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肾病儿童
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  nephropathy children
     Plasma β-EP,cAMP & cGMP in Nephropathy Children and Their Diagnostic Significance
     肾病儿童血浆β-内啡肽、环磷腺苷及环磷鸟苷变化的临床诊断意义
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     SUPPERSSION OFIL-6 ACTIVITY AND IGG PRODUCTION IN VITRO INDUCEK BY SOLUBLE IMMUNE RESPONSE SUPPRESSOR IN CHILIREN WITH IDIOPATHIC NEPHROTIC SYNDRONE
     单纯性肾病儿童可溶性免疫应答抑制物对IL-6活性及体外IgG产生的影响
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     Abnormal DNA binding abilities of activator protein 1 and glucocorticoid receptor in children with nephrotic syndrome
     肾病儿童外周血单个核细胞活化蛋白1和糖皮质激素受体的DNA结合活性的变化
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     In the present investigation we compared 18 simple nephrotic syndromechildren and 16 remission cases with 14 matched healthy controls to determine their ability to generate suppressor cells activated by histamine and ConA in vitro.
     对34例单纯性肾病儿童(肾病期18例、缓解期16例)和14例正常儿童,分别用组织胺和ConA诱导抑制性T细胞活性。
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     Helicobacter pylori gastritis in children can be diagnosed by obtaining antral biopsy specimens for culture and histologic study during upper gastrointestinal endoscopy.
     儿童H.
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     With antibiotic-resistant H.pylori strains increasing, in vivo efficacy of anti-H.
     儿童H.
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     Immunologic studies of nephrotic syndrome in children.
     儿童肾病综合征免疫学检查的观察
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     Expression of Tumer Necrosis Factor Alpha in Children’s Nephrotic Syndrome
     肿瘤坏死因子在儿童肾病综合征中的变化
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     Das nephrotische Syndrom
     肾病综合征
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In the present investigation we compared 18 simple nephrotic syndromechildren and 16 remission cases with 14 matched healthy controls to determine their ability to generate suppressor cells activated by histamine and ConA in vitro. Histamine-induced suppressor cell activity(HA-SCA)was increased in nephrotic period(P<0. 05)and became normal in remission after treated with glucocorticoids. (P>0. 05). Whereas, ConA-induced suppressor cell activity was decreased in nephrotic period (P<0. 01). HA-SCA was correlated...

In the present investigation we compared 18 simple nephrotic syndromechildren and 16 remission cases with 14 matched healthy controls to determine their ability to generate suppressor cells activated by histamine and ConA in vitro. Histamine-induced suppressor cell activity(HA-SCA)was increased in nephrotic period(P<0. 05)and became normal in remission after treated with glucocorticoids. (P>0. 05). Whereas, ConA-induced suppressor cell activity was decreased in nephrotic period (P<0. 01). HA-SCA was correlated to serum IgG negatively(r=-0. 79, P<0. 001). Therefore, we suggest that histamineinduced suppressor cell activity may reflect the suppressor function in simple nephrotic syndrome.

对34例单纯性肾病儿童(肾病期18例、缓解期16例)和14例正常儿童,分别用组织胺和ConA诱导抑制性T细胞活性。结果表明,肾病期患儿组织胺诱导抑制性T细胞活性(HA-SCA)明显高于对照组(P<0.05),经激素治疗后恢复正常;肾病期ConA诱导抑制性T细胞活性(ConA-SCA)明显低于对照组(P<0.01);HA-SCA与血浆IgG呈显著负相关(γ=-0.79,P<0.001)。分析结果提示,不同刺激原通过不同途径诱导出不同的抑制性细胞活性。组织胺通过免疫细胞表面的组织胺受体发挥负性调节作用,诱导出Ts。因而HA-SCA可反映单纯性儿童肾病综合征Ts功能状态。

Minimal Change Nephropathy(MCN)is the commonest pathological type of primary Nephrotic Syndrome(NS)in children.To deve lop animal model of MCN is very important in the research of mechanism and d rug t herapy of NS.This article mainly introduces the metholds and the advance of anim al model development of MCN,the advantage and disadvantage of these methods are analysed as well.

微小病变型肾病是儿童原发肾病综合征最常见的病理类型 ,其动物模型的建立为探索肾病综合征的发病机理和药物防治提供了良好的实验基础。本文介绍了微小病变型肾病大鼠模型的建立及其研究进展 ,并比较了不同方法的优缺点

 
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