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大鼠
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  rat (
     The relative concentration of Ch, bile acid and phosphatidc in hamster bile ( 3.4±0.5mol%, 78.9±1.8mol% and 17.7±1.6mol% respectively) are different from those of rat (P<0.05, 0.01 and 0.05 respectively), but similar to those of human.
     仓鼠肝胆汁中胆固醇、胆汁酸和磷脂的相对浓度(分别为3.4±0.5mol%、78.9±1.8mol%和17.7±1.6mol%)不同于大鼠(P<0.05、P<0.01和P<0.05)而与人类相似。
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     After in-travenous administration of BQ_(123) (0.1, 1.0 and 2.0 mg/kg) into spontaneously hyperten-sive rat(SHR) and normotensive WKY rat, their blood pressure decreased in a dose-depen-dent manner, which continued 40-60 min.
     静脉注射BQ_(123)(0.1,1和2mg/kg)后,自发性高血压大鼠(SHR)和正常血压大鼠(WKY)血压呈剂量依赖地降低, 持续40~60分钟。
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     (3) 24h rm IL-12 preincubation failed to sensitize islets to the effects of 10nmol/L of rm or recombinant rat (rr) IL-18 alone or to prime islets to IL-1β actions on insulin release and nitrite production.
     (3) rm IL- 12预培养 2 4h不能促使胰岛对 10 nmol/L rm或基因重组大鼠 (rr) IL- 18的反应性出现 ,也未使 IL- 18呈现加强 IL- 1β的上述效应 ;
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     AIM: To detect different expression of pre-proenkephalin mRNA (PPE mRNA) in 16-wk-old spontaneously hypertensive rat (SHR) and age-matched normotensive Wistar-Kyoto rat ( WKY) .
     目的:检测前脑啡肽原信使RNA(PPE mRNA)在16周自发性高血压大鼠(SHR)和Wistar-Kyoto大鼠(WKY)中的不同表达。
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     Objective To study the effects of norepinephrine (NE) and α_ 1 -adrenergic receptor antagonist prazosin on ATPase activity and mRNA expression of Na~+-K~+-ATPase α_ 1 subunit in aorta smooth muscle cells (ASMCs) derived from spontaneously hypertensive rat (SHR).
     目的观察去甲肾上腺素(NE)及其α1肾上腺素能受体(α1-AR)拮抗剂哌唑嗪(Prazosin)对自发性高血压大鼠(SHR)动脉血管平滑肌细胞Na+-K+-ATPase活性及mRNA表达的影响。
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  “大鼠(”译为未确定词的双语例句
     Analysis of Mechanism on the Immune Deficiency in Spontaneously Hypertensive Rats(SHR)
     高血压大鼠(SHR)免疫缺陷机理分析
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     INFLUENCE OF HIGH AND LOW PROTEIN FOOD ON SHRsp
     高、低蛋白饲料对卒中易感型自发性高血压大鼠(SHRsp)的影响
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     Observation of Urine 6-keto-PGF_(1α) and TXB_2 Excretion in Spontaneous Hypertensive Rats
     自发性高血压大鼠(SHR)尿6-keto-PFG_(1α)、TXB_2排出的观察
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     AN OBSERVATION OF B. P. & rCBF IN SHR BY 650nM,10mW DIODE LASER ACUPUNCTURE
     半导体激光光针(650nm,10mW)对高血压大鼠(SHR)血压及脑血流(rCBF)影响的初步观察
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     Objective To observe the depressor effect of Zhenganxifeng Decoction in rats with essential hypertension and the influence on brain endothelin (ET) content and the expression of peroxisome proliferating activator receptor γ (PPARγ) mRNA.
     目的观察镇肝熄风汤对自发性高血压大鼠(SHR)的降压效果及其对血浆、脑组织中内皮素(ET)含量,脑组织中过氧化物酶体增殖物激活受体γ(PPARγ)mRNA表达的影响。
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     The authors held that the immune reaction of the rats with P.w.
     作者认为大鼠P. w.
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     Rat was used as experiment animal.
     动物采用大鼠
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     (2) hyperglycemic rats, P. O.
     (2)高血糖大鼠试验;
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  rat (
All compounds were characterized by binding affinity determination for 5-HT2A and 5-HT2C subtypes and antagonistic activity for 5-HT2B receptor in rat stomach fundus.
      
None of the new compounds showed affinity for 5-HT2A and 5-HT2C subtypes, but some of them displayed antagonistic activity in rat stomach fundus at micromolar concentrations.
      
Antioxidant activity of melatonin and some new melatonin analogue indole derivatives were investigated, using lipid peroxidation and superoxide anion radical scavenger activity assays, in rat liver tissue homogenate.
      
Screening and evaluation of rat kidney aldose reductase inhibitory activity of some pyridazine derivatives
      
We evaluated a series of 2H-pyridazine-3-one and 6-chloropyridazine analogues via an in vitro spectrophotometric assay for their ability to inhibit rat kidney AR.
      
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(1) In order to avoid the postmortem changes Richter and Dawson and proposed to fix the brain in situ with liquid air. We found that a mixture of solid carbon dioxide and acetone was a serviceable substitute for liquid air, at least for the purpose of ammonia analysis. (2) A modification of Conway's micro-diffusion method for the determination of ammonia was described. The modified method enabled us to determine ammonia in the range from 0.05 to 0.50μg. (3) Conway's "half-diffusion" method was adapted to minimize...

(1) In order to avoid the postmortem changes Richter and Dawson and proposed to fix the brain in situ with liquid air. We found that a mixture of solid carbon dioxide and acetone was a serviceable substitute for liquid air, at least for the purpose of ammonia analysis. (2) A modification of Conway's micro-diffusion method for the determination of ammonia was described. The modified method enabled us to determine ammonia in the range from 0.05 to 0.50μg. (3) Conway's "half-diffusion" method was adapted to minimize the error introduced by hydrolysis of glutamine in the alkaline solutions. (4) Illustrative results of analysis of the ammonia contents in different parts of the normal adult rat brain were given.

(一) 我們用固體二氧化碳和丙酮的混合液來代替液體空氣固定動物,所测得的大鼠腦氨含量與用液體空氣所得結果基本上一致。 (二) 改良了Conway測定氨的微量瀰散器皿使之適用於少量組織及0.05—0.50微克氨的测定。 (三) 採用了Conway的半量瀰散法,減少了由榖氨酰胺水解所引起的誤差。 (四) 利用上述改良的方法我們分別测定了大鼠腦各部的氨含量。

The stability of synthetic phosphoramides of aniline,p-chloroaniline,p-amino- benzoic acid,o-methoxyaniline sulfanilamide and benzylamine has been tested separately in acid and alkaline(pH 5.0 and pH 9.0)solutions.It was found that all these compounds are hydrolyzed in different degrees;among which N-(p-chlorophenyl)amidophosphoric acid is the most stable.This compound was thus used as substrate for most enzyme studies in spite of its low solubility.Phosphoramides of p-aminobenzoic acid and benzylamine are unsuitable...

The stability of synthetic phosphoramides of aniline,p-chloroaniline,p-amino- benzoic acid,o-methoxyaniline sulfanilamide and benzylamine has been tested separately in acid and alkaline(pH 5.0 and pH 9.0)solutions.It was found that all these compounds are hydrolyzed in different degrees;among which N-(p-chlorophenyl)amidophosphoric acid is the most stable.This compound was thus used as substrate for most enzyme studies in spite of its low solubility.Phosphoramides of p-aminobenzoic acid and benzylamine are unsuitable as substrates,due to their instability in solution in which the enzyme activity is measured. The phosphoamidase aetivity of the purified enzyme preparation from ox spleen on the phos- phoramide compounds is higher at pH 5.0 than at pH 9.0.The rate of hydrolysis and the affinity of the enzyme with the substrate are different for different phosphoramides.It is therefore evident that phosphoamidase activity is closely related to the structure of the substrate. Among the splitting products of phosphoramides,amines have little effect on the enzyme activity,while phosphate ion has quite significant inhibitory effect. From the experiments on the enzyme activity of rat tissue ertracts,it is seen that: (1)The ratio.of the activities on substrates with similar structures is parallel in all tissues, but different in substrates with different structures,indicating that there may exist more than one phosphoamidases. (2)The content of phosphoamidase in the various tissues of the rat varies to a considerable extent.Spleen has the highest phosphoamidase content. (3)Muscle-tissue extract contains a considerable amount of phosphoamidase activity upon synthetic compounds containing P-N linkage.It would appear that phosphocreatine,which is rich in muscle,might be the natural substrate for this enzyme.

(一)磷酰胺类化合物在酸性及碱性溶液中都不稳定。在所试过的化合物中,以磷酰对氯苯胺最稳定,但它的溶解度较小。磷酰参羧基苯胺和磷酰苯甲胺的自行分解速度甚大,不过宜用为底物。 (二)牛脾部分提纯制剂在 pH5.0对于磷酰胺类化合物的活力比在 pH9.0的高。而对于不同底物的水解速度与亲和力都不相同,显示磷酸氨基酶活力与底物的结构有密切关系。在分解产物中,胺类对于该酶的活力无大影响,而磷酸根离子则有较为显著的抑制作用。(三)大鼠组织提取液对于结构相似的底物的活力之比也相似,而对于结构不同的底物,则活力之比也不相同,显示有不同磷酸氨基酶存在的可能。(四)各组织中磷酸氨基酶的含量不同,以脾脏的含量最高。(五)肌肉组织中合有磷酸氨基酶的活力,它的研究可能对于肌肉中磷酸肌酸代谢的了解有所帮助。

The LD_(50) of ammonium antimony gluconate (AAG) after intraperitoneal injection was 16.8mg/kg for mice fed on a diet containing 0.01% thyroxine, 166mg/kg for mice on a diet containing 0.1% propylthiouracil and 90mg/kg for control mice It is concluded that feeding mice with thyroxine for two weeks significantly increases the susceptibility of the mice to the acute toxicity of AAG, whereas propylthiouracil feeding increases the resistance of the mice. After intraperitoneal injection of Sb~(124)-labelled AAG to...

The LD_(50) of ammonium antimony gluconate (AAG) after intraperitoneal injection was 16.8mg/kg for mice fed on a diet containing 0.01% thyroxine, 166mg/kg for mice on a diet containing 0.1% propylthiouracil and 90mg/kg for control mice It is concluded that feeding mice with thyroxine for two weeks significantly increases the susceptibility of the mice to the acute toxicity of AAG, whereas propylthiouracil feeding increases the resistance of the mice. After intraperitoneal injection of Sb~(124)-labelled AAG to normal rats or rats fed thyroxine or propylthiouracil, high radioactivity levels were found in the liver and the gastrointestinal tract (including its contents), while the Sb~(124) levels in the kidney, thyroid, blood, spleen, lung and other tissues were very low. There seems to be no significant difference between the distribution patterns of radioactivity in tissues for the three groups of rats. The excretions of Sb~(124) for the three groups were also similar. It appears that the difference in toxicity of AAG between control rats and rats with altered thyroid function is not explicable by differences in the distribution and excretion of antimony after administration of AAG.

小鼠連續服用甲狀腺素兩週後,對銻銨急性毒性的敏感性顯著增加,而連續服用丙基硫氧嘧啶,則可增加對銻銨急性毒性的耐受性。腹腔注射銻銨於甲狀腺機能亢進狀態,甲狀腺機能不足及正常大鼠後,銻~(124)在组織中分佈的濃度均以肝及胃腸道为最高,腎臟次之,在甲狀腺中的濃度均很低。腹腔注射銻”銨後,銻~(124)的排泄總量三组動物無明顯區别。因此,銻銨對甲狀腺機能亢進狀態,甲狀腺機能不足及正常小鼠毒性的不同,似並非由於注射銻銨後,銻的分佈和排泄不同所致。

 
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