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细胞周期增殖
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  cell proliferative cycle
     Conclusion (1) K ras gene activation and MTS1/p16 gene mutation/deletion lend to the lose of control of cell proliferative cycle, which is important in carcinoma development (2)The Homozygous deletion of extronl of MTSI/p16 gene in endometrial carcinoma is possibly one of the pathogenesis of p16 protein low expression;
     结论  (1)K ras基因激活与MTS1/ p16基因突变 /缺失导致细胞周期增殖失控 ,是内膜癌发生发展的一个重要环节 ; (2 )子宫内膜癌中p16基因外显子 1纯合子缺失可能是p16蛋白表达降低的机制之一 ;
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     Results indicated that MTS1/p16 gene mutation/deletion lend to the lose of control of cell proliferative cycle, which is important in carcinoma development.
     提示p16基因突变导致细胞周期增殖失控 ,是内膜癌发生发展的一个重要环节。
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     Conclusion (1) Ki\|ras gene activation lend to the lose of control of cell proliferative cycle. Which is improtant in carcinoma development;
     结论  1 .Ki- ras基因激活可导致细胞周期增殖失控 ,是内膜癌发生发展的一个重要环节 ;
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     Conclusions Ki - ras gene activation can result in uncontrol of the cell proliferative cycle, which is important to carcinoma development;
     结论:①Ki-ras基因激活可导致细胞周期增殖失控,是内膜癌发生发展的一个重要环节;
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  “细胞周期增殖”译为未确定词的双语例句
     Recent studies have revealed that uncontrolled cell cycle is very important to uncontrolled cell proliferation and carcinogenesis.
     近年研究表明,肿瘤是多因素、多阶段、多基因变化所致的细胞失控性生长的一类细胞周期性疾病,细胞周期失控是细胞周期增殖失控而导致癌变的重要原因。
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     c-myc is one of important factors in myc carcinoma gene family which is intensively related to growth, differentiation, apoptosis of cell and with the oncogenesis and progression of carcinoma.
     c-myc基因是myc癌基因家族中最重要的一员,它与细胞周期增殖、分化、凋亡以及肿瘤发生发展密切相关。
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     There was a statistical significance (t=206, P<005) between p27 expressions of chondromas and gradeⅠchondrosarcomas.
     p27是新近发现的CDKIs家族之一,在细胞周期增殖和分化调控中起非常重要作用。
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     Conclusion:NaPA could exert a marked inhibitory effect on cell proliferation and glioma malignancy becomes lower.
     结论:苯乙酸可阻抑细胞增殖周期,使细胞周期增殖循环中止于S期中DNA合成准备期S0期,DNA合成减少,抑制细胞增殖。
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     Objective:To observe the affect of morphine on proliferation of cyclic cells and IL 2R in mice, and effect of Ginseng SiWu decoction.
     目的:观察吗啡对胸腺细胞CD4,CD8细胞周期增殖、IL2的影响及人参四物汤对其调节作用。
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     The ALP granul es in the cells stained thicker and th e cells' proliferation cycle shortened.
     细胞增殖周期缩短。
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     The cycle of the adventitions buds multiplication is 35 days every time.
     增殖周期为 35
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     While cell proliferation is carried out through cell cycle.
     细胞增殖是通过细胞周期而实现的 .
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     however,CsA did not influence the proliferation of the MHCC97H cells.
     CsA对细胞周期增殖无影响。
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     rate of S period is rise inproliferation of cell period .
     细胞增殖周期中的S期细胞百分比升高。
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Purpose To investigate the practical significance of p27 expression in the diagnosis and prognostic assessment of chondrosarcomas. Methods p27 expressions were sutdied in paraffinembdded sections of the conventional chondrosarcoma by means of an immunohistochemical(SP) assay, and DNA ploidy were measured by flow cytometry. Results Chondrosarcomas with high histological grade showed a bias toward an increase in p27 expression, while normal cartilaginous tissues and benign cartilaginous tumors...

Purpose To investigate the practical significance of p27 expression in the diagnosis and prognostic assessment of chondrosarcomas. Methods p27 expressions were sutdied in paraffinembdded sections of the conventional chondrosarcoma by means of an immunohistochemical(SP) assay, and DNA ploidy were measured by flow cytometry. Results Chondrosarcomas with high histological grade showed a bias toward an increase in p27 expression, while normal cartilaginous tissues and benign cartilaginous tumors gave negative results. There was a statistical significance (t=206, P<005) between p27 expressions of chondromas and gradeⅠchondrosarcomas.In normal cartilaginous tissues, benign cartilaginous tumors and low grade (grade Ⅰ and grade Ⅱ) chondrosarcomas were mainly diploid, and in high grade ( gradeⅢ) chondrosarcomas were aneuploid. The higher p27 protein expressed, the more DNA aneuploid presented. p27 expression showed a significant direct correlation with DNA aneuploid (r=0925, P<005). Conclusions p27 protein will probably become a marker in differentiating chondromas from grade Ⅰ chondrosarcomas and a useful prognostic index of chondrosarcoma, and it may also be of some guiding significance in grading chondrosarcoma.

目的:软骨肉瘤是常见的骨恶性肿瘤之一。其形态多变、生物学行为复杂,对软骨瘤和高分化软骨肉瘤,只凭病理组织学特征鉴别它们通常是很困难的,并且软骨肉瘤组织学分级与其生物学行为时常不一致。因此,需要更为客观可靠的指标来协助诊断,指导软骨肉瘤的分级和估计软骨肉瘤的预后。肿瘤细胞周期的研究是当前肿瘤研究热点之一,肿瘤细胞周期受一系列细胞周期调节因子控制,包括G1期细胞周期素(cyclins)和相应的细胞周期素依赖激酶(cyclin-dependentkinases,CDKs),CDKs活性又受一系列细胞周期素依赖激酶抑制物(cyclin-dependentkinaseinhibitors,CDKIs)控制。p27是新近发现的CDKIs家族之一,在细胞周期增殖和分化调控中起非常重要作用。p27蛋白主要抑制G1期cyclinE-CDK2复合物及cy-clinD-CDK4/6复合物活性,它过度表达可使细胞周期停滞在G1中期。软骨肉瘤p27表达国内外尚未见报道。检测软骨肉瘤中p27表达,从而探讨p27表达与软骨肉瘤组织分级和DNA倍体的关系及其对软骨肉瘤的诊断和预后判断是否具有应用价值十分必要。方法:36例经典软骨...

目的:软骨肉瘤是常见的骨恶性肿瘤之一。其形态多变、生物学行为复杂,对软骨瘤和高分化软骨肉瘤,只凭病理组织学特征鉴别它们通常是很困难的,并且软骨肉瘤组织学分级与其生物学行为时常不一致。因此,需要更为客观可靠的指标来协助诊断,指导软骨肉瘤的分级和估计软骨肉瘤的预后。肿瘤细胞周期的研究是当前肿瘤研究热点之一,肿瘤细胞周期受一系列细胞周期调节因子控制,包括G1期细胞周期素(cyclins)和相应的细胞周期素依赖激酶(cyclin-dependentkinases,CDKs),CDKs活性又受一系列细胞周期素依赖激酶抑制物(cyclin-dependentkinaseinhibitors,CDKIs)控制。p27是新近发现的CDKIs家族之一,在细胞周期增殖和分化调控中起非常重要作用。p27蛋白主要抑制G1期cyclinE-CDK2复合物及cy-clinD-CDK4/6复合物活性,它过度表达可使细胞周期停滞在G1中期。软骨肉瘤p27表达国内外尚未见报道。检测软骨肉瘤中p27表达,从而探讨p27表达与软骨肉瘤组织分级和DNA倍体的关系及其对软骨肉瘤的诊断和预后判断是否具有应用价值十分必要。方法:36例经典软骨肉瘤未脱钙?

Objective:To investigate phenylacetate′s function of suppressing the growth of glioma C 6 cell and inducing differentitation and find the mechanism of this effect on molecular level.Methods:Cell proliferation was evaluated Using 3H -TdR and cell numeration,using a hemocytometer.Cell proliferation cycle was tested by flow cytometry (FCM).Results:NaPA (2.5 mmol/L and 5.0 mmol/L) exerted a marked inhibitory effect on cell Proliferation. Exposure to NaPA (2.5 mmol/L and 5.0 mmol/L for 5 days) resulted...

Objective:To investigate phenylacetate′s function of suppressing the growth of glioma C 6 cell and inducing differentitation and find the mechanism of this effect on molecular level.Methods:Cell proliferation was evaluated Using 3H -TdR and cell numeration,using a hemocytometer.Cell proliferation cycle was tested by flow cytometry (FCM).Results:NaPA (2.5 mmol/L and 5.0 mmol/L) exerted a marked inhibitory effect on cell Proliferation. Exposure to NaPA (2.5 mmol/L and 5.0 mmol/L for 5 days) resulted in a decrease of cells in G 0/G 1 Phase as being analyzed by flow cytometry.Conclusion:NaPA could exert a marked inhibitory effect on cell proliferation and glioma malignancy becomes lower.NaPA made cell cycle distribition on G 1 phase decreased and cell cycle stopped on S 0 phase (prepare period of DNA synthesis) by indreasing RNA and protein.

目的:观察诱导分化剂苯乙酸对胶质瘤细胞C6的诱导分化作用,并在分子水平上探讨其作用机理。方法:细胞计数和〔3H〕-TdR掺入法检测细胞增殖,流式细胞术分析细胞周期。结果:苯乙酸对细胞增殖存在剂量(25mmol/L,50mmol/L)依赖性抑制;免疫细胞化学检测CPM值降低,肿瘤细胞DNA合成减少;细胞周期分析G0/G1期所占比例下降,S期相对升高。结论:苯乙酸可阻抑细胞增殖周期,使细胞周期增殖循环中止于S期中DNA合成准备期S0期,DNA合成减少,抑制细胞增殖。其作用机理为抑制细胞周期中G1期的RNA和蛋白质合成

Objectives To construct the recombinant adenovirus encoding antisense c myc fragment and to investigate its effect on tumor cell proliferation and apoptosis Methods The shuttle plasmid encoding antisense c myc was constructed by cloning c myc cDNA fragment in the reverse direction into the pAdCMV Then the plasmid pJM17 and the shuttle plasmid were co transferred into 293 cells with liposome for homologous recombination to acquire recombinant adenovirus The cell cycle, apoptosis, and the expression...

Objectives To construct the recombinant adenovirus encoding antisense c myc fragment and to investigate its effect on tumor cell proliferation and apoptosis Methods The shuttle plasmid encoding antisense c myc was constructed by cloning c myc cDNA fragment in the reverse direction into the pAdCMV Then the plasmid pJM17 and the shuttle plasmid were co transferred into 293 cells with liposome for homologous recombination to acquire recombinant adenovirus The cell cycle, apoptosis, and the expression of related genes of the in vitro transferred human adenocarcinoma cell lines GLC 82 and SPC A 1, as well as the human embryonic diploid lung cell line 2BS were studied The effects on colony formation and treating effect on transplanted tumor in nude mice were also studied Results The recombinant adenovirus encoding antisense c myc fragment was obtained with the titer of 3 3×10 10 pfu/ml RT PCR and Western blot showed that the expression of c myc was reduced 3~5 days after infection Simultaneously, obvious G1 arrest and apoptosis as well as the alteration of cyclin D1, bcl 2 and bax gene expression were observed in the infected tumor cells The infected 2BS cells showed no such changes The colony formation ability in vitro and the growth of the hetero transplanted tumor in nude mice were also reduced Conclusions The reduced expression of c myc gene could induce human adenocarcinoma cells tumor cell specific G1 arrest and apoptosis, while it has no effect on normal cell

目的 构建介导反义cmyc 的重组腺病毒,研究其对人肺腺癌细胞的细胞周期、增殖和凋亡的影响。方法 将cmyc 基因反向克隆于穿梭质粒载体p Ad C M V 中,通过脂质体与p J M17 共转染293 细胞,经同源重组产生编码反义cmyc 的重组腺病毒。体外观察和检测重组腺病毒感染人肺腺癌细胞系 G L C82 和 S P C A1 以及人胚肺二倍体细胞2 B S后,细胞周期的改变、凋亡的发生和相关基因表达的变化;体内观察对肿瘤细胞致瘤能力和裸鼠皮下移植瘤生长的影响。结果 构建并扩增、纯化得到编码反义cmyc 的重组腺病毒 Ad A Smyc,滴度达33 ×1010 噬斑形成单位(pfu)/ml。肿瘤细胞感染 Ad A Smyc 3 ~5 天后,逆转录聚合酶链反应( R T P C R) 和 Western Blot 分析显示cmyc 基因表达下调;同时出现了明显的 G1 期阻滞和凋亡, G1 期正调控基因cyclin D1 表达下调,凋亡相关基因bcl2 和bax基因的表达分别出现下调和上调;人胚肺二倍体细胞感染 Ad A Smyc 后无上述变化。肿瘤细胞体外克隆形成能力和...

目的 构建介导反义cmyc 的重组腺病毒,研究其对人肺腺癌细胞的细胞周期、增殖和凋亡的影响。方法 将cmyc 基因反向克隆于穿梭质粒载体p Ad C M V 中,通过脂质体与p J M17 共转染293 细胞,经同源重组产生编码反义cmyc 的重组腺病毒。体外观察和检测重组腺病毒感染人肺腺癌细胞系 G L C82 和 S P C A1 以及人胚肺二倍体细胞2 B S后,细胞周期的改变、凋亡的发生和相关基因表达的变化;体内观察对肿瘤细胞致瘤能力和裸鼠皮下移植瘤生长的影响。结果 构建并扩增、纯化得到编码反义cmyc 的重组腺病毒 Ad A Smyc,滴度达33 ×1010 噬斑形成单位(pfu)/ml。肿瘤细胞感染 Ad A Smyc 3 ~5 天后,逆转录聚合酶链反应( R T P C R) 和 Western Blot 分析显示cmyc 基因表达下调;同时出现了明显的 G1 期阻滞和凋亡, G1 期正调控基因cyclin D1 表达下调,凋亡相关基因bcl2 和bax基因的表达分别出现下调和上调;人胚肺二倍体细胞感染 Ad A Smyc 后无上述变化。肿瘤细胞体外克隆形成能力和裸鼠皮下移植瘤生长被 Ad A Smyc 抑制。结论 反义?

 
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