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例健康志愿者
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  healthy volunteers
     The mean serum level of CatB in 83 patients with colorectal cancer was (5.9±2.9) ng/ml,higher than (2.3±1.1) ng/ml in the controls of 30 healthy volunteers(t=6.6975,P< 0.01).
     83例结直肠癌患者外周静脉血CatB平均水平为(5.9±2.9)ng/ml,30例健康志愿者CatB平均水平为(2.3±1.1)ng/ml,两者差异有统计学意义(t=6.6975,P<0.01)。
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     Methods:15 healthy volunteers were examined at 3.0T and 1.5T in ascending Willis circle using 3D TOF MRA.
     方法15例健康志愿者分别在3.0T和1.5T上行Willis环3D-TOFMRA检查。
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     Methods Interferon-γ(IFN-γ) and interleukin-4 (IL-4) secreted by CD4 + T-cells were detected by flow cytometry in 40 patients with CA and 20 healthy volunteers, and significance of Th1/Th2 cell ratio in the etiology of the CA was analyzed.
     方法采用流式细胞分析技术检测40例CA患者及20例健康志愿者的外周血CD4+ T淋巴细胞中胞内细胞因子(IFN-γ、IL-4),并分析Th1/Th2比值在CA发病中的作用。
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     Methods ~(99)Tc~m-TRODAT-1 SPECT imaging was performed in 30 PD patients and 16 age-matched healthy volunteers.
     方法对30例 PD患者及16例健康志愿者行~(99)Tc~m-TRODAT-1脑 SPECT 显像。
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     RESULTS: There was no positive expression of CK20 mRNA in the patients with benign intestinal diseases and the healthy volunteers, which was significantly different from that in the patients with rectal cancer (72.34%, 34/47) (χ2 = 37.434, P <0.01).
     结果:10例良性肠道病患者及10例健康志愿者外周血中均检测不到CK20的表达,与直肠癌组有明显差异(72.34%,34/47)(χ2=37.434,P<0.01).
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  “例健康志愿者”译为未确定词的双语例句
     The pharmacokinetics parameters of test and reference tablets were shown as C_(max)(52.94±12.21) vs. (57.63±9.82) ng·mL~(-1), T_(max)(1.65± 0.59)vs.
     20例健康志愿者口服比索洛尔受试及参比制剂后,C_(max)分别为(52.94±12.21)和(57.63±9.82)ng·mL~(-1); T_(max)分别为(1.65±0.59)和(1.55±0.54)h;
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     Methods The venous blood of 18 healthy volumteers was adopted and determined the maximal aggregating rate of platelet (PAGmax) induced by adding different concentration of ADP in various level of Aβ25~35 (0, 5, 10, 20, 40 μmol/L).
     方法采集18例健康志愿者肘静脉血,检测在不同浓度Aβ25~35(0、5、10、20、40μmol/L)的作用下二磷酸腺苷诱导的血小板最大聚集率(PAGMax);
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     The non-linear kinetics of Aprindine(AP)was studied in 6 healthy volunteersby taking AP single doses 40mg,80mg,160mg and multiple doses 40mg×bid for 7dayt at two week intervals.
     对6例健康志愿者进行了安搏律定(AP)口服单剂量40mg、80mg、160mg 及多剂量40mgbid×7d 的药动学研究。
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     Methods 76 colorectal cancer and 30 volunteers of CK19mRNA,CK20mRNA and CEAmRNA in peripheral blood were detected by Real-time RT-PCR.
     方法采用荧光定量PCR技术,检测大肠癌患者76例,健康志愿者30例外周血CK19mRNA、CK20mRNA和CEAmRNA水平。
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     The allelic frequencies of CYP2D6 were 8.3% (CYP2D6*2W*10W), 13.5% (CYP2D6*2H*10W), 10.6% (CYP2D6*2M*10W),
     2.中国人群CYP2D6基因多态性对曲马多药代动力学的影响按照变异位点,筛选40例健康志愿者,分为四组进行试验,每组10人。 第一组:CYP2D6*2W*10W,第二组:CYP2D6*2H*10W和CYP2D6*2M*10W,
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     and group E, healthy volunteers(n=20).
     E组,健康志愿者20
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     Meanwhile,80 healthy volunteers served as control group.
     对照组为健康志愿者80
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     Group D, 10 cases of normal healthy volunteers.
     D组,正常健康志愿者10
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     Methods:Thirty healthy volunteers and 30 patients with carotid atherosclerosis were examined.
     方法 健康志愿者 30 ;
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     15 healthy volunteers were taken as the normal control group.
     正常健康志愿者 15为对照。
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  healthy volunteers
Methylation of the 5'-region of the calcitonin gene was investigated in bone marrow and peripheral blood cells of 27 healthy volunteers and 25 leukemic patients.
      
As an experimental model, a group of 18 healthy volunteers from 18 to 44 years old (median is equal 19) was used.
      
When approved in a group of 30 healthy volunteers, the test revealed principal cognitive strategies of performing creative tasks which formed the basis for elaborating criteria for selecting subjects for physiological study.
      
The process of muscular fatigue under cooling conditions (+10°C, 30 min) was studied on seven healthy volunteers (males aged 20 to 34 years) by the surface electromyography (EMG) method using the turn-amplitude analysis.
      
Specific Characteristics of Healthy Volunteers with Different Reactions to Psychological Stress
      
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Two danazol capsule formulations were given orally to nine healthy female volunteers in a random crossover design. One formulation(A) was imported from USA, and another(B) was a developing formulation product made in China. The two experiments on each volunteer were separated by four weeks at least. Serum danazol concentrations were determined by RPHPLC method. The C×t data were Jitted to One Compartment Open Model with lagtime of absorption by PCNONLIN program, and the population pharmacokinetic parameters...

Two danazol capsule formulations were given orally to nine healthy female volunteers in a random crossover design. One formulation(A) was imported from USA, and another(B) was a developing formulation product made in China. The two experiments on each volunteer were separated by four weeks at least. Serum danazol concentrations were determined by RPHPLC method. The C×t data were Jitted to One Compartment Open Model with lagtime of absorption by PCNONLIN program, and the population pharmacokinetic parameters for formulation A were calculated by NONMEM program. The pharmacokinetic parameters(SD) for formulation A and B are:V_d/F(KL)=0.740(0.338) and 1.335(0.439); k. (h~(-1))=1.900(2.328) and 1.948(3.611); t_(lag)(h)=0.604(0.515) and 0.962(0.322), k_(el)(h~(-1))=0.297(0.145) and 0.343(0.057), respectively. The population pharmacokinetic parameters for formulation A in Chinese women are: k_a=1.06h(-1), k_(el)=0.324h~(-1), V_d/F=0.960KL.The corresponding ETA value are 1.48h~(-1), 0.367h~(-1) and 0.697KL, respectively. The epsilon value is 0.00103. For formulation A and B the average AUC(ng·h/ml) amount to 1185 and 503.2, respectively, while C_(max)(ng/ml)=169.0 and 74.7, t_(max)(h)=2.5 and 3.5. The relative bioavailability for the Chinese developing product is thus estimated about 0.425.The clinical implications of the above results are discussed.

本文报道中国妇女服二种丹那唑胶囊剂后的药代动力学分析。9例健康志愿者按随机交叉设计,每人口服进口品(A)及国产试制品(B)单剂量各一次。血清的丹那唑浓度用RPHPLC法测定。药时数据用PCNONLIN程序,按有吸收延滞时间的口服一室开放模型拟合。结果剂量200mg剂型A和B的PK参数的均值(SD)分别为:V_d/F(KL)=0.740(0.338)及1.335(0.439);ka(h~(-1))=1.900(2.328)及1.948(3.611);t_(lag)(h)=0.604(0.515)及0.962(0.322);k_(el)(h~(-1))=0.297(0.145)及0.343(0.057)。剂型A的9例药时曲线数据,还用NONMEM程序计算群体参数,结果V_d/F=0.960KL,k_a及k_(el)分别为1.06h~(-1)及0.324h~(-1);个体间误差(ETA值)依次为0.697KL,1.48h~(-1)及0.367h~(-1)。其它误差(EPSILON值)甚小,仅0.00103。对研究结果的临床意义进行了讨论。

Ten Patients with serious lower respiratory infection including 7pseudomonas aeruginosa infection with no response to other antibiotics got satisfactoriesto ceftazidime. 5 of the 10 patiente were cured. 3 clinically cured, 1 improved, and 1unassessable.No serlous toxicity and adverse effects were observed except 1 case of hypersensitive reac- tion.The pharmacokinetics of after inftazidime of in-travenous infusion or 2g in 6 healthyvolunteers were meassured. The half life was 1.87h, volume of distributidn 18.35...

Ten Patients with serious lower respiratory infection including 7pseudomonas aeruginosa infection with no response to other antibiotics got satisfactoriesto ceftazidime. 5 of the 10 patiente were cured. 3 clinically cured, 1 improved, and 1unassessable.No serlous toxicity and adverse effects were observed except 1 case of hypersensitive reac- tion.The pharmacokinetics of after inftazidime of in-travenous infusion or 2g in 6 healthyvolunteers were meassured. The half life was 1.87h, volume of distributidn 18.35 l / kg,rate of clearance 117.27 mg / l.min.Accord-ing to Eagl's theory and the serum cefatzidimeconcentration 7 hours after adminstration in 6 healthy volunteers most bacteria, evenstaphylococcus aureus, can be inhibited; so, the administration of 2g q 12 h. iv ofceftazidime is reasonable.

用头孢噻甲羧肟ceftazidime(fortum)CAZ)治疗用其它抗菌素无效的严重下呼吸道感染10例(其中7例为绿脓杆菌感染)治愈5例,显效3例、有效1例、总有效9例.对G~-菌(尤其是绿脓杆菌)显示了强大的抗感染效果.在使用中未发现明显不良反应.对6例健康志愿者静脉滴注单剂量CAZ 2g后进行了药代动力学的测定,其半衰期为1.87h.分布容量为18.35L/kg,清除率为117.27g/L/min.根据投药后7h的血药浓度尚能抑制绝大多数的细菌(甚至金黄色葡萄球菌亦能被抑制)及Eagl氏的理论,作者认为每12h静脉投药2g是合理的.

A high performance liquid chromatographic (HPLC) method has been deye-lopde for the determination of debrisoquine(D)and its 4-hydroxy metabolite (HD) in urine. Guanoxane (G) was used as an internal standard. D, HD and G were derivatized by acetylacetone, extracted from urine sample, separated on an ODS column with a mobile phase of methanol and water (73:27, v/v). The working pH was 3.5. The detecting UV wavelength was 2-18 nm. The calibration curves of D and HD were both linear for concentrations from 0.1-20μg/ml...

A high performance liquid chromatographic (HPLC) method has been deye-lopde for the determination of debrisoquine(D)and its 4-hydroxy metabolite (HD) in urine. Guanoxane (G) was used as an internal standard. D, HD and G were derivatized by acetylacetone, extracted from urine sample, separated on an ODS column with a mobile phase of methanol and water (73:27, v/v). The working pH was 3.5. The detecting UV wavelength was 2-18 nm. The calibration curves of D and HD were both linear for concentrations from 0.1-20μg/ml urine, r= 0.999 8, and their lowest detectable urine concentrations were 10ng/ml, The recoveries were between 97 %- 103% and precision studies of D and HD both within and between days at different levels provided 0V values within 5%. Our preliminary study in volunteers has identified the reliability of this assay method. A small population of 10 native Chinese living in Shanghai were typed as extensive metabolizers, according to the antimode of the metabolite ratio (D/HD) of 12.6.

本文报道用高效液相色谱法(HPLC)检测尿中异喹胍(Debrisoquine,D)及其在体内的代谢产物4-羟异喹胍(4-hydroxydebrisoquine,HD)排泄量的新方法。并依此计算人体对D的代谢比值,进行志愿者药物羟化代谢的初步研究。胍生(G)为内标,样本用乙酰丙酮衍生化后,经碱化-酸化-碱化溶剂提取。流动相为甲醇:水73:27(v/v),pH3.5,分析柱ODS C_(18),紫外检测波长248nm。尿中D和HD的浓度在0.1~20μg/ml范围内直线相关,r=0.9998,最低检测浓度为0.01μg/ml,四个浓度的方法回收率为97%~103%,天内精密度(CV)1.4%~3.3%,天间精密度(CV)3.0%~5.2%,10例健康志愿者一次口服10 mg D,测算服药后8h内尿中D和HD的含量,代谢比值在0.16—7.95间,均属快代谢型者。

 
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