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|  | | 为了更好的帮助您理解掌握查询词或其译词在地道英语中的实际用法,我们为您准备了出自英文原文的大量英语例句,供您参考。 | |
The opiate-sparing effect of dipyrone in post-operative pain therapy with morphine using a patient-controlled analgesic system
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We evaluated the performance characteristics (bias and precision) of this pharmacokinetically based patient-controlled analgesic infusion system (PKPCA) in a group of 15 cancer patients over six to 14 days.
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Alfentanil was administered through a patient controlled analgesic device.
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The patient-controlled analgesic technique gave analgesia of good quality and it aided the comparison of the two drugs.
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| | The pharmacokinetics of lidocaine was reported in 7 patients in patient controlled epidural analgesia (PCEA). We also monitored the change of serum concentration by time in 8 patients in PCEA. The results show that patient controlled epidural analgesia is safe. The serum concentration of lidocaine is in the safety range. | | 报道7例硬膜外病人自控镇痛时利多卡因的药物动力学参数,并监测8例硬膜外PCA时利多卡因血药浓度随时间的波动情况.结果表明,硬膜外PCA的给药方式是安全的,利多卡因血药浓度的波动在安全范围内. | | 文摘来源 | | AIM: To report the pharmacokinetics of morphine in patients controlled anal-gesia and the change of serum concentration by time in 8 patients in the mode of loading con-tinued patients (LCP). METHODS: A radioimmunoassay method was used for the determi-nation of morphine in the patient's serum. RESULTS: The concentration-time curve was fit-ted with a two compartment model. The patients had a good analgesic effect and no signifi-cant adverse drug reactions when the serum concentration of morphine was between ... | | 目的:研究病人自控镇痛(PCA)时吗啡(Mor)的药物动力学,监测Mor在硬膜外麻醉病人自控镇痛时以负荷剂量-持续注射(LCP)模式给药时血药浓度的波动情况.方法:采用放射免疫法测定Mor血药浓度.结果:Mor iv时符合开放型二室模型.在 LCP模式给药时,Mor的平均血药浓度在273.94~74.5μg/L之间,此时镇痛效果良好.病人无明显不良反应.结论:本实验为Mor应用于LCP模式中的安全性提供一定的理论依据. | | 文摘来源 | | The aim of this study was to compare analgesic effect and side effect among fentanyl, morphine and pethidine in equivalent dose with 0.1% bupivacaine during postoperative controlled epidural analgesic (PCEA). Sixty adult patients undergoing abdominal or lower extremity operation in epidural anesthesia were treated with PCEA pump postoperatively. All patients were randomly divided into 3 groups according their narcotics used,20 in each. The analgesic solution contained fentanyl 0.1 mg (groupⅠ), morphine 1... | | 为比较手术后硬膜外自控镇痛(PCEA)时等效剂量芬太尼、吗啡或哌替啶的镇痛效果及不良反应,选择在硬膜外麻醉下完成腹部或下肢手术的成年患者60例,术后用硬膜外自控镇痛泵治疗。按镇痛药将患者随机分成三组,每组20例。镇痛药液为0.1%布吡卡因40ml中加入芬太尼0.1mg(Ⅰ组)、吗啡10mg(Ⅱ组)或哌替啶100mg(Ⅲ组)。患者感到手术创口疼痛时自行揿压PCEA泵的自控按钮。结果显示48h镇痛药液累积用量Ⅰ组和Ⅲ组是Ⅱ组的三倍;Ⅱ组镇痛效果达优者比Ⅲ组多。镇痛治疗期间平均动脉压、脉率和呼吸率与麻醉前比较均无明显差异,SpO2都保持在95%以上。Ⅱ组恶心发生率高于Ⅲ组;仅Ⅱ组发生皮肤瘙痒;Ⅰ、Ⅱ、Ⅲ组尿潴留发生率分别为57.1%、40.0%和30.8%。结论:用低浓度布吡卡因和麻醉性镇痛药复合液行PCEA能获得良好的术后镇痛效果,对呼吸循环功能无明显影响。吗啡镇痛复合液用量最少,效果最好。 | | 文摘来源 | |   | | << 更多相关文摘 |
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