METHODS:Expression of MMP 9, microvessel density (MVD) labeled by CD34 and proliferation index of cancer cells labeled by Ki 67 in 75 cases of early invasive carcinoma of cervix (ICC), 18 cases of cervical intraepithelial neoplasm (CIN), and 15 cases of normal cervical epithelium (NCE) were detected by immunohistochemistry SP method.
Methods :The expression of MMP-9, TIMP-1,and microvessel density(MVD) labeled by CD 34 were detected by immunohistochemistry SP method in 75 cases of early invasive carcinoma of cervix(ICC),18 cases of cervical intraepithelial neoplasm(CIN) and 15 cases of normal cervical epithelium(NCE) remoted from tumor lesion.
Methods: Expression of VEGF, and KDR of cancer cells and microvessel density (MVD) in tumor stroma labeled by CD34 in 18 cases of cervical intraepithelial neoplasm (CIN), 75 cases of early invasive carcinoma of cervix (ICC) and 15 cases of normal cervical epithelium (NCE) were detected by immunohistochemistry SP method.
Survivin ,P21~(WAF1/CIP1),Cyclin D1 proteins expression in cervical carcinoma:correlations with recurrence of early stage cervical cancer of the uterus
The total coincidence rate of cervical pathological changes and chronic inflammation and early cervical carcinoma was 91.04%(305/335),97.84% and 75%,respectively.
Objective: To study the expressions of gene and protein levels of metastasis-enhancing gene S100A4 and adhesion molecule CD44v6,E-cad,integrinα_vβ_3 in early stage squamous cervical carcinoma (SCC), explore their roles in lymphatic metastasis of SCC.
In addition, patients with high-risk features, notably positive troponin, ST segment changes and diabetes, benefit from an early invasive as compared to a conservative strategy.