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临床病理生理学
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  clinical pathophysiology
     Comparison of pre-headache phases and trigger factors of migraine and episodic tension-type headache: Do they share similar clinical pathophysiology?
     对比偏头痛和发作性紧张型头痛的头痛前期症状和触发因素:二者是否具有相似的临床病理生理学机制
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     Objective To study the clinical pathophysiology on myelodysplasia.
     目的研究脊髓发育不良脊髓神经损害的临床病理生理学特点。
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  “临床病理生理学”译为未确定词的双语例句
     Objective:To study the effect of tetramethylpyrazine (TMP) on the vascular endothelial cell (VEC) related humoral factors, including endothelin (ET), factor Ⅷ related antigen (i.e.von Willebrand factor, vWF) and thromboxane A 2 (TXA 2) in patients of congenital heart disease with pulmonary hypertension (CHD-PH) during cardiopulmonary bypass (CPB), and explore the clinical physiopathologic significance of them.
     目的 :观察川芎嗪 (tetramethylpyrazine,TMP)对先天性心脏病 (先心病 )伴肺动脉高压体外循环(CPB)下血管内皮细胞 (vascularendothelialcell,VEC)相关的体液因子内皮素 (endothelin ,ET)、因子Ⅷ相关抗原 (vonWillebrandfactor ,vWF)、血栓素A2 (TXA2 )的影响并探讨这些改变的临床病理生理学意义。
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     Conclusion The expression of CD44V6 and p53 is correlated with progression and metastasis of colorectal carcinoma, so CD44V6 and p53 may be used as a hopeful marker for predicting the metastastic potential of colorectal carcinoma and the prognosis of these patients.
     结论  CD44 V6的表达与大肠癌的临床病理生理学行为密切相关 ,而 p5 3与大肠癌浸润深度关系密切。 因此 CD44 V6和 p5 3蛋白可为一个准确预测大肠癌预后的生物学指标。
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     The clinical follow-up was performed.
     临床随访。
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     The clinical follow up was performed.
     临床随访。
短句来源
     Objective To study the clinical pathophysiology on myelodysplasia.
     目的研究脊髓发育不良脊髓神经损害的临床病理生理学特点。
短句来源
     Preliminary Study on Pathophysiology of Liver-Qi Deficiency Syndrome
     肝气虚证临床证型的病理生理学初步研究
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  clinical pathophysiology
Symptomatology and clinical pathophysiology of myofascial pain
      
Arginine as a regulator of the immune response II Clinical Pathophysiology 30.
      
In this review, we attempt to correlate the clinical pathophysiology with the primary defect and secondary changes in cellular electrolyte transport.
      


Objective To study the relation between the expression of CD44V6, p53 and PCNA and the prognosis of colorectal carcinoma. Methods Immnohistochemical method was used to detect the expression or CD44V6, p53 and PCNA in 51 patients with colorectal cacinoma.Results The positive rate of CD44V6 was 41.18%(21/51). It was 53.85%(7/13) in low differentiated colorectal carcinoma,markedly higher than that in highly differemtiated carcinoma (36.84%,7/19)( P <0 05) The expression rate outside of serosa was 53.34%(8/15),...

Objective To study the relation between the expression of CD44V6, p53 and PCNA and the prognosis of colorectal carcinoma. Methods Immnohistochemical method was used to detect the expression or CD44V6, p53 and PCNA in 51 patients with colorectal cacinoma.Results The positive rate of CD44V6 was 41.18%(21/51). It was 53.85%(7/13) in low differentiated colorectal carcinoma,markedly higher than that in highly differemtiated carcinoma (36.84%,7/19)( P <0 05) The expression rate outside of serosa was 53.34%(8/15), markedly higher than that in muscular layer (33.33%,2/6)( P <0 05)Also, it was much higher in carcinoma with lymph node metastasis (63.16%, 12/19) than that in carcinoma without lymph node metastasis (31.25 %,10/32)( P <0 05).The positive rate of p53 was (50.59% 26/51) and was only related with the depth of infiltration of carcinoma. The expression of p53 in the outer layer of serosa was (53.33%, 8/15),apparently higher than that in muscular layer (33.33%,2/6)( P <0 05),while the expression of PCNA was not related to pathological grade, depth of infiltration and lymph node metastasis ( P <0 05).Conclusion The expression of CD44V6 and p53 is correlated with progression and metastasis of colorectal carcinoma, so CD44V6 and p53 may be used as a hopeful marker for predicting the metastastic potential of colorectal carcinoma and the prognosis of these patients.

目的 探讨 CD44 V6、p5 3、PCNA在大肠癌中的表达与病理及生理学行为之间的关系。方法 采用免疫组化S- P法检测 CD44 V6、p5 3、PCNA在 5 1例大肠癌中的表达。结果  5 1例大肠癌 CD44 V6阳性表达率 41.18% (2 1/ 5 1)。CD44 V6在低分化大肠癌的检出率为 5 3.85 % (7/ 13)明显高于高分化大肠癌 36 .84% (7/ 19) (P<0 .0 5 ) ,在浆膜外的阳性表达率 5 3.38% (8/ 15 )明显高于肌层 33.33% (2 / 6 ) (P<0 .0 5 ) ,有淋巴结转移者阳性表达率为 6 3.16 % (12 / 19)明显高于无淋巴结转移者 31.2 5 % (10 / 32 ) (P<0 .0 5 )。p5 3在 5 1例大肠癌中阳性检出率为 5 0 .5 9% (2 6 / 5 1) ,其表达与大肠癌的组织类型、分化程度和淋巴结转移未见明显相关。而与浸润深度呈正相关 ,p5 3在浆膜外层的阳性表达率为5 3.33% (8/ 15 )明显高于肌层 33.33% (2 / 6 ) (P<0 .0 5 )。 PC-NA的...

目的 探讨 CD44 V6、p5 3、PCNA在大肠癌中的表达与病理及生理学行为之间的关系。方法 采用免疫组化S- P法检测 CD44 V6、p5 3、PCNA在 5 1例大肠癌中的表达。结果  5 1例大肠癌 CD44 V6阳性表达率 41.18% (2 1/ 5 1)。CD44 V6在低分化大肠癌的检出率为 5 3.85 % (7/ 13)明显高于高分化大肠癌 36 .84% (7/ 19) (P<0 .0 5 ) ,在浆膜外的阳性表达率 5 3.38% (8/ 15 )明显高于肌层 33.33% (2 / 6 ) (P<0 .0 5 ) ,有淋巴结转移者阳性表达率为 6 3.16 % (12 / 19)明显高于无淋巴结转移者 31.2 5 % (10 / 32 ) (P<0 .0 5 )。p5 3在 5 1例大肠癌中阳性检出率为 5 0 .5 9% (2 6 / 5 1) ,其表达与大肠癌的组织类型、分化程度和淋巴结转移未见明显相关。而与浸润深度呈正相关 ,p5 3在浆膜外层的阳性表达率为5 3.33% (8/ 15 )明显高于肌层 33.33% (2 / 6 ) (P<0 .0 5 )。 PC-NA的表达与病理分级、浸润深度和淋巴结转移未见显著相关性 (P>0 .0 5 )。结论  CD44 V6的表达与大肠癌的临床病理生理学行为密切相关 ,而 p5 3与大肠癌浸润深度关系密切。因此 CD44 V6和 p5 3蛋白可为一个准确预测大肠癌预后的生物学指标。而 PCNA作为大肠癌预后的标记物不够理想

Objective:To study the effect of tetramethylpyrazine (TMP) on the vascular endothelial cell (VEC) related humoral factors, including endothelin (ET), factor Ⅷ related antigen (i.e.von Willebrand factor, vWF) and thromboxane A 2 (TXA 2) in patients of congenital heart disease with pulmonary hypertension (CHD-PH) during cardiopulmonary bypass (CPB), and explore the clinical physiopathologic significance of them. Methods:Thirty non-cyanotic patients of CHD-PH were randomly divided into the control group and the...

Objective:To study the effect of tetramethylpyrazine (TMP) on the vascular endothelial cell (VEC) related humoral factors, including endothelin (ET), factor Ⅷ related antigen (i.e.von Willebrand factor, vWF) and thromboxane A 2 (TXA 2) in patients of congenital heart disease with pulmonary hypertension (CHD-PH) during cardiopulmonary bypass (CPB), and explore the clinical physiopathologic significance of them. Methods:Thirty non-cyanotic patients of CHD-PH were randomly divided into the control group and the treated group. TMP was given to the treated group by intravenous dripping 3 mg/kg after anesthesia induction and adding 1 mg/kg in oxygenator during CPB. Blood samples were collected from radial artery at the time points of after anesthesia induction, 15 min after beginning CPB, 5 min after opening aorta, 20 min, 6 hrs and 24 hrs after stopping CPB, to determine the plasma contents of ET and vWF, as well as TXB 2, the stable metabolite of TXA 2. The pulmonary vascular reactivity 6 hrs (6h-PVR) after CPB and the mechanical ventilatory support time (VST) after operation were calculated. Results:Levels of ET, vWF and TXB 2 increased obviously during CPB, but the degree of increasing in the treated group was lower than that in the control group (P<0.05), and the 6h-PVR and VST in the former were also lower than those in the latter respectively. Conclusion:TMP could obviously reduce the production of ET, vWF and TXB 2 during CPB and relieve the pulmonary vascular reactivity after operation, indicating that TMP could reduce the injury of CPB on VEC, and is benefit to enhance the efficacy of treatment.

目的 :观察川芎嗪 (tetramethylpyrazine,TMP)对先天性心脏病 (先心病 )伴肺动脉高压体外循环(CPB)下血管内皮细胞 (vascularendothelialcell,VEC)相关的体液因子内皮素 (endothelin ,ET)、因子Ⅷ相关抗原 (vonWillebrandfactor ,vWF)、血栓素A2 (TXA2 )的影响并探讨这些改变的临床病理生理学意义。方法 :将 30例非紫绀型先心病肺动脉高压患者随机分为对照组和用药组 ,用药组于麻醉诱导后静脉滴注TMP3mg/kg体重 ,转流后于氧合器中追加 1mg/kg体重。于麻醉诱导后、转流 15min、升主动脉开放 5min、停体外循环机后 2 0min、6h及 2 4h从桡动脉穿刺管中采血 ,测定血浆中ET、vWF及TXA2 的稳定代谢产物TXB2的含量 ,计算停机后 6h的肺血管反应性、机械辅助呼吸时间。结果 :体外循环下ET、vWF和TXB2 均明显上升 ,但用药组上升幅度明显小于对照组 (P <0 0 5 ) ,且停机后 6h的肺血管反应性、机械辅助呼吸时间也短于对照组。结论 :TMP能显著减少先心病肺动...

目的 :观察川芎嗪 (tetramethylpyrazine,TMP)对先天性心脏病 (先心病 )伴肺动脉高压体外循环(CPB)下血管内皮细胞 (vascularendothelialcell,VEC)相关的体液因子内皮素 (endothelin ,ET)、因子Ⅷ相关抗原 (vonWillebrandfactor ,vWF)、血栓素A2 (TXA2 )的影响并探讨这些改变的临床病理生理学意义。方法 :将 30例非紫绀型先心病肺动脉高压患者随机分为对照组和用药组 ,用药组于麻醉诱导后静脉滴注TMP3mg/kg体重 ,转流后于氧合器中追加 1mg/kg体重。于麻醉诱导后、转流 15min、升主动脉开放 5min、停体外循环机后 2 0min、6h及 2 4h从桡动脉穿刺管中采血 ,测定血浆中ET、vWF及TXA2 的稳定代谢产物TXB2的含量 ,计算停机后 6h的肺血管反应性、机械辅助呼吸时间。结果 :体外循环下ET、vWF和TXB2 均明显上升 ,但用药组上升幅度明显小于对照组 (P <0 0 5 ) ,且停机后 6h的肺血管反应性、机械辅助呼吸时间也短于对照组。结论 :TMP能显著减少先心病肺动脉高压体外循环 (CPB)下ET、vWF和TXB2 的产生和减轻术后肺血管反应性的上升幅度。说明TMP能减轻CPB对VEC的损伤作用 ,有利于提高术后疗效。

Objective To study the clinical pathophysiology on myelodysplasia.Methods One hundred and twelve patients with myelodysplasia were evaluated and diagnosed depending on the disease history,physical examination,MRI,EMG,urodynamics,and then underwent surgical correction.The patients were divided into 6 types depending on the intraspinal anomalies and the morphological changes of spinal cords: tethered spinal cords(including 2 subtypes: A with pathogenesis of terminal filum,B with fibrous adhesions),lipoma on spinal...

Objective To study the clinical pathophysiology on myelodysplasia.Methods One hundred and twelve patients with myelodysplasia were evaluated and diagnosed depending on the disease history,physical examination,MRI,EMG,urodynamics,and then underwent surgical correction.The patients were divided into 6 types depending on the intraspinal anomalies and the morphological changes of spinal cords: tethered spinal cords(including 2 subtypes: A with pathogenesis of terminal filum,B with fibrous adhesions),lipoma on spinal cord,intraspinal cyst,diastematomyelia and absences of sacral segments of spinal cords and /or their nerve roots.The lesion of myelodysplasia was classified into 5 stages according to the different degrees of impairment.The relationship between the patients' age at the onset symptom and morphological types or clinical stages was analyzed.Results There was a significant relationship between the lesion of spinal cord and the patient's age.The closely correlation between the levels of conus medullaris and the age at onset was also noted.Conclusions Myelodysplasia is a process of progressive neurological deterioration which results from intraspinal anomalies.It is necessary to manage it as soon as possible to avoid further impairment.

目的研究脊髓发育不良脊髓神经损害的临床病理生理学特点。方法本组共112例患儿,111例施行椎管内手术;单纯末段脊髓缺失1例,未手术。有脊膜修补史46例。依据112例患儿病史、体检以及MRI、尿流和肛肠动力学检查结果及肌电图(EMG)评价并行脊髓手术治疗。术中观察脊髓形态学改变并按照椎管内病变及其脊髓病理解剖改变将其分为终丝栓系(又分为A、B两亚型)、脊髓粘连、脊髓脂肪瘤、囊性占位、脊髓纵裂、静态病变等6型。依据综合评价结果将脊髓损害的病程分为5期,每期给予相应评分并做统计学分析。结果7组脊髓神经损害综合评分的方差分析和临床分期的秩和检验差异都有非常显著性意义(P<0.001或0.05)。直线相关与回归分析表明患儿年龄与脊髓神经损害间(r=0.55,P<0.001)和栓系组圆锥末端位置与首发症状年龄之间(r=0.44,P<0.001)都有显著正相关关系。结论脊髓神经损害是一个由椎管内病变及其脊髓形态学改变引起并进行性加重的动态病理过程。诊治方针应是早期诊断和施行椎管内手术治疗以改善预后,临床分期和病理学分型具有一定临床价值。

 
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