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吸附治疗
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  adsorption therapy
    The effect of staphylococcal protein A adsorption therapy on the panel reactive antibody
    葡萄球菌蛋白A吸附治疗对群体反应性抗体水平的影响
短句来源
    Objective To evaluate the effect of staphylococcal protein A(SPA)adsorption therapy on panel reactive antibody(PRA).
    目的 研究葡萄球菌蛋白A(StaphylococcalProteinA .SPA)吸附治疗对群体反应性抗体 (PRA)水平的影响。
短句来源
    After (6.70± 3.11)times SPA adsorption therapy, the PRA levels decreased to lower than 12% in 29 patients(90.62%)and 7 000~9 000ml circulated plasma involved in every SPA adsorption therapy.
    每次SPA吸附治疗的循环血浆量为 70 0 0~ 90 0 0ml。 本组经 (6 .70± 3.11)次SPA吸附治疗后 ,2 9例 (占90 .6 2 % )PRA降至 <12 % ;
短句来源
    Conclusions To sensitive patients, the levels of PRA could be reduced by the SPA adsorption therapy which had a definitely therapeutic effects on the acute rejections following renal transplantation if combined with better HLA matching model of kidney and new type immunosuppressants.
    结论 SPA吸附治疗可降低致敏患者体内预存的PRA水平。 SPA吸附治疗辅以配型良好的肾脏及新型免疫抑制剂 ,对预防和减轻肾移植后排斥反应疗效确切。
短句来源
  “吸附治疗”译为未确定词的双语例句
    Results ①About 450~600ml blood plasma was given out in one SPA adsorption treatment.
    结果 ①单次SPA吸附治疗可处理循环血浆 4 5 0~ 6 0 0ml;
短句来源
    The clinical study of resin absorptive devices combined with hemodialyzer in series treatment for patients with uremia
    血液透析结合树脂吸附治疗尿毒症患者的临床观察
短句来源
    Objective To study the effects of resin absorptive devices combined with hemodialyzer in series treatment for patients with uremia.
    目的探讨血液透析(HD)结合树脂吸附治疗尿毒症患者的临床效果。
短句来源
    Conclusion With the treatment of resin absorptin combined with hemodialysis,the MMS and β_2-MG can be cleared effectively,and the relief of skin itching,depressed blood pressure,improved symptoms such as heart-throb,appetite and sleep et al,are obvious in the patients with uremia. The treatment of resin absorptin combined with hemodialysis is a good mode of hemodialysis in the treatment of uremia.
    结论HD结合树脂吸附治疗尿毒症患者能够有效清除MMS及β2-MG,明显减轻皮肤瘙痒、降低血压、改善心悸、食欲及睡眠等症状,是目前治疗尿毒症患者较佳的血液净化方式。
短句来源
    (3) Follow up data showed that the proteinuria and serum creatinine levels increased slower in patients who received immunoadsorption treatment than in patients of the control group after six-month,one-year and two-year follow-up.
    (3)治疗后半年、1年及2年随访资料显示,吸附治疗组患者尿蛋白改善较非吸附组明显,且血清肌酐上升速度较非吸附组缓慢。
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  adsorption therapy
The protein A column was exploited for the process monitoring of dog IgG in clinical experiments on immuno-adsorption therapy.
      
We developed a new adsorbent utilizing hydrophobic amino acids in order to treat severe rheumatoid arthritis patients with extracorporeal adsorption therapy.
      
Furthermore, after granulocyte adsorption therapy, the number of CD10-negative premature granulocytes increased, indicating increased turnover of these cells in the circulation.
      
Each of the direct hemoperfusion and billirubin adsorption therapy was performed for 3 h with blood flow at 100 ml/min.
      
In each of the patients, Lixelle column was used twice in direct hemoperfusion alone, or in combination with billirubin adsorption therapy.
      


Objective:To investigate the clinical efficacy of protein A immunoadsorption treatment (IA) in patients with anti glomerular basement membrane disease (Anti GBM) disease. Methodology:Five patients with Anti GBM disease (4 complicated with diffuse pulmonary hemorrhage) with rapidly progressive glomerulonephritis (serum creatinine levels 312~ 1 290 μmol/L) and pathologically diffusive crescentic nephritis ( crescent percentage 26.3%~100%) were included in this study. All patients had positive serum IgG...

Objective:To investigate the clinical efficacy of protein A immunoadsorption treatment (IA) in patients with anti glomerular basement membrane disease (Anti GBM) disease. Methodology:Five patients with Anti GBM disease (4 complicated with diffuse pulmonary hemorrhage) with rapidly progressive glomerulonephritis (serum creatinine levels 312~ 1 290 μmol/L) and pathologically diffusive crescentic nephritis ( crescent percentage 26.3%~100%) were included in this study. All patients had positive serum IgG Anti GBM antibodies in the range of 40.6~203.2 RU/ml by ELISA method. All patients received intravenous methyprednisolone pulse therapy and 10 cycles of immunoadsorption with Protein A column, with 3 000 ml plasma processed in each treatment cycle. Results:The levels of serum Anti GBM antibody decreased to normal in four patients after IA for 10 treatment cycles and remained negative during the first four months' follow up. While in the other 1 patient, serum Anti GBM did not turned negative although there was significant decrement of 62.8% at the end of 10 cycles of IA treatment (serum Anti GBM turned negative after another 10 cycles of IA treatment). Pulmonary hemorrhage resolved completely in all the 4 patients, including the one who was unresponsive to methylprednisolone pulse therapy before IA. Renal function was significantly improved in 1 of 4 patients who required haemodialysis prior to IA treatment, 3 patients whose renal biopsy showed 100% of glomerular crescents formation needed maintenance haemodialysis. Renal function remained stable in the patient whose serum creatinine levels not above that requiring haemodialysis before treatment. Conclusion:Immunoadsorption could rapidly decrease serum anti GBM antibody, resolve pulmonary hemorrhage and improve renal function.

目的 :探讨免疫吸附 (IA)治疗对抗肾小球基膜抗体 (抗 GBM)疾病患者血清抗 GBM水平的影响及其临床疗效。  方法 :5例抗 GBM疾病患者 ,4例伴有明显肺出血 ,1例仅有肾损害 ,临床均表现为急进性肾炎 ,SCr312~ 12 90 μmol/L。肾活检显示肾小球新月体比例 2 6 3%~ 10 0 %。血清抗 GBM抗体 4 0 6 %~ 2 0 3 2RU/ml。在激素治疗同时 ,应用葡萄球菌A蛋白吸附柱进行免疫吸附治疗 ,一疗程共 10次 ,再生血浆 30~ 6 0L。  结果 :吸附治疗 10次后 ,3例血清抗 GBM抗体转阴 ,随访 4个月时抗 GBM抗体仍阴性。 1例吸附治疗后血清抗 GBM抗体仍阳性 ,但较治疗前下降 6 2 8% ,进行第二个疗程吸附后 ,抗 GBM抗体转阴。 4例伴有肺出血患者治疗后肺出血迅速消失。 4例治疗前需血液透析的患者治疗后 1例摆脱透析 ,SCr由 5 0 5 μmol/L降至 15 7μmol/L ,另 3例肾活检病理显示10 0 %新月体形成者仍需维持性血液透析。 1例治疗前不需血液透析者肾功能保持稳...

目的 :探讨免疫吸附 (IA)治疗对抗肾小球基膜抗体 (抗 GBM)疾病患者血清抗 GBM水平的影响及其临床疗效。  方法 :5例抗 GBM疾病患者 ,4例伴有明显肺出血 ,1例仅有肾损害 ,临床均表现为急进性肾炎 ,SCr312~ 12 90 μmol/L。肾活检显示肾小球新月体比例 2 6 3%~ 10 0 %。血清抗 GBM抗体 4 0 6 %~ 2 0 3 2RU/ml。在激素治疗同时 ,应用葡萄球菌A蛋白吸附柱进行免疫吸附治疗 ,一疗程共 10次 ,再生血浆 30~ 6 0L。  结果 :吸附治疗 10次后 ,3例血清抗 GBM抗体转阴 ,随访 4个月时抗 GBM抗体仍阴性。 1例吸附治疗后血清抗 GBM抗体仍阳性 ,但较治疗前下降 6 2 8% ,进行第二个疗程吸附后 ,抗 GBM抗体转阴。 4例伴有肺出血患者治疗后肺出血迅速消失。 4例治疗前需血液透析的患者治疗后 1例摆脱透析 ,SCr由 5 0 5 μmol/L降至 15 7μmol/L ,另 3例肾活检病理显示10 0 %新月体形成者仍需维持性血液透析。 1例治疗前不需血液透析者肾功能保持稳定。  结论 :葡萄球菌A蛋白免疫吸附能有效降低血清抗 GBM抗体水平 ,迅速缓解肺出血 ,但改善肾功能的疗效受肾脏损害程度的影响

Objective To evaluate the effect of staphylococcal protein A(SPA)adsorption therapy on panel reactive antibody(PRA). Methods The experiment of SPA adsorption-system was carried out in vitro and in vivo for 32 sensitive recipients [Population reactive antibody (PRA)>25%] patients and clinical kidney transplantation of these patients were observed.Results ①About 450~600ml blood plasma was given out in one SPA adsorption treatment. The mean levels of IgG adsorbtion saturated was (3.98 ± 0.51)g/L; at the end...

Objective To evaluate the effect of staphylococcal protein A(SPA)adsorption therapy on panel reactive antibody(PRA). Methods The experiment of SPA adsorption-system was carried out in vitro and in vivo for 32 sensitive recipients [Population reactive antibody (PRA)>25%] patients and clinical kidney transplantation of these patients were observed.Results ①About 450~600ml blood plasma was given out in one SPA adsorption treatment. The mean levels of IgG adsorbtion saturated was (3.98 ± 0.51)g/L; at the end of the experiment the mean level was (19.54 ± 3.13)g/L. The levels of plasma IgG after absorption was decreased by 51.2%; ②Before SPA adsorption therapy,the levels of PRA were: 98%~51% for 5cases、 50%~40% for 15 cases and 39%~25% for 12 case. After (6.70± 3.11)times SPA adsorption therapy, the PRA levels decreased to lower than 12% in 29 patients(90.62%)and 7 000~9 000ml circulated plasma involved in every SPA adsorption therapy.③Twenty-seven cases(83.37%)accepted kidney transplantation, no serious rejection occurred and all recovered. Conclusions To sensitive patients, the levels of PRA could be reduced by the SPA adsorption therapy which had a definitely therapeutic effects on the acute rejections following renal transplantation if combined with better HLA matching model of kidney and new type immunosuppressants.

目的 研究葡萄球菌蛋白A(StaphylococcalProteinA .SPA)吸附治疗对群体反应性抗体 (PRA)水平的影响。方法 采用SPA吸附系统对 32例等待肾移植的致敏受者进行体外吸附实验、体内吸附实验和临床移植观察。结果 ①单次SPA吸附治疗可处理循环血浆 4 5 0~ 6 0 0ml;其饱和吸附的IgG量为 (3.98±0 .5 1)g ;实验终点饱和吸附的IgG量 (M1)为 (19.5 4± 3.13)g/L ,吸附后血浆IgG(M2 )水平降低 5 1.2 % ;②本组体内吸附实验前 ,PRA为 98%~ 5 1%者 5例 ,PRA为 5 0 %~ 4 0 %者 15例 ,PRA为 39%~ 2 5 %者 12例。每次SPA吸附治疗的循环血浆量为 70 0 0~ 90 0 0ml。本组经 (6 .70± 3.11)次SPA吸附治疗后 ,2 9例 (占90 .6 2 % )PRA降至 <12 % ;③ 2 7例 (83.37% )顺利地接受肾移植手术。术后未发生超急或急性排斥反应 ,肾功能均得以恢复。结论 SPA吸附治疗可降低致敏...

目的 研究葡萄球菌蛋白A(StaphylococcalProteinA .SPA)吸附治疗对群体反应性抗体 (PRA)水平的影响。方法 采用SPA吸附系统对 32例等待肾移植的致敏受者进行体外吸附实验、体内吸附实验和临床移植观察。结果 ①单次SPA吸附治疗可处理循环血浆 4 5 0~ 6 0 0ml;其饱和吸附的IgG量为 (3.98±0 .5 1)g ;实验终点饱和吸附的IgG量 (M1)为 (19.5 4± 3.13)g/L ,吸附后血浆IgG(M2 )水平降低 5 1.2 % ;②本组体内吸附实验前 ,PRA为 98%~ 5 1%者 5例 ,PRA为 5 0 %~ 4 0 %者 15例 ,PRA为 39%~ 2 5 %者 12例。每次SPA吸附治疗的循环血浆量为 70 0 0~ 90 0 0ml。本组经 (6 .70± 3.11)次SPA吸附治疗后 ,2 9例 (占90 .6 2 % )PRA降至 <12 % ;③ 2 7例 (83.37% )顺利地接受肾移植手术。术后未发生超急或急性排斥反应 ,肾功能均得以恢复。结论 SPA吸附治疗可降低致敏患者体内预存的PRA水平。SPA吸附治疗辅以配型良好的肾脏及新型免疫抑制剂 ,对预防和减轻肾移植后排斥反应疗效确切。

Objectives To investigate the efficacy of Protein A immunoadsorption (IA)in the treatment of rapidly progressive glomerulonephritis and its influence the serum level ofantineutrophil cytoplasmic antibody (ANCA) and anti-GBM antibody. Methods Five cases of rapidlyprogressive glomerulonephritis were involved whose renal biopsy showed that crescents waspresent in more than 50% of the glomeruli (56.7~5.9%). Of those cases, 3 accompanied with type2 diabetes mellitus and 3 accompanied with interstitial pneumonia....

Objectives To investigate the efficacy of Protein A immunoadsorption (IA)in the treatment of rapidly progressive glomerulonephritis and its influence the serum level ofantineutrophil cytoplasmic antibody (ANCA) and anti-GBM antibody. Methods Five cases of rapidlyprogressive glomerulonephritis were involved whose renal biopsy showed that crescents waspresent in more than 50% of the glomeruli (56.7~5.9%). Of those cases, 3 accompanied with type2 diabetes mellitus and 3 accompanied with interstitial pneumonia. All of the 5 patients hadundertaken IA as well as the drug therapy with glucocorticoids and cyclophosphamides. ResultsSerum level of ANCA-MPO was reduced significantly after a single IA(54.34±31.73 vs 87.96±46.67, P=0.003).There was also a reduction of serum anti-GBM antibody, but there was nostatistic significance(13.00±11.61 vs 23.53±24.27,P=0.079).Renal function were improvedsignificantly in two cases who need dialysis therapy before IA. One of them didn't need dialysissupport after IA therapy whose serum creatinine reduced from 710μmol/L to 350μmol/L. The otherthree cases also resulted in obvious amelioration of renal impairment after IA therapy, serumcreatinine dropped from 586 μ mol/L、197μ mol/L、367μ mol/L to 261 μmol/L、136 μmol/L、236μmol/L respectively after several sessions of IA. Pulmonary interstitial lesions wereimproved in all cases. There were no changes in liver function, serum electrolytes, serumglucose, oxygen saturation or blood routine after IA therapy. Patients' vital signs such as bloodpressure, heart rate and respiratory rate also kept steady during each session. All of the 5patients survived. Conclusions Staphylococcus protein A immunoadsorption therapy combinedwith impulse therapy of glucocorticoids and cyclophosphamides significantly lowered the auto-antibodies like ANCA and anti-GBM antibody in the circulation of the patients with rapidly progressive glomerulonephritis. This combined therapy can resulted in improvement in renalfunction and rapid remission of the disease.

目的探讨蛋白A免疫吸附治疗急进性肾炎的临床疗效及对血清抗中性粒细胞胞浆抗体(ANCA)或抗肾小球基膜抗体(抗-GBM)水平的影响。方法复旦大学附属中山医院肾内科5例急进性肾小球肾炎患者,3例合并2型糖尿病,3例伴有两肺间质性炎症。肾活检示新月体比例为56.7%~5.9%,在糖皮质激素及环磷酰胺治疗的同时,运用葡萄球菌A蛋白吸附柱进行免疫吸附治疗。结果单次免疫吸附治疗后,血清ANCA-MPO较治疗前明显下降([54.34±31.73)vs(87.96±46.67),P=0.003];抗-GBM亦较治疗前下降,但差异无显著性([13.00±11.61)vs(23.53±24.27),P=0.079]。肾功能显著改善,2例治疗前需透析的患者中有1例无需维持透析,血肌酐由治疗前710μmol/L降至350μmol/L;3例治疗前无需透析的患者肾功能明显好转,由治疗前586μmol/L、197μmol/L、367μmol/L降至261μmol/L、136μmol/L、236μmol/L。肺部间质性炎症均有明显好转。免疫吸附治疗前后,患者肝功能、电解质、血糖、血常规、血压、...

目的探讨蛋白A免疫吸附治疗急进性肾炎的临床疗效及对血清抗中性粒细胞胞浆抗体(ANCA)或抗肾小球基膜抗体(抗-GBM)水平的影响。方法复旦大学附属中山医院肾内科5例急进性肾小球肾炎患者,3例合并2型糖尿病,3例伴有两肺间质性炎症。肾活检示新月体比例为56.7%~5.9%,在糖皮质激素及环磷酰胺治疗的同时,运用葡萄球菌A蛋白吸附柱进行免疫吸附治疗。结果单次免疫吸附治疗后,血清ANCA-MPO较治疗前明显下降([54.34±31.73)vs(87.96±46.67),P=0.003];抗-GBM亦较治疗前下降,但差异无显著性([13.00±11.61)vs(23.53±24.27),P=0.079]。肾功能显著改善,2例治疗前需透析的患者中有1例无需维持透析,血肌酐由治疗前710μmol/L降至350μmol/L;3例治疗前无需透析的患者肾功能明显好转,由治疗前586μmol/L、197μmol/L、367μmol/L降至261μmol/L、136μmol/L、236μmol/L。肺部间质性炎症均有明显好转。免疫吸附治疗前后,患者肝功能、电解质、血糖、血常规、血压、心率、呼吸频率及血氧饱和度均保持稳定。5例患者全部存活。结论葡萄球菌A蛋白吸附联合糖皮质激素及环磷酰胺冲击治疗,能快速、显著降低急进性肾炎患者循环中的ANCA、抗-GBM等自身抗体,改善肾功能和肺部病变,使患者迅速达到临床缓解,安全性好。

 
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