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间质微血管
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  interstitial microvascular
     Expression of VEGF and its correlation with tumor interstitial microvascular density and tumor metastasis in bladder transitional cell carcinoma
     膀胱移行细胞癌VEGF与间质微血管密度及肿瘤转移
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     The relationship between laminin receptor and nm23 protein expression and its correlation with interstitial microvascular density and tumor metastasis in breast carcinoma
     层粘连蛋白受体和nm23蛋白在乳腺癌组织中的表达及其与间质微血管密度和肿瘤转移的关系
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     Expression of matrix metalloproteinase-9 and its correlation with tumor interstitial microvascular density and tumor metastasis in transitional cell carcinoma of the bladder
     膀胱移行细胞癌MMP-9表达与间质微血管密度、肿瘤转移的关系
短句来源
     Objective To study the relationship between 67 000 laminin, laminin receptor (LN R) and nm23 protein expression, interstitial microvascular density(MVD) and tumor metastasis in breast carcinomas.
     目的 探讨乳腺癌组织层粘连蛋白 (LN)及其受体 (LN R)和nm2 3蛋白的表达与间质微血管密度及肿瘤转移的关系。
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     Purpose To study the expression of matrix metalloproteinase 2 (MMP-2) and its correlation with interstitial microvascular density (MVD) and tumor metastasis in breast carcinoma.
     目的 :研究乳腺癌组织中基质金属蛋白酶 2 (MMP 2 )的表达特点 ,探讨其与间质微血管密度及肿瘤转移的关系。
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  interstitial microvessel
     Objective: To evaluate the clinical and prognostic significance of proliferating cell nuclear antigen (PCNA) expression and tumor interstitial microvessel density (MVD) in transitional cell bladder cancer.
     目的 :探讨膀胱移行细胞癌组织中增殖细胞核抗原 (PCNA)与肿瘤间质微血管密度 (MVD)的表达及其临床与预后的意义。
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     Results: As compared with the non HQZMP treated control group, quantity of interstitial mastocyte, focal lymphocytic aggregation and interstitial microvessel damage in the HQZMP treated group were more obvious (P<0 01).
     结果 :与对照组比较 ,治疗组食管癌间质肥大细胞数量和淋巴细胞灶状聚集增多 ,间质微血管损伤现象明显 (P <0 0 1)。
短句来源
     Objective To evaluate the clinical and prognostic significance of proliferating cell nuclear antigen (PCNA) expression and to study tumor interstitial microvessel density (MVD) in transitional cell bladder cancer.
     目的 探讨膀胱移行细胞癌组织中增殖细胞核抗原 (proliferatingcellnuclearantigen ,PCNA)与肿瘤间质微血管密度 (microvesseldensity ,MVD)和肿瘤侵袭力、复发的关系及意义。
短句来源
  interstitial vascular
     Clinical and Prognostic Significance of PCNA Expression and Tumor Interstitial Vascular Density in Transitional Cell Bladder Cancer
     膀胱移行细胞癌增殖细胞核抗原与肿瘤间质微血管密度的表达与临床及预后的意义
短句来源
     Clinical and Prognostic Significance of PCNA Expression and Tumor Interstitial Vascular Density in Transitional Cell Bladder Cancer
     膀胱移行细胞癌组织间质微血管密度和增殖细胞核抗原的表达及意义
短句来源
     Results The expression of VEGF in bladder carcinoma was positively correlated to the tumor interstitial vascular density;
     结果 VEGF的表达与肿瘤间质微血管密度之间存在正相关性,二者均与膀胱移行细胞癌的病理分级显著相关,浸润性肿瘤明显高于浅表性肿瘤(P<0 .05) ;
短句来源
     Objective To study the expression of VEGF and tumor interstitial vascular density in transitional cell bladder carcinoma and their clinical significance.
     目的 探讨膀胱移行细胞癌组织中血管内皮细胞生长因子(VEGF) 的表达与肿瘤间质微血管密度(MVD)检测的临床意义。
短句来源
     Results It was shown that the expression of PCNA in bladder cancer was positively correlated with tumor interstitial vascular density.
     结果 PCNA增殖指数与肿瘤间质微血管密度之间存在正相关性 ,两者的表达皆与膀胱移行细胞癌的病理分级显著相关 ,Ⅰ级与Ⅱ级、Ⅱ级与Ⅲ级之间存在显著性差异 (P <0 .0 1)。
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     Objective To research the association of the expression of CD44v6(CD44 splice variant v6),MMP-9(matrix metalloproteinase-9)and microvessel density(MVD) with the clinicobiologic behavior in gastric carcinoma(GC),and to explore correlations between 3 factors.
     目的探讨黏附分子CD44拼接变异体v6(CD44 splice variant v6,CD44v6)、基质金属蛋白酶9(matrix metallopro-teinase-9,MMP-9)表达和癌间质微血管密度(MVD)与胃癌临床病理生物学行为的关系以及它们之间的相关性。
短句来源
     There was a negative correlation between scores of Fn immunofluorescence and c-erb-B2 oncoprotein expression (r = -0. 8728,P <0. 05).
     6例有转移的胃癌中癌组织间质微血管周围的Fn免疫荧光明显减弱,与c-erb-B_2表达间呈明显负相关(r=-0.8728,P<0.05)。
短句来源
     Methods Expression of CD34,EphB4 receptor and its ligand EphrinB2 was examined with immunohistochemistry in tumor specimens from 93 gastric cancer cases and paratumor normal specimens from 30 cases.
     方法应用免疫组织化学(免疫组化)SABC法检测93例胃癌和30例癌旁组织中EphB4受体与其配体EphrinB2的表达及间质微血管密度(MVD)。
短句来源
     ObjectiveTo detect the expression of MMP-9,TIMP-1 and CD34 in oral squamous cell carcinomas(OSCC) and the invasive tumor front(ITF) of OSCC, to investigate microvessel density(MVD) stained by monoclonal antibody CD34. The correlations between MMP-9,TIMP-1 at ITF and MVD and clinicopathological features were analyzed.
     检测基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶抑制剂-1(TIMP-1)及CD34在口腔鳞状细胞癌及癌浸润前沿的表达、观察分布,并记数CD34标记的肿瘤间质微血管密度,分析三者的关系及在口腔鳞癌侵袭中的意义。
短句来源
     In groups of injecting MT, three kinds of NOS positive cell appearance in epididymal epithelium, NOS3 positive cell appearance in microvessel endothelium of interstitium.
     在MT注射组中附睾上皮出现三种NOS阳性细胞 ,间质微血管内皮出现NOS3阳性细胞。
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  interstitial vascular
Immunohistochemistry revealed the loops of Henle to be positive for αB crystallin, whereas HSP27 staining was positive in glomerular and interstitial vascular walls and epithelial cells of proximal and distal tubules.
      
It should be noted that this technique does not distinguish between glomerular and interstitial vascular endothelial VCAM-1 expression.
      
We found evidence of net interstitial vascular regression in both CFA and FASSc lung biopsies.
      


Combined effects of α-chlorohydrin and glycidol on the ultrastructure of theinitial segment and the tail region of the rat epididymis have been studied by ultra-thin sections under electronmicroscope.Individual effects of the both drugs on thesame tissues were also examined simultaneously.The major results are as follows.1.Numbers of swollen and degenerated mitochondria were observed in principalcells,clear cells,apical cells and basal cells of epididymal epithelium,as well as insmooth muscle cells of the ductus...

Combined effects of α-chlorohydrin and glycidol on the ultrastructure of theinitial segment and the tail region of the rat epididymis have been studied by ultra-thin sections under electronmicroscope.Individual effects of the both drugs on thesame tissues were also examined simultaneously.The major results are as follows.1.Numbers of swollen and degenerated mitochondria were observed in principalcells,clear cells,apical cells and basal cells of epididymal epithelium,as well as insmooth muscle cells of the ductus epididymidis and in endothelial cells of the capil-laries in epididymal interstitium during a period of 3~30 days after administrationof low dose of α-chlorohydrin combined with glycidol(5 mg α-chlorohydrin plus75mg glycidol/kg/day×2),which previously has been proved to be effective inmale rat antifertility.Additionally,Golgi vacuoles,pinocytotic vesicles,multivesicularbodies,stereocilia and smooth endoplasmic reticulum in the apical cytoplasm of someprincipal cells occasionally were found to decrease in number.No Morphologicalchanges of the nuclei were found in these affected cells.The number of morphologi-cally unchanged mitochondria appears to become more with extended time after drugswithdrawal.2.In the group treated with the large combined dose of the drugs(20 mg α-chlorohydrin plus 100 mg glycidol/kg/day×2),apart from the changes mentionedabove,necrosis and exfoliation of some epididymal epithelial cells could be found.Some lesions of the sperm,such as the destruction of the cytoplasmic membrane,swelling of mitochondria and pyknosis of nucleus were present in a few specimenstaken from this group.3.Effects similiar to that of the combined use of the drugs were also found ingroups using α-chlorohydrin or glycidol alone,but a less degree of lesions revealed.These observations suggested that the antifertile effects of α-chlorohydrin andglycidol either used in combination or alone could result injury of mitochondria inepididymal epithelial cells,which should lead to the decrease of the function ofepididymis,hence to interfere with the maturation of the sperm in it.

本研究用电镜(辅以半薄切片的光镜检查)观察了3-氯丙二醇及2,3-氧丙醇合并用药对大白鼠附睾起始部及尾部超微结构的影响。同时,对二者单独使用时的作用进行了对比观察。结果表明:在较低有效抗生育剂量合并用药(α-ch 5mg+gly 75mg/kg/天×2)3天后,多数动物附睾管的主细胞、顶端细胞、基底细胞及亮细胞,管壁平滑肌细胞以及间质微血管内皮细胞的线粒体出现了不同程度的肿胀和退变。部分动物附睾上皮主细胞的高尔基大泡,吞饮小泡、多泡小体、不动纤毛及顶部滑面内质网亦有减少。细胞核未见明显改变。随着停药时间的延长,正常形态的线粒体的数量有相对增加的趋向,其它因药物作用而变化的细胞器亦趋向恢复。在高剂量合并用药组(α-ch 20mg+gly 100 mg/kg/天×2),除见有上述变化外,在部分动物的少数附睾管断面见到上皮细胞坏死、脱落,精子的质膜破裂、线粒体肿胀及核固缩等改变。单独使用3-氯丙二醇及2,3-氧丙醇对附睾超微结构的影响与合并用药相似。但二者影响的程度不及合并用药明显。这类药物在较低有效抗生育剂量下引起的附睾上皮细胞线粒体的损伤,主细胞高尔基复合体、滑面内质网及吞饮小泡的减少或功能降低,可...

本研究用电镜(辅以半薄切片的光镜检查)观察了3-氯丙二醇及2,3-氧丙醇合并用药对大白鼠附睾起始部及尾部超微结构的影响。同时,对二者单独使用时的作用进行了对比观察。结果表明:在较低有效抗生育剂量合并用药(α-ch 5mg+gly 75mg/kg/天×2)3天后,多数动物附睾管的主细胞、顶端细胞、基底细胞及亮细胞,管壁平滑肌细胞以及间质微血管内皮细胞的线粒体出现了不同程度的肿胀和退变。部分动物附睾上皮主细胞的高尔基大泡,吞饮小泡、多泡小体、不动纤毛及顶部滑面内质网亦有减少。细胞核未见明显改变。随着停药时间的延长,正常形态的线粒体的数量有相对增加的趋向,其它因药物作用而变化的细胞器亦趋向恢复。在高剂量合并用药组(α-ch 20mg+gly 100 mg/kg/天×2),除见有上述变化外,在部分动物的少数附睾管断面见到上皮细胞坏死、脱落,精子的质膜破裂、线粒体肿胀及核固缩等改变。单独使用3-氯丙二醇及2,3-氧丙醇对附睾超微结构的影响与合并用药相似。但二者影响的程度不及合并用药明显。这类药物在较低有效抗生育剂量下引起的附睾上皮细胞线粒体的损伤,主细胞高尔基复合体、滑面内质网及吞饮小泡的减少或功能降低,可能导致附睾正常生理功能的改变,从而造成不利于精子成熟的环境而产生抗生育作用。此外,药物对附睾管壁平滑肌细胞的线粒体及附睾微血管内皮细胞线粒体均引起不同程度的损伤,其程度严重者可能导致精液囊肿的产生。

Structural and functional changes of

通过外置大鼠小肠局部加温损伤模型,研究了小肠局部加热损伤后实质结构与间质微血管结构和功能的变化。结果在明,小肠组织损伤表现早(2—6h即有显著损伤),不同部位热损伤敏感性不同,远离肠系膜部位是热损伤最敏感部位,且绒毛的损伤明显重于隐窝。其敏感性不同与局部微血管结构和功能差异有密切关系。微血管结构与功能的损伤是实质细胞损伤加重的重要因素。由于热损伤时隐窝损伤较轻,因而再生修复发生早,能力强。

The purpose of this study is to evaluate hemorrheologic alteration in dogs with acute necrotizing pancreatitis (ANP) and the possible action of Tetramethylprazine (TMP) on it.ANP models were made in 107 healthy mongreal dogs by retrograde ductal injection of a mixture of autologus bile and trypsin. Dogs were randomly assigned to three groups:sham operation, untreated, and TMP treated groups. Hemorrheologic parameters and serum amylase activity were measured at 1h, 6h, and 24h after induction of ANP. Results...

The purpose of this study is to evaluate hemorrheologic alteration in dogs with acute necrotizing pancreatitis (ANP) and the possible action of Tetramethylprazine (TMP) on it.ANP models were made in 107 healthy mongreal dogs by retrograde ductal injection of a mixture of autologus bile and trypsin. Dogs were randomly assigned to three groups:sham operation, untreated, and TMP treated groups. Hemorrheologic parameters and serum amylase activity were measured at 1h, 6h, and 24h after induction of ANP. Results of this study showed that all hemorrheologic parameters were significantly elevated at the early stage of ANP, and increased further until 24h after induction of ANP. Microthrombus were observed in pancreatic interstitial tissue. After treated with TMP, all the above-mentioned changes were prevented.The results suggest that hemorrheologic alteration is one of the key factors for a series of changes in ANP such as microcirculatory disturbance, microthrombsis, and ischemia in pancreatic tissue.Antagonistic action of TMP on hemorrheologic disturbances might account for the mechanism of TMP in treating experimental ANP.

采用胰管内逆行加压注射犬自身胆汁和胰蛋白酶混合物诱发犬急性坏死性胰腺炎模型。术后动态观察血液流变学各项指标变化及川芎嗪的影响。结果表明,在犬急性坏死性胰腺炎早期即有全血粘度、红细胞聚集指数、红细胞和血小板电泳率等异常改变,而川芎嗪治疗组上述指标改变与假手术组接近:病理学检查显示非治疗组胰间质微血管中可见微血栓形成,腺泡及脂肪细胞环死。川芎嗪治疗组鲜见。本文结果提示在犬急性坏死性胰腺炎早期异常改变的血液流变学为胰组织微循环障碍、微血栓形成、组织缺血环死等一系列改变的重要因素,川芎嗪可有效地阻止或改善这些变化。

 
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