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钙感觉
相关语句
  calcium-sensing
     Association of Polymorphisms in Calcium-sensing Receptor Gene A986S with Bone Mineral Density in Male Chinese
     钙感觉受体基因A986S多态性与中国男性骨密度相关性研究
短句来源
     Association study of two new polymorphisms in calcium-sensing receptor gene and bone mineral density in chinese men
     两个新的钙感觉受体基因多态性与中国男性骨密度相关性研究
短句来源
     Objective: To investigate the Association of A986S Polymorphism of the Calcium-sensing Receptor Gene with Bone Mineral Density (BMD) in male Chinese.
     目的:研究钙感觉受体(CaSR)基因A986S位点多态性与中国男性骨密度 (BMD)的关系。
短句来源
     Objective To investigate the association of two new sites polymorphism of calcium-sensing receptor gene and bone mineral density (BMD) in chinese men.
     目的研究钙感觉受体(CaSR)基因两个新位点多态性与中国男性骨密度的关系。
短句来源
     Association between two new single-nucleotide polymorphisms in calcium-sensing receptor gene and bone mineral density in Chinese women
     两个新钙感觉受体基因多态性与中国女性骨密度相关性研究
短句来源
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  相似匹配句对
     The Feeling of Love
     爱的感觉
短句来源
     Impressions on USA
     感觉美国
短句来源
     calcium channel block drug
     通道阻滞剂
短句来源
     However, the calcium and iron intake were in lower quality.
     、铁质量不高。
短句来源
     Association study of two new polymorphisms in calcium-sensing receptor gene and bone mineral density in chinese men
     两个新的感觉受体基因多态性与中国男性骨密度相关性研究
短句来源
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  calcium-sensing
Possible participation of an islet B-cell calcium-sensing receptor in insulin release
      
The calcium-sensing receptor gene was recently shown to be expressed in rat pancreatic islets and purified islet B-cells.
      
It is speculated that a negative insulinotropic action mediated by the calcium-sensing receptor, and possibly attributable to a fall in cytosolic Ca2+ concentration, may prevent excessive insulin secretion in pathological situations of hypercalcemia.
      
Missense mutations in the calcium-sensing receptor (CaSR) gene have previously been identified in patients with familial hypocalciuric hypercalcemia (FHH) and neonatal severe hyperparathyroidism.
      
Mutation of the calcium-sensing receptor gene has been identified to be thegenetic trigger of neonatal severe hyperparathyroidism and familial hypocalciuric hypercalcemia.
      
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Objective: To investigate the Association of A986S Polymorphism of the Calcium-sensing Receptor Gene with Bone Mineral Density (BMD) in male Chinese. Methods: The bone mineral density of lumbar vertebrae (L2-4) and femur was measured by dual-energy X-ray absorptiometry in 374 subjects. PCR-restriction fragment length polymorphism (PCR-RFLP) was utilized to examine the A986S polymorphism of the CaSR gene. Generalized linear model was used to analyze the association of A986S polymorphism with the bone mineral...

Objective: To investigate the Association of A986S Polymorphism of the Calcium-sensing Receptor Gene with Bone Mineral Density (BMD) in male Chinese. Methods: The bone mineral density of lumbar vertebrae (L2-4) and femur was measured by dual-energy X-ray absorptiometry in 374 subjects. PCR-restriction fragment length polymorphism (PCR-RFLP) was utilized to examine the A986S polymorphism of the CaSR gene. Generalized linear model was used to analyze the association of A986S polymorphism with the bone mineral density of the lumbar vertebrae (L2-4) and femur. Results: Before and after adjustment of environmental covariates, no significant correlation was found between A986S polymorphism of the CaSR gene and BMD, including femoral neck BMD, Ward triangle BMD and femoral shaft BMD. Conclusion: The results suggest that there is no significant relationship between A986S polymorphisms of CaSR gene and femoral BMD and lumbar vertebrae BMD in Chinese male population.

目的:研究钙感觉受体(CaSR)基因A986S位点多态性与中国男性骨密度 (BMD)的关系。方法:采用双能X线吸收仪对 374名研究对象进行腰椎及股骨扫描,应用PCR-限制性片段长度多态性 (PCR-RFLP)方法检测CaSR基因A986S位点多态性基因型,用广义线性模型分析A986S多态性与腰椎 2 ~4及股骨骨密度关系。结果:在调整环境危险因素前后,均未发现CaSR基因的A986S位点多态性与男性股骨颈、股骨柄和股骨三角区及腰椎 2~4的骨密度呈相关性。结论:在中国男性人群中CaSR基因A986S多态性与股骨及腰椎骨密度无显著性相关。

Objective To investigate the association of two new sites polymorphism of calcium-sensing receptor gene and bone mineral density (BMD) in chinese men. Methods The bone mineral density of lumbar spine (L2-4) and femur bone was measured by dual-energy X-ray absorptiometry in 374 study subjects. PCR-restriction fragment length polymorphism (PCR-RFLP) was applied to examine R990G and E1011Q two sites polymorphism of the CaSR gene. Generalized linear model was used to analysis the association of this polymorphism...

Objective To investigate the association of two new sites polymorphism of calcium-sensing receptor gene and bone mineral density (BMD) in chinese men. Methods The bone mineral density of lumbar spine (L2-4) and femur bone was measured by dual-energy X-ray absorptiometry in 374 study subjects. PCR-restriction fragment length polymorphism (PCR-RFLP) was applied to examine R990G and E1011Q two sites polymorphism of the CaSR gene. Generalized linear model was used to analysis the association of this polymorphism and the bone mineral density of the lumbar spine (L2-4) and femur. Results Without or with adjustment for environmental covariates, no significant correlation was found between the two sites of the CaSR gene and BMD, including femoral neck BMD, ward triangle BMD and Femoral shaft BMD. Conclusions There are no significant relationship between R990G and E1011Q polymorphisms of CaSR gene and femoral BMD and lumbar spine BMD in Chinese men population.

目的研究钙感觉受体(CaSR)基因两个新位点多态性与中国男性骨密度的关系。方法采用双能X线吸收仪对374名研究对象进行腰椎及股骨扫描,应用PCRRFLP方法检测CaSR基因R990G和E1011Q两个多态位点基因型,用广义线性模型分析CaSR基因多态性与第2~4腰椎及股骨骨密度关系。结果在调整环境危险因素前后,均未发现CaSR基因的两个位点多态性与男性股骨颈、股骨柄和股骨三角区及第2~4腰椎的骨密度相关。结论在中国男性人群中CaSR基因R990G和E1011Q位点多态性与股骨及腰椎骨密度无显著性相关。

Objective To investigate the association between two new sites of gene polymorphisms of calcium-sensing receptor and bone mineral density(BMD) in Chinese women.Methods The bone mineral density was measured at the lumbar spine(L2-4) and femur using dual-energy X-ray absorptiometry in 352 Chinese women.PCR-restriction fragment length polymporphisms (PCR-RELP) was used to examined R990G,E1011Q,two new sites polmyorphisms of the CaSR gene.Generalized linear model was used to analyze the association of CaSR gene...

Objective To investigate the association between two new sites of gene polymorphisms of calcium-sensing receptor and bone mineral density(BMD) in Chinese women.Methods The bone mineral density was measured at the lumbar spine(L2-4) and femur using dual-energy X-ray absorptiometry in 352 Chinese women.PCR-restriction fragment length polymporphisms (PCR-RELP) was used to examined R990G,E1011Q,two new sites polmyorphisms of the CaSR gene.Generalized linear model was used to analyze the association of CaSR gene and the BMD.Results Significant correlation was found between E1011Q and femoral neck BMD,ward triangle BMD and femoral shaft BMD with or without adjustment of other factors(P=0.011,0.04 and <0.001,respectively);The relation ship was showed between R990G and BMD of femoral neck,before and after adjusting for other factors(P=0.055),but no relationship was found between A986S and BMD of the lumbar spine(L2-4) and femur.Conclusions The E1011Q of the CaSR gene might be a risk factor for low bone density of femur in Chinese women.Further studies including larger population are required.

目的钙感觉受体(CaSR)基因是引人关注的与骨质疏松症敏感性相关的侯选基因,为了解CaSR基因两个新多态位点与中国女性人群骨密度(BMD)的关系。方法采用双能X线吸收仪对352名研究对象进行腰椎及股骨扫描,应用PCR限制性片段长度多态性(PCRRFLP)方法检测CaSR基因R990G和E1011Q两个新多态位点基因型,用广义线性模型分析CaSR基因与腰椎及股骨BMD关系。结果发现CaSR基因的E1011Q多态位点在调整相关影响因素前后均与女性股骨颈、股骨柄和股骨三角区的BMD呈显著相关,P值分别为0.011、0.04和<0.001;R990G多态位点在调整影响因素前后,显示与女性股骨颈密度有相关趋势P=0.055,而A986S基因多态未显示与股骨、腰椎BMD相关。结论这一结果提示,CaSR基因E1011Q多态性可能是中国女性股骨BMD降低的危险因素。这个发现的意义及是否适用于大样本人群还有待进一步研究证实。

 
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