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大鼠胰腺癌
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  rat pancreatic cancer
    Inhibition of angiogenesis inhibitor SU5416 on growth and metastasis of experimental rat pancreatic cancer
    血管生成抑制剂SU5416对大鼠胰腺癌生长和转移的抑制作用
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    In group B, the expression of SST2R protein and mRNA also decreased significantly after the rats were treated with octreotide (P<0.05, vs pretreatment or group A), but there was no statistic difference 3,7 and 14 days after the octreotide therapy in group B. Conclusions The SST2R protein and mRNA decreased significantly in rat pancreatic cancer tissue.
    B组在治疗后3d、7d、14d时相互比较无显著性差异(P>0.05),但与其治疗前比较有显著性差异(P<0.05)。 结论 SD大鼠胰腺癌组织SST2R mRNA和SST2R的表达量明显减少;
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    Establishment of a model for pancreatic cancer in Sprague-Dawely(SD) rat and study on the relationship among IL-8,MCP-1,MIP-1α mRNA and MC count in the rat pancreatic cancer
    SD大鼠胰腺癌模型及其化学趋化因子mRNA表达与MC计数的关系研究
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  “大鼠胰腺癌”译为未确定词的双语例句
    Effect of Estrogen on Ultramicrostructure of Rats Pancreatic Precancerous Lesion Induced by Azaserine
    雌激素对大鼠胰腺癌前病变超微结构的影响
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    THE EXPERIMENTAL STUDY OF ESTROGEN EFFECT ON PRECANCEROUS LESION AND K-ras MUTATION IN RATS ' PANCREATIC ACINAR CELLULAR CANCER
    雌激素对大鼠胰腺癌前病变及K-ras基因突变影响的实验研究
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    THE EXPERIMENTAL STUDY OF ESTROGENS EFFECT ON DNA CONTENT IN PRECANCEROUS LESION OF RATS PANCREATIC CANCER INDUCED BY AZASERINE
    雌激素对Azaserine诱导大鼠胰腺癌癌前病变DNA含量影响的实验研究
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    Development of a new rat model of pancreatic cancer
    一种新型大鼠胰腺癌模型的制备
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    Effects of Angiogenesis Inhibitor SU5416 on Microvessel Density in Rat Model of Pancreatic Cancer
    SU5416对大鼠胰腺癌微血管密度的影响及意义
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  rat pancreatic cancer
Gene expression of gonadotropin-releasing hormone and its receptor in rat pancreatic cancer cell lines
      


Objective To develop a model of pancreatic cancer in common Sprague Dawely rat.Methods The membrane and partial parenchyma (about 1 mm depth) of rat pancreas was opened to put a high dose (9 mg) of dimethylbenzanthracine(DMBA), and then the incision was closed with interrupted sutures. Results The prevalence of pancreatic cancer among DMBA-treated rats within 3-5 months was 65% (33/50). Among the 33 rats with pancreatic cancer, 30 rats developed pancreatic ductal adenocarcinomas with glandular duct-like...

Objective To develop a model of pancreatic cancer in common Sprague Dawely rat.Methods The membrane and partial parenchyma (about 1 mm depth) of rat pancreas was opened to put a high dose (9 mg) of dimethylbenzanthracine(DMBA), and then the incision was closed with interrupted sutures. Results The prevalence of pancreatic cancer among DMBA-treated rats within 3-5 months was 65% (33/50). Among the 33 rats with pancreatic cancer, 30 rats developed pancreatic ductal adenocarcinomas with glandular duct-like distribution of cancer cells, various sizes of glandular cavities, obvious nuclei heterotpic and atypical cocus of cancer cells under a microscope. And the remaining 3 cases were diagnosed having pancreatic fibrosarcoma with a great number of fibrosarcoma cells substituting for pancreas.Conclusion High dose of DMBA directly put into the parenchyma of pancreas under the membrane could obtained a pancreatic cancer model with high incidence in a short time.

目的 研制一种普通大鼠胰腺癌模型。方法 切开SD大鼠胰腺被膜及部份胰腺实质 ,深 1mm ,置入 9mg的二甲基苯并蒽 (DMBA) ,缝合胰腺被膜。结果  3~ 5个月内大鼠胰腺癌发生率为 6 5 % (33/ 5 0 ) ,其中 30只为胰腺导管上皮腺癌 ,镜下癌细胞呈腺管样分布 ,腺腔大小不一 ,核异型明显 ,并可见癌细胞巢 ;3只大鼠形成胰腺纤维肉瘤 ,胰腺完全消失 ,被弥漫分布的纤维肉瘤细胞取代。结论 采用较大剂量的DMBA直接置入胰腺被膜下的实质内 ,可在短期内获得较高发生率的鼠胰腺癌模型。

Objective To observe the effect of somatostatin analogues (octreotide) on the expression of protein and mRNA of somatostatin receptor-2(SST2R) in Sprauge Dawley (SD) rats with pancreatic cancer. Methods The rats pancreatic cancer was induced with dimethylbenzanthracine (DMBA). Fifty rats were divided into 4 groups: pancreatic cancer group (group A, rats with pancreatic cancer treated with saline), somatostatin analogues (octreotide, Sandostadin) group (group B, rats with pancreatic cancer treated with Sandostadin),...

Objective To observe the effect of somatostatin analogues (octreotide) on the expression of protein and mRNA of somatostatin receptor-2(SST2R) in Sprauge Dawley (SD) rats with pancreatic cancer. Methods The rats pancreatic cancer was induced with dimethylbenzanthracine (DMBA). Fifty rats were divided into 4 groups: pancreatic cancer group (group A, rats with pancreatic cancer treated with saline), somatostatin analogues (octreotide, Sandostadin) group (group B, rats with pancreatic cancer treated with Sandostadin), negative control group (group C, rats given DMBA but no pancreatic cancer found), and normal control group (group D). In group A and B, the rats were treated with saline and octeotide (subcutaneous injection, 100 fig, qid) respectively, the protein and mRNA of SST2R in pancreatic cancer tissue were detected by radioimmunoassay or reverse transcription PCR (RT-PCR) 3, 7 and 14 days after treatment. Results The expression of SST2R protein and mRNA decreased significantly in group A and B, especially in group B (P<0.05, vs group C and D). In group B, the expression of SST2R protein and mRNA also decreased significantly after the rats were treated with octreotide (P<0.05, vs pretreatment or group A), but there was no statistic difference 3,7 and 14 days after the octreotide therapy in group B. Conclusions The SST2R protein and mRNA decreased significantly in rat pancreatic cancer tissue. Octreotide can decrease the expression, possibly because of low response of somatostatin analogues in pancreatic cancer.

目的 探索SD大鼠胰腺癌组织SST2R及SST2R mRNA的表达以及外源性生长抑素类似物善得定治疗后其表达量的变化。方法 采用二甲基苯丙蒽(DMBA)诱导鼠胰腺癌模型。将实验大鼠随机分为胰腺癌组(A组)、胰腺癌治疗组(B组)、模型制作后未形成胰腺癌的假阳性组(C组),以及正常大鼠组(D组)。在善得定(10μg/kg,每6h1次)治疗前和治疗后的3d、7d、14d,分别取各组胰腺组织标本。分别采用放射免疫法、逆转录聚合酶链法(RT-PCR)分析各组胰腺癌组织SST2R及SST2RmRNA的表达。结果 A、B组SST2R及SST2R mRNA的表达比C、D组显著减少(P<0.05),尤以善得定治疗后的B组减少更为明显,其与A组比较有显著性差异(P<0.05)。B组在治疗后3d、7d、14d时相互比较无显著性差异(P>0.05),但与其治疗前比较有显著性差异(P<0.05)。结论 SD大鼠胰腺癌组织SST2R mRNA和SST2R的表达量明显减少;在善得定治疗后其表达量下降更为明显(P<0.05)。我们认为,胰腺癌组织SST2R mRNA表达量明显减少可能是导致SSTR表达量显著减少和外源...

目的 探索SD大鼠胰腺癌组织SST2R及SST2R mRNA的表达以及外源性生长抑素类似物善得定治疗后其表达量的变化。方法 采用二甲基苯丙蒽(DMBA)诱导鼠胰腺癌模型。将实验大鼠随机分为胰腺癌组(A组)、胰腺癌治疗组(B组)、模型制作后未形成胰腺癌的假阳性组(C组),以及正常大鼠组(D组)。在善得定(10μg/kg,每6h1次)治疗前和治疗后的3d、7d、14d,分别取各组胰腺组织标本。分别采用放射免疫法、逆转录聚合酶链法(RT-PCR)分析各组胰腺癌组织SST2R及SST2RmRNA的表达。结果 A、B组SST2R及SST2R mRNA的表达比C、D组显著减少(P<0.05),尤以善得定治疗后的B组减少更为明显,其与A组比较有显著性差异(P<0.05)。B组在治疗后3d、7d、14d时相互比较无显著性差异(P>0.05),但与其治疗前比较有显著性差异(P<0.05)。结论 SD大鼠胰腺癌组织SST2R mRNA和SST2R的表达量明显减少;在善得定治疗后其表达量下降更为明显(P<0.05)。我们认为,胰腺癌组织SST2R mRNA表达量明显减少可能是导致SSTR表达量显著减少和外源性生长抑素类似物治疗临床胰腺癌效果不佳的主要原因之一。

Objective To investigate the effect of ischemia-reperfusion plus particle embolism on the pathology and cell apoptosis of pancreatic cancer (PC) in Sprague Dawely rats. Methods Dimethybeneanthracine (DMBA) was implanted into the parenchyma of pancreas tail.When the tumor model was established, the rats were randomly divided into 5 groups:(A)control group;(B)PC Control group;(C)PC ischmia group;(D)PC ischeia reperfusion (I/R) group;(E)PC I/R plus particle infusion embolism(PC I/R plus embolism) group. Pathological...

Objective To investigate the effect of ischemia-reperfusion plus particle embolism on the pathology and cell apoptosis of pancreatic cancer (PC) in Sprague Dawely rats. Methods Dimethybeneanthracine (DMBA) was implanted into the parenchyma of pancreas tail.When the tumor model was established, the rats were randomly divided into 5 groups:(A)control group;(B)PC Control group;(C)PC ischmia group;(D)PC ischeia reperfusion (I/R) group;(E)PC I/R plus particle infusion embolism(PC I/R plus embolism) group. Pathological changes and cell apoptosis indix(AI) of pancreatic cancer were detected by light microscopy and ISEL, respectively 14 days after the operation. Results There was a significant difference in AI between Group E and the other groups (Group D ,Group C and Group B) (P<0.01),respectivcly. The volume of tumor in Group E was significantly smaller than that in the other groups (P<0.01) and was associated with infiltration of inflammatory cells proliferation, wide necrosis and hemorrhage.Conclusions The necrosis and cell apoptosis of pancreatic cancer in Group E(PC I/R+emblism) were more significant than those in PC ischemia group(Group C) or PC I/R group(Group D).

目的 探讨缺血再灌注 (I/R )加微球栓塞对病理大鼠的胰腺癌形态学和癌细胞凋亡的影响。 方法  将二甲基苯并蒽 (DMBA )置入鼠胰腺尾部被膜下的实质内 ,待胰腺肿瘤形成后 ,随机分为 4组 :A组即正常对照组 ;B组即胰腺癌对照组 ;C组即胰腺癌缺血组 ;D组即胰腺癌I/R组 ;E组即胰腺癌I/R加微球栓塞组。 14d后观察病理改变并采用原位末端标记法 (ISEL)检测凋亡指数 (AI)。 结果  E组的AI与D组 ,C组和B组差异均有显著性 (均P <0 .0 1) ;E组肿瘤体明显缩小 ,与D组和C组比较均有显著性差异 (P <0 .0 1) ;E组炎性细胞浸润 ,纤维组织增生 ,并且出现广泛的坏死和出血。结论  胰腺癌缺血再灌注和微球栓塞可诱发肿瘤坏死 ,且其细胞凋亡的程度明显大于单纯的胰腺癌缺血组或胰腺癌缺血再灌注组。

 
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