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   胸腺癌 的翻译结果: 查询用时:0.019秒
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胸腺癌
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  thymic carcinoma
     Results:Clinically,the median age of the patients with the tumor was 43.5 years old. All the tumors displayed a pattern of infiltration growth. Immunohistochemical staining of the tumors indicated that the expressions of EGFR,survivin,P53 protein and PCNA in thymic carcinoma were 77.8%(7/9),88.8%(8/9),77.8%(7/9) and 100%(9/9),respectively.
     结果:免疫标记显示胸腺癌对EGFR、survivin、P53蛋白和PCNA阳性表达率分别为77.8%(7/9)、88.8%(8/9)、77.8%(7/9)和100%(9/9)。
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     Objective:To investigate the expression of epidermal growth factor receptor(EGFR),survivin,P53 protein and proliferating cell nuclear antigen(PCNA) in thymic carcinoma and type-B3 thymoma.
     目的:探讨表皮生长因子受体(EGFR)、生存素(survivin)、P53蛋白和增殖细胞核抗原(PCNA)在胸腺癌和B3型胸腺瘤(高分化胸腺癌)中的表达。
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     Methods:The clinicopathological changes of thymic carcinoma in 9 cases and of type-B3 thymoma(well differentiated thymic carcinoma) in 21 cases were examined by microscopic observation of immunohistochemical stained EGFR,survivin,P53 protein and PCNA,respectively.
     方法:9例胸腺癌和21例B3型胸腺瘤手术切除标本,用免疫组化(S-P)法分别标记EGFR、survivin、P53蛋白和PCNA,光镜下观察。
短句来源
     Expression of epidermal growth factor receptor and cell proliferative protein in thymic carcinoma and type-B3 thymoma
     表皮生长因子受体和细胞增殖蛋白在胸腺癌与B3型胸腺瘤中的表达
短句来源
     Methods 37 cases of the mediastinal thymomas proved by surgery and pathology,in which male 25 cases,female 12,ages were 12 to 64 years average 34.1.Operation and pathology:benign thymomas were 8 cases malignent 18,thymic carcinoma 7 ,thymolipoma 3,Thymic liposarcoma 1.The X ray films of the chest were taken in all of the 37 cases,in which CT examination was done in 20 cases.
     方法 报告经手术与病理证实的纵隔胸腺瘤37 例,其中男性25 例,女性12 例,年龄为12 ~64 岁,平均341 岁。 手术与病理证实:良性胸腺瘤8 例,恶性胸腺瘤18 例,胸腺癌7 例,胸腺脂肪瘤3 例,胸腺脂肪肉瘤1 例,全部病例均有胸部X 线正侧位片,其中20 例作了CT 检查。
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  “胸腺癌”译为未确定词的双语例句
     Results P53 positive rate was as follows: non-invasive thymoma was7.70%; malignant thymoma (category I) was 50.00% and thymus cancer was100%.
     结果P53阳性表达率分别为:良性胸腺瘤7.70%,恶性胸腺瘤I型50.00%,胸腺癌100%。
短句来源
     Relationship between p16, Rb Expression and Prognosis in Thymoma
     p16、Rb蛋白在胸腺癌中表达及与预后的关系
短句来源
     Results: p53 positive cells were found in 19 out of 20 cases thymic carcinomas, the expression rate reached 95% and the overexpression rate was 35% (7/20) .
     结果:20例胸腺癌中的19例可见p53阳性癌细胞,p53蛋白表达率为95%(19/20),过表达率达35%(7/20)。
短句来源
     Objects To study the relationship between activation of pro-MMP-2 and expression of matrix metalloproteinases(MMP)-2,MT1-MMP and tissue inhibitor of metalloproteinases(TIMP)-2 mRNA in thymoma and thymic cancinoma;
     目的探讨胸腺瘤和胸腺癌中基质金属蛋白酶(MMP)-2、Ⅰ型膜型(MT1)-MMP、金属蛋白酶组织抑制剂(TIMP)-2 mRNA的表达和MMP-2蛋白活性的关系。
短句来源
     Results Of the 9 cases 2 cases were diagnosed as thymus cysts,1 cases thymoma,1 case malignant thymoma,1cases thymus carcinoma and 4 cases myasthenia gravis.
     结果 胸腺囊肿 2例 ,胸腺瘤 1例 ,恶性胸腺瘤 1例 ,胸腺癌 1例 ,重症肌无力4例。
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  相似匹配句对
     THYMIC CARCINOMA——Analysis of 30 cases
     腺癌30例临床分析
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     Cutaneous metastasis to the chest wall from prostate cancer
     前列腺癌壁皮肤转移
短句来源
     Adenocarcinoma of the Esophagus
     食管腺癌
短句来源
     BARRETT'S ADENOCARCINOMA
     Barrett食道腺癌
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     THE TYPES OF THE THORACIC DUCT
     导管的类型
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  thymic carcinoma
Radiotherapy for invasive thymoma and thymic carcinoma
      
Severe aplastic anemia associated with thymic carcinoma and partial recovery of hematopoiesis after thymectomy
      
We now report that a previously healthy, 72-year-old woman had a well-differentiated squamous cell thymic carcinoma and severe aplastic anemia, as detected on a simultaneous basis.
      
After extirpation of the thymic carcinoma, hematological recovery was achieved.
      
A case of thymic carcinoma arising within a lymphocyte rich thymoma is reported.
      
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This paper aims at improvement of understanding of the clinical manifestations,diagnostic methods,surgical management and postoperative adjuvant therapy of thymic carcinoma through retrospective analysis of 14 such cases treated surgically and confirmed by pathological examination.Most cases had nonspecific symptoms of chest pain and discomfort,but none accompanied with extrathoracic syndrome.The tumor is always large in size and frequently invades the neighbouring organs,hence its resection rate is low.In this...

This paper aims at improvement of understanding of the clinical manifestations,diagnostic methods,surgical management and postoperative adjuvant therapy of thymic carcinoma through retrospective analysis of 14 such cases treated surgically and confirmed by pathological examination.Most cases had nonspecific symptoms of chest pain and discomfort,but none accompanied with extrathoracic syndrome.The tumor is always large in size and frequently invades the neighbouring organs,hence its resection rate is low.In this series,complete excision was accomplished in only 2 cases,partial resection in 7,and 5 patients had only exploratory thoracotomy.There was no operative death.Besides,ten developed extrathoracic metastases.Therefore,thymic carcinoma patients have poor prognosis.In this series,14 patients had postoperative adjuvant therapy,10 of the 14 died,5 within the first postoperative year,3 within 2 years,1 within 5 and 1 within 8.Four patients are still alive at present.Emphases are placed on early diagnosis,thorough surgical resection and postoperative adjuvant therapy in order to improve the result of treatment.

对外科手术及病理证实的14例胸腺癌进行回顾性分析,旨在提高对胸腺癌临床表现、诊断方法和外科处理的认识。大多数胸腺癌病人表现有胸痛或胸部不适等非特异性症状,但不合并胸外综合征。胸腺癌肿瘤较大、多侵犯周围脏器,手术切除率低。本组2例肿瘤完整切除,7例部分切除,5例行开胸探查,无手术死亡。除胸内广泛浸润外,胸腺癌常发生胸外转移,故预后很差。14例术后均行辅助治疗,死亡10例;其中5例于术后1年内死亡,3例死于术后2年,另2例分别于术后5、8年死亡;现生存4例。作者强调胸腺癌比胸腺瘤恶性程度高,预后差,应早期诊断,彻底手术切除;术后辅以放疗和化疗,以提高治疗效果。

From January 1988 to December 1996, 31 Patients with myasthenia gravis (MG) underwent extended thymectomy (15 nonthymomatous, 16 thymomatous). Follow-up results were reviewed and influential factors were investigated. Patients with MG underwent extended thymectomy during which an enbloc resection of the anterior mediastinal fat tissue and the thymus was performed using a method of the transsternum. Favorable prognostic factors included absence of thymoma, younger age and short duration of disease,and the palliation...

From January 1988 to December 1996, 31 Patients with myasthenia gravis (MG) underwent extended thymectomy (15 nonthymomatous, 16 thymomatous). Follow-up results were reviewed and influential factors were investigated. Patients with MG underwent extended thymectomy during which an enbloc resection of the anterior mediastinal fat tissue and the thymus was performed using a method of the transsternum. Favorable prognostic factors included absence of thymoma, younger age and short duration of disease,and the palliation rate was 70%. The authors conclude that extended thymectomy is an effective treatment for MG regardless of nonthymomatous or thymomatous.

目的:评估根治性胸腺切除术对重症肌无力的疗效。方法:采用根治性胸腺切除术治疗31例重症肌无力。结果:发现年龄小于41岁(P<0.01),术前病期短(P<0.01),无合并胸腺瘤的病人预后好。缓解率达70%。结论:对胸腺瘤和非胸腺癌的各型重症肌无力病人均应采取根治性胸腺切除术

Objective: To investigate the effects of p53 overexpression on neoplastic cell proliferation and apoptosis in 20 cases thymic carcinomas. Methods: Twenty surgical samples of thymic carcinoma were collected for this study. Immunohistochemical staining was performed by using LsAB method with anti p53 monoclonal antibody (DAKO DO 7) and prolife rating cell nuclear antigen (PCNA, DAKO clone PC10) antibody as primary antibodies. The p53 expression rate was indicated by number of p53 positive cells per 100 carcinoma...

Objective: To investigate the effects of p53 overexpression on neoplastic cell proliferation and apoptosis in 20 cases thymic carcinomas. Methods: Twenty surgical samples of thymic carcinoma were collected for this study. Immunohistochemical staining was performed by using LsAB method with anti p53 monoclonal antibody (DAKO DO 7) and prolife rating cell nuclear antigen (PCNA, DAKO clone PC10) antibody as primary antibodies. The p53 expression rate was indicated by number of p53 positive cells per 100 carcinoma cells. More than 20% of p53 positive cells found in tissue section was considered as p53 overexpression. Proliferation index (PI) was indicated as average number of PCNA positive cells in 100 carcinoma cells. Boehringer mannheim in situ cell death detection kit was used for observation of apoptotic neoplastic cells,and apoptotic index(AI) was defined as apoptotic cells averagely found in a high power view microscopically. Results: p53 positive cells were found in 19 out of 20 cases thymic carcinomas, the expression rate reached 95% and the overexpression rate was 35% (7/20) . There was a negative correlation between p53 expression rate and AI. The mean AI (0.5/HPF) of 7 cases thymic carcinomas with p53 overexpression was lower than that (4.5/HPF) of 13 cases thymic carcinomas without p53 overexpression, P< 0.05. Conclusion: The p53 alteration might involve in carcinogenesis of some thymic carcinoma. The overexpressed p53 protein had lost its wild type functions as proliferation inhibitor and apoptosis inducer, and hence could promote the growth of thymic carcinomas.

目的:探讨胸腺癌中p53蛋白过表达对癌细胞增殖和凋亡的影响。方法:收集手术切除的胸腺标本20例。用抗p53蛋白(DAKODO7)和抗增殖细胞核抗原(PCNA,DAKOclonePC10)的单抗,采用LsAB免疫组化法染色。以平均每100个癌细胞中p53阳性细胞数为p53表达率,阳性p53蛋白细胞数超过20%者称为p53蛋白过表达,以平均每100个癌细胞中PCNA阳性细胞数为增殖指数(proliferationindex,PI)。采用BoehringerMannheim公司的原位细胞死亡试剂盒检测凋亡细胞,癌细胞的凋亡指数(apoptosisindex,AI)定为平均每个高倍视野中的凋亡细胞数。结果:20例胸腺癌中的19例可见p53阳性癌细胞,p53蛋白表达率为95%(19/20),过表达率达35%(7/20)。p53蛋白表达率与AI之间有负相关性(P<0.05)。7例有p53蛋白过表达的平均AI为0.5/HPF,明显低于13例无p53蛋白过表达的平均AI(4.5/HPF),P<0.05。结论:95%的胸腺癌中有p53蛋白表达,35%有p53蛋白过表达,说明p53的基因变异可...

目的:探讨胸腺癌中p53蛋白过表达对癌细胞增殖和凋亡的影响。方法:收集手术切除的胸腺标本20例。用抗p53蛋白(DAKODO7)和抗增殖细胞核抗原(PCNA,DAKOclonePC10)的单抗,采用LsAB免疫组化法染色。以平均每100个癌细胞中p53阳性细胞数为p53表达率,阳性p53蛋白细胞数超过20%者称为p53蛋白过表达,以平均每100个癌细胞中PCNA阳性细胞数为增殖指数(proliferationindex,PI)。采用BoehringerMannheim公司的原位细胞死亡试剂盒检测凋亡细胞,癌细胞的凋亡指数(apoptosisindex,AI)定为平均每个高倍视野中的凋亡细胞数。结果:20例胸腺癌中的19例可见p53阳性癌细胞,p53蛋白表达率为95%(19/20),过表达率达35%(7/20)。p53蛋白表达率与AI之间有负相关性(P<0.05)。7例有p53蛋白过表达的平均AI为0.5/HPF,明显低于13例无p53蛋白过表达的平均AI(4.5/HPF),P<0.05。结论:95%的胸腺癌中有p53蛋白表达,35%有p53蛋白过表达,说明p53的基因变异可能参与了某些胸腺癌的癌变过程。过表达的p53蛋白在胸腺癌中已丧失了野生型p53蛋白抑制细胞增殖和诱导受损细胞凋亡的作用,从而促进了胸腺癌的生长进展。

 
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