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阿尔茨海默病动物模型
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  animal model of alzheimer ' s disease
     Establishment of an animal model of Alzheimer's disease and therapeutic effects of neural stem cells on Alzheimer's disease
     阿尔茨海默病动物模型的建立及神经干细胞对阿尔茨海默病的治疗作用
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  “阿尔茨海默病动物模型”译为未确定词的双语例句
     The experimental study on an animal model of Alzheimer′s disease by intraventricular injection of the immunotoxin 192-IgG-saporin
     免疫毒素192-IgG-saporin侧脑室注射建立阿尔茨海默病动物模型的实验研究
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     Effects of Bradykinin on β-amyloid Protein Induced Alzheimer's Disease Animal Model
     缓激肽对β-淀粉样蛋白所致阿尔茨海默病动物模型的影响
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     Study on Establishment of Alzheimer′s Disease Animal Model and Intervening Effect of Zhinao Capsule on It
     阿尔茨海默病动物模型的建立及智脑胶囊干预作用的研究
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     Establishment of novel animal model with Alzheimer′s disease
     一种新型阿尔茨海默病动物模型的建立
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     A Study of Animal Model with Alzheimer's Disease
     阿尔茨海默病动物模型制备方法的研究
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  相似匹配句对
     A Study of Animal Model with Alzheimer's Disease
     阿尔茨海默动物模型制备方法的研究
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     Establishment of novel animal model with Alzheimer′s disease
     一种新型阿尔茨海默动物模型的建立
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     Establishment of the Transgenic Model of Alzheimer's Disease and the Study of Pathogenesis
     阿尔茨海默转基因动物模型的建立与发机理研究
短句来源
     Effects of Bradykinin on β-amyloid Protein Induced Alzheimer's Disease Animal Model
     缓激肽对β-淀粉样蛋白所致阿尔茨海默动物模型的影响
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     Injection of bradykinin to hippocampus induces Alzheimer-like phosphorylation of tau and abnormal behavior in rat
     海马注射缓激肽复制阿尔茨海默神经原纤维变性动物模型
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  animal model of alzheimer ' s disease
These studies, which provide in vitro support for the hypothesis, are being pursued in an animal model of Alzheimer's disease.
      
We have switched to mice so that we can prepare to perform our experiments in a transgenic animal model of Alzheimer's disease.
      
A small number of neuroprotective compounds appear to have potential to enter the brain and thus might be tested to see if they slow progression of neurodegeneration in an appropriate animal model of Alzheimer's disease.
      
Enhanced behavioral response to nicotine in an animal model of Alzheimer's disease
      
Memory loss by glutamate antagonists: An animal model of Alzheimer's disease
      
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AIM To explore the possibility that the combined use of D galactose and AlCl 3 may make an animal model for study on Alzheimer′s disease. METHODS Kunming strain mice were given D galactose 60 mg·kg -1 ·d -1 , ip, and AlCl 3 5 mg·kg -1 ·d -1 , ig, once daily for 90 d. Morris water maze was used to test learning and memory, biochemical methods to assay acetylcholine (ACh) and acetylcholinesterase (AChE) contents in whole brain, RT PCR to determine the expression of amyloid β protein...

AIM To explore the possibility that the combined use of D galactose and AlCl 3 may make an animal model for study on Alzheimer′s disease. METHODS Kunming strain mice were given D galactose 60 mg·kg -1 ·d -1 , ip, and AlCl 3 5 mg·kg -1 ·d -1 , ig, once daily for 90 d. Morris water maze was used to test learning and memory, biochemical methods to assay acetylcholine (ACh) and acetylcholinesterase (AChE) contents in whole brain, RT PCR to determine the expression of amyloid β protein precursor (APP), presenilin 1 (PS1) and β site APP cleaving enzyme (BACE) genes, and conventional HE and Aβ 1-40 immunohistochemical staining to observe morphological changes in hippocampus and cortex. RESULTS The combined use of D galactose and AlCl 3 induced some alterations in mice, such as learning and memory impairment, ACh content decline, AChE activity reinforcement, and the expression increase in APP, PS1 and BACE genes and formation of senile plaque in hippocampus and cortex, which emerged Alzheimer like pathological changes. CONCLUSION The combined use of D galactose and AlCl 3 may well make an animal model whose pathological changes are very similar to those of Alzheimer′s disease.

目的 探讨D 半乳糖和三氯化铝 (AlCl3 )联合使用制备阿尔茨海默病动物模型的可能性。方法昆明种小鼠 ,腹腔注射D 半乳糖 (60mg·kg-1 ·d-1 )和灌胃AlCl3 (5mg·kg-1 ·d-1 )每天 1次 ,连续 90d。给药结束后 ,通过Morris水迷宫、生化指标测定、RT PCR及常规HE染色和Aβ1 -4 0 免疫组化染色 ,观察D 半乳糖和AlCl3 对小鼠学习记忆、胆碱能系统及脑内β淀粉样前体蛋白 (APP)、早老素 1 (PS1 )、β位点APP内切酶 (BACE)基因表达的影响 ,并观察海马、皮质的形态学改变。结果 D 半乳糖和AlCl3共同作用导致小鼠学习记忆力减退 ;脑内ACh含量下降 ,AChE活性升高 ;APP ,PS1和BACE基因表达增强 ;海马和皮质老年斑形成。结论 D 半乳糖和AlCl3 联合使用可使小鼠产生类阿尔茨海默病变 ,该方法可用于制备阿尔茨海默病动物模型

Having the combined advantages of noninvasiveness, versatility and wide-availability, magnetic resonance imaging (MRI) and in vivo magnetic resonance spectroscopy (MRS) nowadays are widely used in clinical diagnosis and experimental investigations of Alzheimer disease. This paper reviews some recent technological developments of magnetic resonance and their applications in studying Alzheimer disease.

痴呆是当前世界上的流行病之一 ,阿尔茨海默病是最常见的痴呆类型 ,其诊断和治疗目前都还非常困难。磁共振成像 (MRI)和活体磁共振波谱 (MRS)技术相对于其他诊断和研究手段而言 ,具有其特有的无损伤性和多功能性。随着近年来磁共振成像仪在全世界范围内的广泛普及 ,磁共振技术在阿尔茨海默病的临床诊断和实验研究中应用发展迅速并日趋广泛。本文综述了磁共振成像和活体磁共振波谱技术近几年来的最新进展及其在阿尔茨海默病研究中的应用 ,还简述了磁共振在阿尔茨海默病动物模型中的研究。

AIM: To observe the interventional effect of estrogen on the expressions of nicotinic acetylcholine receptor at different sites of brain in rats with Alzheimer disease. METHODS: The experements were completed in the Institute of Brain, Medical College of Qingdao University in November 2003. Ten healthy female Wistar rats were randomly divided into fimbria-fornix transection+ovariectomy group (n=5) and estrogen treatment group (n=5). Fimbria-fornixs of brain were transected and bilateral ovaries were cut off...

AIM: To observe the interventional effect of estrogen on the expressions of nicotinic acetylcholine receptor at different sites of brain in rats with Alzheimer disease. METHODS: The experements were completed in the Institute of Brain, Medical College of Qingdao University in November 2003. Ten healthy female Wistar rats were randomly divided into fimbria-fornix transection+ovariectomy group (n=5) and estrogen treatment group (n=5). Fimbria-fornixs of brain were transected and bilateral ovaries were cut off to establish models of Alzheimer disease accompanied by decreased level of estrogen in vivo. From the 3rd day, the rats in the estrogen treatment group were treated with subcutaneous injection (1 mg/kg), and then once every 7 days. The expressions of the positive cells of nicotinic acetylcholine receptor in the hippocampal CA1, cortex, amygdale and basal forebrain Meynert nucleus of rat models of Alzheimer disease were observed with the technique of immunohistochemistry. RESULTS: Ten rats were involved in the analysis of results after completion.The numbers of positive cells of nicotinic acetylcholine receptor in the hippocampal CA1, cortex, amygdale and basal forebrain Meynert nucleus were all higher in the estrogen treatment group than in the fimbria-fornix transection+ovariectomy group [(30.20±8.65), (64.40±3.52) cells per visual sight; (41.95±9.63), (96.81±9.13) cells per visual sight; (38.18±9.19), (84.50±5.48) cells per visual sight; (18.18±1.65), (89.33±10.24) cells per visual sight; P < 0.01].CONCLUSION: After supplement of ectogenous estrogen, the expressions of nicotinic acetylcholine receptor in the brain areas of rats with Alzheimer disease were significantly increased, and then the function of cholinergic neuron was enhanced.

目的:观察雌激素对阿尔茨海默病大鼠脑内不同部位烟碱型乙酰胆碱受体表达的干预作用。方法:实验于2003-11在青岛大学医学院脑病研究所进行。取健康雌性Wistar大鼠10只,随机分为穹隆-海马伞切断+卵巢切除组和雌激素组,每组5只大鼠。所有大鼠在脑立体定位仪上切断穹隆-海马伞,并切除双侧卵巢,建立模拟伴有体内雌激素水平下降的阿尔茨海默病动物模型。雌激素组大鼠术后第3天皮下注射雌二醇1mg/kg,以后每7d给药1次,30d后应用免疫组织化学技术观察两组阿尔茨海默病大鼠海马CA1区、皮质区、杏仁复合体区和基底前脑Meynert核等部位的烟碱型乙酰胆碱受体阳性细胞的表达。结果:经补充后10只大鼠进入结果分析。雌激组大鼠脑海马CA1区、脑皮质、杏仁复合体区、Meynert核区的烟碱型乙酰胆碱受体阳性细胞数均高于穹隆-海马伞切断+双侧卵巢切除组(30.20±8.65),(64.40±3.52)个/视野;(41.95±9.63),(96.81±9.13)个/视野;(38.18±9.19),(84.50±5.48)个/视野;(18.18±1.65),(89.33±10.24)个/视野;P<0.01。结论:补充外源...

目的:观察雌激素对阿尔茨海默病大鼠脑内不同部位烟碱型乙酰胆碱受体表达的干预作用。方法:实验于2003-11在青岛大学医学院脑病研究所进行。取健康雌性Wistar大鼠10只,随机分为穹隆-海马伞切断+卵巢切除组和雌激素组,每组5只大鼠。所有大鼠在脑立体定位仪上切断穹隆-海马伞,并切除双侧卵巢,建立模拟伴有体内雌激素水平下降的阿尔茨海默病动物模型。雌激素组大鼠术后第3天皮下注射雌二醇1mg/kg,以后每7d给药1次,30d后应用免疫组织化学技术观察两组阿尔茨海默病大鼠海马CA1区、皮质区、杏仁复合体区和基底前脑Meynert核等部位的烟碱型乙酰胆碱受体阳性细胞的表达。结果:经补充后10只大鼠进入结果分析。雌激组大鼠脑海马CA1区、脑皮质、杏仁复合体区、Meynert核区的烟碱型乙酰胆碱受体阳性细胞数均高于穹隆-海马伞切断+双侧卵巢切除组(30.20±8.65),(64.40±3.52)个/视野;(41.95±9.63),(96.81±9.13)个/视野;(38.18±9.19),(84.50±5.48)个/视野;(18.18±1.65),(89.33±10.24)个/视野;P<0.01。结论:补充外源性雌激素治疗后阿尔茨海默病大鼠各脑区内的烟碱型乙酰胆碱受体表达显著增加,从而提高了胆碱能神经元的功能。

 
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