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   p16基因突变 的翻译结果: 查询用时:0.199秒
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肿瘤学
妇产科学
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p基因突变
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  p 16 gene mutation
     3)It is not found correlation between expression of p16 protein and p16 gene mutation.
     3)未发现p16蛋白表达与p16基因突变有相关性.
短句来源
     In addition, p16 gene mutation was not related to site, location, grade of tumor differentiation and lymph node metastases, respectively (P>0.05) .
     另外,P16基因突变与肿瘤的大小、位置、分化程度和有无淋巴结转移无关(P>0.05)。
短句来源
     Objective To discuss the relationship between K ras gene activation and MTS1/p16 gene mutation/deletion and the progression of endometrial carcinoma.
     目的 探讨K ras激活与MTS1/ p16基因突变 /缺失在子宫内膜癌中的发生发展关系。
短句来源
     PCR SSCP and DNA sequencing were used for the analysis of p16 gene mutation.
     用PCR单链构象多态性(SSCP)和DNA测序技术进行了p16基因突变分析;
短句来源
     It showed that the rate of p16 gene mutation and HPV 16 18 infections were both 53 6%(15/28) in ovarian epithelial tumor. Seven cases with p16 mutatioin were positive of HPV 16 18. The ratio was 46 7%(7/15).
     结果,28例卵巢上皮性肿瘤组织中p16基因突变15例,突变率为53.6%(15/28),其中7例伴有HPV16型或HPV18型感染,占突变率的46.7%。
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  “p16基因突变”译为未确定词的双语例句
     The P16 gene exon 2 mutation rate in Ⅰ,Ⅱ,Ⅲ,Ⅳstages was 25.0%(1/4),33.3%(3/9),50.0%(5/10)和55.5%(5/9),respectively. The rate of mutation in Ⅲ,Ⅳstages NSCLC was higher than that in Ⅰ,Ⅱ stages(P<0.05).
     TNM分期Ⅰ,Ⅱ,Ⅲ,Ⅳ期NSCLC患者血浆P16基因突变率分别为25.0%(1/4),33.3%(3/9),50.0%(5/10)和55.5%(5/9),Ⅲ,Ⅳ期明显高于Ⅰ,Ⅱ期(P<0.05)。
短句来源
     Objective Clarify the relationship between mutations of CDKN 2/(P16) gene and sub-set of HCC.
     目的 阐明 CDKN2 / P16基因突变与原发性肝癌发生的关系。
短句来源
     MUTATION OF CDKN 2/P16 GENE IN HUMAN HEPATOCELLULAR CARCINOMA (HCC).
     原发性肝癌中CDKN_2/P16基因突变的研究
短句来源
     (2)A total of 3 homozygous deletions and no mutations of MTS1/p16 gene exon1 and exon2 in HCCs were found in the subset of HCCs.
     (2)只有3例(10.34%,3/29)肝细胞癌中发现MTS1/p16基因纯合性缺失,未发现MTS1/p16基因突变
短句来源
     Expression of p16 protein and mutations of p16 gene in breast hyperplasia
     乳腺增生病p16蛋白表达及p16基因突变
短句来源
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  相似匹配句对
     Mutation Frequency of the P16 Gene in Primary Esophageal Squamous Cell Carcinomas
     食管癌P16基因突变
短句来源
     * (16!)
     *(16!)
短句来源
     Mutation analysis of p16 gene in acute lymphoblastic leukemias
     白血病细胞p16基因突变分析
短句来源
     MUTATION ANALYSIS OF P16 GENE IN LEUKEMIAS
     白血病中P16基因突变的检测
短句来源
     Mutation of p16/mts1 gene in human primary cancers in the upper digestive tract
     上消化道恶性肿瘤中p16基因突变的研究
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The exon 5 , 6 , 7 of p53 gene in frozen breast cancer specimen was detected. Using PCR-SSCP method , the abnormal shifting of the single stranded DNA ( ssDNA ) was identified in 15 out of 30 cases. The distribution of mutation among these cases were 1. according to stage of diseaae , stage Ⅱ 7 / 14 , stage Ⅲ 6 / 11 , stage Ⅳ 2 / 2; 2 . according to pathological type , infiltrative ductal carcinoma 13/26 , papillary adeno carcinoma 1 / 1 , intraductal carcinoma 1 / 1 ; 3. According to axillary nodal status ,...

The exon 5 , 6 , 7 of p53 gene in frozen breast cancer specimen was detected. Using PCR-SSCP method , the abnormal shifting of the single stranded DNA ( ssDNA ) was identified in 15 out of 30 cases. The distribution of mutation among these cases were 1. according to stage of diseaae , stage Ⅱ 7 / 14 , stage Ⅲ 6 / 11 , stage Ⅳ 2 / 2; 2 . according to pathological type , infiltrative ductal carcinoma 13/26 , papillary adeno carcinoma 1 / 1 , intraductal carcinoma 1 / 1 ; 3. According to axillary nodal status , positive axillary lympho node 11/18,megative axillary lympho mode 4/12.The result indicates that the mutation of p53 gene is intimatly related to clinical stage and pathological type . The carcinoma with positive p53 gene mutation in more invassive , recurred and metastaticl.

应用聚合酶链式反应-单链构象多态性分析(PCK-SSCP)法检测30例乳腺癌组织中P基因的5、6、73个外显子。结果显示,15例有异常电泳带,表明这些病例相应的DNA片段发生突变。结合临床分析发现:在(1)Ⅱ期7/14例、Ⅲ期6/11例、Ⅳ期2/2例,(2)浸润性导管癌13/26例、乳头状腺癌1/1例、导管内癌1/1例,(3)腋窝淋巴结阳性11/18例、腋窝淋巴结阴性4/12例中发现P基因突变。提示P基因突变与临床分期及病理改变有关,有P53基因突变的原发病灶具有较强的侵袭能力,易复发和转移。

Objective: To verify the quality of the mciroarr ay genechips(made in China) that can be used to detect the gene mutation of HBV. Methods: 14 cases of chronic hepatitis B were selected. Aft er they had taken lamivudine for 48 weeks, the HBV - DNA in their blood were st ill positive based on quantitative analysis. Then their blood samples were colle cted and detected for YMDD motif mutation in HBV - DNA polymerase gene by the m icroarray genechips for HBV mutation. At the same time, P gene of HBV in these b...

Objective: To verify the quality of the mciroarr ay genechips(made in China) that can be used to detect the gene mutation of HBV. Methods: 14 cases of chronic hepatitis B were selected. Aft er they had taken lamivudine for 48 weeks, the HBV - DNA in their blood were st ill positive based on quantitative analysis. Then their blood samples were colle cted and detected for YMDD motif mutation in HBV - DNA polymerase gene by the m icroarray genechips for HBV mutation. At the same time, P gene of HBV in these b lood samples were amplified by PCR, and the gene sequences were detected to inve stigate the YMDD motif mutation. Results: HBV - DNA was fou nd in the blood samples from 14 cases detected by microarray genechips. Among th em, 9 cases were wild type, YMDD mutation were found in the other 5 ones. Among these 5 cases, 3 ones were M552I(YIDD) mutation and the other 2 ones were M552V( YVDD) mutation accompanied by L528M mutation. These results were the same as tho se obtained by sequencing of the PCR products. Conclusion: T he microarray gengchip for HBV gene mutation detection made in China was specifi c, sensitive and convenient, and it can be used to replace DNA sequencing and ma ybe become a routine method to detect HBV - DNA mutation.

 目的:验证国产基因芯片检测HBV P基因突变的准确性和敏感性。方法:选择14例服用拉米夫定48周时HBV DNA定量检测仍阳性的慢性乙型肝炎病人的血清标本,用HBV基因突变检测基因芯片检测患者血清中HBV DNA聚合酶基因,观察发生YMDD变异的情况。同时用聚合酶链反应(PCR)技术扩增上述血清标本中编码HBV DNA聚合酶的P基因片段并直接测序,以对比检查 P基因发生 YMDD变异的情况。结果:14 例患者血清标本用基因芯片均检出 HBV DNA,9例为野生株,5 例发生 YMDD变异,其中 3 例为 M552I(YIDD)变异, 2 例为 M552V(YVDD)变异,同时均伴有L528M变异。与用PCR扩增产物直接测序的结果完全相同。结论:国产HBV基因突变检测芯片具有特异性强、灵敏性高、快速、简便等优点,可以替代繁琐的DNA序列测定和分析,可作为临床监测HBV DNA变异的常规方法。

 
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