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下游基因
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  downstream target gene
     In this period, transcription of En-2, a downstream target gene of Wnt signal, increased evidenily.
     在此期间,Wnt下游基因En-2的表达量也有明显增加。
短句来源
  “下游基因”译为未确定词的双语例句
     Expression of proteins in p53 (p14~(ARF)-mdm2-p53-n21~(WAF/CIP1)) pathway and their significance in exocrine pancreatic carcinoma
     胰腺癌p53上下游基因mdm2、p21~(WAF/CIP1)以及p14~(ARF)蛋白的表达及相互关系
短句来源
     STAT5 Decoy ODNs had decreased the mRNA expression of cyclin D1 and c-myc by RT-PCR and the protein expression of cyclin D1 and c-myc by Western blotting.
     RT-PCR实验和Western blot实验证实Decoy ODNs作用引起STAT5下游基因cyclin D1和c-myc mRNA和蛋白表达下调。
短句来源
     It's known that p53 downstream genes in the regulatory region(promoter or intron) contain p53 consensus binding sequence,5' RRRCWWGYYYN(0-13) RRRCWWGYYY-3',R=G or A,W=T or A,Y=C or T,N=A,C,T,G.
     根据p53下游基因在其调节区域(启动子或内含子)含有与P53蛋白特异性结合的一致性序列5’? RRRCWWGYYYN(0-13)RRRCWWGYYY-3’,R=G或A,W=T或A,Y=C或T,N=A,C,T,G。
短句来源
     Decreased DNMT3B by RNAi Influences on the Expression of Its Downstream Genes and Cell Proliferation in HCC Cell Line, SMMC-7721
     用RNAi技术抑制肝癌细胞系SMMC-7721中DNMT3B对下游基因表达及细胞增殖的影响
短句来源
     Study on human P53 downstream genes' consensus sequences
     人类P53下游基因一致性序列研究
短句来源
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  相似匹配句对
     4 new genes were obtained.
     U基因
短句来源
     A transcription termination signal was found downstream of TCS gene.
     TCS基因下游为转录终止信号。
短句来源
     A couple of primers, the upstream and downstream primer of human angiogenin gene fragment(h-Angf) (# 1 ~ # 123 bp) were designed.
     方法:设计目的基因hAngf的上、下游引物。
短句来源
     Genetic Information Carrier Gene
     基因简史
短句来源
     Z is the difference between upsteam and downstream water surface;
     Z为上下游水位差;
短句来源
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  downstream target gene
A major BRCA1 downstream target gene is the DNA damage-responsive gene GADD45.
      
The transgenic plants also showed an increased expression of AtP5CS2, which was confirmed to be a downstream target gene of DREB in Arabidopsis.
      
We evaluated whether the gap junction protein Connexin43 (Cx43), an important regulator of osteoblast function and bone development, may be a downstream target gene regulated by Tbx2.
      
Previously, we demonstrated that HDAC inhibitors, such as sodium butyrate and trichostatin A (TSA), transcriptionally induce the cyclin-dependent kinase inhibitor p21WAF1/Cip1, a downstream target gene of p53, in a p53-independent manner.
      
Furthermore, we have recently shown that HDAC inhibitors activate Gadd45, another downstream target gene of p53, and p19INK4d, a gene functionally similar to p16INK4a.
      
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A plasmid carrying lambda PL promoter was constructed to efficiently express unfused human interferon αD in E.coli using TGATG site present in its signal sequence. This'translational coupling' initiation mode had been found to occur between two consecutive genes in trp operon and λ DNA sequence. The unfused human interferon aD expressed by pBV867 in E .coli ( BMH 71-18 ) was confirmed by the following evidences: First, the purified interferon showed a single band of 19.5 k in SDS-PAGE, the band of 27k representative...

A plasmid carrying lambda PL promoter was constructed to efficiently express unfused human interferon αD in E.coli using TGATG site present in its signal sequence. This'translational coupling' initiation mode had been found to occur between two consecutive genes in trp operon and λ DNA sequence. The unfused human interferon aD expressed by pBV867 in E .coli ( BMH 71-18 ) was confirmed by the following evidences: First, the purified interferon showed a single band of 19.5 k in SDS-PAGE, the band of 27k representative λN-human interferon aD fusion protein was not detected in SDS-PAGE) Second, the peak of interferon activity was focused on the band of 19.5 k protein; Third, the peak of absorbent titer of human leucocyte interferon antibody coincided with that of interferon activity; Finally, result obtained by N terminal sequencing of purified interferon demonstrated an unfused human interferon. It was also suggested that E .coli is able to process the signal sequence of human interferon aD.Study on the machanism of 'translational coupling' initiation mode of gene expression was carried out by construction of a series of hybrid plas-mids and titration of their interferon activities. Result indicated that the expression level by ATG-TGATG initiation mode was 10 times higher than that of the simple ATG mode. The distance between the two reading frames ranging from 12-39 amino acids did not markedly affect the expression level of interferon.

本文利用人αD型干扰素基因信号多肽编码区内自身的TGATG序列,在大肠杆菌中有效地表达非融合的人αD型干扰素。其根据是:第一,纯化干扰素的分子量为19.5k,而不是27k的融合蛋白;第二,干扰素活性峰的分布集中在19.5k附近;第三,干扰素抗体的吸收峰与其活性峰相一致;第四,纯化干扰素N端序列分析证明DNA水平设计的准确性。同时,还证明大肠杆菌能够识别并加工人αD型干扰素信号多肽。 在探讨TGATG序列对下游基因表达的影响时发现,“翻译联结”(ATG-TGATG)方式起始的基因表达水平比一般ATG起始方式高约10倍;而在ATG-TGATG起始方式中,第一和第二种读码框架之间的距离,即使相差27个氨基酸编码序列,后一种基因的表达水平也无明显差异。

By using flj B,flj A selecting system,we investigated the effects of the insertion of IS2 into certain genes and found that IS2 could be inserted into the gene from either the left side or the right side resulting in the loss of its activity and inhibition of the next gene's expression within the same transcripton. The polarities were different when IS_2 was inserted from the left side or the right side.The results from the artifical testing system were the same as those obtained from the natural state.

本研究利用f1jB、f1jA选择系统对IS_2进行研究发现,IS_2可以左、右两个方向插入某基因,插入后不仅使该基因失去活性,而且使同一转录子内下游基因的表达受到抑制。IS_2左右插入后的极性效应不同。在人工检测系统中得到的结果和自然状态的相同。

The widespread basal expression of fragile X gene (FMR 1)suggests that it is a house keeping gene,essential to the survival and function of the cells,but unrelated to proliferation and phenogenesis. The spatial temporal specific expression of FMR1 further suggests that it is an important development-regulating gene,essential to development,particularly to the development of CNS and reproductive system,and may play an important role in cell migration and differantiation.It may also be a posttranscription regulator,by...

The widespread basal expression of fragile X gene (FMR 1)suggests that it is a house keeping gene,essential to the survival and function of the cells,but unrelated to proliferation and phenogenesis. The spatial temporal specific expression of FMR1 further suggests that it is an important development-regulating gene,essential to development,particularly to the development of CNS and reproductive system,and may play an important role in cell migration and differantiation.It may also be a posttranscription regulator,by binding to mRNA,regulates the posttranscription processing,transportation,translation and localization of mRNAs.The diversity of pathogenesis of Fra (x) individuals may be caused by the variation of the downstream genes regulated by FMR1.

FMRl基因无时空特异性地表达提示它具有管家基因性质,其正常表达对于每个细胞发挥正常的功能都是必不可少的,而与增殖过程和表型发生过程无关。FMR1基因在某些组织的时空特异性表达又提示,它也是一种在发育过程起重要作用的调节基因,对于中枢神经系统、生殖系统及其它许多组织的正常发育是必不可少的,可能在细胞的迁移和分化过程中起重要的调控作用。FMR1基因表达一种定位于胞浆中的RNA结合蛋白FMRP。FMRP可能是一种转录后水平的调控因子,与胞浆中的mRNA结合,在mRNA的转录后加工、转运、翻译以及细胞内定位过程中起调控作用,能够特异性地调控多种下游基因,因而该基因的表达异常能够导致脆性X综合征所具有的广泛的病理学改变。

 
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