The proposed procedures could be applied successfully for the determination of the investigated drugs in their pharmaceutical preparations with good recovery ; percent ranged (%) from 98.87±1.42 to 99.63±1.26 in the TCBQ method, 98.49±1.46 to 99.21±1.62 in the DDQ method.
Novel Mechanisms of Drug Action: Functional Selectivity at D2 Dopamine Receptors
Analogue-Based Drug Research: Lead and Drug Optimization
Drug Development in the 21st Century: Medicines, Man and Receptors
NEW TECHNOLOGY FOR DRUG DISCOVERY BASED UPON INSERTION OF LIGANDS INTO GENE SEQUENCES BY NUCLEAR RECEPTOR PROTEINS
The pharmacokinetics of α- and β-diastereomers of Arteether, a well-known antimalarial drug and its active metabolite dihydroartemisinin (DHA) were studied in Sprague-Dawley rats, Rhesus monkeys and human volunteers.
albicans indicates the possibility to develop drugs for skin diseases.
This has brought the total of licensed anti-HIV drugs to nineteen.
A gene regulatory mechanism has been proposed in which steroid hormones and certain other drugs bind to nuclear receptor proteins followed by transfer to DNA where they are inserted between base pairs.
Here, we report using the estrogen receptor that the location of drugs in x-ray crystal structures of the receptors matches closely their predicted spatial locations in the DNA.
These findings provide compelling evidence that DNA is the ultimate target of these drugs that act on the human genome.
The pharmaceutical sciences are advancing rapidly in the post-genomic era of the 21st century with the completion of the human genome, as well as those of many other organisms including bacteria and parasites, and the rapid advances in proteomics.
IMPLICATIONS FOR INDIAN PHARMACEUTICAL SECTOR IN THE NEW WORLD TRADE ORGANISATION (WTO) REGIME
The paper examines the factors that are likely to influence the pharmaceutical industry in India in the new WTO regime and the preparedness of government, research organizations and firms to compete in this scenario.
Utilizing analysis of similarity (ANOSIM) on the ten pharmaceutical descriptors provides a discrete numerical result that indicates overall dissimilarity among these agents.
These features were exploited to improve analytical performances in simultaneous determination of the minor ingredient of pseudoephedrine hydrochloride and the major ingredient of ibuprofen in a pharmaceutical preparation.