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肺癌癌组织
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  lung cancer biopsy
     Alteration and clinical value of microsatellite DNA in lung cancer biopsy specimens
     肺癌癌组织标本中微卫星DNA检测及临床意义
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  “肺癌癌组织”译为未确定词的双语例句
     Results Among 75 cases, the positive rates of VEGF-C and Flt4 of cancer cells were 77.3% and 46.7% respectively.
     结果 75例非小细胞肺癌癌组织中VEGF C阳性率为77 3 % (5 8 75 ) ,Flt4阳性率为46 7% (3 5 75 ) ;
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     Methods The mRNA expression of RASSF1A, RASSF1B and RASSF1C was detected by RT PCR in 51 human lung cancer tissues and 51 matched normal tissues.
     方法采用RT PCR方法检测 5 1例肺癌癌组织及相应癌旁正常组织中RASSF1A、RASSF1B及RASSF1CmRNA的表达情况。
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     Results:Negative p-Akt expression and positive PTEN expression were found in normal lung tissues, while the positive incidences of p-Akt expresssion and loss of incidences of PTEN expresssion in NSCLC were 41.2% (42/102) and 46.1% (47/102)respectivtly.
     结果:正常肺组织p-Akt为阴性表达,而PTEN为阳性表达; 非小细胞肺癌癌组织中p-Akt表达的阳性率为41.2%(42/102),PTEN失表达率为46.1%(47/102)。
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     Objective To explore the relationship of the p73 gene transcript expression and the apoptosis level in cancerous tissues with the incidence and development of human non small cell lung cancer(NSCLC).
     目的 通过观察肺癌癌组织、对应癌旁组织和远癌肺组织中细胞凋亡及p73基因转录表达水平的变化 ,探讨细胞凋亡及p73基因转录表达水平与肺癌发生、发展的关系。
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     Results ΔNp73 mRNA was highly expressed in lung cancer tissues (62.7%, 32/51) while negative in neighboring noncancerous tissue.
     结果51例非小细胞肺癌癌组织中有32例(62.7%)呈ΔNp73mRNA高表达,而在癌旁肺组织中低表达。
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  相似匹配句对
     Carcinoma of the lung and multiple primary malignant tumors
     与多原发
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     Paraneoplastic syndromes related to lung cancer: an analysis of 104 cases
     综合征104例
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     Pancreatic Cancer
     胰
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     Temporal bone carcinoma
     颞骨
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     HISTOPATHOLOGICAL STUDY OF THE BRONCHIAL EPITHELIA ADJACENT TO PRIMARY LUNG CANCER
     原发性旁支气管上皮的病理组织学研究
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  lung cancer biopsy
We plan to examine metaplastic, dysplastic, and neoplastic cells in lung cancer biopsy specimens.
      


Object To study the pathogenesis of Bronchogenic carcinoma and to learn the relationship Between sex hormones and their receptors, Methods Examining estradiol receptor and progesterone reCeptor in the tissues of 53 patients by using enzyme Linked affinity histochemical method, and examing estradiol level (SEL) and progesterone level (SPL)in the blood of the same person by using double andtibody radioimmune method .Results The postiive rates of ER and PR were 49.1% and 54.7% respectively . SEL and SPL rose notably...

Object To study the pathogenesis of Bronchogenic carcinoma and to learn the relationship Between sex hormones and their receptors, Methods Examining estradiol receptor and progesterone reCeptor in the tissues of 53 patients by using enzyme Linked affinity histochemical method, and examing estradiol level (SEL) and progesterone level (SPL)in the blood of the same person by using double andtibody radioimmune method .Results The postiive rates of ER and PR were 49.1% and 54.7% respectively . SEL and SPL rose notably (P<0.05).whether the results of ER and PR were positive of negative, SEL rose obviously than that of control Group (P<0.05). The SEL and SPL of ER(+) Group ,PR(+)group . ER(+)and PR(+)group were lower than those of ER(-)group, PR(-) group ER(-) and PR(-)group. Conclusions Patients with ER(+)and PR(+) are more influenced by sex hormones.

为研究肺癌的发病机制,探讨其性激素及其受体之间的关系,运用酶联亲合组化法对53例肺癌癌组织中雌激素受体(ER)和孕激素受体(PR)进行了检测,同时采用R抗体放射免疫分析法测定了患者外周血中的雌二醇(SEL)和孕酮水平(SPL)。结果显示ER阳性率49.1%,PR阳性率54.7%。SEL、SPL均有明显的升高(P<0.05),无论ER(+)组还是ER(-)组,SEL均有显著的升高(P<0.05);ER(+)组、PR(+)组、ER(+)和PR(+)组的SEL、SPL较ER(-)组、PR(-)组、ER(-)和PR(-)组的相对低。提示受体阳性者更多地受到性激素的影响。

Objective To explore the relationship between the Bcl 2 gene transcript expression and the oncogenesis, and development of lung cancer.Methods The expression of Bcl 2 mRNA was detected in 31 human lung cancer tissues, para cancer tissues, non cancer tissues and 13 benign lesion tissues by Northern blot.Results (1)The expression level of the Bcl 2 mRNA in the cancer tissues was significantly higher than that in the non cancer tissues and benign lesion tissues(P<0.01), but there was no significant difference...

Objective To explore the relationship between the Bcl 2 gene transcript expression and the oncogenesis, and development of lung cancer.Methods The expression of Bcl 2 mRNA was detected in 31 human lung cancer tissues, para cancer tissues, non cancer tissues and 13 benign lesion tissues by Northern blot.Results (1)The expression level of the Bcl 2 mRNA in the cancer tissues was significantly higher than that in the non cancer tissues and benign lesion tissues(P<0.01), but there was no significant difference among the cancer and para cancer tissues,non cancer and benign lesion tissues, para cancer,non cancer and benign lesion tissues either(P>0.05).(2)The Bcl 2 expression in poor differentiated lung cancers was significantly higher than that in moderate well differentiated lung cancers.(3)No significant difference was observed in Bcl 2 expression in different histoclassification of the cancer and P TNM stages of the cancer.Conclusion There is an overexpression of Bcl 2 mRNA in lung cancer tissues, and it may be involved in the oncogenesis and development of lung cancer.

目的 探讨Bcl 2基因转录表达与肺癌发生、发展的关系。方法 采用Northern印迹杂交方法检测 3 1例肺癌癌组织、癌旁组织、远癌肺组织和 13例肺良性病变组织Bcl 2mRNA表达水平。结果  ( 1)肺癌组织中Bcl 2mRNA表达水平 ( 179.91± 2 5 .0 2 )明显高于远癌肺组织 ( 13 3 .70± 2 0 .45 )和肺良性病变组织 ( 13 2 .5 3± 13 .85 ) (P <0 .0 1) ;( 2 )低分化肺癌组织 ( 193 .0 7± 2 7.98)中Bcl 2表达强度明显高于中~高分化肺癌 ( 113 .46± 2 1.2 0 ) (P <0 .0 5 ) ;( 3 )Bcl 2mRNA表达水平与肺癌组织学类型、P TNM分期无明显关系 (P >0 .0 5 )。结论 肺癌组织中存在Bcl 2基因的过度转录表达 ,它可能参与调控肺癌的发生、发展过程

Objective To investigate the significance of p53 gene mutations in non small cell lung cancer, with focusing on the four highly conserved regions of the p53 gene. Methods Point mutations of the p53 gene were detected in 40 lung cancer tissues and 8 benign pulmonary lesions as control by polymerase chain reaction single strand conformation polymorphism (PCR SSCP) analysis. Results Mutations of the p53 gene were found in 19 of 40 lung cancer samples ( 47.5%) . The frequency of the p53 gene mutations...

Objective To investigate the significance of p53 gene mutations in non small cell lung cancer, with focusing on the four highly conserved regions of the p53 gene. Methods Point mutations of the p53 gene were detected in 40 lung cancer tissues and 8 benign pulmonary lesions as control by polymerase chain reaction single strand conformation polymorphism (PCR SSCP) analysis. Results Mutations of the p53 gene were found in 19 of 40 lung cancer samples ( 47.5%) . The frequency of the p53 gene mutations varied among the different stage (stage Ⅰ+Ⅱ vs stage Ⅲ+Ⅳ was 22.2% vs 68.2%,P<0.005), and lymph node netastasis status (N1 2 vs N0 was 57.1% vs 16.7%, P<0.025) of non small cell lung cancers. Conclusion The results suggest that p53 gene mutations may be associated with the carcinogenesis and progression of non small cell lung cancer.

目的 探讨p5 3基因点突变与人非小细胞肺癌临床病理生理特征的联系。方法 应用聚合酶反应 -单链构象多态性分析方法 (PCR SSCP)检测原发性非小细胞肺癌癌组织的p5 3基因第 5~ 8外显子点突变。结果  40例肺癌组织中 19例 ( 4 7.5 % )有点突变发生 ,8例良性肿瘤组织均无p5 3基因点突变发生。点突变发生与病理分期和淋巴结转移有明显关系 (P <0 .0 2 5 )。结论 p5 3基因点突变在非小细胞肺癌的发生和进展中可能起重要作用。

 
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