Results The linearity between concentrations and the peak ratio was obtained from 5.05～40.4μg·ml-1(r=1.000 0). The within-day and between- days variation coefficients were less than 2% (n=5). The average recoveries were 99.79%,99.50% and 99.11%, respectively.

The limit of determination,based on a signal-to-noise ratio of 3∶1,was 250ng. The reveals linearity equation was in concentration range 0.4099～0.6149mg·ml-1,A=7351270.8C-4136.7,r=0.9990.The cefpiramide could be separated effectively from its degradation product with the method.

Results The linearity between concentrations and the peak ratio was obtained from 5.05～40.4μg·ml-1(r=1.000 0). The within-day and between- days variation coefficients were less than 2% (n=5). The average recoveries were 99.79%,99.50% and 99.11%, respectively.

Results The linearity was obtained over the range of 0.050 to 5.000 mg·L-1 of fluorouracil in saline with a good correlation coefficient (r=0.9996, n=4).

The detection wavelength:320nm. RESULTS The methodproved to be linear over the range of 0.9756～9.756 μg,r=0.99998; The average recovery was 100.2%,RSD=0.2%(n=9).

RESULTS The method was linear over the concentration range of 0.2 ~ 400 ng/ml and the lower limit of quantification was 0.2 ng/ml for both imrecoxib and hydroxyimrecoxib. The intra- and inter-day precision (RSD) was within 8.2% and the assay accuracy (RE) was within ±7.1% for both analytes.

Results The assay was reproducible and linear over the range of 1.0 - 4000 ng·mL~(-1). The lower limit of quantification of the analyte was 1.0 ng·mL~(-1).

Res ults The method was proved to be linear in the range of 100.1～1 001.2 μg/mL wi th a regression coefficient of 0.999 9.The average recovery rate was 100.3%with RSD < 1.0%(n=9). The RSD of average contents of intra-day and inter-day was 0.4%and 0.9%respectively.

RESULTS The method was proved to be linear in the range of 10.3～103.1 mg·L2-1,the regression coefficient was 0.999 9.The recovery of method was 100.4%(RSD 0.95%,2n=9).

The detection wavelength:320nm. RESULTS The methodproved to be linear over the range of 0.9756～9.756 μg,r=0.99998; The average recovery was 100.2%,RSD=0.2%(n=9).

RESULTS The method was proved to be linear in the range of 10.0 - 2 000.0μg·L-1 with correlation coefficients 0. 999 5. The average recovery was 90. 7% - 93. 2% and the RSD was 3.03% -4.17% .

Studies in rats revealed dose dependency/ non-linearity in arteether pharmacokinetics with in the dose levels used.

The linearity of calibration curve provided by SEKI was similar to that offered by non-bias hydrodynamic injection (HDI) but significantly better than that obtained by EKI.

The characteristics of good linearity, high resolution, and high-frequency response were approved.

For the correlation between effects and doses, the former presented a particular saddle-like pattern, while the latter showed a pattern of linearity.

The linearity of the Stokes equations makes it possible to develop effective methods of solution of the problem for two and many particles [1].

The linearity of calibration curve provided by SEKI was similar to that offered by non-bias hydrodynamic injection (HDI) but significantly better than that obtained by EKI.

The linearity of the Stokes equations makes it possible to develop effective methods of solution of the problem for two and many particles [1].

The linearity of Darcy's law is known to be disturbed at both high and low flow velocities [1-3].

It was found that smoothing by these two filters did not distort noticeably the signal shape and the linearity of calibration plots.

It was shown that, for staircase stripping voltammetry, the linearity of calibration plots decreases substantially in this series of signal processing methods.

However, a similar dependence of respiration in state 4 is linear over the whole temperature range and corresponds to the activation energy of 17 kJ/mol.

The calibration curve is linear over the concentration range 2.0-100 Μg of nickel in 5 mL of the final dimethylformamide solution.

For linear sweep, calibration plots were linear over the entire concentration range for all signal-processing methods.

The calibration graph was linear over the range of 0.050-1.20 μg/mL, with a limit of detection of 0.03 μg/mL.

The Stern-Volmer relationships for phosphorescence quenching are linear over the entire range of oxygen concentrations.

13C-NMR spectroscopy revealed both polysaccharides to be linear partially acetylated 1,4-β-D-glucomannans.

The unknown multidimensional plant whose parameter vector should be estimated was assumed to be linear and static, and uncertainty of its "input-output" model, to have both additive and multiplicative components.

The antigenic determinants recognized by antibodies from group III PO1 and 36F9 were shown to be linear (continuous) and formed by amino acid residues 261-267 and 271-277, respectively, as determined by the peptide scanning method (PEPSCAN).

The distribution of the stationary longitudinal velocity on the body is assumed to be linear.

At the same time, the dependence of its pulse heights on the β-particle energy is shown to be linear.

The direct detection of plasma angiotensin Ⅱ (AT Ⅱ) by radioimmunoassay with 0.5 ml of human blood was achieved by utilizing fine-quality antisera, ~(125)Ⅰ. AT Ⅱ of high speoifio aotivity and the double antisera separation technique.The detecting limit for competitive inhibition ourve (n =28) was 3.6 ± 1.6 pg (m. ± S. D.), and the preoision was 4.7 ±1.4% (m. ±S. D.).The C. V. in plasma measurement were 7~14% for the within assay, and 8.7~ 18 % for the between assays respectively.AT Ⅱ showed a linear increase...

The direct detection of plasma angiotensin Ⅱ (AT Ⅱ) by radioimmunoassay with 0.5 ml of human blood was achieved by utilizing fine-quality antisera, ~(125)Ⅰ. AT Ⅱ of high speoifio aotivity and the double antisera separation technique.The detecting limit for competitive inhibition ourve (n =28) was 3.6 ± 1.6 pg (m. ± S. D.), and the preoision was 4.7 ±1.4% (m. ±S. D.).The C. V. in plasma measurement were 7~14% for the within assay, and 8.7~ 18 % for the between assays respectively.AT Ⅱ showed a linear increase concomittantly with the inorement of the plasma from 0.1 to 1.5 ml.AT Ⅱ added into the plasma could be quantitatively recovered (97～117%).There was no evidenoe of interference by the addition of eight peptide hormones, human plasma proteins, proteolytio enzymes and enzyme inhibitors.The mean concentrations of the peripheral venous plasma AT Ⅱ of normall persons on free diet were as follows: 26±10 pg/ml(n=54) while assuming a recumbent position for 1.5 hour, with a negative correlation to 24 hours urinary sodium exeretion (p<0.01); 46±22 pg/ml (n=17) after assuming an erect position for 2 hours.The plasma AT Ⅱ values were markedly elevated after provocation either with a low sodium diet or an intramuscular injection of furosemide (p<0.01).As a sensitive, speoifio, accurate and simple method for the deteotion of minute quantities of plasma AT II, this method should be useful for clinical investigations and for research on the renin-angiotensin system.

Experiments were performed in anesthetized rabbits.When Changrolin wasadministered intravenously alone in the doses ranging from 1-8 mg/kg,the electri-cally induced ventricular fibrillation threshold(EIVFT)increased linearly withthe dose.In addition,five well known antiarrhythmic drugs were also tested,namely,lidocaine(10 mg/kg),procainamide(40 mg/kg),sodium phenytoin(10mg/kg),quinidine(10 mg/kg)and practolol(0.05,0.1,0.2 mg/kg).Four ofthem increased EIVFT significantly(P<0.01 or 0.05),while one of them,practololdid...

Experiments were performed in anesthetized rabbits.When Changrolin wasadministered intravenously alone in the doses ranging from 1-8 mg/kg,the electri-cally induced ventricular fibrillation threshold(EIVFT)increased linearly withthe dose.In addition,five well known antiarrhythmic drugs were also tested,namely,lidocaine(10 mg/kg),procainamide(40 mg/kg),sodium phenytoin(10mg/kg),quinidine(10 mg/kg)and practolol(0.05,0.1,0.2 mg/kg).Four ofthem increased EIVFT significantly(P<0.01 or 0.05),while one of them,practololdid not affect EIVFT with the mentioned dose range.The effects of simultaneous administration of Changrolin and one of the fiveantiarrhythmic drugs mentioned above had also been studied.The results showedthat the effects of Changrolin(2.0 mg/kg)and lidocaine(5 mg/kg),as well asthose of Changrolin(1.3 mg/kg)and procainamide(20 mg/kg)were simply ad-ditive,while the effects of Changrolin(2.0 mg/kg)and procainamide(20 mg/kg)were more than simply additive.

Changrolin is a new antiarrhythmic drug discovered by our institute. It has an inhibitory effect on the myocardial electrical conduction. The purpose of this paper is to report the effects of 3 different infusion rates (group A: 5mg/kg/min for 2 min; group B: 1mg/kg/min for 30min; group C: 0.13 mg/kg/min for 120 min) on the plasma drug concentration and ECG changes in anesthesized dogs.The low infusion rate of C group possesses a lot of benefits: It can avoid the abrupt ascending and. descending of the drug...

Changrolin is a new antiarrhythmic drug discovered by our institute. It has an inhibitory effect on the myocardial electrical conduction. The purpose of this paper is to report the effects of 3 different infusion rates (group A: 5mg/kg/min for 2 min; group B: 1mg/kg/min for 30min; group C: 0.13 mg/kg/min for 120 min) on the plasma drug concentration and ECG changes in anesthesized dogs.The low infusion rate of C group possesses a lot of benefits: It can avoid the abrupt ascending and. descending of the drug concentration in blood, which are observed in group A. The ECG changes are lighter, ahhough the total dosage is higher than group A by 1/2 times. In comparison with group B, the total dosage of group C is only one half of that of group B, but the drug concentration in blood is maintained at a definite level for a longer time. Therefore, it is advisable to use the low infusion rate in the clinic.During the course of infusion in group C, the heart rate increased slightly at the beginning. And, as the drug concentration rose to above 5μg/ml, the heart rate decreased gradually and the ECG changed with a prolongation of P-R interval and a widening of QRS complex. These exhibitions are "quinidine-like". The linear relations of the plasma Changrolin concentration to the length of P-R interval and to the width of QRS obey the following mathematical equations:Y_1=0.00484X+0.0652Y_2=0.00190X+0.0456 where Y_1 is the length of P-R interval, Y_2 is the width of QRS complex and X is the plasma Changrolin concentration.From these 2 equations, it can be shown that the A-V conduction is more sensitive to Changrolin than intraventricular conduction.At the drug concentration lower than 8μg/ml, the changes of the ECG did not exceed the first degree block.