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肿瘤学
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癌移植
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  carcinoma in
     Establishment of Transplantable Model of VX2 Carcinoma in Rabbit Tongue and Studies on its Major Biological Properties
     兔VX2舌癌移植瘤模型的建立及其生物学特性研究
     Objective: This study is aimed to observe the effect of combining cytosinedeaminase(CD)/5-fluorocytosine(5-FC) gene therapy with radiotherapy on cervical carcinoma in nude mouse and to observe if there is a synergistic effect between the two therapies.
     目的:使用胞嘧啶脱氨酶(cytosine deaminase,CD)基因/5-氟胞嘧啶(5—fluorocytosine,5-FC)联合放疗治疗裸鼠宫颈癌移植瘤,观察CD/5-FC基因治疗与放疗之间是否具有协同作用。
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     Objective To observe the effect of combining cytosine deaminase (CD)/5-fluorocytosine (5-FC) gene therapy with radiotherapy on cervical carcinoma in nude mice, and to explore if there is a synergistic effect between the two therapies.
     目的探讨胞嘧啶脱氨酶(CD)/5-氟胞嘧啶(5-FC)基因治疗联合放疗对裸鼠宫颈癌移植瘤的生长抑制作用,以及CD/5-FC基因治疗与放疗之间是否具有协同作用。
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     Objective To explore the effect of norcantharidin (NCTD) on proliferation and apoptosis of implanted human gallbladder carcinoma in nude mice.
     目的探讨去甲斑蝥素(norcantharidin,NCTD)对荷瘤裸鼠胆囊癌移植瘤增殖和凋亡的影响。
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     [Purpose]To compare the expression of cyclin D1 in CNE-2 transplanted nasopharyngeal carcinoma in nude mice before and after chemotherapy,and to estimate the influence of chemotherapy on the expression of cyclin D1.[Methods]The nude mice beared with transplanted tumor were randomly assigned into 3 groups:5-Fu group,DDP group and control group.
     [目的]通过比较化疗前后裸小鼠CNE-2鼻咽癌移植瘤cyclinD1蛋白表达的变化,评价化疗对cyclinD1蛋白表达的影响。 [方法]将荷瘤小鼠随机分成3组:5-Fu组、DDP组和对照组,取肿瘤组织活检后开始化疗。
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     The xenografts inhibition rate for oral squamous cell carcinoma was 69.6% (HCPT 3mg/kg/qd)74.1% (HCPT 10 mg/kg/qd) 59.8% (HCPT 3 mg/kg/qod) and 85.6% (HCPT/PEG-PBLG 3 mg/kg/qod), respectively.
     对口腔鳞癌移植瘤的抑瘤率分别为69.6%(HCPT,3mg/kg,qd)、74.1%(HCPT,10mg/kg,qd)、59.8%(HCPT,3mg/kg,qod)和85.6%(HCPT/PEG-PBLG3mg/kg,qod);
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     The Combination of 8-Br-cAMP and HSV-TK/GCV System in the Treatment of Tongue Squamous Carcinoma Xenografts
     8-Br-cAMP联合HSV-TK/GCV治疗舌鳞癌移植瘤的研究
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     Therapeutic effects of nano-magnetoliposomes containing As_2O_3 combined with magnetic fluid hyperthermia on xenograft cervical carcinoma
     纳米As_2O_3磁性脂质体磁感应加热治疗裸鼠人宫颈癌移植
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     Meanwhile, the mRNA transcription activity of NF-κB-activating related genes, like TRAF5, TRAF6, TRAP2, p67, p68 kinase, IκBα and LAP-1, were obviously changed as well, showing up-regulated transcription activities of IκBα and TRAF6 and down-regulated transcription activities of the remainders.
     结果复方黄连在抑制移植瘤生长的同时 ,尚可改变包括TRAF5、TRAF6、TRAP2、p67、p68激酶、IκBα以及LAP—1在内的一些NF—κB活化相关基因在鼻咽癌移植瘤组织的表达。
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     [Conclusion] 8-Br-cAMP and HSV-TK/GCV system have synergetic anticancer effect on tongue squamous carcinoma xenografts.
     [结论]8-Br-cAMP与HSV-TK/GCV系统具有协同的抑制舌鳞癌移植瘤生长作用。
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  相似匹配句对
     Progress in Hepatocelluar Carcinoma Transplantation
     肝细胞移植现状
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     Is liver transplantation indicated for cholangiocarcinoma
     肝移植能否用于治疗胆管
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     CARCINOMA OF VULVA
     女阴
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     Gastric-ulcer Cancer
     胃溃疡
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     Immunology on Transplantation
     移植免疫
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  carcinoma in
It is totally different from pancreatic carcinoma in epidemiology, histology, pathology and prognosis.
      
Immune subunit LMP2 was undetectable by this technique in the ascitic carcinoma in contrast to the lung, spleen, and liver.
      
Increasing incidence of renal cell carcinoma in Western countries raises particular attention to its etiology.
      
Dietary omega-3-polyunsaturated fatty acids prevent the development of metastases of colon carcinoma in rat liver
      
The clinical and pathological features of encephalitis associated with a carcinoma in the absence of cerebral metastases are described as occurring in a 54-year-old man with a bronchial carcinoma and a 59-year-old woman with an ovarian cancer.
      
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Two kinds of models of rude mice and rats bearing the human gastric cancer were established from fresh surgical specimens and cell line (GGC-8340), Tumor lustological structure and cell morphology were similar before and after transplantation. The monoclonal antibody GMG1:1 D 1-2 against human gastric cancer was labeled by 125I and 131I. The binding radioactivity of radio -iodinated 1D1-2 with GGC-8140 was determined by vitro binding assay, suggesting ihat 1D1-2 reacted specifically with GGC-8140. Radioimmunodetection...

Two kinds of models of rude mice and rats bearing the human gastric cancer were established from fresh surgical specimens and cell line (GGC-8340), Tumor lustological structure and cell morphology were similar before and after transplantation. The monoclonal antibody GMG1:1 D 1-2 against human gastric cancer was labeled by 125I and 131I. The binding radioactivity of radio -iodinated 1D1-2 with GGC-8140 was determined by vitro binding assay, suggesting ihat 1D1-2 reacted specifically with GGC-8140. Radioimmunodetection study showed that 72 hr after injection of 125I-1D1-2, all the two kinds of xenograf;s were specifically located by 1 D 1-2. Tumor location index was 4.5, while that of the normal tissue was only 1. 3. The ratio of tumor to normal tissue ( T/NT ) in the brain was 12; T/NT in the slomach was 3.2; T/NT in the blood increased gradually and was 2, 0. Radioimmunoimaging was performed in tumor bearing nude mice and rats. The tumor was clearly visualized 72 hr after injection of 125I-1D1-2. Radioactivity was higher in tumor region than in other region. It is suggested that McAb:1D1-2 has the possibility of location in the tumor diagnosis and the treatment guidance.

本文应用人胃癌组织及细胞株移植建立了裸大鼠和裸小鼠两种胄癌移植模型。用~(125)I和~(131)I标记抗人胃癌单克隆抗体1D1-2,体外试验表明碘化1D1-2具有特异性的结合活性。注入荷瘤裸鼠体内72h后,显示该抗体高度浓集于肿瘤组织,浓聚指数为4.5,而正常组织仅为1.3,T/NT比分别为2~12倍,与胃组织比为3.2倍、放射免疫显像显示出清晰的肿瘤图像。提示单克隆抗体1D1-2应用于肿瘤定位诊断及导向治疗的可能性。

The results of in vitro cell experiment and cervical carcinoma xenograft treatmentshowed that combined anticancer drugs and radiation had a more marked anticancereffect than radiation alone. On the bases of experiment, 25 cases with carcinomaof uterine cervix, FIGO stage Ib-IV, were chosen for our study. A weekly ~(60)Co intra-cavitary irradiation plus cisplatinum (30mg/m~2) and bleomycin (15mg/m~2) were givento 11/25 cases, while the remaining 14, radiotherapy alone. The former group showeda superior response...

The results of in vitro cell experiment and cervical carcinoma xenograft treatmentshowed that combined anticancer drugs and radiation had a more marked anticancereffect than radiation alone. On the bases of experiment, 25 cases with carcinomaof uterine cervix, FIGO stage Ib-IV, were chosen for our study. A weekly ~(60)Co intra-cavitary irradiation plus cisplatinum (30mg/m~2) and bleomycin (15mg/m~2) were givento 11/25 cases, while the remaining 14, radiotherapy alone. The former group showeda superior response in tumor regression and histologic improvement than the later one.The toxic side effect was acceptable. The results indicate that concomitant radiationtherapy and chemotherapy may be of benefit for treating cervical carcinoma.

实验研究示放射合并抗癌药对HeLa细胞及裸鼠人宫颈癌移植肿瘤的抑制作用均大于单纯放射。25例Ⅰ_b~Ⅳ期宫颈癌分别接受~(60)Co腔内放疗(A点照射量800cGy/次)和腔内放疗合并化疗(顺铂30mg/m~2+博莱霉素15mg/m~2),照射后即刻用药,每周1次。结果示合并化疗组(11/25)肿瘤缩小及病理改变明显较单纯放疗组显著,毒副反应不明显。作者认为放射后即刻化疗(顺铂+博莱霉素)治疗子宫颈癌的方案,可能提高晚期宫颈癌的疗效。

Tumor tissue of lymph node metastasis of human ovarian carcinoma was directly implanted into nude mice subcutaneously and 26 generations have been propagated successfully. The tumor doubling time was 7. 17 days. Histological and electron microscopic observation identified the same characteristics as those of the human ovarian carcinoma on chromsome pattern,CEA secretion and PS carcino-genesis studying. DNA content of the implanted tumor was measured by flow cy-tometer and microspectrophotometry. The DNA contents...

Tumor tissue of lymph node metastasis of human ovarian carcinoma was directly implanted into nude mice subcutaneously and 26 generations have been propagated successfully. The tumor doubling time was 7. 17 days. Histological and electron microscopic observation identified the same characteristics as those of the human ovarian carcinoma on chromsome pattern,CEA secretion and PS carcino-genesis studying. DNA content of the implanted tumor was measured by flow cy-tometer and microspectrophotometry. The DNA contents of the successive generations were similar to the first generation(DI 1. 05-1. 40). Using transplant tumor tissue,colony antibody to human ovarian carcinoma was made.

研究用1例人卵巢癌淋巴转移的癌组织直接移植于裸鼠皮下,建成一株人卵巢癌移植瘤动物模型,已传至第26代.移植成功率达100%,平均裸鼠带瘤存活中位数为102天.肿瘤倍增时间为7.17(SD=±1.02天).组织学和超微结构形态证实保持了原人肿瘤的特征,有淋巴结转移行为.人类肿瘤染色体特征.保留了分泌癌胚抗原的能力.具有P53癌基因蛋白的异常表达.移植瘤细胞可在体外培养并传至5代.流式细胞仪及显微分光光度计检测移植瘤,提示肿瘤为多倍体,各代移植瘤的DNA指数与第一代肿瘤基本一致(DI1.05~1.40).经初步应用研究,用传代移植瘤组织提取抗原免疫BALB/C小鼠,将免疫小鼠的脾细胞与小鼠缺欠型骨髓瘤系进行融合,制备了一株抗卵巢癌单克隆抗体,经免疫组化染色(ABC法)可显示有与人卵巢癌阳性反应.说明裸鼠人体卵巢癌模型的建立,为深入进行该类肿瘤诊断及治疗研究提供了有效途径.

 
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