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晚发型阿尔茨海默病
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  late-onset alzheimer ' s disease
     Correlation between the Promoter Polymorphism of Fibroblast Growth Factor 1 gene and Late-onset Alzheimer's Disease
     成纤维细胞生长因子1基因启动子多态性与晚发型阿尔茨海默病的相关性研究
短句来源
     ObjectiveTo evaluate the correlation between the promoter polymorphism of Fibroblast Growth Factor 1 (FGF-1) and late-onset Alzheimer's disease (LOAD).
     目的探讨成纤维细胞生长因子1(FGF-1)基因启动子多态性是否与晚发型阿尔茨海默病(LOAD)相关。
短句来源
  “晚发型阿尔茨海默病”译为未确定词的双语例句
     Trend of research on late onset Alzheimer disease and alpha 2-macroglobulin
     晚发型阿尔茨海默病与α2巨球蛋白的研究动态(英文)
短句来源
     AIM:To investigate the relationship between Alzheimer disease(AD) and alpha 2 macroglobulin(α2M) initially so as to provide evidence for the pathogenesis of late onset AD.
     目的:初步探讨晚发型阿尔茨海默病(Alzheimerdisease,AD)与α2巨球蛋白的关系,为晚发型AD发病机制提供依据。
短句来源
     Objective It was our aim to study the association between late-onset Alzheimer’s disease (LOAD) and the polymorphisms of microsatellite repeat on 10q24. Methods By using case-control method we examined microsatellite repeat polymorphisms of D10S583 marker and apolipoprotein E (APOE) gene in an ethnically homogeneous Japanese population of 82 LOAD patients and control of 168 healthy subjects.
     目的研究染色体10q24微卫星重复序列多态性与晚发型阿尔茨海默病(late-onsetAlzheimer’sdisease,LOAD)的相关性。 方法我们采用病例一对照方法研究染色体10q24区域微卫星重复序列的多态性、载脂蛋白E(APOE)基因多态性与LOAD相关性,病例组82人,健康对照组168人。
短句来源
  相似匹配句对
     Trend of research on late onset Alzheimer disease and alpha 2-macroglobulin
     发型阿尔茨海默与α2巨球蛋白的研究动态(英文)
短句来源
     An investigation of the rehabilitation efficacy in Alzheimer's disease
     阿尔茨海默的康复治疗
短句来源
     Amyloid-β immunotherapy for Alzheimer's disease
     阿尔茨海默的免疫治疗
短句来源
     Correlation between the Promoter Polymorphism of Fibroblast Growth Factor 1 gene and Late-onset Alzheimer's Disease
     成纤维细胞生长因子1基因启动子多态性与发型阿尔茨海默的相关性研究
短句来源
     Report of a case of Hallervorden-Spatz disease
     发型Hallervorden-Spatz(附尸检报告)
短句来源
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  late-onset alzheimer ' s disease
We have previously demonstrated with MRI that as well as marked white matter involvement in late-onset Alzheimer's disease (AD), atrophy of the corpus callosum may also be present.
      
Variable expression of presenilin 1 is not a major determinant of risk for late-onset Alzheimer's Disease
      
For late-onset Alzheimer's disease (LOAD), numerous studies have reported inconsistent associations with a PSEN1 intronic polymorphism.
      
Complement Factor H Y402H Polymorphism is not Associated with Late-onset Alzheimer's Disease
      
We have genotyped the common complement factor H Y402H polymorphism in a large case-control cohort to investigate association with late-onset Alzheimer's disease susceptibility and find no evidence that this SNP is associated with disease risk.
      
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AIM:To investigate the relationship between Alzheimer disease(AD) and alpha 2 macroglobulin(α2M) initially so as to provide evidence for the pathogenesis of late onset AD. METHODS:The significance of α2M in the late onset AD was revealed through pathology of α2M in AD and the polymorphism of α2M in AD patients. RESULTS:The association between AD and α2M region on the twelfth chromatosome was analyzed with the genic linkage, and pathological symptom of α2M in AD patients was supported by many evidences....

AIM:To investigate the relationship between Alzheimer disease(AD) and alpha 2 macroglobulin(α2M) initially so as to provide evidence for the pathogenesis of late onset AD. METHODS:The significance of α2M in the late onset AD was revealed through pathology of α2M in AD and the polymorphism of α2M in AD patients. RESULTS:The association between AD and α2M region on the twelfth chromatosome was analyzed with the genic linkage, and pathological symptom of α2M in AD patients was supported by many evidences. Two polymorphism sites of α2M were located on the 12P12-13,which could increase more risks to AD patients. CONCLUSION:It is significant to investigate the frequency, mutation, polymorphism and expression of gene α2M for the pathogenesis of late onset AD and its genic diagnosis.

目的:初步探讨晚发型阿尔茨海默病(Alzheimerdisease,AD)与α2巨球蛋白的关系,为晚发型AD发病机制提供依据。方法:通过α2巨球蛋白在AD病理中的表现和AD患者中α2巨球蛋白的多态性,揭示α2巨球蛋白在晚发型AD中的意义。结果:AD与12号染色体上α2M区的关联是通过基因连锁分析得到的,有大量的数据支持α2巨球蛋白基因在AD患者病理中的表现。在12P12-13位置上有两个α2巨球蛋白多态性位点,可增加AD的患病危险性。结论:研究α2巨球蛋白基因的频率、突变、多态性或表达对晚发型AD的发病机制和基因诊断有重要意义。

ObjectiveTo evaluate the correlation between the promoter polymorphism of Fibroblast Growth Factor 1 (FGF-1) and late-onset Alzheimer's disease (LOAD). MethodsClinic pathological data from 206 autopsies were analyzed, including 100 autopsy-confirmed LOAD patients and 106 age-matched non-demented controls. PCR-RFLP (Restriction fragment length polymorphism) approach was used to determine the genotype of the promoter polymorphism of FGF-1 gene. ResultsThe genotyping frequencies of the promoter polymorphism (-1385...

ObjectiveTo evaluate the correlation between the promoter polymorphism of Fibroblast Growth Factor 1 (FGF-1) and late-onset Alzheimer's disease (LOAD). MethodsClinic pathological data from 206 autopsies were analyzed, including 100 autopsy-confirmed LOAD patients and 106 age-matched non-demented controls. PCR-RFLP (Restriction fragment length polymorphism) approach was used to determine the genotype of the promoter polymorphism of FGF-1 gene. ResultsThe genotyping frequencies of the promoter polymorphism (-1385 A/G) were AA 20 (10%), GA 89 (43%), GG 97 (47%), respectively. There was significant (P=0.027) difference of genotyping frequencies between the cases and controls; GG genotype was positively associated with LOAD (odds ratio=2.02, 95%CI:1.16~3.52). ConclusionThe promoter polymorphism (-1385 A/G) of FGF-1 gene was associated with LOAD.

目的探讨成纤维细胞生长因子1(FGF-1)基因启动子多态性是否与晚发型阿尔茨海默病(LOAD)相关。方法收集206例尸体检查的样本,包括100例LOAD和年龄匹配的对照组106例。PCRRFLP(Restrictionfragmentlengthpolymorphism)法分析FGF1基因启动子(-1385A/G)的基因型。结果FGF1基因启动子(-1385A/G)的基因型频率分布是:AA型20例(10%),GA型89例(43%),GG型97例(47%),在LOAD组和对照组之间,不同基因型频率分布有显著性差异(P=0.027);GG基因型与LOAD呈正相关(oddsratio=2.02,95%CI:1.16~3.52)。结论FGF1基因启动子(-1385A/G)多态性与LOAD显著相关。

Objective It was our aim to study the association between late-onset Alzheimer’s disease (LOAD) and the polymorphisms of microsatellite repeat on 10q24. Methods By using case-control method we examined microsatellite repeat polymorphisms of D10S583 marker and apolipoprotein E (APOE) gene in an ethnically homogeneous Japanese population of 82 LOAD patients and control of 168 healthy subjects. Results The frequency of D10S583 199bp allele carriers in cases and control is 31.0% (53/171), 12.2% (10/82)respectively,...

Objective It was our aim to study the association between late-onset Alzheimer’s disease (LOAD) and the polymorphisms of microsatellite repeat on 10q24. Methods By using case-control method we examined microsatellite repeat polymorphisms of D10S583 marker and apolipoprotein E (APOE) gene in an ethnically homogeneous Japanese population of 82 LOAD patients and control of 168 healthy subjects. Results The frequency of D10S583 199bp allele carriers in cases and control is 31.0% (53/171), 12.2% (10/82)respectively, and there is a significant difference (χ2=10.8,P = 0.001, RR=0.30, 95%CI=0.15~0.64); The frequency of APOEε4 allele carriers in cases and control is 52.4%(43/82) and 16.1%(27/168), respectively, and there is also a significant difference (χ2= 36.2, P <0.0001, RR=5.76, 95%CI=3.17~10.47). Conclusions These data indicated that the frequency of D10S583 199bp allele is negatively associated with LOAD, and the effect of APOEε4 allele is inverse. The presumption is supported, in which there is a candidate gene for LOAD in this region of chromosome 10.

目的研究染色体10q24微卫星重复序列多态性与晚发型阿尔茨海默病(late-onsetAlzheimer’sdisease,LOAD)的相关性。方法我们采用病例一对照方法研究染色体10q24区域微卫星重复序列的多态性、载脂蛋白E(APOE)基因多态性与LOAD相关性,病例组82人,健康对照组168人。结果在LOAD病例组和正常对照组中D10S583微卫星重复序列等位基因199bp携带者的频率分别是31.0%(53/171)和12.2%(10/82),其差别有显著性(χ2=10.8,P=0.001,RR=0.30,95%CI=0.15~0.64);APOEε4携带者的频率在LOAD组中是52.4%(43/82),对照组16.1%(27/168),其差别有显著性(χ2=36.2,P<0.0001,RR=5.76,95%CI=3.17~10.47)。结论D10S583重复序列等位基因199bp的频率与LOAD呈负相关,而APOEε4携带者的频率与LOAD呈正相关,这个结果支持在10q24区域有LOAD候选相关基因的论点。

 
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