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血小板游离钙
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  platelet free calcium
     The results showed that XSH could obviously decrease the platelet free calcium level in the rabbits with experimental arteriosclerosis and enhance the activity of erythrocyte membrane Ca2 + - Mg2+ - ATPase and contraction of the aorta.
     结果:XSH可明显降低实验性动脉粥样硬化兔血小板游离钙水平,提高红细胞膜Ca~(2+)-Mg~(2+)-ATPase活性及主动脉收缩性;
短句来源
     In order to study the functuon of "Xu Shao Huo Capsules" (XSH) on platelet free calcium and calcium pump in the rabbits with the experimental arteriosclerosis, cholesterol was poured into the stomach of the rabbit to create AS.
     为研究“煦少火胶囊”(XSH,主药:附子、西洋参、瓜蒌、丹参、葛根)对实验性动脉粥样硬化兔血小板游离钙和钙泵的作用。
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  “血小板游离钙”译为未确定词的双语例句
     Results The concentrations of free calcium in platelets were 169.66 ± 36.46nmol/L in 14 young men aged 20 - 39, 237.40±31 .0nmol/L in 17 males aged 50 - 59, and 367.36 ± 220. 0nmol/L in 8 males over 60 (P < 0.01 and 0.05 respectively).
     结果 随年龄增高血小板游离钙明显增高,20~39岁血小板游离钙为169.66±36.46nmol/L; 50~59岁为237.40±31.0(P<0.01),≥60岁为367.36±220.0(P<0.05).
短句来源
     ANTIHYPERTENSIVE DRUGS AND PLATELETS IONIZED CALCIUM
     抗高血压药与血小板游离钙
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     Changes in cytosolic free calcium and thromboxane B2synthesis in platelets from diabetic
     糖尿病患者血小板游离钙变化与血栓素B_2生成的关系
短句来源
     Measurement and clinical significance of free calcium contentration of platelets in patients with sudden deafness
     突发性聋患者血小板游离钙离子浓度检测及临床意义
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     Quantitative Analysis on Platelets Cytosolic Free Calcium Concentration and Ulcerous Tissue Calcium in Patients with Recurrent Aphthous Ulceration
     复发性阿弗它溃疡患者血小板游离钙及溃疡组织钙含量定量分析
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  相似匹配句对
     ANTIHYPERTENSIVE DRUGS AND PLATELETS IONIZED CALCIUM
     抗高血压药与血小板游离
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     The dynamic observation of intracellular free Ca~(2+) concentration in pregnant period.
     孕期血小板游离离子浓度动态观察
短句来源
     Effect of SJAMP on Platelet Cytosolic Free Ca~(2+)
     SJAMP对血小板胞内游离水平的影响
短句来源
     Measurement of Intracellular Ionic Calcium Concentration of Platelets with Fura-2
     应用Fura-2测定血小板游离浓度
短句来源
     Measurement of Cytoplasmic Free Calcium in Blood Platelets from Patients with Stroke
     急性脑血管病患者血小板胞浆游离浓度测定的意义
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There are several common features between platelets and smooth muscle cells, andthe increment of platelets [Ca~(2+)]i might be a reflection of high arteriolar tension. Following the studyof the relations between nifedipine, indapamide, clonidine and platelets [Ca~(2+)]i, 40 patients (female12, male 28) with essential hypertension devided into 4 groups (EH) were studied with the adminis-tration of capton (captopril, 25mg/d), prazosin (2 mg/d), dihydrochlorothiazide (50mg/d), meto-prolol(50~100mg/d)respectively....

There are several common features between platelets and smooth muscle cells, andthe increment of platelets [Ca~(2+)]i might be a reflection of high arteriolar tension. Following the studyof the relations between nifedipine, indapamide, clonidine and platelets [Ca~(2+)]i, 40 patients (female12, male 28) with essential hypertension devided into 4 groups (EH) were studied with the adminis-tration of capton (captopril, 25mg/d), prazosin (2 mg/d), dihydrochlorothiazide (50mg/d), meto-prolol(50~100mg/d)respectively. Results showed: (1)All 4 drugs decreased blood pressure (BP)sig-nificantly. (2)Platelets[Ca~(2+)]i decreased 38.889±43.791, 22.700±25.743nmol/l (p<0.05) re-spectively in capton and DCT groups; while in prazosin and metoprolol groups no change has beenfound. (3)Blood total Ca increased after administering prazosin and the blood Ca~(2+) increased after ap-plying both prazosin and DCT. (4)RBC[Na~+]i decreased after administering capton and ΔSBP (pre minus post value) was associated positively with ΔRBC [Na~(2+)]i; pre-RBC [Na~(2+)]iand ΔRBC [Na~+]i correlated positively with ΔDBP after applying DCT, indicating that the decrea-ment of [Na~+]i might also be implicated in the antihypertensive mechanisms of these two drugs. (5)Pre-blood phosphate (P) was associated inversely with ΔSBP in Capton group. In metoprolol group,it was also inversely associated with ΔSBP, ΔDBP. Taking 226nmol/l as the upper normal limit of platelets [Ca~(2+)]i, which is the X±2SD valuefrom the controlled group of 42 normal persons, 52.5% of 40 EH patients was equal to or higher thanthis limit. On this basis, a working hypothesis can be raised: EH patients can be grouped as those withhigh or normal cell [Ca~(2+)]i and the antihypertensive drugs can also be grouped as those decreasing ornot decreasing platelets [Ca~(2+)]i parallelly with BP. The former might be more effective to the preven-tion and treatment of hypertensive thromboplastic complications.

血小板和血管平滑肌细胞有不少共同特徵.血小板游离钙([Ca~(2+)]i)的增加可能间接反映小动脉高张力和高周围阻力。继对硝苯啶、吲达帕胺、可乐宁和血小板[Ca~(2+)]i关系的报道,对40例高血压病患者(男28、女12)分成以巯甲丙脯酸(25mg/d)、哌唑嗪(2mg/d)、双氢克尿噻(50mg/d)、美多心安(50—100mg/d)治疗的4组作观察,每组10例。发现:(1)4药均有明显降压效果。(2)血小板[Ca~(2+)]i在巯甲丙脯酸和双氢克尿噻组分别降低38.889±43.791、22.700±25.743nmol/l(p均<0.05);在哌唑嗪、美多心安组未见相应变化。(3)哌唑嗪组血总Ca和Ca~(2+)在治后升高;双氢克尿噻组治后血Ca~(2+)也升高。(4)RBC[Na~+]i在巯甲丙脯酸组在治后降低,且治后ΔRBC[Na~+]i与ΔSBP(治前-治后值)呈正相关;双氢克尿噻组治前RBC[Na~+]i和ΔRBC[Na~+]i与ΔDBP呈正相关,提示细胞[Na~+]i的降低可能也参与该两药的降压机制。(5)治前血磷(P)在巯甲丙脯酸组与治后ΔSBP、美多心安组与治后ΔSBP、ΔD...

血小板和血管平滑肌细胞有不少共同特徵.血小板游离钙([Ca~(2+)]i)的增加可能间接反映小动脉高张力和高周围阻力。继对硝苯啶、吲达帕胺、可乐宁和血小板[Ca~(2+)]i关系的报道,对40例高血压病患者(男28、女12)分成以巯甲丙脯酸(25mg/d)、哌唑嗪(2mg/d)、双氢克尿噻(50mg/d)、美多心安(50—100mg/d)治疗的4组作观察,每组10例。发现:(1)4药均有明显降压效果。(2)血小板[Ca~(2+)]i在巯甲丙脯酸和双氢克尿噻组分别降低38.889±43.791、22.700±25.743nmol/l(p均<0.05);在哌唑嗪、美多心安组未见相应变化。(3)哌唑嗪组血总Ca和Ca~(2+)在治后升高;双氢克尿噻组治后血Ca~(2+)也升高。(4)RBC[Na~+]i在巯甲丙脯酸组在治后降低,且治后ΔRBC[Na~+]i与ΔSBP(治前-治后值)呈正相关;双氢克尿噻组治前RBC[Na~+]i和ΔRBC[Na~+]i与ΔDBP呈正相关,提示细胞[Na~+]i的降低可能也参与该两药的降压机制。(5)治前血磷(P)在巯甲丙脯酸组与治后ΔSBP、美多心安组与治后ΔSBP、ΔDBP呈负相关。以正常对照组42人血小板[Ca~(2+)]i的“?±2SD”即226nmol/l为正常高界,52.5%本组患者大或等于此值。据以提出下述工作假设:高血压病患者可能区分为高及正常细胞[Ca~(2+)]i两种模式;不同抗高血压药也可分为血小板[Ca~(2+)]i与血压平行或不平行降低的两类。选用能降[Ca~(2+)]i的降压药可能对防治高血压性血栓性并发症更有益。

To study the relationship between the abnormal behavior of calcium (Ca 2+ ) and the pathogensis of recurrent aphthous ulceration (RAU) by measuring quantitatively the concentration of platelets' cytosolic free calcium ions ([Ca 2+ ] i) and tissue calcium (W Ca 2+ ), the patients with RAU (n=50) and the healthy volunteers (n=30) were chosen radomly. Then platelets [Ca 2+ ] i was determined in calcium fluorescent indicator Fura2/AM loaded washed platelets by spectrofluorophotometer and tissue W Ca 2+...

To study the relationship between the abnormal behavior of calcium (Ca 2+ ) and the pathogensis of recurrent aphthous ulceration (RAU) by measuring quantitatively the concentration of platelets' cytosolic free calcium ions ([Ca 2+ ] i) and tissue calcium (W Ca 2+ ), the patients with RAU (n=50) and the healthy volunteers (n=30) were chosen radomly. Then platelets [Ca 2+ ] i was determined in calcium fluorescent indicator Fura2/AM loaded washed platelets by spectrofluorophotometer and tissue W Ca 2+ was measured quantitatively by OCPC autoanalyzer method. The results showed that the concentration levels of platelets [Ca 2+ ] i in patients with RAU in attack stage and attackfree stage were significantly higher than that of the control group (P<0.01, P<0.05), and the concentration level of the ulcerous tissue W Ca 2+ was also obviously higher than that of the normal control group (P<0.001). There was a significantly positive correlation between the platelets [Ca 2+ ] i and the ulcerous tissue W Ca 2+ (P<0.01). The results suggested that the influx disorder and overload of Ca 2+ might play an important role in the pathogensis of RAU.

为探讨钙离子(Ca2+)异常活动与复发性阿弗它溃疡(RAU)发生的关系,随机收集50例RAU患者及30例健康志愿者,分别采集外周全血及口腔正常或溃疡粘膜组织,应用Fura-2/AM荧光比值法及邻甲酚酞复合物(OCPC)自动分析法分别检测血小板游离钙浓度([Ca2+]i)及组织钙含量(WCa2+)。结果发现:RAU患者不论发作期还是间歇期血小板[Ca2+]i均显著高于正常对照者(P<0.01;P<0.05);溃疡组织WCa2+明显升高,与正常对照组比较具有极显著性差异(P<0.001);血小板[Ca2+]i与同期溃疡组织WCa2+呈显著正相关(P<0.01)。提示:血小板游离钙及组织钙超载可能在RAU发生中起重要作用

Objective\ To investigate the mechanism of hemorrhagic tendency after phosphorus poisoning.Methods\ 45% phosphoric acid and 20 mg/cm 2 phosphorus were used to produce burn injury in rabbits. The total content of phosphorus remaining on the wound and 7 day mortality were similar in both groups.Results\ The results showed that plasma free calcium contents were significantly lower in both phosphorus groups than healthy and thermal burn controls (0.80 vs 1.40 mol/l, P<0.01 ). The free calcium content of platelet...

Objective\ To investigate the mechanism of hemorrhagic tendency after phosphorus poisoning.Methods\ 45% phosphoric acid and 20 mg/cm 2 phosphorus were used to produce burn injury in rabbits. The total content of phosphorus remaining on the wound and 7 day mortality were similar in both groups.Results\ The results showed that plasma free calcium contents were significantly lower in both phosphorus groups than healthy and thermal burn controls (0.80 vs 1.40 mol/l, P<0.01 ). The free calcium content of platelet was lowered to 116 ̄140 nmol/l, which was significantly lower than that of healthy control (285 nmol/l) and thermal injury group (480 ̄504 nmol/l). Concomitantly, the platelet aggregation rate was lowered to 1.29% and 10.78% in phosphoric acid group and phosphorus group, respectively, while it was 67.01% in healthy control and 82.1% ̄84.9% in thermal injury group; the difference was statistically significant.Conclusion\ Calcium therapy brought back intracellular and extracellular free calcium contents to normal in phosphorus burn group. Also platelet aggregation rate approached normal level after calcium therapy. The results suggest that the bleeding tendency after phosphorus burn is due to combination of phosphorus with intracellular and extracellular calcium of platelets, thus inhibiting aggregation of platelets.

目的探讨磷烧伤中毒的出血机理。方法采用45%磷酸烫伤及20mg/cm2磷粉烧伤模型,两种模型致伤后创面残留总磷量及动物7天死亡率相同。结果磷酸与黄磷致伤后血浆游离钙显著低于正常及烧烫伤对照组(P<0.01),两组血小板游离钙显著降低,与正常组及烫伤烧伤组比较差异均有非常显著意义(P<0.01)。同时,磷酸组与黄磷组血小板聚集率与正常组及烧伤烫伤组比较也显著降低(P<0.01),黄磷及磷酸的钙剂治疗组血小板内外游离钙恢复至正常水平,血小板聚集也接近正常。结论磷烧伤后主要是磷酸与细胞内外的游离钙结合,通过降低血小板内游离钙水平,抑制血小板聚集,导致出血倾向。钙治疗可恢复细胞内外游离钙水平及血小板聚集功能而达到临床迅速止血的目的。

 
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