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   肿瘤靶 的翻译结果: 查询用时:0.016秒
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肿瘤靶
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  tumor target
     Natural-killer activity Splenic cells in 615-strain mice was observed by the release test of ~(125)Ⅰ-udR labeled tumor target cell(mouse YAC-1 lymphoma) DNA.
     实验采用~(125)Ⅰ—udR标记肿瘤靶细胞(YAC—1小鼠淋巴瘤细胞)DNA释放试验,对615近交系小鼠脾细胞自然杀伤活性进行了观察。
短句来源
     Labelling of Tumor Target Cells with ~(125)I-UdR Isotope and its Application to Detection of LAK Cell Activity
     肿瘤靶细胞~(125)Ⅰ-UdR标记方法的建立及其在LAK活性测定中的应用
短句来源
     The results showed:1.PJV had no direct cytotoxicity on the YAC-1 tumor cells,but it could stimulate the mononuclear spleen cells to proliferate in the concentration of 3.9 to 62.5% μg/ml,and the proliferating cells had no killer activity on the tumor target cells.
     结果表明:1.PJV对YAC-1肿瘤靶细胞在3.9~62.5μg/ml浓度范围内对单个核脾细胞有明显的刺激增殖作用,此增殖细胞对肿瘤靶细胞无杀伤作用; 2.PJV在LAK细胞的诱导阶段可增加其诱导数量和增殖活性,提高杀伤活性,但PJV在LAK细胞杀伤阶段对其活性无影响;
短句来源
     CONCLUSION: The tissue distributions and pharmacokinetics characteristics of()~(99m)Tc-ASODN-EGF could fulfil the basic requirement of clinical imaging for opacification of tumor target gene.
     h-1。 结论:99mTc-ASODN-EGF的组织器官分布和药动学特性能满足临床显像的要求,可用于肿瘤靶基因的显像。
短句来源
     Object:to prepare Fe_3O_4 magnetic nanoparticles for tumor target therapy.
     目的:制备用于肿瘤靶向治疗的纳米级Fe3O4磁性粒子。
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  “肿瘤靶”译为未确定词的双语例句
     Survivin gene and its target therapy to tumor
     Survivin基因及其与肿瘤靶向治疗
短句来源
     HER2 and Tumor Targeting Therapy
     HER2分子与肿瘤靶向治疗
短句来源
     The prescription dosage of study group included GTV 60~62 Gy,CTV_1 56~58 Gy,CTV_2 50~54 Gy;
     计划性IMRT的处方剂量为:肿瘤靶区(GTV)60~62 Gy,高危临床靶区(CTV1)56~58 Gy,亚临床靶区(CTV2)50~54Gy。
短句来源
     The mean D_(90) to the tumor was 108.12 Gy(range 27-166 Gy),with 31.9 Gy(range 6.2-70.0 Gy) in 10 patients with spinal column or paraspriral lesions.
     ~(125)I粒子治疗90%肿瘤靶体积接受的最小剂量(D_(90))中位值为108.12Gy(27~166Gy),10例脊柱或椎旁肿瘤患者脊髓的中位D_(90)为31.9Gy(6.2~74.0Gy)。
短句来源
     The mean gross target volume (GTV) was 478.5? cm3 (30~2015?cm3).
     肿瘤靶体积为30~2015cm3(平均478.5cm3)。
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  相似匹配句对
     Target for tumor hypoxia
     肿瘤缺氧
短句来源
     Advances in targeting therapy of cancer
     肿瘤向治疗
短句来源
     Tumor lymphangiogenesis
     肿瘤淋巴管生成
短句来源
     malignant tumor group:I.
     肿瘤组 :I.
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  tumor target
It has been shown that lysis of tumor target cells caused by lymphokine-activated killers is possible both upon a direct contact and in the presence of isolated nongranular cytotoxic proteins.
      
CD161B: ClrB interactions mediate activation of enhanced lysis of tumor target cells following NK cell:DC co-culture
      
Co-culture of natural killer (NK) cells and dendritic cells (DCs) results in their reciprocal co-activation, and an enhancement of lysis of tumor target cells.
      
Cloning of CD4-8- peripheral blood lymphocytes, under limiting dilution conditions, revealed that they are homogeneously composed of cytolytic cells which efficiently lyse tumor target cells.
      
Disease-specific cytotoxicity (CTX) is defined as statistically significant and selective destruction of disease-related tumor target cells by the test lymphocytes in comparison with the baseline controls.
      
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Previous works from Herberman'sLab,and later from ours and otherLabs have shown that activated ma-crophages from tumor bearing micehave the ability to kill tumor cells andto suppress immune response in vitro.It has been considered that these cellsmay play an important role in thehost response against tumor cellsand may also impair the host immunefunction,leading eventually to hostdeath.Thus it would be interest toinvestigate the modulation of suppres-sor macrophages by reducing theirsuppressor activity but at...

Previous works from Herberman'sLab,and later from ours and otherLabs have shown that activated ma-crophages from tumor bearing micehave the ability to kill tumor cells andto suppress immune response in vitro.It has been considered that these cellsmay play an important role in thehost response against tumor cellsand may also impair the host immunefunction,leading eventually to hostdeath.Thus it would be interest toinvestigate the modulation of suppres-sor macrophages by reducing theirsuppressor activity but at the same timeretaining their antitumor function.The ??present experiments were carried out towhether "activated" mouse peritonealmacrophages can be modulated byimmunomodulating agent,like lipo-polysaccharide(LPS),and if so,whetherthis modulation leads to any changes inthe anti-tumor function and suppressoractivity. Balb/c mouse peritoneal adherentmacrophages which were elicited byip injection 3—4 days earlier with 1 mlof 10% thioglycollatewere plated inPetri dishes(10mm)in 10 ml of 5%FCS-RPMI 1640 basic medium withor without 10 μg LPS/ml.After in-cubation at 37℃ 5% GO_2 for 18 hr,the medium was removed and washedtwice.These adherent cells weredetached in cold condition and themacrophage purity was greater than90% as assessed by morphology. MBL-2,a Moloney virus-inducedlymphoma from C57BL/6 mice wasused as the target of macrophages inthe cytostasis assay.YAC-1,a Mo-loney virus-induced lymphoma of A/Snorigin was used as the target of naturalkiller(NK)and/or natural cytotoxic(NC)cells.Both cell lines were ob-tained from Dr.R.B.Herberman'sLab(NCI,NIH,USA). Assay for suppression of NK and/orNG cells:The inhibition of NK andNG cells mediated cytotoxicity was mea-sured in a 42 hr ~(125)IUdR releaseassay in the presence and absence ofmacrophages.Assay for suppression oflymphoproliferation:Balb/c mousesplenic lymphocytes were stimulatedwith T、B lymphocyte mitogens in thepresence and absence of macrophages.After incubation for 48 hr at 37℃ 5%CO_2,each well received 0.1 μci of~(125)IUdR and microculture plates wereincubated for another 18 hr before thecells were harvested and assessed for thelevel of isotope incorporation.Assayfor cytostasis:Macrophages to be as-sayed and MBL-2 tumor cells weremixed at ratios between 20:1 and 5:1,and incubated for 48 hr in microculturewells.0.1 μci of ~(125)IUdR was addedto the cells for the last 2—4 hr of theincubation and the amount of isotopeincorporated into the tumor cells wasdetermined. The experimental results weresummarized as follows. Mouse peritoneal activative adher-ent macrophages which were elicited bythe injection of thioglycollate exhibitedstrong immune suppressor activity,asindicated by their ability to inhibitsplenic NK and/or NC cell activity andthe proliferation of splenic lymphocytesin response to the stimulation inducedby ConA,PHA,PWM and LPS.Thesesuppressor functions can be modulated(depressed)in vitro by the treatmentof these activated macrophages withhigh dose LPS(10μg/ml)(Fig.1,Table1).In contrast,the same treatment re-tained the cytostatic action of thesemacrophages against tumor cells(Table ??2.),indicating a major dissociationbetween the regulation of suppressorand cytostatic activities of macrophages.Indomethacin,an inhibitor of prostag-landin syntyetase,could not relieve orreduce the observed suppression(Table ??3 and 4).The overall result of ourpresent experiments is shown in table 5.It is suggested that in our system,macrophage population which regulatesthe immune suppressor responsivenessmay be a kind of indoimethacin-insensitive activated macrophage.Fur-ther studies to elucidate the possiblemechanism of action of such modulatedmacrophages seem warranted.

巯基乙酸盐(Thioglycollate)诱发的小鼠腹腔激活巨噬细胞显示了天然的抑制活性,即对Con A,PHA,PWM和LPS致分裂原诱导的T,B淋巴细胞的增殖能产生显著的抑制效应,同时也能抑制脾脏NK细胞对YAC-1肿瘤靶细胞的杀伤功能。但是这些巨噬细胞却同时具有明显的抗肿瘤的细胞静止效应。在体外用脂多糖(LPS,10微克/毫升)处理粘附性激活巨噬细胞明显地降低了对NK活性和T,B淋巴细胞增殖功能的抑制,然而这些免疫调变巨噬细胞仍然保持了显著的抗肿瘤的细胞静止效应。实验还表明,这类激活巨噬细胞的抑制功能不为前列腺素合成酶的抑制剂In-dom所阻断,从而提示了它们的免疫抑制效应似乎不是前列腺素介导的。本实验结果提示,体外用脂多糖处理后的免疫调变巨噬细胞是一类具有抗肿瘤功能和低免疫抑制性的巨噬细胞亚群,这为进一步研究它们的产生以及作用机理准备了条件。

This study was aimed at looking

人体单核-巨噬细胞通过塑料培皿粘附技术从外周血单个核细胞(PBMNC)中分离,并在体外短期培养。培养8天后,这些细胞已发生形态和功能上的分化,成为成熟的巨噬细胞。培养8天的巨噬细胞和PBMNC的比例为2:1和1:1时能引起NK活性的显著抑制。本实验应用4小时~(51)Cr释放试验来测定NK细胞对K562肿瘤细胞的细胞毒性。然而,培养1天的粘附性单核细胞不能观察到对NK活性的抑制。这提示,巨噬细胞对NK活性的抑制与体外分化、成熟、激活有关。培养1天和8天的单核-巨噬细胞对肿瘤靶细胞MBL-2和EAC都有很强的细胞静止效应。应用免疫调变剂脂多糖(LPS)体外处理粘附性单核细胞或巨噬细胞,仅培养8天的巨噬细胞能显著增强NK活性,而培养1天的单核细胞不能引起这种功能。这表明,免疫调变效应的诱导期发生在细胞明显增大的巨噬细胞形成期。与此同时,免疫调变巨噬细胞增强了IL-1的分泌和保持了抗肿瘤功能,从而证明,培养8天的巨噬细胞其抗肿瘤和免疫调节两类功能是可以分离的。本实验应用免疫调变剂寻找到既抗肿瘤又增强NK活性的人体新表型的巨噬细胞亚群。进一步支持了先前在小鼠激活的腹腔巨噬细胞免疫调变研究中的观察。

The NK cell activities in peripheral bloodof 93 patients with NPC and 83 normal subjects were examined by 51Cr release assay. The serum EB VCA-IgA antibody titers of 31 patients with NPC were simultaneously tested. The resultsindicated that there was no significant difference of NK cell activity level between the patient group and normal group. No difference was observed among the NPC patients at various TNM stages. The NK cell activity levelofthe patients with matastatic tumor was not lower than that of the...

The NK cell activities in peripheral bloodof 93 patients with NPC and 83 normal subjects were examined by 51Cr release assay. The serum EB VCA-IgA antibody titers of 31 patients with NPC were simultaneously tested. The resultsindicated that there was no significant difference of NK cell activity level between the patient group and normal group. No difference was observed among the NPC patients at various TNM stages. The NK cell activity levelofthe patients with matastatic tumor was not lower than that of the patient s withont matastatic tumor. There existed a posi -tivecorrelation between the NK cell activity levels andthe correspoding ser-um EB VCA-IgA antibody titers of the patients with NPC.These results supported the supposition that the. infect ion of EBV might enhance the NK cell activity of the patients with NPC.

用~(51)Cr释放试验检测93例鼻咽癌病人和83例正常人外周血自然杀伤细胞活性,其裂解K_(562)肿瘤靶细胞率分别为58±18.0%和54.0±12.8%。两组间没有明显差异。31例鼻咽癌病人同时检测了血清EB病毒VCA—IgA抗体滴度,分析了病期、肿瘤转移和EB病毒VCA—IgA抗体滴度与病人NK细胞活性的关系。结果表明。病期和肿瘤转移对鼻咽癌病人的NK细胞活性和EB病毒VCA—IgA抗体滴度之间有正相关关系。本文结果支持EB病毒感染可以提高病人NK细胞活性的推测。

 
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