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This is the first report of protective immunity conferred against intracellular bacteria by an RNA vaccine.
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| | Genetic vaccines were introduced less than a decade ago, but have already applied to a wide range of that fight off infectious, immunological, malignant diseases, and some genetic vaccines have been in clinical trials. Tumor genetic vaccines can break the immune tolerance, activate the immunogenicity, and induce the humoral and cellular responses to tumor cells. The anti tumor genetic vaccines have proved to be effective prophylactic and curative vaccination against tumor. Progress in anti tumor genetic v... | | 基因疫苗技术自从 2 0世纪 90年代问世以来被迅速应用到传染病、免疫缺陷、肿瘤等重大疾病的预防和治疗的研究中 ,有一部分已经进入临床试验阶段 .肿瘤基因疫苗可以打破免疫耐受 ,增强免疫原性 ,诱导机体产生针对肿瘤的体液和细胞反应 ,既有预防又有治疗肿瘤的作用 .能够防治肿瘤的基因疫苗发展迅猛 ,主要包括与肿瘤相关抗原 (TAAs)有关的全长、表位、独特型 (Id)和融合DNA疫苗 ,能够自主复制的RNA疫苗 ,与树突细胞 (DCs)相关的肿瘤基因疫苗等 .肿瘤基因疫苗的分子作用机制及其存在的弊端也日益成为关注的问题 | | 文摘来源 | | Nucleic acid vaccine is also called gene vaccine or DNA vaccine which is a kind of new vaccine from gene remedial research field. Nucleic acid vaccine has a lot of advantage but it also has inevitable defect. Thus, researchers reconstruct nucleic acid vaccine in order to keep it merits and avoid its shortcomings. Suicidal DNA vaccine is based on normal regulation DNA vaccine and self-replicating RNA vaccine. It not only has safe and efficient character of self-replicating RNA vaccine but also has advantage ... | | 核酸疫苗又称基因疫苗、DNA疫苗 ,是从基因治疗研究领域发展起来的一种全新的免疫防制剂。核酸疫苗具有许多优点 ,但是同时也有其不可避免的缺陷 ,这就使人们不得不把注意力集中在对传统的核酸疫苗进行改造以保持其优点 ,避免其缺陷上。“自杀性”DNA疫苗(suicidalDNAvaccine)就是基于常规DNA疫苗和“自主复制型”RNA疫苗 (self replicatingRNAvaccine)基础上发展起来的一种新型疫苗 ,不仅具有常规DNA疫苗易制备、运输、保存等方面的优点 ,而且还有“自主复制型”RNA疫苗的安全性与有效性 ,这使得其成为目前核酸疫苗研究的热点。文章就“自杀性”DNA疫苗的载体、构建、作用机理、优点以及研究现状作了综述 | | 文摘来源 | |   |
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