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阿尔茨海默病小鼠
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  ad mice
     Effect of soybean isoflavones active-extracts on learning and memory in AD mice
     大豆异黄酮活性组分对阿尔茨海默病小鼠学习记忆能力的影响
短句来源
     Antioxidative effects of soybean isoflavone active-extracts in AD mice
     大豆异黄酮活性组分对阿尔茨海默病小鼠抗氧化作用的研究
短句来源
     INTERVENTIONS:When the experimental animals were bred till 21 months,AD mice were screened from the aged animals according to International Universal Standards and Methods.
     干预:实验动物饲养至21月龄,按国际通用标准和方法从老龄动物中筛选阿尔茨海默病小鼠;
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  相似匹配句对
     An investigation of the rehabilitation efficacy in Alzheimer's disease
     阿尔茨海默的康复治疗
短句来源
     Risk Factors for Alzheimer's Disease
     阿尔茨海默的危险因素
短句来源
     Construction of Transgene and Transgenic Mice of Amyloid Precursor Protein Gene with Swedish Mutation
     阿尔茨海默相关转基因小鼠模型的构建
短句来源
     Development of the Study on the Transgenic Mouse Model of Alzheimer' s Desease
     转基因小鼠模型在阿尔茨海默中的应用进展
短句来源
     Effects of naoyikang on capability of learning and memory in Alzheimer’s disease model mice
     脑益康对阿尔茨海默模型小鼠学习记忆的影响
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  ad mice
Passive immunization of transgenic AD mice caused a significant and rapid reduction in brain amyloid plaques within 24?h.
      
Accordingly, overexpression of the antioxidant enzyme superoxide dismutase 1 (SOD1) in neuronal cells and transgenic AD mice reduces Aβ toxicity and accumulation.
      


BACKGROUND:The theory of free radical on onset of Alzheimer disease(AD) and the relationship between oxidative damage and onset of AD have made anti oxidative drugs become the hot topic in researches.Whether does the action of natural Chinese herbs on anti injury of oxygenic free radical produce intervention on AD? OBJECTIVE:To observe the effects of developed and researched tiantai I,the natural Chinese herb,on learning and memory function and metabolism of oxygenic free radical in the model of spontaneous...

BACKGROUND:The theory of free radical on onset of Alzheimer disease(AD) and the relationship between oxidative damage and onset of AD have made anti oxidative drugs become the hot topic in researches.Whether does the action of natural Chinese herbs on anti injury of oxygenic free radical produce intervention on AD? OBJECTIVE:To observe the effects of developed and researched tiantai I,the natural Chinese herb,on learning and memory function and metabolism of oxygenic free radical in the model of spontaneous AD. DESIGN:Completely randomized experimental study based on the experimental animals. SETTING:Clinical Institute of Chinese Western integration of City grade. MATERIALS:The experiment was performed in 2nd grade Animal Experimental Room of Clinical Institute of Chinese Western integration in Shenzhen.Kunming male mice of clean grade were employed, at the age of 13 months,mass weighted varied from 40 to 50 g and from Experimental Animal Center of Zhongshan Medical University(Qualified No.95A07). INTERVENTIONS:When the experimental animals were bred till 21 months,AD mice were screened from the aged animals according to International Universal Standards and Methods.The experimental animals were randomized into blank control,western drug control,the small dosage of tiantai I group(small dosage group),the large dosage of tiantai I group(large dosage group) and learning and senile normal memory group(senile normal group) in addition.In western drug control,hydergine 0.6 mg/kg was administrated,and in small and large groups,tiantai I of 6.80 g/kg and 20.41 g/kg were administrated respectively,continuously for 60 days.The double distilled water of equal dosage was infused in both blank control and senile normal group. MAIN OUTCOME MEASURES:Step down test was applied to determine learning and memory scores.Froze sections of brain tissue were prepared and immuno histological chemical method was used to display the superoxidative dismutase(SOD) activity in cerebral cortex and hippocampus.Ultrathin section of brain tissue in hippocampal CA1 was prepared and transmission electron microscope(TEM) was used to observe cellular lipofuscin in neuron.Automatic image analysis system for biomedical application was used to determine in quantity SOD and lipofuscin. RESULTS:Learning and memory of AD mice were significantly decreased(P< 0.01).Tiantai I improved significantly learning and memory disturbance of mice in the model of spontaneous AD(P< 0.05-0.01),markedly enhanced SOD activity in central cerebral cortex and hippocampus(P< 0.05-0.01) and reduced cellular lipofuscin content of neuron(P< 0.05-0.01).In addition,it provided certain of quantitative reaction. CONCLUSION:For the mice with spontaneous senile dementia,learning and memory as well as SOD activity of neuron in relevant cerebral areas are decreased remarkably and lipofuscin is increased significantly.Tiantai I acts significantly in pharmacodynamics on anti injury of oxygenic free radical,increases significantly SOD activity, decreases lipofuscin content and improves the ultrastructure of neuron in cortex and hippocampus in AD mice.

背景:阿尔茨海默病发病的自由基学说以及氧化损害与阿尔茨海默病发病的关系使抗氧化药物研究成为热点,天然中药中的抗氧自由基损伤作用是否可产生对阿尔茨海默病的干预效应?目的:观察天然中药科研制剂天泰1号对自发阿尔茨海默病模型学习记忆功能及氧自由基代谢的影响。设计:以实验动物为研究对象,完全随机分组设计的实验研究。单位:一所市级中西医结合临床研究所。材料:实验在深圳市中西医结合临床研究所二级动物实验室完成。实验动物为昆明种小鼠,清洁级,雄性,13月龄,体质量40~50g,购自中山医科大学实验动物中心(合格证号:粤检证字第95A07号)。干预:实验动物饲养至21月龄,按国际通用标准和方法从老龄动物中筛选阿尔茨海默病小鼠;实验动物随机分为空白对照组、西药对照组、天泰1号小剂量组、天泰1号大剂量组、另设老年学习记忆正常组(简称老年正常组下同)。西药对照组给以甲磺酸双氢麦角毒碱片(Hydergine)0.6mg/kg,天泰1号小、大剂量组分别予天泰1号6.80g/kg及20.41g/kg,连续60d空白对照组和老年正常组均灌以等量双蒸水。主要观察指标:用跳台实验检测学习记忆成绩;脑组织冰冻切片,免疫组织化学法示大...

背景:阿尔茨海默病发病的自由基学说以及氧化损害与阿尔茨海默病发病的关系使抗氧化药物研究成为热点,天然中药中的抗氧自由基损伤作用是否可产生对阿尔茨海默病的干预效应?目的:观察天然中药科研制剂天泰1号对自发阿尔茨海默病模型学习记忆功能及氧自由基代谢的影响。设计:以实验动物为研究对象,完全随机分组设计的实验研究。单位:一所市级中西医结合临床研究所。材料:实验在深圳市中西医结合临床研究所二级动物实验室完成。实验动物为昆明种小鼠,清洁级,雄性,13月龄,体质量40~50g,购自中山医科大学实验动物中心(合格证号:粤检证字第95A07号)。干预:实验动物饲养至21月龄,按国际通用标准和方法从老龄动物中筛选阿尔茨海默病小鼠;实验动物随机分为空白对照组、西药对照组、天泰1号小剂量组、天泰1号大剂量组、另设老年学习记忆正常组(简称老年正常组下同)。西药对照组给以甲磺酸双氢麦角毒碱片(Hydergine)0.6mg/kg,天泰1号小、大剂量组分别予天泰1号6.80g/kg及20.41g/kg,连续60d空白对照组和老年正常组均灌以等量双蒸水。主要观察指标:用跳台实验检测学习记忆成绩;脑组织冰冻切片,免疫组织化学法示大脑皮质及海马超氧化物歧化酶活性;海马CA1区脑组织超薄切片,透射电镜法观察神经元细胞脂褐素;全自动显?

AIM: To investigate the effect of Chinese herb compound naoyikang on the mRNA expression of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) in mice model of Alzheimer disease. METHODS: (1)The experiment was conducted in the Laboratory of Pathophysiology, School of Basic Medical Sciences, Nantong University from October 2004 to March 2005. (2)The mice models of Alzheimer disease were established by intraperitoneal injection of D-galactosamine and natrium nitrosum. 120 ICR mice were randomly...

AIM: To investigate the effect of Chinese herb compound naoyikang on the mRNA expression of nerve growth factor (NGF) and brain derived neurotrophic factor (BDNF) in mice model of Alzheimer disease. METHODS: (1)The experiment was conducted in the Laboratory of Pathophysiology, School of Basic Medical Sciences, Nantong University from October 2004 to March 2005. (2)The mice models of Alzheimer disease were established by intraperitoneal injection of D-galactosamine and natrium nitrosum. 120 ICR mice were randomly divided into normal control group, model control group, naofukang control group (0.4 g/kg per day), and low, middle and high dose naofukang groups (2.4, 7.2, 24 g/kg per day). Naoyikang was composed of shouwu, bajitian and so on (produced by the Pharmaceutical Room of Nantong Hospital of Chinese Medicine,1.98 g crude drug in per g granule). The model control group and all the treated groups were intraperitoneally injected with 10 g/L D-galactosamine 120 mg/kg per day and 10 g/L natrium nitrosum 90 mg/kg per day for 60 days; the normal control group was injected with normal saline at the same dosage. Naoyikang and naofukang prepared with 5 g/L sodium carboxymethycellulose were intragastrically infused for 60 days. (3)Six mice in each group were randomly selected to take the brain tissues. The mRNA expression of NGF and BDNF were tested by RT-PCR. RESULTS: (1)Compared with the control group, the expression of NGF mRNA in low, middle and high doses naofukang groups had no significant difference [(1.05±0.25), (0.83±0.46), (0.99±0.46), (1.12±0.22), P > 0.05]; Compared with the control group, the expression of BDNF mRNA in low, middle and high doses naofukang groups had no significant difference [(0.73±0.20), (0.49±0.12), (0.63±0.15), (0.32±0.22), P > 0.05]. (2)The expressions of NGF and BDNF mRNA of the model group were significantly higher than that of the normal control group [NGF mRNA (1.98±0.60), (1.12±0.22); BDNF mRNA (1.32±0.37), (0.32±0.22), P < 0.05]. (3)Compared with the model group, the expressions of NGF and BDNF mRNA in the naofukang control group and low, middle and high doses naofukang groups were obviously decreased (P < 0.05). CONCLUSION: Naoyikang can improve part mechanism of learning and memory ability of mice with Alzheimer disease by protecting cholinergic neurons and improving the reversal transportation of NGF and BDNF.

目的:观察中药复方脑益康对阿尔茨海默病模型小鼠脑组织脑神经生长因子、脑源性神经营养因子mRNA表达的影响,。方法:①实验于2004-10/2005-03在南通大学基础医学院病理生理学实验室完成。②采用D-半乳糖和亚硝酸钠腹腔注射建立阿尔茨海默病小鼠模型,ICR小鼠120只,采用随机数字法分为6组,正常对照组,模型对照组,脑复康对照组[0.4g/(kg·d)],脑益康小、中、大剂量组[(2.4,7.2,24g/(kg·d)]。脑益康由制首乌、巴戟天等组成(南通市中医院制剂室制成颗粒剂,每克颗粒剂含生药1.98g)。模型对照组、各给药组腹腔注射10g/LD-半乳糖120mg/(kg·d)和10g/L亚硝酸钠90mg/(kg·d),连续60d,正常对照组腹腔注射等容量的生理盐水。脑益康和脑复康均以5g/L羧甲基纤维素钠配制灌胃,连续60d。③每组随机取6只小鼠,取脑组织,采用反转录-聚合酶链反应方法检测脑组织中脑神经生长因子、脑源性神经营养因子mRNA的表达。结果:①脑益康小、中、大剂量组脑神经生长因子mRNA的表达与正常对照组比较差异无显著性(1.05±0.25,0.83±0.46,0.99±0.46...

目的:观察中药复方脑益康对阿尔茨海默病模型小鼠脑组织脑神经生长因子、脑源性神经营养因子mRNA表达的影响,。方法:①实验于2004-10/2005-03在南通大学基础医学院病理生理学实验室完成。②采用D-半乳糖和亚硝酸钠腹腔注射建立阿尔茨海默病小鼠模型,ICR小鼠120只,采用随机数字法分为6组,正常对照组,模型对照组,脑复康对照组[0.4g/(kg·d)],脑益康小、中、大剂量组[(2.4,7.2,24g/(kg·d)]。脑益康由制首乌、巴戟天等组成(南通市中医院制剂室制成颗粒剂,每克颗粒剂含生药1.98g)。模型对照组、各给药组腹腔注射10g/LD-半乳糖120mg/(kg·d)和10g/L亚硝酸钠90mg/(kg·d),连续60d,正常对照组腹腔注射等容量的生理盐水。脑益康和脑复康均以5g/L羧甲基纤维素钠配制灌胃,连续60d。③每组随机取6只小鼠,取脑组织,采用反转录-聚合酶链反应方法检测脑组织中脑神经生长因子、脑源性神经营养因子mRNA的表达。结果:①脑益康小、中、大剂量组脑神经生长因子mRNA的表达与正常对照组比较差异无显著性(1.05±0.25,0.83±0.46,0.99±0.46,1.12±0.22,P>0.05);脑益康小、中、大剂量组脑源性神经营养因子mRNA的表达与正常对照组比较差异无显著性(0.73±0.20,0.49±0.12,0.63±0.15,0.32±0.22,P>0.05)。②模型对照组脑神经生长因子mRNA、脑源性神经营养因子mRNA显著高于正常对照组(1.98±0.60比1.12±0.22,1.32±0.37比0.32±0.22,P<0.05)。③与模型对照组脑神经生长因子mRNA和脑源性神经营养因子mRNA比较,阳性药脑复康对照组、脑益康小、中、大剂量组表达明显减少(P<0.05)。结论:脑益康提高阿尔茨海默病小鼠学习记忆作用的部分机制与其保护胆碱能神经元、改善神经生长因子、脑源性神经营养因子的逆行运输有关。

 
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