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前列腺间质
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  prostatic stromal
     Role of bFGF and TGF-β1 in Primaritity Cultured Prostatic Stromal Cells
     bFGF和TGF-β1对原代培养的前列腺间质细胞的作用
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     Both DHT and E2 couldstimulate the proliferation of human prostatic stromal cells.
     DHT和E2都能刺激人类前列腺间质细胞增殖。
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     Establishment of Rats Prostatic Stromal Hyperplasia Model
     大鼠前列腺间质增生模型的建立
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     Thus, human prostatic stromal cell of BPH was cultured to observe the effects of bFGF and TGF- β1 on it.
     故本研究培养了人BPH前列腺间质细胞,并分别观察不同浓度bFGF和TGF-β1对培养的间质细胞的影响及其相互间的作用。
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     (2) Human prostatic stromal cells weresuccessfully cultured from 11 BPH patients.
     (2)成功地培养出11例BPH病人的前列腺间质细胞。
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  prostate stromal
     Objective\ To investigate the role of insulin like growth factor 1 (IGF1) and TGFβ1 in the regulation of IGFBP 3 in prostate stromal cells.
     目的 探讨类胰岛素生长因子(IGF1) 和转化生长因子(TGFβ1) 在调节前列腺间质细胞IGF结合蛋白———类胰岛素生长因子结合蛋白3(IGFBP3) 中的作用。
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     Methods Primary cultured prostate stromal cells were derived from benign prostatic hyperplasia patients. The cells were then treated with PSA (1μg/ml),(TGFβ 1,5ng/ml) and PSA+TGFβ 1 respectively. The dose dependent effect of PSA was studied with increasing doses of PSA.
     方法原代培养前列腺间质细胞,分别用PSA(1μg/ml),β型转化生长因子(TGFβ1,5ng/ml)、PSA+TGFβ1及无血清培养液处理,分别于第1~4天作MTT试验测定细胞生长曲线。
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     Objective To study the effect of prostate specific antigen (PSA) on the growth of human prostate stromal cells.
     目的探讨前列腺特异性抗原(PSA)对前列腺间质细胞的生长调控作用。
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     Estrogen is a strong growth regulator of the prostate stromal cells, it produces a marked effect by means of binding to specific receptors.
     雌激素是前列腺间质细胞强有力的生长调节剂 ,它与其特异性受体结合后发挥作用。
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  prostatic stroma
     The percentage of positive staining nuclei in prostatic stroma was(24.59±7.37)%, and(33.89±3.90)% ( P <0.01)in NP and BPH, respectively.
     前列腺间质中核染色阳性的细胞的百分率 :在正常前列腺为 (2 4 .5 9± 7.37) % ,在良性增生前列腺中为 (33.89± 3.90 ) % ,较正常前列腺显著增多 (P <0 .0 1) .
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     Results PSS originated in specialized prostatic stroma.
     结果前列腺间质肉瘤是发生于前列腺特异性间质细胞的肿瘤。
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     But both these levels in the groups of castration plus exogenous androgen and castration plus exogenous estrogen were much higher than those in the control group ( P <0.01). Furthermore, estrogen could increase the level of HO 1 protein expression in prostatic stroma.
     外源性给予雄激素组和雌激素组的 HO- 1m RNA转录水平和 HO- 1蛋白表达水平明显增高 (P<0 .0 1) ,且雌激素引起前列腺间质 HO- 1表达增加。
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     Conclusion Hypertension may be closely related to the increased expression of VEGF in prostatic stroma.
     结论高血压与前列腺间质中VEGF的表达升高密切相关。
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  “前列腺间质”译为未确定词的双语例句
     Conclusion\ IGF1 can significantly inhibit the induction of IGFBP 3 in prostate stroma cells by TGFβ1.\;
     结论 IGF1 有抑制TGFβ1 诱导前列腺间质细胞IGFBP3 表达的作用。
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     Conclusion:TGFβ1 might be a causative factor in mysenchymal proliferation of BPH,the starting and promoting factor of BPH regulates the expression of TGFβ1 on the level of posttranscription.
     结论 :TGFβ1 是导致 BPH前列腺间质增生的重要物质 ,启动 BPH发生发展的因素在转录后水平调控 TGFβ1 的表达。
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     In order to study the interaction of bFGF and TGF-β1 on the stromal cells, we determined the effects of 5ng/ml bFGF and different concentration TGF- β1 on the stromal cells. The results showed that the stromal cells proliferated after 6days in 0.001ng/ml and 0.01ng/ml TGF- β1(P<0.01);
     为了研究bFGF和TGF一pl对前列腺间质细胞生长的相互作用,本研究检测了sng/ml的bFGF与不同浓度TGF一pl对间质细胞生长的作用,结果显示0.ooing/inl和0.oing/ml剂量的TGF一旦1作用间质细胞后第六天,培养细胞出现增殖现象(p<0.01);
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     It has the effects of repairing prostatic tissue,and alleviating mesenchymal inflammatory reaction. The effect of qianyu to regulate the local immunity in the rat's prostate may be its mechanism in the treatment of chronic prostatitis.
     结论前愈煎剂能显著调节慢性前列腺炎大鼠前列腺局部免疫功能,减轻病变前列腺间质炎症反应,促进病损修复作用,调节前列腺局部免疫功能的作用与其治疗慢性前列腺炎的作用机制有关。
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     To study the responsiveness to sex steroids,stromal cells from human hyperplastic prostates were isolated and grown in culture.
     为了了解前列腺间质细胞对性激素的反应性,用体外细胞培养技术分离培养人增生性前列腺间质细胞,观察了细胞纯度和由性激素诱导的细胞增殖反应。
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  prostatic stromal
Antiproliferative activity was mediated by a diffusible factor in the stromal cell conditioned medium and was found to be produced specifically by prostatic stromal cells.
      
Prostatic stromal cells synthesize and secrete IGF-II; there is evidence that prostatic cell lines also synthesize IGFs, but this has not been confirmed in primary cultures of prostatic epithelial cells.
      
Prostatic stromal and epithelial cells secrete a number of IGFBPs.
      
The FN mRNA was expressed by LNCaP and primary prostatic stromal cells, respectively.
      
This review focuses on the differential diagnosis between the various benign and malignant entities and compares the new WHO classification with a recently published typing of prostatic stromal lesions of unknown malignant potential.
      
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  prostate stromal
In addition, normal prostate epithelial cells co-cultured with normal prostate stromal cells did not exhibit PCAN1 expression at any time.
      
Absence of TGF-? activity was shown by the lack of inhibitory response of the TGF-?-sensitive mink lung cell line CCL-64 to prostate stromal cell conditioned medium and to concentrated partially purified preparations of the inhibitor.
      
Expression of m2 muscarinic acetylcholine receptor mRNA in primary culture of human prostate stromal cells
      
Using an explant method, we obtained a primary culture of prostate stromal cells from three patients with benign prostatic hypertrophy.
      
Primary cultures of benign prostate stromal and epithelial cells and the LNCaP (androgen sensitive) and PC-3 (androgen insensitive) prostate carcinoma cell lines were treated with doxazosin (0-50?μM).
      
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  prostatic stroma
The paracrine influence of prostatic stroma on the proliferation of prostatic epithelial cells was investigated.
      
Only LY was noted within the prostatic stroma of the rats 2?h after bladder instillation.
      
Non-neoplastic human tissues such as vessels, nerve plexus, pancreatic islets, prostatic stroma, adrenal medulla, spleen and germinal centres of the lymphoid tissues preferentially expressed sst2.
      
A model is proposed whereby androgen regulates TGFβ, influencing FGF2 and FGF7 expression, and in turn regulating growth of the prostatic stroma and epithelium.
      
Primary cultures of smooth muscle cells (SMCs) were obtained by a two-step enzymatic digestion of guinea pig prostatic stroma.
      
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Immunohistochemistry and computer-assisted quantitative immage analysis were carried out the investigation of fibronectin(FN)in benign prostatic hyperplasia(BPH). 20 normal prostate specimens and 20BPH specimens were investigated.The result showed that the FN immunoreactivity of BPH stroma(0.110±0.022) was significantly higher than FN immunoreactivity of normal prostate stroma(0.086±0.027)(P<0.00l).The FN immunoreactivity had no relationship with the age.But,there was a significant direct relationship between...

Immunohistochemistry and computer-assisted quantitative immage analysis were carried out the investigation of fibronectin(FN)in benign prostatic hyperplasia(BPH). 20 normal prostate specimens and 20BPH specimens were investigated.The result showed that the FN immunoreactivity of BPH stroma(0.110±0.022) was significantly higher than FN immunoreactivity of normal prostate stroma(0.086±0.027)(P<0.00l).The FN immunoreactivity had no relationship with the age.But,there was a significant direct relationship between the FN,immunoreactivity of BPH stroma and the percent area density of stroma in BPH.Thus,it was postulated that the enhancement of expression of FN might relate to the proliferation of stroma in the pathogenesis of BPH.

利用免疫组织化学和计算机辅助图像分析的方法对20例正常前列腺和20例良性前列腺增生组织中的纤维连接蛋白(FN)进行形态学和定量研究。结果表明,FN主要分布于前列腺间质和腺体的基底膜,呈线网状或弥漫状分布。间质中FN的相对含量与年龄无明显相关。良性前列腺增生组织间质中FN的相对含量(0.110±0.022)明显多于正常前列腺组织间质中的FN相对含量(0.086±0.027,P<0.01),而且FN的含量与良性前列腺增生组织中间质的增生程度密切相关。提示FN在前列腺良性增生的发生中起重要作用。

in order to study the relationship between growth factor and the pathogenesis of benign prostatic hyperplasia,a growth factor was purified about 1 000-fold from human benign hyperplastic prostates by ammonium sulfate precipitation and Heparin-Sepharose chromatography.The fraction containing the majority of mitogenic activity was eluted with 1. 31-7 mol/L NaCl.In SDS/PAGE it showed a molecular weight about 17 kD.The purified growth factor showed potent stimulatory effect on isolated human fetal prostatic fibroblasts.We...

in order to study the relationship between growth factor and the pathogenesis of benign prostatic hyperplasia,a growth factor was purified about 1 000-fold from human benign hyperplastic prostates by ammonium sulfate precipitation and Heparin-Sepharose chromatography.The fraction containing the majority of mitogenic activity was eluted with 1. 31-7 mol/L NaCl.In SDS/PAGE it showed a molecular weight about 17 kD.The purified growth factor showed potent stimulatory effect on isolated human fetal prostatic fibroblasts.We conclude that this purified growth factor may be a mediator with androgen action.

从人良性增生前列腺组织中经硫酸铵沉淀和肝素-琼脂糖凝胶层析纯化出人前列腺生长因子(hPGF),纯化倍数约1000倍,SDS-PAGE和等电聚焦电泳示分子量约为17kD、等电点同标准bFGF,利用分离培养的人前列腺间质成纤维细胞进行活性鉴定,发现以1.3~1.7mol/LNaCl洗脱部分为hPGF,活性最高,对间质成纤维细胞有显著刺激增殖作用。

Expression levels of bFGF and bFGFR were quantitatively assayed by immunohistochemical technique and computer-assisted image analysis with the tissue components studied in 30 cases of BPH tissues and in 6 normal prostatic tissue(NP), The area density of bFGF and bFGFR expression levels were 48.32 0132 14.63 and 21.67±11.76 respectively in BPH tissue,being significantly higher than those in NP tissue(25.16±10.87 and 4.35 ± 3.49).The expression levels of these two were positively related to the enhancement of...

Expression levels of bFGF and bFGFR were quantitatively assayed by immunohistochemical technique and computer-assisted image analysis with the tissue components studied in 30 cases of BPH tissues and in 6 normal prostatic tissue(NP), The area density of bFGF and bFGFR expression levels were 48.32 0132 14.63 and 21.67±11.76 respectively in BPH tissue,being significantly higher than those in NP tissue(25.16±10.87 and 4.35 ± 3.49).The expression levels of these two were positively related to the enhancement of stromal components of prostatic tissue, The present study designated that bFGF and bFGFR might play an important role in the development of BPH.

对6例正常前列腺和30例前列腺增生(BPH)患者组织中成纤维细胞生长因子bFGF、bFGFR表达以及前列腺组成成分的改变进行定量分析。bFGF和bFGFR在BPH组织中表达水平(48.32±14.63,21.67±11.76)明显高于正常前列腺(25.16±10.87,4.35±3.49),其表达水平与前列腺间质成分增生呈正相关。本研究表明bFGF以及受体在BPH形成中可能起重要的作用。

 
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