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张力-时间
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  tension time
     The rabbits were anethetized with urethanum 1g/kg. Lanshejian alkaloids (0.1ml/kg, 0.5ml/kg Ⅳ)markedly decreased blood pressure (BP) , left ventricular pressure (LVP) , the maximum derivative of the left ventricular pressure (dp/dt max) , tension time index of ventricular ejection (TTI) , and reduced the area of acute myocardial ischemia.
     用乌拉坦1g/kg麻醉家兔,静注拦蛇箭混合生物碱(0.1ml/kg,0.5ml/kg),血压(BP),左心室内压(LVP),室内压最大上升速率(dp/dt max)和张力-时间指数(TTI)均明显下降,且心肌梗塞范围与对照组相比显著缩小。
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     Time is...
     时间
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     Time
     时间
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     Apply time sequence model to predict and control spinning tension
     运用时间序列模型预测和控制纺纱张力
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     The Timely Strain and Its Aesthetic Implication in Tang and Song Dynasties Ci-classical Poetry
     唐宋词中的时间张力及其美学意义
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     Tension analysis of glass roving
     无捻粗纱张力分析
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  tension time
-After ISDN, LV and aortic pressures, stroke volume and work as well as tension time index were significantly lower under exercise of identical load, the reduction correlating significantly with the lower MBF.
      
The validity of the diastolic pressure time index (DPTI) as an estimate of myocardial O2 supply and tension time index (TTI) as an estimate of O2 demand has been examined in 10 closed-chest anesthetized dogs.
      
The tension time index bears a close relationship to myocardial oxygen consumption only under normal and moderate stimulation of inotropism (r=0.96), but there is no significant correlation under high positive inotropic stimulation (r=0.39).
      
By 2s, myocardial O2 requirements, as estimated from either the tension time index (TTI) or calculated wall tension, had increased significantly above resting values.
      
Combined cable tension time histories were estimated fromrelative DED deflections coupled with the tension-deflection calibration curve and the orientation of the rings cables, and were compared to measured values to evaluate the proposed technique.
      
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Myocardial infarct was produced by occluding the apical branch of the left anteriordescending coronary artery. The effect of the corolla extract of Flos Carthami, the Chinese medicinal plant "Hong-Hua", on the extent of myocardial ischemia was evaluated by means of the epicardial electrographic mapping. During the 15 rain-occlusion the mapping was performed in 5 min interval, then the coronary occlusion was released. After reperfusion for 1 hr, while the Hong-Hua extract was being infused, a second occlusion...

Myocardial infarct was produced by occluding the apical branch of the left anteriordescending coronary artery. The effect of the corolla extract of Flos Carthami, the Chinese medicinal plant "Hong-Hua", on the extent of myocardial ischemia was evaluated by means of the epicardial electrographic mapping. During the 15 rain-occlusion the mapping was performed in 5 min interval, then the coronary occlusion was released. After reperfusion for 1 hr, while the Hong-Hua extract was being infused, a second occlusion and mapping was applied again as before@Hong-Hua extract (25%) in a dose of 2 g/kg reduced the average ST segment elevation. In the central infarct zone, 15 min after the first and second occlusion were 7.5±0.6 and 3.3±0.5mV respectively (P<0.001), whereas in the border zone the correspoding values of were 3.5±0.4 and 0.9±0.2mV(P<0.001). Reduction of was more Significant in the border zone than in the central zone (P<0.001).@Hong-Hua extract administered during the second occlusion markedly reduced the number of sites showing equal or greater than 2 mV ST segment elevation (NST) in the border zone as compared with occlusion alone, but NST remained unchanged in the central zone.@After administration of Hong-Hua extract, heart rate decreased from initial value of 164±11 to 144±9 beats/min (P<0.05) and tension-time index from 129.0±6.3 to 116.8±6.3 (P<0.01).@Our data suggest that Hong-Hua may reduce the infarct size following acute coronary occlusion by salving a lot of jeopardized myocardium in the border ischemic zone, and that the reduction of myocardial oxygen consumption was involved in the beneficial action of Hong-Hua.

由结扎左前降冠状动脉尖支的方法造成犬的心肌梗塞,用心外膜电图标测术评价中药红花提取液对心肌缺血程度的影响。本研究发现,红花液显著减少心外膜电图标测点ST段平均抬高程度,这种变化尤以梗塞边缘区为甚。红花液还可明显减少梗塞边缘区ST段显著抬高的标测点数。输入红花液后,心率及张力时间指数明显减少。说明红花可以挽救梗塞边缘区濒危缺血心肌而缩小急性冠脉闭塞后的梗塞范围,这种有益作用可能与其降低心肌耗氧量有关。

In order to elucidate the mechanism of hypertensive and antishock effects of Citrus aurantium L. and its active principles (synephrine and N-methyltyramine), carotid arterial blood pressure (BP), left ventricular pressure (LVP), left ventricular end diastolic pressure (LVEDP), the first derivative of the left ventricular pressure (dp/dt), central venous pressure (CVP), EGG, heart rate (HR), and cardiac output (CO) were monitored in 6 anethetized open chest dogs. The tracings were recorded on RM-86 Polygraph....

In order to elucidate the mechanism of hypertensive and antishock effects of Citrus aurantium L. and its active principles (synephrine and N-methyltyramine), carotid arterial blood pressure (BP), left ventricular pressure (LVP), left ventricular end diastolic pressure (LVEDP), the first derivative of the left ventricular pressure (dp/dt), central venous pressure (CVP), EGG, heart rate (HR), and cardiac output (CO) were monitored in 6 anethetized open chest dogs. The tracings were recorded on RM-86 Polygraph. EGG, LVP, LVEDP and dp/dt signals were recorded simultaneously on Data Recorder and were reproduced in speed of 100 mm per sec. after experiment, so as to measure the numeral value of LVEDP, t-dp/dt, tension time index of ventricular ejection (TTI) and common peak isovolumetric pressure (CPIP). Cardiac index (CI), stroke index (SI), left ventricular work index (LVWI), peripheral vascular resistance (PVR), and dp/dt/CPIP (VcEat CPIP)were calculated. Citus auruntium extract (0.5g/kg), synephrine (1 mg/kg), N-methyltyramine (0.25 mg/kg) with the well-known cardiac stimulants dopamine (DA), dobutamine (DB) as positive control were injected in sequence of Latinsquare design.All drugs markedly increased the cardiac function indices in similar patterns including increase of dp/dt max, V_(CE) at CPIP and CI; shortening of t-dp/dt max. and lowering of LVEDP. Since V_(CE) at CPIP is independent of variations of ventricular afterload initiated by these drugs, it was concluded that similar to DA and DB, crude extract of Citrus aurantiurn and its active principlcs do possess inotropic action by increasing myocardial contractility. It is their pump-stimulant action and elevation of PVR that offer the pharmacological basis to their anti shock effect. As to the relative efficiency on PVR, N-methyltyramine was weaker than crude extract of Citrus aurantiurn and synephrine. As to the heart rate stimulant action, the reverse was true.At the equivalent dosage to CI increment, crude extract of Citus aurantiurn synephrine, N-methyltyramine and hypertensive dose of DA augmented the LVWI and TTI×HR (as energy and oxygen consumption index) far beyond the ratio of CI increment. This difference could attribute to the increase of ventricular afterload as a result of vasoconstriction.DB and DA in small doses lowered arterial blood pressure and PVR. Consequently the LVWI and TTI×HR were not significantly altered.

麻醉犬实验表明枳实及其有效成分辛弗林和N-甲基酪胺与多巴胺、多巴酚丁胺相似,能显著增强多种心肌收缩性和泵血功能的指标:增大左室压变化速率峰值和在共同最高等容收缩压(CPIP)时的心肌收缩成分的缩短速率(V_(CE)),增加心脏指数(GI),缩短左室从开始收缩到开始射血的时间,降低左室舒张末压。由于在CPIP时的V_(CE)不受心室后负荷(动脉压)的影响,故可以排除上述指标的增强是由于药物对血压的影响。由于枳实及其有效成分的强心、增加心输出量和收缩血管提高总外周阻力,导致左室压力和动脉血压上升,这是它们抗休克的药理学基础。N-甲基酪胺升高外周阻力的作用比枳实和辛弗林稍弱,但加快心率的作用则较强。这两种成分在作用上是各有特点的。在增加心搏指数等效剂量下,枳实、辛弗林、N-甲基酪胺与大剂量多巴胺增加左室作功指数和射血的张力-时间指数的比值远超过增加心搏指数的百分率,这可能是升压增加左室后负荷造成的。多巴酚丁胺和小剂量多巴胺不同于枳实及其有效成分在于能降低外周血管阻力,降低动脉血压,而不明显增加左室作功指数和射血的张力-时间指数,提示不象枳实那样增加心肌的能...

麻醉犬实验表明枳实及其有效成分辛弗林和N-甲基酪胺与多巴胺、多巴酚丁胺相似,能显著增强多种心肌收缩性和泵血功能的指标:增大左室压变化速率峰值和在共同最高等容收缩压(CPIP)时的心肌收缩成分的缩短速率(V_(CE)),增加心脏指数(GI),缩短左室从开始收缩到开始射血的时间,降低左室舒张末压。由于在CPIP时的V_(CE)不受心室后负荷(动脉压)的影响,故可以排除上述指标的增强是由于药物对血压的影响。由于枳实及其有效成分的强心、增加心输出量和收缩血管提高总外周阻力,导致左室压力和动脉血压上升,这是它们抗休克的药理学基础。N-甲基酪胺升高外周阻力的作用比枳实和辛弗林稍弱,但加快心率的作用则较强。这两种成分在作用上是各有特点的。在增加心搏指数等效剂量下,枳实、辛弗林、N-甲基酪胺与大剂量多巴胺增加左室作功指数和射血的张力-时间指数的比值远超过增加心搏指数的百分率,这可能是升压增加左室后负荷造成的。多巴酚丁胺和小剂量多巴胺不同于枳实及其有效成分在于能降低外周血管阻力,降低动脉血压,而不明显增加左室作功指数和射血的张力-时间指数,提示不象枳实那样增加心肌的能量消耗。

Using self-designed counterpulsator,24 paired experiments were performed in 9mongrel dogs.The aortic and left atrial pressures were monitored,and coronary sinuswas cannulated via right atrium for measuring blood flow and for blood sampling.Each paired experiment included 30 min normal heart beating which served as con-trol and 30 min of counterpulsation.After counterpulsation,the average decrease oftension time index was 1044.30±221.47 mmHg.sec/min,and the average increase ofdiastolic pressure time index(DPTI)was...

Using self-designed counterpulsator,24 paired experiments were performed in 9mongrel dogs.The aortic and left atrial pressures were monitored,and coronary sinuswas cannulated via right atrium for measuring blood flow and for blood sampling.Each paired experiment included 30 min normal heart beating which served as con-trol and 30 min of counterpulsation.After counterpulsation,the average decrease oftension time index was 1044.30±221.47 mmHg.sec/min,and the average increase ofdiastolic pressure time index(DPTI)was 660.56±158.31 mmHg.sec/min.The incrementof endocardial viability ratio was 0.94±0.12.The coronary sinus blood flow wasincreased from 20.38±1.77 to 24.50±1.70 ml/min/100g and myocardial oxygen con-sumption increased from 2.41±0.28 to 2.98±0.32 ml/min/100g.The mean incrementof myocardial lactate extraction was 0.58±0.27 mg/min/100g.The coefficient of cor-relation(r)between DPTI and coronary sinus flow was 0.41.All these were statisticallysignificant.The data suggested that arterial counterpulsation could increase coronaryblood flow,activate heart function depressed by surgical stress and prevent subendoeardialischemia

本文报道用助搏反搏器对9只狗作动脉反搏,观察全麻下正常动物心脏在反搏前后的血液动力学与代谢变化。在反搏后,张力时间指数下降,舒张压时间指数增加,心内膜活力比率增加,冠状窦流量增加,心肌耗氧量增加,经统计均有显著意义,心肌乳酸摄取量亦有增加。实验结果提示反搏可使正常心脏冠状血流量增加,心肌细胞摄取更多的氧和乳酸,使受抑制的心肌细胞功能恢复;有利于防止手术时心内膜下缺血等并发症。

 
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