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只scid
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Mouse IgG concentrations in serum obtained by tail vein bleeding,of all 10 SCID mice were found to be below the "non-leaky"level of 5ug/ml > before or after maintaining the mice in our laboratary for 4 months. In order to humanize the SCID mouse (hu-PBL-SCID) ,2 or 4X107 human peripheral blood lymphocytes were transplanted to 5 SCID mice. Four and twelve weeks later human IgG could be detected in their sera, the highest concentration being 109ug/ml. After repeatde (5 times) immunization of 5 hu-PBL-SCIDs with...

Mouse IgG concentrations in serum obtained by tail vein bleeding,of all 10 SCID mice were found to be below the "non-leaky"level of 5ug/ml > before or after maintaining the mice in our laboratary for 4 months. In order to humanize the SCID mouse (hu-PBL-SCID) ,2 or 4X107 human peripheral blood lymphocytes were transplanted to 5 SCID mice. Four and twelve weeks later human IgG could be detected in their sera, the highest concentration being 109ug/ml. After repeatde (5 times) immunization of 5 hu-PBL-SCIDs with Polio-1, each of them could produce human anti-Polio-1 antibodies and the top litre amounted to 1 : 640. These results indicate that the hu-PBL-SCIDs does exhibit human immune response to some extents.

经测定鼠尾采血获取的血清,10只SCID鼠在所设实验室条件下饲养4个月前后均达到鼠IgG含量低于5μg/ml的合格标准,5只SCID鼠腹腔移植入2或4×10~7个人外周血淋巴细胞(hu—PBL),建立人化SCID(hu-PBLSCID)鼠,可在移植后4周和12周测到其血清中人IgG的存在,最高可达109μg/ml。以脊髓灰质炎Ⅰ型病毒(Polio—1 virus,Polio-1)作抗原免疫5只hu-PBL-SCID各5次,每鼠均能产生抗Polio-1的特异性人抗体,滴度最高达1:640,表明所建立的人化SCID鼠具备了一定的免疫应答能力。

LTEP-a-2 human lung adenocarcinoma cells and CVE-2Z human nasopharygcal carcinoma cells were usedin prcsent experiment.Tumor cells were injected into different sites(including site of subeutaneous costal region and subcu-taneous footpad)and different ways(including inoculation of suspension of tumor cells and tumor fragment)into 24 scidrnice(severe combined immunodeficience mice)and 48 sitcs. Experiments were divided into two groups,named as group ofsuhcdtaneous inoclatuon into costal region(including 6 LTEP-a-2...

LTEP-a-2 human lung adenocarcinoma cells and CVE-2Z human nasopharygcal carcinoma cells were usedin prcsent experiment.Tumor cells were injected into different sites(including site of subeutaneous costal region and subcu-taneous footpad)and different ways(including inoculation of suspension of tumor cells and tumor fragment)into 24 scidrnice(severe combined immunodeficience mice)and 48 sitcs. Experiments were divided into two groups,named as group ofsuhcdtaneous inoclatuon into costal region(including 6 LTEP-a-2 tumor-bearing scid mice and 6 CNE-2Z tumor-bearing scidmice)and group of subcutancous inoculation into footpad(including 6 LTEP-a-2 tumor-bearing scid mice and 6 CVE-2Z tu-mor bearing scid mic).Two transplantable sites in cach mouse were chosen for this study,i.e the suspcnsion of tumorcclls was implanted into one site,and the tumor fragments were implanted into opposed site in same mouse:All tumor-bcar-ing scid mice were sacrificed on 68th day.In the group of subcutancous inoculation into costal rcgion,CNE-2Z tumor couldgive rise to growth(100%)with progrcssive invasion.and lung mctastasis which occurred in 50%(3/6).LTEP-a-2 tumorwere grown in the form of nodule with incomplete thinner fibrous capsule(100%).slight tumor invasions were noticed insome mice. metastasis was not observed In the group of subcutaneous inoculation into footpad,after inoculation of tumorfragment of CNE-2Z tumor cells into 6 scld mice tumor give rise to growth(100%)with progressive invasion and lymphaticnetastasis which occurred in 66%(4/6)of cascs,And after inoculation of suspcnsion of CNE-2Z tumor cells into 6 scidrnicetumor give rise to growth(50%)without invasion and mctastasis. In thc group of subcutancous inoculation LTEP-a-2 tumorcclls into footpad tumor growth was observed in the form of module with fibrous capsul(100%).and slight invatsion was pre-xented in the some cascs,metastasis was not observed In the solid tumors of some cases of CNE-2Z and LTEP-a-2 tumorsthere was an accompanying squarnous element.the mcchainsm was unclcar. These results showed that human tumor growthin seidmicc is obviously influcnced by the sites and was of inoculation

本文用人体肺腺癌(LTEp-a·2)和人体鼻咽癌(CNE-2Z)两株细胞系,在严重联合免疫缺陷(SCID)小鼠的背侧皮下和后肢爪垫移植:(1)爪垫移植组,两种肿瘤细胞系各用6只scid小鼠,分别于每只动物左后肢爪垫移植2个瘤组织小块;同一只动物右后肢爪垫接种2.5×10 ̄6/0.03ml瘤细胞悬液。(2)背部皮下移植组:两种肿瘤亦各6只:cid小鼠,在每只动物的左侧背部皮下移植2个瘤组织小块;对侧皮下接种2.5×10 ̄6/0.03ml瘤细胞悬液。24只scid小鼠分48个部位同时移植,动物均于肿瘤移植后68天全部处死。实验结果:两种肿瘤在scid小鼠的背部皮下无论是用瘤组织小块或瘤细胞悬液移植,镜下均能见到肿瘤生长,而在爪垫移植后除了CNE-27瘤悬液接种的右侧3只爪垫未见肿瘤结节外,其他亦均见肿瘤生长。组织学观察,CNT-27细胞无论是用瘤小块或瘤悬液在背部皮下移植,局部一般都发生不同程度的侵袭,有3/6例(50%)发生肺内转移;爪垫移植仅瘤小块移植组全部呈侵袭性生长,瘤悬液接种均未见侵袭发生;瘤小块移植组有4/6例(66%)发生同侧腹股沟淋巴结转移。LTEP-a.2细胞系无论是在哪...

本文用人体肺腺癌(LTEp-a·2)和人体鼻咽癌(CNE-2Z)两株细胞系,在严重联合免疫缺陷(SCID)小鼠的背侧皮下和后肢爪垫移植:(1)爪垫移植组,两种肿瘤细胞系各用6只scid小鼠,分别于每只动物左后肢爪垫移植2个瘤组织小块;同一只动物右后肢爪垫接种2.5×10 ̄6/0.03ml瘤细胞悬液。(2)背部皮下移植组:两种肿瘤亦各6只:cid小鼠,在每只动物的左侧背部皮下移植2个瘤组织小块;对侧皮下接种2.5×10 ̄6/0.03ml瘤细胞悬液。24只scid小鼠分48个部位同时移植,动物均于肿瘤移植后68天全部处死。实验结果:两种肿瘤在scid小鼠的背部皮下无论是用瘤组织小块或瘤细胞悬液移植,镜下均能见到肿瘤生长,而在爪垫移植后除了CNE-27瘤悬液接种的右侧3只爪垫未见肿瘤结节外,其他亦均见肿瘤生长。组织学观察,CNT-27细胞无论是用瘤小块或瘤悬液在背部皮下移植,局部一般都发生不同程度的侵袭,有3/6例(50%)发生肺内转移;爪垫移植仅瘤小块移植组全部呈侵袭性生长,瘤悬液接种均未见侵袭发生;瘤小块移植组有4/6例(66%)发生同侧腹股沟淋巴结转移。LTEP-a.2细胞系无论是在哪一部位或用哪种方式移植?

SCID hPBL and SCID hPLNL mice models have been established by intraperitoneal injection of lymphocytes isolated from normal human peripheral blood or peritoneal lymph nodes into severe combined immunodeficient disease (SCID) mice.The mice were then immunized by EB VCA positive B958 cells.Two months after reconstitution of Hu SCID mice,the presence of human B cells(CD20 +) and T cells(CD3 +) were shown in the spleen,thymus and peritoneal lymph nodes in both Hu SCID mice with immunoperoxidase staining...

SCID hPBL and SCID hPLNL mice models have been established by intraperitoneal injection of lymphocytes isolated from normal human peripheral blood or peritoneal lymph nodes into severe combined immunodeficient disease (SCID) mice.The mice were then immunized by EB VCA positive B958 cells.Two months after reconstitution of Hu SCID mice,the presence of human B cells(CD20 +) and T cells(CD3 +) were shown in the spleen,thymus and peritoneal lymph nodes in both Hu SCID mice with immunoperoxidase staining technique.The sera from the SCID mice were then tested for the level of human IgG and induction of human IgG to EB VCA (IgG/VCA).The results revealed that 70%(7/10) of sera had positive human IgG/VCA in the immunized mice,in comparison to 17%(2/12) in the control group.The GMT of human IgG/VCA and the level of human IgG in the sera were 1∶108 and 96 2±56 4 μg/L in 14 SCID hPLNL mice and 1∶7 9 and 13 84±6 0μg/L in 8 SCID hPBL mice,respectively.The results suggest that SCID hPLNL mice may be more effective for induction of human IgG to some specific immunogen than the SCID hPBL mice.

将人外周血淋巴细胞(PBL)和腹腔淋巴结淋巴细胞(PLNL)移植入严重联合免疫缺陷疾病(SevereCombinedImmunodeficientDisease,SCID)小鼠腹腔,建立人化SCID小鼠(即SCID-hPBL,SCID-hPLNL)。两个月后,两种人化小鼠体内淋巴器官都可以检测到人T、B淋巴细胞分布;小鼠血清人源性IgG和抗EB病毒壳抗原IgG抗体水平(IgG/VCA)比较显示,用B958死细胞作为VCA来源所诱导的实验组10只小鼠,IgG/VCA阳性率为70%(7/10),对照组为17%(2/12)。14只SCID-hPLNL小鼠血清内人IgG/VCA的几何平均滴度(GMT)和血清IgG浓度在1∶108和96.2±56.4μg/L;在另8只SCID-hPBL中为1∶7.9和13.84±6.0μg/L。实验提示,SCID-hPLNL小鼠较SCID-hPBL小鼠更适合于人源性特异IgG的诱导。

 
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