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临床病理特征
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  clinical-pathological characteristics
     STUDIES ON CLINICAL-PATHOLOGICAL CHARACTERISTICS AND THE PATHOGENESIS OF SELENIUM DEFICIENCY
     畜禽硒缺乏症的临床——病理特征及其发病机理
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     The typical clinical features are as follows.
     临床特征为;
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Thirteen cases of IgA nephropathy were identified by immuno-fluoreoent method on renal biopsies. Clinically, the initial manifestation of all these patients was hematuria, including 7 oases with various degree of proteinuria in addition, but none of them had nephrotic syndrome. Among 18 patients, 6 had lowered creatinine clearance rate, 1, slightly increased urea nitrogen, 3, mild hypertension, 7, elevated serum IgA value and 3, elevation of serum antistreptolysin. Pathologically, the essential changes of glomeruli...

Thirteen cases of IgA nephropathy were identified by immuno-fluoreoent method on renal biopsies. Clinically, the initial manifestation of all these patients was hematuria, including 7 oases with various degree of proteinuria in addition, but none of them had nephrotic syndrome. Among 18 patients, 6 had lowered creatinine clearance rate, 1, slightly increased urea nitrogen, 3, mild hypertension, 7, elevated serum IgA value and 3, elevation of serum antistreptolysin. Pathologically, the essential changes of glomeruli were proliferation of mesangial cells and matrix. The predominant IgA deposition in glomeruli was confirmed by immunofluorecent stain as well as IgG deposition in 4 eases. Electron-dense deposits could be found in mesangial, subendothelial or intramembranous areas of glomeruli under eleotron-mioroscopic examination. The clinical and pathological features, the relation between IgA deposition in glomeruli and serum IgA level, and the treatment and prognosis of the disease were discussed.

本文报道经肾穿刺活组织免疫荧光染色证实的13例免疫球蛋白A(IgA)肾病病例。临床上,患者均以血尿起病,其中7例还伴有不同程度的蛋白尿,但无1例属于肾病综合征。13例中,内生肌酐清除率低于正常者5例,尿素氮轻度升高者1例,血压升高者3例,血清IgA升高者7例,抗“O”升高者3例。病理上,肾小球的病变主要表现为系膜细胞和系膜基质增生,免疫荧光染色证实小球内以系膜区IgA沉积为主,其中4例还伴有免疫球蛋白G(IgG)沉积。电镜下发现电子致密物以系膜区为突出,内皮细胞下或膜内也有稀疏的电子致密物沉积。最后就本病的临床、病理特征、肾小球内IgA。沉积和血清IgA水平的相互关系,治疗及预后等问题作了讨论。

Seven cases of immature teratoma of the ovary with a neural component were analysed in the past 10 years. These constituted 1. 75 per cent, of all ovary tumors collected in the same period. All the primary tumors in the present series contained at least some immature tissues(predominantly of neural origin) and were thus graded from 1 to 3 according to the criteria of Norris. A close relationship definitely exists between the histologic grade of the tumor and that of the survival in patients. 6 of the 7 cases...

Seven cases of immature teratoma of the ovary with a neural component were analysed in the past 10 years. These constituted 1. 75 per cent, of all ovary tumors collected in the same period. All the primary tumors in the present series contained at least some immature tissues(predominantly of neural origin) and were thus graded from 1 to 3 according to the criteria of Norris. A close relationship definitely exists between the histologic grade of the tumor and that of the survival in patients. 6 of the 7 cases had been followed up; 2 cases with grade III died in several months after operation and 4 cases with grade I or II have survived. Immature teratoma of the ovary is a unioue malignancy. The diagnosis and treatment of these tumors are discussed

卵巢未成熟是一种恶性程度较高的肿瘤,发病率约占所有卵巢肿瘤的1%,瘤多见于少女青年妇女,源于原始生殖细胞,生长迅速,恶性程度依组织学分级而定。本瘤具有独特的生物学行为,可由未成熟向成熟方向逆转。本文报告卵巢未成熟型畸胎瘤7例,结合文献复习就其临床、病理特征,组织学分级、治疗和后等问题进行讨论

Using the principles of experimental pathological and the method ofcomparative testing,we succeeded in replicating animal selenium deficiency byfeeding chicks and piglets a low-selenium base diet supplemented with 0.0 or0.2 ppm selenium,and discovered some new phenomena and presented somenew viewpoints in the expressions of exudative diathesis,the lessions of smoothmuscles,the pathological feature of the pancreas,and the effects of low-seleniumnutrition on lymphatic organs,and immune functions or reproductive...

Using the principles of experimental pathological and the method ofcomparative testing,we succeeded in replicating animal selenium deficiency byfeeding chicks and piglets a low-selenium base diet supplemented with 0.0 or0.2 ppm selenium,and discovered some new phenomena and presented somenew viewpoints in the expressions of exudative diathesis,the lessions of smoothmuscles,the pathological feature of the pancreas,and the effects of low-seleniumnutrition on lymphatic organs,and immune functions or reproductive organseand hormones.We also discussed the clinical pathological characteristics and thrpathogenesis of selenium deficiency in detail,designed and drew its completesketch map;moreover,analyzed the different endurance and reactive abilitiesof various Kinds of animals to the low-selenium nutrition,and found that theanimals had certain abilities to regulate the selenium metabolism.

本课题根据实验病理学原则和分组对比的方法,通过用低硒基础日粮分别加硒(0.2ppm)或不加硒,对雏禽、仔猪进行饲喂,取得畜禽硒缺乏症病例复制的成功。经对实验过程的临诊观察及多种项目的检测,得到了系统的基础资料和大量数据。并在渗出性素质的表现、平滑肌损害、胰腺的病变特征以及对淋巴器官与免疫功能和对生殖器官与生殖激素的影响等方面,发现一些新现象,提出一些新观点。研究结果为明确该病的临床病理特征、澄清动物种属间的异同,提供了客观依据。综合实验结果,系统地论述了发病机理并设计、绘制了示意图,取得理论研究的重要成果。实验结果还提示:不同种属畜禽对低硒营养的耐受力及其反应性不尽相同;而机体本身对硒的体内代谢过程,具有一定的调节能力。

 
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