疫组化染色技术,检测82例胃癌、18例异型增生及36例正常胃黏膜组织中Syndecan鄄1和MMP鄄1的表达。结果:胃癌组织Syndecan鄄1表达阳性率为57.32%(47/82),胃异型增生组织为83.33%(15/18),正常胃黏膜组织均呈Syndecan鄄1阳性表达。胃癌组织的Syndecan鄄1表达与正常胃黏膜上皮、胃异型增生组织中的表达相比差异显著(P<0.01)。胃癌组织的MMP鄄1表达阳性率为98.78%(81/82),其中强阳性表达占45例(54.88%);胃异型增生组织MMP鄄1阳性率为88.89%(16/18),无强阳性表达;正常胃黏膜组织MMP鄄1表达阳性率为5.56%(2/36)。胃癌组织的MMP鄄1表达与正常胃黏膜上皮、胃异型增生组织中的表达相比差异显著(P<0.01)。Syndecan鄄1表达的减弱、MMP鄄1表达的增强与胃癌的淋巴结转移、静脉侵犯、淋巴管侵犯、浸润深度、TNM分期显著相关(P<0.05)。Syndecan鄄1表达与MMP鄄1表达呈负相关。结论:联合检测Syndecan鄄1和MMP鄄1对胃癌的早期诊断及判断预后有参考价值。

To investigate the relationship between expression of E-cadherin(E-cad),matrix met-alloproteinases-9(MMP-9),vascular endothelial growth factor(VEGF)and invasion,metastasis of rectal cancer.The streptavidin-peroxidase immunohistochemistry was taken in90cases of rectal cancer.The expression of E-cad was reduced with the lowing of differentiation degree,the increase of the depth of invasion and lymph node metastasis.The expression of MMP-9was enhanced with the increase of the depth of invasion and lymph node metastasis.The...

To investigate the relationship between expression of E-cadherin(E-cad),matrix met-alloproteinases-9(MMP-9),vascular endothelial growth factor(VEGF)and invasion,metastasis of rectal cancer.The streptavidin-peroxidase immunohistochemistry was taken in90cases of rectal cancer.The expression of E-cad was reduced with the lowing of differentiation degree,the increase of the depth of invasion and lymph node metastasis.The expression of MMP-9was enhanced with the increase of the depth of invasion and lymph node metastasis.The expression of VEGF was correlated with the lymph node metastasis.[Conclusion]The positive expression of E-cad,MMP-9and VEGF in rectal cancer tissue was cor-related with the invasion and metastasis of rectal cancer.The expression may be important to the determina-tion of the malignant biological property and the prognosis of rectal cancer.

[目的]检测直肠癌组织中与浸润转移过程相关的蛋白钙粘素(E-cad)、基质金属蛋白酶-9(MMP-9)、血管内皮细胞生长因子(VEGF)的表达,探讨这些因素与大肠癌浸润、转移的相关性,以期寻找能够进一步判断大肠癌浸润转移潜能的分子生物学指标。[方法]采用免疫组化SP方法检测90例直肠癌中E鄄cad、MMP-9、VEGF的表达。[结果]E-cad的表达随着癌组织的分化程度的降低而降低,随浸润深度的加深及转移的出现逐渐下调。MMP鄄9的表达随着浸润深度的加深及淋巴结转移的出现而逐渐增强。VEGF的表达与淋巴结转移呈正相关。[结论]直肠癌的浸润和转移与E-cad、MMP-9、VEGF的表达具有显著相关性。应用多种抗体检测肿瘤相关蛋白并分析其表达的意义,将有助于判断直肠癌的浸润、转移潜能及预后,为临床治疗方案的选择提供理论依据。

To explore the expression and clinical significance of matrix metalloproteinase-9(MMP-9)and its inhibitor (tissue inhibitor of metalloproteinase-1,TIMP-1)in nasopharyngeal carcinoma.The expres-sion of MMP-9and TIMP-1was detected by immunohistochemisty staining(labled streptavidin method),in tissues from77cases with nasopharyngeal carcinoma tissues(48male and29female,age between39years and78years,22cases in cl inical stageⅠ~Ⅱand55cases in clinical stageⅢ~Ⅳ,28cases in pathological sta ge T 1 ~T 2 and49cases in...

To explore the expression and clinical significance of matrix metalloproteinase-9(MMP-9)and its inhibitor (tissue inhibitor of metalloproteinase-1,TIMP-1)in nasopharyngeal carcinoma.The expres-sion of MMP-9and TIMP-1was detected by immunohistochemisty staining(labled streptavidin method),in tissues from77cases with nasopharyngeal carcinoma tissues(48male and29female,age between39years and78years,22cases in cl inical stageⅠ~Ⅱand55cases in clinical stageⅢ~Ⅳ,28cases in pathological sta ge T 1 ~T 2 and49cases in pathological stage T 3 ~T 4 ,39cases with lymph node metastasis and42cases of normal tissues used as neg ative control.The results were analyzed by SPSS.①The positive rates of MMP-9and TIMP-1in na-sopharyngeal carcinoma tissues were70.1%(54/77)and46.8% (36/77),respectively.There were significantly dif-ference between carcinoma tis sues and controls(P<0.05).②MMP-9was significantly different among clinical sta ges,and among TNM stages(P<0.05),but there was no significant correlation betwee n TIMP-1expression and clinicopathologic stages(P>0.05).③No significant diff erences of MMP-9and TIMP-1in gender and age distri-bution was found(P>0.05) .[Conclusions]Increase of MMP-9and decrease of TIMP-1play important roles in N PC's course.Their expression do not correlate to gender and age.

[目的]探讨鼻咽癌组织中基质金属蛋白酶鄄9(MMP鄄9)及其特异抑制剂TIMP鄄1的表达及二者在临床中的意义。[方法]采用免疫组化SP法检测了77例鼻咽癌组织(男性48例,女性29例;年龄39岁~78岁,平均年龄53.7岁;临床分期Ⅰ~Ⅱ期22例,Ⅲ~Ⅳ期55例;原发灶分期T1~T2期28例,T3~T4期49例;伴淋巴结转移者39例及42例正常对照组织中的MMP鄄9、TIMP鄄1的表达,检测结果利用SPSS统计软件进行统计学分析。[结果]①MMP鄄9及TIMP鄄1在鼻咽癌组织中的阳性表达率分别为70.1%(54/77)及46.8%(36/77),与正常对照差异有显著性(P<0.05)。②MMP鄄9阳性表达率在鼻咽癌原发灶分期、临床分期中差异具显著性(P<0.05),而TIMP鄄1阳性表达与上述临床病理因素无关(P>0.05)。③MMP鄄9及TIMP鄄1的阳性表达率在年龄、性别上差异无显著性(P>0.05)。[结论]鼻咽癌组织中MMP鄄9表达升高、TIMP鄄1表达降低在鼻咽癌病程进展中具重要作用,二者表达与年龄、性别无关。

 
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