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  thymic carcinoma
Radiotherapy for invasive thymoma and thymic carcinoma
      
Severe aplastic anemia associated with thymic carcinoma and partial recovery of hematopoiesis after thymectomy
      
We now report that a previously healthy, 72-year-old woman had a well-differentiated squamous cell thymic carcinoma and severe aplastic anemia, as detected on a simultaneous basis.
      
After extirpation of the thymic carcinoma, hematological recovery was achieved.
      
A case of thymic carcinoma arising within a lymphocyte rich thymoma is reported.
      
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This paper aims at improvement of understanding of the clinical manifestations,diagnostic methods,surgical management and postoperative adjuvant therapy of thymic carcinoma through retrospective analysis of 14 such cases treated surgically and confirmed by pathological examination.Most cases had nonspecific symptoms of chest pain and discomfort,but none accompanied with extrathoracic syndrome.The tumor is always large in size and frequently invades the neighbouring organs,hence its resection rate is low.In this...

This paper aims at improvement of understanding of the clinical manifestations,diagnostic methods,surgical management and postoperative adjuvant therapy of thymic carcinoma through retrospective analysis of 14 such cases treated surgically and confirmed by pathological examination.Most cases had nonspecific symptoms of chest pain and discomfort,but none accompanied with extrathoracic syndrome.The tumor is always large in size and frequently invades the neighbouring organs,hence its resection rate is low.In this series,complete excision was accomplished in only 2 cases,partial resection in 7,and 5 patients had only exploratory thoracotomy.There was no operative death.Besides,ten developed extrathoracic metastases.Therefore,thymic carcinoma patients have poor prognosis.In this series,14 patients had postoperative adjuvant therapy,10 of the 14 died,5 within the first postoperative year,3 within 2 years,1 within 5 and 1 within 8.Four patients are still alive at present.Emphases are placed on early diagnosis,thorough surgical resection and postoperative adjuvant therapy in order to improve the result of treatment.

对外科手术及病理证实的14例胸腺癌进行回顾性分析,旨在提高对胸腺癌临床表现、诊断方法和外科处理的认识。大多数胸腺癌病人表现有胸痛或胸部不适等非特异性症状,但不合并胸外综合征。胸腺癌肿瘤较大、多侵犯周围脏器,手术切除率低。本组2例肿瘤完整切除,7例部分切除,5例行开胸探查,无手术死亡。除胸内广泛浸润外,胸腺癌常发生胸外转移,故预后很差。14例术后均行辅助治疗,死亡10例;其中5例于术后1年内死亡,3例死于术后2年,另2例分别于术后5、8年死亡;现生存4例。作者强调胸腺癌比胸腺瘤恶性程度高,预后差,应早期诊断,彻底手术切除;术后辅以放疗和化疗,以提高治疗效果。

Objective: To investigate the effects of p53 overexpression on neoplastic cell proliferation and apoptosis in 20 cases thymic carcinomas. Methods: Twenty surgical samples of thymic carcinoma were collected for this study. Immunohistochemical staining was performed by using LsAB method with anti p53 monoclonal antibody (DAKO DO 7) and prolife rating cell nuclear antigen (PCNA, DAKO clone PC10) antibody as primary antibodies. The p53 expression rate was indicated by number of p53 positive cells per 100 carcinoma...

Objective: To investigate the effects of p53 overexpression on neoplastic cell proliferation and apoptosis in 20 cases thymic carcinomas. Methods: Twenty surgical samples of thymic carcinoma were collected for this study. Immunohistochemical staining was performed by using LsAB method with anti p53 monoclonal antibody (DAKO DO 7) and prolife rating cell nuclear antigen (PCNA, DAKO clone PC10) antibody as primary antibodies. The p53 expression rate was indicated by number of p53 positive cells per 100 carcinoma cells. More than 20% of p53 positive cells found in tissue section was considered as p53 overexpression. Proliferation index (PI) was indicated as average number of PCNA positive cells in 100 carcinoma cells. Boehringer mannheim in situ cell death detection kit was used for observation of apoptotic neoplastic cells,and apoptotic index(AI) was defined as apoptotic cells averagely found in a high power view microscopically. Results: p53 positive cells were found in 19 out of 20 cases thymic carcinomas, the expression rate reached 95% and the overexpression rate was 35% (7/20) . There was a negative correlation between p53 expression rate and AI. The mean AI (0.5/HPF) of 7 cases thymic carcinomas with p53 overexpression was lower than that (4.5/HPF) of 13 cases thymic carcinomas without p53 overexpression, P< 0.05. Conclusion: The p53 alteration might involve in carcinogenesis of some thymic carcinoma. The overexpressed p53 protein had lost its wild type functions as proliferation inhibitor and apoptosis inducer, and hence could promote the growth of thymic carcinomas.

目的:探讨胸腺癌中p53蛋白过表达对癌细胞增殖和凋亡的影响。方法:收集手术切除的胸腺标本20例。用抗p53蛋白(DAKODO7)和抗增殖细胞核抗原(PCNA,DAKOclonePC10)的单抗,采用LsAB免疫组化法染色。以平均每100个癌细胞中p53阳性细胞数为p53表达率,阳性p53蛋白细胞数超过20%者称为p53蛋白过表达,以平均每100个癌细胞中PCNA阳性细胞数为增殖指数(proliferationindex,PI)。采用BoehringerMannheim公司的原位细胞死亡试剂盒检测凋亡细胞,癌细胞的凋亡指数(apoptosisindex,AI)定为平均每个高倍视野中的凋亡细胞数。结果:20例胸腺癌中的19例可见p53阳性癌细胞,p53蛋白表达率为95%(19/20),过表达率达35%(7/20)。p53蛋白表达率与AI之间有负相关性(P<0.05)。7例有p53蛋白过表达的平均AI为0.5/HPF,明显低于13例无p53蛋白过表达的平均AI(4.5/HPF),P<0.05。结论:95%的胸腺癌中有p53蛋白表达,35%有p53蛋白过表达,说明p53的基因变异可...

目的:探讨胸腺癌中p53蛋白过表达对癌细胞增殖和凋亡的影响。方法:收集手术切除的胸腺标本20例。用抗p53蛋白(DAKODO7)和抗增殖细胞核抗原(PCNA,DAKOclonePC10)的单抗,采用LsAB免疫组化法染色。以平均每100个癌细胞中p53阳性细胞数为p53表达率,阳性p53蛋白细胞数超过20%者称为p53蛋白过表达,以平均每100个癌细胞中PCNA阳性细胞数为增殖指数(proliferationindex,PI)。采用BoehringerMannheim公司的原位细胞死亡试剂盒检测凋亡细胞,癌细胞的凋亡指数(apoptosisindex,AI)定为平均每个高倍视野中的凋亡细胞数。结果:20例胸腺癌中的19例可见p53阳性癌细胞,p53蛋白表达率为95%(19/20),过表达率达35%(7/20)。p53蛋白表达率与AI之间有负相关性(P<0.05)。7例有p53蛋白过表达的平均AI为0.5/HPF,明显低于13例无p53蛋白过表达的平均AI(4.5/HPF),P<0.05。结论:95%的胸腺癌中有p53蛋白表达,35%有p53蛋白过表达,说明p53的基因变异可能参与了某些胸腺癌的癌变过程。过表达的p53蛋白在胸腺癌中已丧失了野生型p53蛋白抑制细胞增殖和诱导受损细胞凋亡的作用,从而促进了胸腺癌的生长进展。

Objective:To study the efficacy of high-dose cytoxan (CTX) based combined chemotherapy in treating the patients with superior vena cava syndrom (SVCS)caused by malignant tumors.Methods:Patients with lung cancer or malignant thymoma were treated with CAP regimen.Maliglant lymphoma patients were treated with ABCOP regimen.Rusults:The response rates were:lymphoma CR 66.67%(4/6),PR 33.33%(2/6);SCLC CR 28.57%(4/14),PR 35.71%(5/14),NC 28.57%(4/14),PD 7.14%(1/14),NSCLC CR 9%(1/11),PR 36.36%(4/11),NC 36.36%(4/11),PD...

Objective:To study the efficacy of high-dose cytoxan (CTX) based combined chemotherapy in treating the patients with superior vena cava syndrom (SVCS)caused by malignant tumors.Methods:Patients with lung cancer or malignant thymoma were treated with CAP regimen.Maliglant lymphoma patients were treated with ABCOP regimen.Rusults:The response rates were:lymphoma CR 66.67%(4/6),PR 33.33%(2/6);SCLC CR 28.57%(4/14),PR 35.71%(5/14),NC 28.57%(4/14),PD 7.14%(1/14),NSCLC CR 9%(1/11),PR 36.36%(4/11),NC 36.36%(4/11),PD 18.18%(2/11) malignant thymoma NC(1/1).The response rate of SVCS in two days was 21.9%(7/32) ;43.8% (14/32) from three to five days;18.8% (6/32) from 5 to 7 days;15.6% (5/32) beyond seven days.Conclusion:The high-dose CTX was effective and well tolerated in treating the cancer patients with SVCS.

目的 :采用以大剂量环磷酰胺(HD CTX)主为联合化疗方案治疗由恶性肿瘤引起的上腔静脉综合征(SVCS)。方法 :SVCS32例 ,其中肺癌与胸腺癌15例选用CAP方案 ,恶性淋巴瘤6例选用ABCOP方案。结果 :恶性淋巴瘤CR66.67%(4/6) ,PR33.33%(2/6)。SCLCCR28.57%(4/14) ,PR35.71 %(5/14) ,NC28.57%(4/14) ,PD7.14%(1/14)。NSCLSCR9 %(1/11) ,PR36.36 %(4/11) ,NC36.36%(4/11) ,PD18.18%(2/11)。胸腺癌1例为NC。SVCS2天内缓解21.9%(7/32) ,3~5天缓解43.8%(14/32) ,5~7天缓解18.8%(6/32) ,7天以上缓解15.6 %(5/32) ,1周内危象缓解84.5%(26/32)。结论 :HD CTX治疗SVCS缓解率高 ,疗效确切 ,副作用可耐受。

 
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