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Ovarian malignant Brenner Tumors (MBT) and transitional cell carcinoma (TCC) are rare primary ovarian carcinomas. Histologic features of these tumors are closely mimic to carcinoma of urothelium. They were grouped under Brenner Tumor in the past. However,the TCC has no benign Brenner Component and is rather aggressive in behavior. In this report the clinical and pathologic features of 3 MBTS along with 9 TCC are reported . It is considered that MBT could arise from a benign Brenner tumor, whereas TCC most likely... Ovarian malignant Brenner Tumors (MBT) and transitional cell carcinoma (TCC) are rare primary ovarian carcinomas. Histologic features of these tumors are closely mimic to carcinoma of urothelium. They were grouped under Brenner Tumor in the past. However,the TCC has no benign Brenner Component and is rather aggressive in behavior. In this report the clinical and pathologic features of 3 MBTS along with 9 TCC are reported . It is considered that MBT could arise from a benign Brenner tumor, whereas TCC most likely originate directly from the celomic epithelium. Celomic inclusion cysts can undergo urothelial metaplasia to transitional epithelium. The 9 TCC are divided into pure, predominant and focal types and the TCC components are further divided into papillary type and "malignant Brenner-like type". The findings suggest that,TCC is more aggressive and often present with advanced disease.Irrespective of either pure , predominant , papillary or Brenner-like type they all appear to respond well to chemotherapy. 卵巢恶性Brenner氏瘤(MBT)和移行细胞癌(TCC)是两类少见的卵巢原发癌.组织形态类似泌尿道的移行上皮,两者以TCC不含典型的Brenner瘤成分来划分,支持这一观点的理由是TCC中找不见Brenner瘤中所常见的间质钙化,TCC较MBT更具浸润性.本文通过对3例MBT与9例TCC临床及病理资料比较,结合文献复习对TCC进一步探讨,认为MBT应视为由良性Brenner瘤发展而来.而TCC应视为体腔上皮直接化生发展而来.将TCC进一步分为纯型,占优势型,灶性型及对TCC成分划分为乳头状型和MBT样型.进一步研究发现,乳头状型较MBT样型临床分期高,但不管是纯型,占优势型,乳头状型还是MBT样型,化疗反应都有效,灶性型预后可能与其中占优势的其他非TCC成分有关. The T lymphocyte subpopulation of peripheral blood in 22 bladder cancer patients and 18 normal controls was neasured. The CD3 (total T-cells) and CD4 (helper T-cells) decreased significantly as compared with control group(P<0. 01). The CD8 (suppressor T-cell)had no significant difference (P>. 05). The CD4 : CD8 ratio had been lowered (P<0. 05). The results suggested that the reduced cellular immune function exist in patients with blaader cancer. 对22例膀胱移行细胞癌(TCC)患者和18例对照行外周血T淋巴细胞亚群观察。 TCC患者外周血CD3和CD4明显降低(P<0.01),CD8无明显改变(P>0.05),CD4:CD8呈显著性 差异(P<0.05)。提示:TCC患者外周血T淋巴细胞免疫功能低下。 Both SCEA and UCEA were measured in 67 patients with bladder transitional cell carcinoma and 27 postoperative patients with partial cystectomy as well as 5 with total cystectomy. The grade and stage were determined by pathology. The SCEA and UCEA in grade Ⅰ ,stage Ⅰ had no significant differences as compared with normal group,in grade Ⅱ ,stage Ⅱ and higher,the SCEA and UCEA levels had beed increased significantly (P<0. 01). After operation,the SCEA level in patients with any grade and stage and UCEA in grade... Both SCEA and UCEA were measured in 67 patients with bladder transitional cell carcinoma and 27 postoperative patients with partial cystectomy as well as 5 with total cystectomy. The grade and stage were determined by pathology. The SCEA and UCEA in grade Ⅰ ,stage Ⅰ had no significant differences as compared with normal group,in grade Ⅱ ,stage Ⅱ and higher,the SCEA and UCEA levels had beed increased significantly (P<0. 01). After operation,the SCEA level in patients with any grade and stage and UCEA in grade Ⅰ ,stage Ⅰ had no differences,but the UCEA level in grade Ⅱ , stage Ⅱ and higher was much higher compared to normal group. The SCEA and UCEA in patients with total cystectomy returned to normal level. The results showed that the measurement of UCEA has important value in monitoring the patients who have received partial cystectomy. 本文对67例膀胱移行细胞癌(TCC)患者术前行血和尿癌胚抗原(SCEA、UCEA)测定,27例膀胱部分切除术者及5例膀胱全切除术者行术后SCEA和UCEA测定,经病理分级分期,且与正常组比较。术前Ⅰ级Ⅰ期患者SCEA、UCEA值与正常组无显著性差异,Ⅱ级Ⅱ期以上者均较正常组明显增高(P<0.01),膀胱部分切除术后各级期SCEA值与正常组无显著性差异(P>0.05),Ⅰ级Ⅰ期UCEA与正常组无差异(P>0.05),Ⅱ级Ⅱ期以上者术后UCEA值与正常组相比仍呈高度显著性差异(P<0.01),膀胱全切除术后SCEA、UCEA值恢复正常。提示,TCC行膀胱部分切除术后UCEA的监测对TCC患者的预后有重要意义。
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