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平均累积排泄
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  cumulative excretion
     Gambogic acid was mainly excreted through bile and the percentage of the corresponding cumulative excretion was found to be about 36.5% within 16 h.
     静注给药后藤黄酸主要通过胆汁排泄,给药后16 h内藤黄酸在胆汁中的平均累积排泄百分率为36.5%;
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  “平均累积排泄”译为未确定词的双语例句
     The average cumulative excretory rates of original drug were 4.52%,7.73% and 3.28% respectively from 0h to 24h under the administration of 100 mg,200 mg and 400 mg.
     给予法罗培南在100、200、400mg的剂量,受试者尿中0~24h原形药物的平均累积排泄率分别为4.52%、7.73%和3.28%。
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  相似匹配句对
     The 24-h cumulative urinary excretion rate was (88±5)% .
     24h内平均尿累积排泄百分率为(88±5)%.
短句来源
     kg-1. The excreted percentage through feces is 26 .29 %, while through urine is 4.93%. The total amount is 31.22% after 48h of oral administration of Dau.
     48h尿粪累积排泄31.22%。
短句来源
     Results: The dissolution of ciprofloxacin was 99% within 12h.
     结果在12h平均累积释放99%;
     For a sample of 38 sources we derive an average value of
     平均结果为
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     A Mean Cumulative Dominance Method for Priorities in AHP
     一种具有平均累积优势度的排序方法
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  cumulative excretion
The 24-h-cumulative excretion of 363?μg 5cx-MEPP, 353?μg 5OH-MEHP, 309?μg 5oxo-MEHP, 178?μg MEHP and 133?μg 2cx-MMHP indicates an absolute exposure of our volunteer of about 2.6?mg DEHP.
      
In some volunteers urinary excretion of unchanged heptabarbital was measured; cumulative excretion amounted to 0.16 - 0.30% of the administered dose.
      
Cumulative excretion in urine was 67-79% of the dose during 31-37 hrs in 6 subjects; one patient with renal disease was found to excrete only 25.8% of dose during 24 hours.
      
The cumulative excretion of radioactivity in bile amounted to 9.5% of the dose in 4 days.
      
In all the individual patients an approximately linear relationship with wide variation in the slope was found between the cumulative excretion of furosemide and sodium from 0-30 min to 0-60 and to 0-120 min.
      
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AIM:To study the pharmacokinetics of gambogic acid in rats.METHODS:Following i.v. administration,HPLC was used to determine gambogic acid concentration in the rat plasma,tissues,bile,feces and urine.RESULTS:Mean elimination half life time(t_(1/2)) of gambogic acid in rats plasma was about 15 min.The relationship between dose and AUC showed excellent linearity,suggesting that there was linear disposition of gambogic acid in rats in the dose range.Following i.v. administration to rat,gambogic acid mainly distributed...

AIM:To study the pharmacokinetics of gambogic acid in rats.METHODS:Following i.v. administration,HPLC was used to determine gambogic acid concentration in the rat plasma,tissues,bile,feces and urine.RESULTS:Mean elimination half life time(t_(1/2)) of gambogic acid in rats plasma was about 15 min.The relationship between dose and AUC showed excellent linearity,suggesting that there was linear disposition of gambogic acid in rats in the dose range.Following i.v. administration to rat,gambogic acid mainly distributed in the organs such as liver,lung,spleen,kidney,stomach,intestine and heart.Gambogic acid was mainly excreted through bile and the percentage of the corresponding cumulative excretion was found to be about 36.5% within 16 h.In addition,only traces appeared in the feces,and no gambogic acid was detected in the urine.There were four metabolites isolated from the rat bile.Moreover,the mean plasma protein bound fraction of gambogic acid was (31.1%.)CONCLUSION:Gambogic acid was rapidly eliminated from the rat plasma, extensively distributed and metabolized in rats after i.v. administration.Following i.v. administration,gambogic acid was mainly excreted in the bile in both parent and metabolite forms.

目的:研究藤黄酸在大鼠体内的药代动力学。方法:大鼠静注单剂量藤黄酸后,采用HPLC法测定大鼠血浆、组织、粪便、胆汁及尿液中的藤黄酸。结果:藤黄酸在大鼠体内的平均消除半衰期仅为15 min。AUC与剂量呈现良好的线性相关性,提示藤黄酸在大鼠体内的处置属于线性动力学。静注给药后藤黄酸主要分布于肝、肺、脾、肾、胃、肠和心脏。静注给药后藤黄酸主要通过胆汁排泄,给药后16 h内藤黄酸在胆汁中的平均累积排泄百分率为36.5%;粪便中仅有少量的藤黄酸排出,其平均累积排泄百分率为1.04%;尿液中未检测到藤黄酸。在大鼠的胆汁中检测到藤黄酸的4个代谢物。藤黄酸平均血浆蛋白结合率为31.1%。结论:静注给药后,藤黄酸迅速从大鼠体内消除,并可在体内广泛分布和代谢,主要以原型和代谢物的形式从胆汁排泄。

AimTo study the endosomatic pharmacokinetics of faropenem tablets in healthy adults and assess the effect of food on pharmacokinetics. Methods The single dose study was a parallel design with three groups receiving different doses.The study of food effect on pharmacokinetics was conducted according to an open, randomized, 2-period crossover design. The blood samples were determined by LC/MS/MS after pretreatment. Results Linear pharmacokinetics of faropenem in healthy Chinese volunteers was observed when administered...

AimTo study the endosomatic pharmacokinetics of faropenem tablets in healthy adults and assess the effect of food on pharmacokinetics. Methods The single dose study was a parallel design with three groups receiving different doses.The study of food effect on pharmacokinetics was conducted according to an open, randomized, 2-period crossover design. The blood samples were determined by LC/MS/MS after pretreatment. Results Linear pharmacokinetics of faropenem in healthy Chinese volunteers was observed when administered of 100~400mg faropenem. Food affects Tmax and C_ max of faropenem but there are no significant differences between other pharmacokinetic parameters. The average cumulative excretory rates of original drug were 4.52%,7.73% and 3.28% respectively from 0h to 24h under the administration of 100 mg,200 mg and 400 mg. Conclusion The reliable, simple and sensitive LC/MS/ MS method was ideal for evaluating the pharmacokinetics of faropenem.

目的研究法罗培南钠片在健康人体内的药动学及饮食对药动学的影响。方法药动学试验:采用低、中、高三个剂量组的平行试验设计;饮食对人体药动学的影响试验:采用自身对照的双周期交叉试验设计。血浆样品处理后采用LC/MS/MS测定血药浓度。结果空腹po100、200、400mg法罗培南片,主要药动学参数AUC和Cmax随剂量呈线性相关。进餐后影响药物的Tmax和Cmax,其他药动学参数无变化。给予法罗培南在100、200、400mg的剂量,受试者尿中0~24h原形药物的平均累积排泄率分别为4.52%、7.73%和3.28%。结论LC/MS/MS方法操作简单,结果准确,专属性强,灵敏度高,适用于法罗培南人体药动学研究。

 
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