The further PCR-IgH gene rearrangement analysis demonstrated that the monoclonal rearrangement of IgH gene was occurred in cervical lymphoma cases not in lymphoma-like lesions.
Conclusion Cervical lymphoma-like lesions mimic cervical lymphoma in histopathological feasures and immunohistochemical expression. PCR-IgH gene rearrangement analysis and immunohistochemical detection of κ and λ protein are helpful to differential diagnosis between B-cell lymphoma and lymphoma-like lesion of the uterine cervix.
The difference lies in the expression κ and λ. κ positive and λ negative were found in all cervical lymphoma cases. In contrast, double expression of κ and λ were shown in cervical lymphoma-like lesions, and the percentage of κ and λ positive cells were similar.
Methods Seven cases of lymphomatoid lesion of the uterine cervix in the archives of the Department of Pathology were examined by light microscopy,immunohistochemical technique,EBER in situ hybridization and TCR and IgH gene rearrangements,and analysed with clinical features as well as follow-up data.
The lack of involvement of the mucosa, as well as sparing of cervical stroma and uterine junctional zone, are the most important findings to differentiate cervical lymphoma from carcinoma, and are best evaluated with T2 TSE sequences.
Two intrathoracic lymphomas, accidentally discovered during routine X-ray examination, did not cause any discomfort to the patients, whereas one patient with a cervical lymphoma suffered from attacks of fever and general prostration.