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myc基因
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  “—myc基因”译为未确定词的双语例句
     CHROMOSOIVIAL LOCALIZATION OF C-MYC GENE IN MAN
     C—myc基因在人类染色体上的定位
短句来源
     INHIBITION OF HUMAN LEUKEMIA c-myc GENE EXPRESSION BY ANTISENSE OLIGODEOXYNUCLEOTIDES
     反义核酸对人白血病HL—60细胞中c—myc基因表达的抑制
短句来源
     The low expression of c—sis and c—myc and high expression of P~(53) in contractive state cells (Smooth Muscle Cells) were detected.
     本研究发现收缩型平滑肌细胞内c—sis和c—myc基因表达低,P~(53)基因表达高;
短句来源
     Meanwhile, low expression of p~(53) and high expression of c—sis and c—myc were appeared in synthetic state.
     合成型平滑肌细胞c—sis和c—myc基因表达高,p~(53)基因表达低。
短句来源
     The percent of IL — 2R positive cells in activated lymphocytes from aged mice was
     由于c—fos,c—myc编码的蛋白对IL—2基因的转录具有调控作用,因此c—fos,c—myc基因表达的抑制可能和IL—2基
短句来源
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  相似匹配句对
     c myc and P53 may play a role in the transcriptive activation of hTERT gene in endometrial carcinoma.
     c myc基因、P
短句来源
     4 new genes were obtained.
     U基因
短句来源
     CHROMOSOIVIAL LOCALIZATION OF C-MYC GENE IN MAN
     Cmyc基因在人类染色体上的定位
短句来源
     STUDY ON REGULATION OF C-myc ONCOGENE EXPRESSION
     C-myc基因表达调控的研究
短句来源
     coli lac Z gene.
     colilacZ基因
短句来源
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  - myc gene
Silencing of c-myc gene expression using enzymatically and chemically synthesized siRNAs
      
The expression of c-myc gene was found pronouncedly reduced by Western blot analysis.
      
However, the inhibition of PTPase activity may block the induction oftnf-β gene and c-myc gene transcription by IL-2 and ultimately results in cell death.
      
HeLa cells overexpressing Bcl-2 partly resist As2O3 induced apoptosis, which might be relative to preventing the cells from As2O3 caused G2/M block, downregulation of c-myc gene expression and inhibition of viral gene expression was also noted.
      
CSF-1 can induce the c-myc gene expression via Ras and Ets-related proteins.
      
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A recently devised protocol was used to obtain macrophage (M) lines with a variety of derived DNA to see if different oncogenes would lead to generation of M lines with different phenotypes. SV 40 DNA, cellular myc genes, U 937 DNA and Insulin gene have been used and 7 cell lines obtained. All these lines show heterogeneity in the cell phenotype and in each case there are Macrophage-like cells. They all secrete collagenase and lysozyme. 30-40% of these lines have Fc receptor and Fc receptor mediated phagocytosis...

A recently devised protocol was used to obtain macrophage (M) lines with a variety of derived DNA to see if different oncogenes would lead to generation of M lines with different phenotypes. SV 40 DNA, cellular myc genes, U 937 DNA and Insulin gene have been used and 7 cell lines obtained. All these lines show heterogeneity in the cell phenotype and in each case there are Macrophage-like cells. They all secrete collagenase and lysozyme. 30-40% of these lines have Fc receptor and Fc receptor mediated phagocytosis and also complement receptor and phagocytosis. Heterogeneity within the lines is probably due to the fact that the lines are not cloned yet, It is supposed that this protocol can be used not only to derive M lines but also T and B cell lines.

本文报告应用转染技术建立巨噬细胞传代株,探讨应用不同来源的DNA获得具有不同功能特性的巨噬细胞株,应用SV40DNA、C-myc基因,U937DNA和胰岛素基因已获得7株细胞,经鉴定它们均有巨噬细胞的特性,即可分泌胶元酶、溶菌酶,其中有30—40%的细胞带有Fc受体,并有经Fc受体介导的吞噬功能。细胞株内细胞功能各异是因为细胞株尚未克隆化。从本试验结果看不仅经转染方法可获得巨噬细胞株,而且有可能经此法获得B或T淋巴细胞传代株。

Expression of seven oncogenes and their cha nges after induced differentiation in a HGPRT- human promyelocytic leukemia cell mutant (HL-60-AR) were studied by Northern blot and dot blot techniques. Results indicated that in HL-60-AR cells, the c-myc gene was highly expressed, while oncogenes of H-ras, fos, sis, abl and erb-B although expressed actively, yet lower than that of c-myc. The expression of K-ras gene, however, was weak or undetectable. When HL-60-AR cells were chemically induced to differentiate,...

Expression of seven oncogenes and their cha nges after induced differentiation in a HGPRT- human promyelocytic leukemia cell mutant (HL-60-AR) were studied by Northern blot and dot blot techniques. Results indicated that in HL-60-AR cells, the c-myc gene was highly expressed, while oncogenes of H-ras, fos, sis, abl and erb-B although expressed actively, yet lower than that of c-myc. The expression of K-ras gene, however, was weak or undetectable. When HL-60-AR cells were chemically induced to differentiate, the expression of c-myc was significantly decreased. Decrease in expression of H-ras, fos, sis, abl and erb-B oncogenes could also be observed, but without change of K-ras during cell differentiation. Our data also indicated that the decrease in c-myc gene expression after induced differentiation was not due to the decrease of number of c-myc gene copy, but mainly a transcriptional regulation pf c-myc.

用Northern杂交和斑点杂交方法分别探测HL-60-AR细胞中七种癌基因的表达及其在诱导分化后的变化。结果表明,在HL-60-AR细胞中c-myc基因高度活跃表达,H-ras基因次之,fos、sis、abl和erb-B基因表达微弱,而K-ras基因表达极微弱或检测不出。当HL-60-AR细胞被药物诱导成熟分化后,c-myc基因表达大为下降,H-ras、fos、sis、abl和erb-B基因表达亦相应降低,而K-ras的表达则无变化。对诱导分化前后c-myc基因拷贝数的比较分析表明,c-myc基因表达下降可能主要发生在基因的转录或/和转录后调节水平。

Expression of c-myc oncogene of myeloma cells and their changes after hybridization in homo-and hetero-cellular cybrid and hybrid were studied with Northern-blot and dot-blot techniques, using cloned c-myc gene as a probe. Results indicated that c-myc oncogene transcripts could not be detected in cybrids of mouse X mouse (BW-RM), mouse X rabbit (BW-RR) and human X mouse (HMy-RM) hybridization. However, weak transcription of this oncogene was shown to be active in cybrids after 15th passages with a tendency of...

Expression of c-myc oncogene of myeloma cells and their changes after hybridization in homo-and hetero-cellular cybrid and hybrid were studied with Northern-blot and dot-blot techniques, using cloned c-myc gene as a probe. Results indicated that c-myc oncogene transcripts could not be detected in cybrids of mouse X mouse (BW-RM), mouse X rabbit (BW-RR) and human X mouse (HMy-RM) hybridization. However, weak transcription of this oncogene was shown to be active in cybrids after 15th passages with a tendency of increasing expression activity noted during later subcultures. Similarly, no detectable c-myc gene transcript was seen in 4th and 7th subcultures of hetero-cellular hybrids (mouse plasmocytoma Sp 2/0 X rat erythroblasts, SP-ER), suggesting that "cy-toplasmic factor" of erythroid cells could inhibit or reduce expression of originally active c-myc, the inhibition being nonspecific in both cybrid and hybrid and reduction of expression of oncogene closely related to decrease or reversion of malignancy of tumor cells. Mechanisms of regulatory effects of erythroid cell cytoplasmic factors and molecular basis for oncogene repression in tumor cells were discussed.

本实验用Northern杂交方法,以c-myc癌基因为探针,对人和小鼠骨髓瘤细胞以及杂交后的同种和异种胞质体杂交细胞和异种杂交细胞进行了癌基因表达的核酸分子杂交分析。结果表明,在小鼠-小鼠,小鼠-兔及人-小鼠的胞质体杂交细胞(BW-RM,BW-RR,HMy-RM)中均未检测到myc癌基因的表达产物。但自15代以后开始出现微弱或可测的表达活性,并随传代而有上升的趋向。同样,在小鼠浆细胞瘤(Sp2/o)与大鼠有核红细胞(ER)的异种杂交中,杂交细胞(SpER)的第4代和第7代细胞中亦未检查到myc基因转录物。表明细胞杂交后,myc基因受到了抑制。这种抑制作用似无种属特异性。这一结果提示红系细胞内“胞质因子”对肿瘤细胞原来活化的myc基因具有抑制作用,并与杂交细胞的恶性下降有关。论文对胞质因子对癌基因表达的调控作用及其分子生物学机理进行了讨论。

 
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