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模式评估法
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  mode assessment
     The homeostasis mode assessment insulin resistance index(HOMA IR),β cell function index (HOMA β) and earlier excretion index of insulin(△I30/△G30)were analyzed in all the groups.
     分析各组稳态模式评估法(homeostasismodelassessment,HOMA)模型胰岛素抵抗指数(HOMA-IR)、β细胞功能指数(HOMA-β)及胰岛初期分泌指数(ΔI30/ΔG30)。
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     The hemeostasis mode assessment indexes of insulin resistance(HOMA-IR) and insulin secretion of β cells(HOMA-β) in three groups were calculated.
     测定各组血浆TNF-α、空腹血糖、胰岛素、胰高血糖素和皮质醇水平,并观察稳态模式评估法胰岛素抵抗指数(HOMA-IR)和β细胞胰岛素分泌指数(HOMA-β)变化。
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  “模式评估法”译为未确定词的双语例句
     (4)The multiple stepwise regression analysis in which HDL-C as a dependable variable and age, sex, BMI, WHR, FBG, SP, DP, TG, HOMA-IR as independent variables showed that sex, HOMA-IR, BMI, age, TG, FBG and WHR were influencing factors of HDL-C.
     ④以HDL-C为应变量,年龄、性别、BMI、腰臀比(WHR)、FBG、收缩压、舒张压、三酰甘油(TG)和稳态模式评估法的胰岛素抵抗指数(HOMA-IR)为自变量进行多元逐步回归分析,性别、年龄、HOMA-IR、BMI、TG、FBG和WHR是HDL-C的影响因素(P值均<0.01)。
短句来源
     The serum level of triglyceride and the HOMA-IR index, the status of insulin resistance assessed by homeostasis model assessmend (HOMA), were lower in the TT or CT genotype group than that in the CC genotype group (P<0.05).
     男女TT、CT基因型人群的甘油三酯水平、稳态模式评估法(HOMA)评价的胰岛素抵抗指数(HOMA-IR)均显著低于CC基因型人群(P<0.05);
短句来源
     HOMA-IR was calculated by HOMA model.
     利用稳态模式评估法( HOMA Model) 计算胰岛素抵抗指数(HOMA-IR)。
短句来源
     Homeostasis model assessment (HOMA) and the improved insulin sensitivity index were applied to assess the status of insulin sensitivity and function of β cell, HOMA-IR=fasting blood glucose×fasting insulin/22.5, HOMA-β cell=20×fasting insulin/(fasting blood glucose-3.5), insulin sensitivity index (ISI)=ln 1/fasting blood glucose×fasting insulin.
     评价胰岛素敏感性和β细胞功能采用稳态模式评估法的公式及改良胰岛素敏感性指数公式计算,胰岛素抵抗指数=空腹血糖×空腹胰岛素/22.5,β细胞功能指数=20×空腹胰岛素/(空腹血糖-3.5),胰岛素敏感性指数=ln1/空腹血糖×空腹胰岛素。
短句来源
     ②The Age,BMI,W,WHR,SBP,TC,TG,LDL-C,FIN,2hIN and HOMA-IR of hy- pertension with glucose metabolic abnormality group and diabetes group were significantly higher than those of the simple hypertension group.
     ②HTN—IGR及HTN—DM组的年龄、体重指数(BMI)、腰围(W)、腰臀比(WHR)、收缩压(SBP)、胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、空腹胰岛素(FIN)、负荷后2 h胰岛素(2hIN)及稳态模式评估法的胰岛素抵抗指数(HOMA-IR)均显著高于iHTN组;
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     过程化的写作评估模式
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     Homeostasis model assessment(HOMA) was applied to calculate insulin sensitivity.
     按稳态模式评估公式计算胰岛素敏感性。
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  mode assessment
These efforts have brought similarity methods to a level of performance comparable to the well established protein-ligand docking methods for binding mode assessment and molecular database screening.
      
Two-dimensional and M-mode assessment of aortic growth in the normal and growth-retarded (IUGR) human fetuses
      
Alternative failure mode assessment categories may be required for some solder ball configurations.
      


Objective To investigate the impact of insulin resistance and insulin secretion on the development of glucose intolerance in Chinese. Methods Given 75 gram oral glucose tolerance challenge, 466 Chinese (189 normal weight, 277 overweight/obesity) were divided into normal glucose tolerance (NGT) group, impaired glucose tolerance/impaired fasting glucose (IGT/IFG) group, as well as type 2 diabetes (DM) group according to 1997 ADA criteria. Homeostasis model assessment (HOMA) was applied to assess the status...

Objective To investigate the impact of insulin resistance and insulin secretion on the development of glucose intolerance in Chinese. Methods Given 75 gram oral glucose tolerance challenge, 466 Chinese (189 normal weight, 277 overweight/obesity) were divided into normal glucose tolerance (NGT) group, impaired glucose tolerance/impaired fasting glucose (IGT/IFG) group, as well as type 2 diabetes (DM) group according to 1997 ADA criteria. Homeostasis model assessment (HOMA) was applied to assess the status of insulin resistance (HOMA IR) and basic function of pancreatic β cell (HOMA β cell). While insulinogenic index (the ratio of the increment of insulin to that of plasma glucose 30 min after a glucose load, △I 30 /△G 30 ) was performed to evaluate the early phase insulin secretion. Results Adjusted with age, sex, body mass index (BMI), body fat distribution indices (including abdominal visceral, subcutaneous, and femoral subcutaneous adipose tissue areas) and blood pressure, our data indicated that in comparison with NGT group, HOMA IR was increased significantly in IGT/IFG and DM group, especially overt in the overweight or obesity subjects. Meanwhile HOMA β cell and △I 30 /△G 30 were remarkably lower in IGT/IFG and DM group than in NGT group, particularly in DM group. Conclusion Insulin resistance and insulin secretion deficiency may play an important role on the worsening from normal glucose tolerance to glucose intolerance in Chinese individuals.

目的 研究胰岛素抵抗和胰岛素分泌缺陷与中国人糖耐量变化的关系。方法 对 46 6例 (正常体重 189例 ,超重 /肥胖 2 77例 )正常糖耐量 (NGT)、糖耐量减退 /空腹血糖减损 (IGT/IFG)、2型糖尿病 (DM)患者 ,用稳态模式评估法 (HOMA)评价胰岛素抵抗 (HOMA- IR)及胰岛 β细胞基础功能 (HOMA- β cell) ,并用糖负荷 30分钟净增胰岛素 /净增葡萄糖 (△ I30 /△G30 )比值评价早期胰岛素分泌反应。结果 校正年龄、性别、体重指数 (BMI)、体脂分布 (腹内脂肪、腹部及股部皮下脂肪面积 )和血压等因素后 ,无论有无超重 /肥胖 ,IGT/IFG、DM患者胰岛素抵抗指数显著升高 ,超重 /肥胖者尤为明显。并有胰岛β细胞基础功能及早期胰岛素分泌反应降低 ,DM患者更显著。结论 中国人从正常糖耐量到糖耐量异常的变化过程中 ,胰岛素抵抗和胰岛素分泌功能减退起共同作用。

Objective To evaluate the reliability of homeostasis model assessment (HOMA) for estimating insulin sensitivity, as well as to investigate the insulin resistance of base line survey people by HOMA IR. Methods The hyperinsulinemic euglycemic clamp combined with 3 3H glucose infusion were performed in 29 Chinese individuals to determine the glucose disposal rate and assess the sensitivity, specificity and accuracy of HOMA IR (HOMA insulin resistance index). The current status of insulin sensitivity...

Objective To evaluate the reliability of homeostasis model assessment (HOMA) for estimating insulin sensitivity, as well as to investigate the insulin resistance of base line survey people by HOMA IR. Methods The hyperinsulinemic euglycemic clamp combined with 3 3H glucose infusion were performed in 29 Chinese individuals to determine the glucose disposal rate and assess the sensitivity, specificity and accuracy of HOMA IR (HOMA insulin resistance index). The current status of insulin sensitivity in Shanghai Huayang community survey(n=1873)was estimated by HOMA IR. Results 1.In comparison with the glucose disposal rate by glucose clamp, the sensitivity、specificity、accuracy of HOMA IR was 86.4%、71.4% and 82.8%, respectively. 2. In diabetes、impaired glucose tolerance and/or impaired fasting glucose、hypertriglyceridemia and/or low high density lipoprotein cholesterol(H TG/L HDL) and hypertensives, about 62.5%、41.7%、30.8% and 32.0% suffered from insulin resistance respectively. 3.With the rise of BMI or metabolic disorders, the frequency of insulin insensitivity was also increased (P for trend, P <0.001). 4. Results of logistic regression analysis revealed that insulin resistance had a major effect on hyperglycemia, and that on H TG/L HDL being the next. Conclusion HOMA IR in the estimation of insulin resistance has a higher accuracy,while insulin resistance is common among the adults, especially in those with metabolic disorders.

目的 评价胰岛素抵抗指数 (稳态模式评估法HOMA IR)的可靠性 ,并应用HOMA IR估测自然人群中胰岛素抵抗伴发情况。方法 联合应用高胰岛素 正葡萄糖钳夹及 3 3 H葡萄糖示踪技术对 2 9例上海地区中国人进行机体胰岛素敏感性测定 ,同时评价HOMA IR的敏感性、特异性及准确度。应用HOMA IR估测上海华阳社区基线调查人群 (1873人 )胰岛素抵抗伴发情况。结果  1.HOMA IR估测机体胰岛素抵抗的敏感性为 86 .4% ,特异性为 71.4% ,诊断符合率为 82 .8%。 2 .本基线调查人群中糖尿病、糖耐量减退 /空腹血糖减损、高三酰甘油 /低 高密度脂蛋白血症 (高TG/低HDL血症 )、高血压者伴胰岛素抵抗的频率分别为 6 2 .5 %、41.7%、30 .8%及 32 .0 %。 3.胰岛素抵抗发生频率随体块指数 (BMI)及代谢异常成分的增加而升高 (趋势分析P <0 .0 0 1)。 4.Logistic分析表明 ,胰岛素抵抗对高血糖的影响最大 ,其次为高TG/低HDL血症。 结论 以HOMA IR估测机体胰岛素抵抗有较高的准确度。胰岛素抵抗在人群中 ,尤其是成...

目的 评价胰岛素抵抗指数 (稳态模式评估法HOMA IR)的可靠性 ,并应用HOMA IR估测自然人群中胰岛素抵抗伴发情况。方法 联合应用高胰岛素 正葡萄糖钳夹及 3 3 H葡萄糖示踪技术对 2 9例上海地区中国人进行机体胰岛素敏感性测定 ,同时评价HOMA IR的敏感性、特异性及准确度。应用HOMA IR估测上海华阳社区基线调查人群 (1873人 )胰岛素抵抗伴发情况。结果  1.HOMA IR估测机体胰岛素抵抗的敏感性为 86 .4% ,特异性为 71.4% ,诊断符合率为 82 .8%。 2 .本基线调查人群中糖尿病、糖耐量减退 /空腹血糖减损、高三酰甘油 /低 高密度脂蛋白血症 (高TG/低HDL血症 )、高血压者伴胰岛素抵抗的频率分别为 6 2 .5 %、41.7%、30 .8%及 32 .0 %。 3.胰岛素抵抗发生频率随体块指数 (BMI)及代谢异常成分的增加而升高 (趋势分析P <0 .0 0 1)。 4.Logistic分析表明 ,胰岛素抵抗对高血糖的影响最大 ,其次为高TG/低HDL血症。 结论 以HOMA IR估测机体胰岛素抵抗有较高的准确度。胰岛素抵抗在人群中 ,尤其是成人常见病中普遍存在 ,但对不同代谢紊乱成分的影响及参与程度并不一致。

Objective To investigate the glucose stimulated insulin secretion under various glucose tolerant status among Chinese individuals. Methods 634 individuals were included. Individuals were classified as: 1.Normal weight group (NW) and over weight/obese (OW/OB) group according to the obesity criteria of WHO 1998. Both groups were further divided into 7 subgroups on the basis of fasting glucose levels. 2. 6 subgroups according to body mass index (BMI) and glucose tolerant status: NW with normal glucose tolerance...

Objective To investigate the glucose stimulated insulin secretion under various glucose tolerant status among Chinese individuals. Methods 634 individuals were included. Individuals were classified as: 1.Normal weight group (NW) and over weight/obese (OW/OB) group according to the obesity criteria of WHO 1998. Both groups were further divided into 7 subgroups on the basis of fasting glucose levels. 2. 6 subgroups according to body mass index (BMI) and glucose tolerant status: NW with normal glucose tolerance (NGT) (NW NGT), NW with imparied fasting glucose/impaired glucose tolerance (IFG/IGT) (NW IFG/IGT), NW with diabetes(DM) (NW DM), OW/OB with NGT(OW/OB NGT), OW/OB with IFG/IGT (OW/OB IFG/IGT), OW/OB with DM (OW/OB DM). The mean insulin concentration during 2 hour OGTT was applied for estimating glucose stimulated insulin secretion. Homeostasis model assessment was used to assess the degree of insulin resistance. Results 1.The relationship between glucose stimulated insulin secretion and fasting glucose concentration was similar to an inverted U shaped curve. The glucose stimulated insulin secretion reached the peak at fasting glucose level of 5.9mmol/L in normal weight subjects. 2.The highest level of the glucose stimulated insulin secretion was observed in overweight or obese individuals with NGT. 3. In overweight or obese individuals with IGT, there was a decrease in glucose stimulated insulin secretion and increased HOMA IR. 4.Overweight or obese individuals with DM were related to a further decrease in glucose stimulated insulin secretion and worsening of the insulin resistance. Conclusion 1.Among the Chinese individuals, the relationship between glucose stimulated insulin secretion and fasting glucose concentration was similar to an inverted U shaped curve. The peak of the curve was forwardly shifted more than that seen the Caucasians. The fasting glucose concentration was lower than that of the Caucasians when glucose stimulated insulin secretion reached the peak. In the subgroups of NGT, IFG/IGT and DM, they were associated with progressive decrease in glucose stimulated insulin secretion and rise in insulin resistance in overweight or obese Chinese individuals.

目的 探讨中国人不同糖耐量状态下的葡萄糖兴奋胰岛素分泌的特点。方法  6 34例受试者分成两类亚组 :1、以体块指数 (BMI) 2 5为切割点 ,分为正常体重组 (NW )与超重 /肥胖组 (OW /OB) ,并按空腹血糖水平的不同各分为 7个亚组。 2、根据BMI和糖耐量 ,把所有受试者分为以下 6个亚组 :正常体重 正常糖耐量组(NW NGT)、正常体重 空腹血糖减损 /糖耐量减退组 (NW IFG/IGT)、正常体重 糖尿病组 (NW DM )、超重 /肥胖 正常糖耐量组 (OW /OB NGT)、超重 /肥胖 空腹血糖减损 /糖耐量减退组 (OW /OB IFG/IGT) ,及超重 /肥胖 糖尿病组 (OW /OB DM)。以口服葡萄糖耐量试验 (OGTT) 0~ 12 0min的平均胰岛素水平评价葡萄糖兴奋的胰岛素分泌功能 ,采用稳态模式评估法 (HOMA)评价胰岛素抵抗 (HOMA IR)。结果  1、中国人空腹血糖与总体胰岛素分泌呈倒U字型曲线 ,正常体重者中总体胰岛素分泌高峰的空腹血糖值为 5 .9mmol/L ;2、超重 /肥胖伴正常糖耐量的个体总体胰岛素分泌最高 ;3、超...

目的 探讨中国人不同糖耐量状态下的葡萄糖兴奋胰岛素分泌的特点。方法  6 34例受试者分成两类亚组 :1、以体块指数 (BMI) 2 5为切割点 ,分为正常体重组 (NW )与超重 /肥胖组 (OW /OB) ,并按空腹血糖水平的不同各分为 7个亚组。 2、根据BMI和糖耐量 ,把所有受试者分为以下 6个亚组 :正常体重 正常糖耐量组(NW NGT)、正常体重 空腹血糖减损 /糖耐量减退组 (NW IFG/IGT)、正常体重 糖尿病组 (NW DM )、超重 /肥胖 正常糖耐量组 (OW /OB NGT)、超重 /肥胖 空腹血糖减损 /糖耐量减退组 (OW /OB IFG/IGT) ,及超重 /肥胖 糖尿病组 (OW /OB DM)。以口服葡萄糖耐量试验 (OGTT) 0~ 12 0min的平均胰岛素水平评价葡萄糖兴奋的胰岛素分泌功能 ,采用稳态模式评估法 (HOMA)评价胰岛素抵抗 (HOMA IR)。结果  1、中国人空腹血糖与总体胰岛素分泌呈倒U字型曲线 ,正常体重者中总体胰岛素分泌高峰的空腹血糖值为 5 .9mmol/L ;2、超重 /肥胖伴正常糖耐量的个体总体胰岛素分泌最高 ;3、超重 /肥胖个体伴IGT时 ,总体胰岛素分泌减退 ,并伴胰岛素抵抗指数升高 ;4、超重 /肥胖伴糖尿病时 ,同时存在进行性的总体胰岛素分泌功能的减退及胰岛素抵抗指数的持续升高。结论  1、中国人空腹血糖与总体胰岛素分泌呈倒U字型曲线 ,高

 
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