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人类乳腺癌
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  human breast cancer
     Expression and Significance of VEGF-C, FLT-4 and nm23 in Human Breast Cancer
     VEGF-C、FLT-4和nm23在人类乳腺癌中的表达及意义
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     Objective The purpose of this study was to evaluate the relationship between 99mTc-MIBI breast imaging results and expression of the drug resistance proteins(P-glycoprotein(P-gp),mutant p53) in human breast cancer tissues.
     目的探讨99mTc-MIBI乳腺显像与人类乳腺癌组织中耐药蛋白P-gp、突变型P53表达之间的关系。
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     Objective To investigate the expression of the genes of Notchl, Notch3 and Notch4 receptors and JAGGED1 and DLL4 ligands, which are several important protein molecules in Notch signaling pathway, in human breast cancer, and the relationship between expression of these genes and breast cancer-related factors.
     目的 研究Notch信号通路中的几个重要蛋白分子Notch1、Notch3和Notch4受体及JAGGED1和DLL4配体基因在乳腺癌中的表达及其与乳腺癌相关因素的关系,以探讨Notch信号通路在人类乳腺癌中的作用,并为乳腺癌治疗中针对Notch系统的靶向药物研究与开发提供一定的实验依据。
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     Expression and significance of vascular endothelial growth factor-C and nm23 in human breast cancer.
     血管内皮生长因子C和nm23在人类乳腺癌中表达及其意义
短句来源
     Expression of Thymosin β10 (Tβ10) Protein in Human Breast Cancer
     胸腺素β10在人类乳腺癌中的表达
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  “人类乳腺癌”译为未确定词的双语例句
     OBJEICTVES: To investigate the expression of NM23, integrin α_5β_1 and VEGF and their clinical implication in breast cancer.
     目的:研究肿瘤转移抑制基因(nm23)、整合素亚型α_5β_1及血管内皮生长因子(VEGF)在人类乳腺癌组织中的表达及临床意义,以及nm23、α_5β_1、VEGF三者之间的相关性。
短句来源
     Expression of Heat Shock Protein 70 and P53 in Human Primary Breast Cancer and It's Significance
     热休克蛋白70和P53在人类乳腺癌中的表达及意义
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     Methods Epithelial growth factor (EGF) and different concentration of estradiol to induce the expression of phosphospecific ERK1/2 (pERK1/2) in MCF-7 cell line was used and the expression of pERK1/2 with western-bloting was detected.
     方法 分别用上皮生长因子 (EGF)和不同浓度的雌二醇诱导人类乳腺癌细胞系MCF 7细胞 ,诱导不同时间后用Westernblot方法检测磷酸化ERK1/ 2的表达 ;
短句来源
     Relationship of Oncogene Status and Disease Parameters of Breast Cancer
     人类乳腺癌中几种癌基因的状态与临床指征关系的初步探讨
短句来源
     It is believed that there is a relation ship between lymph metastasis and some of tumor associated factors, such as VEGF-C,FLT-4and nm23.In order to explore the expression of VEGF-C, FLT-4 and nm23 in breast carcer and correlate them with various clinic-pathologic characters, the protein expression level of VEGF-C, FLT-4 and nm23 in ninety-eight cases of breast disease were measured by using S-P immunohistochemistry.
     为了探讨VEGF-C、FLT-4和nm23在人类乳腺癌中的蛋白表达及其与临床病理特征的关系,本研究采用免疫组化S-P方法检测98例人类乳腺浸润性导管癌和乳腺良性肿瘤组织石蜡切片中VEGF-C,FLT-4和nm23基因蛋白的表达。
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  相似匹配句对
     Differentially expressed genes in normal breast tissue and breast cancer tissue by cDNA microarray
     人类乳腺癌基因表达分析
短句来源
     Progress in Molecular Genetics of Human Breast Cancer
     人类乳腺癌的分子遗传学研究进展
短句来源
     Human Sperm Bank, MSB
     人类精子库
     The Human's Box
     人类的盒子
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     Chemoprevention of breast cancer
     乳腺癌的药物预防
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  human breast cancer
Synthesis and evaluation of 1-benzhydryl-sulfonyl-piperazine derivatives as inhibitors of MDA-MB-231 human breast cancer cell pr
      
Survival in Human Breast Cancer: Effects of Tumor Laterality and the Time of Year of Surgery
      
The DGM-1 anti-proliferative activity was comparable with that of doxorubicin on three models: cell lines of murine melanoma B16-F1 and human breast cancer MCF-7 (HTB-22) and human colon cancer HT-29 (HTB-38).
      
Regulatory mechanisms for abnormal expression of the human breast cancer specific gene 1 in breast cancer cells
      
Breast cancer-specific gene 1 (BCSG1), also referred as synuclein γ, was originally isolated from a human breast cancer cDNA library and the protein is mainly localized to presynaptic terminals in the nervous system.
      
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Inclusion of sodium molybdate(Mo)in the buffer could stabilize the steroid bindingactivity,inhibit the degradation and minimize the structural heterogenicity of receptors.Effects of M_0 on human breast tumor and benign and malignant endometrial cytosol es-trogen(ER)and progesterone receptors(PR)were studied by glycerol gradient centrifuga-tion and chromatographed on agarose in buffers containing 20 mMM_0.The sedimenta-tion coefficients(S_(20,w))of the receptors were evaluated by glycerol gradient centrifuga-tion...

Inclusion of sodium molybdate(Mo)in the buffer could stabilize the steroid bindingactivity,inhibit the degradation and minimize the structural heterogenicity of receptors.Effects of M_0 on human breast tumor and benign and malignant endometrial cytosol es-trogen(ER)and progesterone receptors(PR)were studied by glycerol gradient centrifuga-tion and chromatographed on agarose in buffers containing 20 mMM_0.The sedimenta-tion coefficients(S_(20,w))of the receptors were evaluated by glycerol gradient centrifuga-tion and the mean value was 9.7±0.3S(n=31).The stoke radii(R_s)were distinguishedby gel filtration and the mean value was 75±4(?)(n=22).The molecular weight(M)and axial ratio(a/b)of the receptors were calculated by combining the data from ultra-centrifuged and gel filtration analysis and the mean values of M=304,000,and a/b=10.The concentration of ER and PR were determined by charcoal-dextron assay follow-ing incubation of cytosols with various concentrations of [~3H]E_2 or [~3H] R 5020 in bufferscontaining 20 mMMo from 47 cases of human breast cancer,10 malignant endometriumand 10 benign endometrium.The ER and PR (>3 fmol/mg protein)finds in the breasttumor specimens were 48% and 72%,respectively.90% of malignant uterine speci-mens contained PR,and 100% of benign endometrium with ER and PR.The concent-tration of PR was the highest,458±275 fmol/mg protein,in benign endometrial samplesfrom premenopausal women.Dissociation constants(Kd)were evaluated from 24 speci-mens.The mean value for Kd of [~3H] E_2 binding to cytosol from breast cancer was 0.4 nMand that for Kd of [~3H] R 5020 binding to cytosol from both breast and uterine malignanttumors was 2-3 nM.

钼酸钠(M_0)能稳定受体对甾体的结合活力、并抑制其降解和减少其结构的多相性。在有M_0存在的缓冲系统中,通过对人类乳腺癌、良性和恶性的子宫内膜细胞溶质雌激素受体(ER)和孕激素受体(PR)进行梯度超离心和琼脂糖凝胶过滤的研究,得到的结果为:受体的沉降系数(S_(20,w))的平均值为9.7±0.3S(n=31),其流体力学半径(R_(?))的平均值为75±4(?)(n=22);综合超离心和凝胶过滤的分析资料计算得到,M_0稳定时受体分子量(M)的平均值为304,000,轴比(a/b)=10。本文报告了47例人乳腺肿瘤、10例恶性子宫内膜、10例良性子宫内膜的细胞溶质ER 和PR 的浓度及受体阳性、阴性及可疑的分布。乳腺肿瘤的ER 阳性率为48%,PR 阳性率为72%(>3fmol/mg 蛋白为阳性),90%恶性子宫内膜的PR 为阳性;100%良性子宫内膜的ER 或PR 均为阳性。绝经前妇女的良性子宫内膜的PR 浓度最高,为458±275fmol/mg 蛋白。对24例标本均测定了解离常数(K_d),其中乳腺和恶性子宫内膜组织中PR-[~3H]R5020复合物的K_d 平均值为2-3nM,乳腺癌组织...

钼酸钠(M_0)能稳定受体对甾体的结合活力、并抑制其降解和减少其结构的多相性。在有M_0存在的缓冲系统中,通过对人类乳腺癌、良性和恶性的子宫内膜细胞溶质雌激素受体(ER)和孕激素受体(PR)进行梯度超离心和琼脂糖凝胶过滤的研究,得到的结果为:受体的沉降系数(S_(20,w))的平均值为9.7±0.3S(n=31),其流体力学半径(R_(?))的平均值为75±4(?)(n=22);综合超离心和凝胶过滤的分析资料计算得到,M_0稳定时受体分子量(M)的平均值为304,000,轴比(a/b)=10。本文报告了47例人乳腺肿瘤、10例恶性子宫内膜、10例良性子宫内膜的细胞溶质ER 和PR 的浓度及受体阳性、阴性及可疑的分布。乳腺肿瘤的ER 阳性率为48%,PR 阳性率为72%(>3fmol/mg 蛋白为阳性),90%恶性子宫内膜的PR 为阳性;100%良性子宫内膜的ER 或PR 均为阳性。绝经前妇女的良性子宫内膜的PR 浓度最高,为458±275fmol/mg 蛋白。对24例标本均测定了解离常数(K_d),其中乳腺和恶性子宫内膜组织中PR-[~3H]R5020复合物的K_d 平均值为2-3nM,乳腺癌组织中ER-[~3H]E_2复合物的K_d 平均值为0.4nM。

Some alterations, including amplification and rearrangement, of oncogene N-ras, c-myc and neu in breast cancer were reported. These structural changes were correlated to some extent with several disease parameters.Our results indicate that t-hese oncogenes may play some roles in the biologic behavior and pathogenesis of human breast cancer.

本文报告了乳腺癌标本中N-ras、c-myc和neu癌基因异常改变,包括扩增和重排,并对这些结构改变与乳腺癌临床指征的关系作了初步的分析。本文的实验结果表明这些癌基因可能在人类乳腺癌的生物学行为和发病方面起着一定的作用。

The study was conducted in vitro with human breast cancer cells BCaP-37, to determine the effects of selenium, vitamin A, vitamin E and a combination of these three nutrients on cell proliferation and cellular nucleic acid content. Selenium as sodium selenite had two phases of effect on cancer cell proliferation: the low concentrations of selenium (less than 5 μM) stimulated cell growth and increased the cellular nucleic acid content; the high concentrations (more than 5 μM) depressed cell growth and reduced...

The study was conducted in vitro with human breast cancer cells BCaP-37, to determine the effects of selenium, vitamin A, vitamin E and a combination of these three nutrients on cell proliferation and cellular nucleic acid content. Selenium as sodium selenite had two phases of effect on cancer cell proliferation: the low concentrations of selenium (less than 5 μM) stimulated cell growth and increased the cellular nucleic acid content; the high concentrations (more than 5 μM) depressed cell growth and reduced the cellular nucleic acid content with dose-dependence. Vitamin A acetate inhibited cancer cell growth significantly, but vitamin A acid inhibited to some extent, and was less effective than vitamin A acetate. Vitamin E had less inhibitory effect compared to vitamin A acetate and the inhibitory percentages were lower than 40% in all treatment groups. Combination of selenium (5 μM) and vitamin E (20mg/L) or selenium and vitamin A acetate (2mg/L), no synergism for the reduction of the contents of cellular nucleic acids (DNA and RNA) were observed. The combination of selenium, vitamin A acetate and vitamin E at such levels reduced cellular DNA and RNA contents obviously; RNA content was significantly lower than any other treatment group and was reduced synergis-tically. It was indicated that the combination of selenium, vitamin A acetate, vitamin E was synergistic for inhibition of cell proliferation. Results also showed the reversible tendency in the inhibition of cell proliferation by combination of these three nutrients. It was suggested that combination of selenium, vitamin A and E might be benificial for the prevention and adjuvant treatment of human breast cancer.

本文研究了Se、VA和VE及其联合作用对人类乳腺癌细胞BCaP-37增殖的影响,结果提示Se对该细胞的增殖有双向作用,浓度高于5μM抑制细胞生长,低于该浓度则刺激细胞生长。醋酸维生素A酯浓度在1.0—10.0mg/L范围内对该细胞生长有明显的抑制。维生素A酸对该细胞的生长仅有很弱的抑制作用。VE对细胞也有弱抑制生长的作用。在稍高于生理浓度的水平下,Se(5μm)与VA(2mg/L)和VE(20mg/L)三者联合处理细胞,细胞核酸含量明显降低,提示Se、VA和VE能协同抑制BCaP-37细胞的增殖,而且这种抑制有可逆的趋势。联合使用Se和VA或VE未观察到二者间对细胞生长有协同抑制。上述结果表明联合使用Se、VA和VE对乳腺癌的防治可能是有益的。

 
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