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肿瘤鼠
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  mice with tumors
     Preliminary observation on the distribution of ~(67)Ga in normal mice and mice with tumors
     ~(67)Ga在正常鼠及肿瘤鼠体内分布的初步观察
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  “肿瘤鼠”译为未确定词的双语例句
     At 8 h post intravenous injection, the uptake of gallbladder was still as high as 106.89%±47.4%ID/g organ.
     肿瘤鼠肺、胆中摄取高于正常鼠,尤其是胆,至注射后8h仍高达106.89%±47.4%ID/g。
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     Regulation of rIFN-γand Sizofiran on TNF-αin Normal and Tumor Mice
     rIFN-γ及Sizofiran对正常和肿瘤鼠TNF的调节
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     The survival time of tumor-bearing rats in B+V+D+N+angiotensin Ⅱ group was longer than that in other chemotherapy group.
     联合化疗组肿瘤鼠生存期长于单独化疗组(B+N)。
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     In the present paper, the absorption, distribution and excretion of ~3H-harringtonine in normal and tumor-bearing rats and mice are reported.
     本文报告~3H-三尖杉酯碱在正常及肿瘤鼠体内的吸收、分布和排泄。
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     Implanted gastric tumor can be inhibited in some degree. Weight inhibit rate is 44% .
     (2)蒙药娜仁满都拉能显著改善肿瘤鼠生存状态,对胃肿瘤具有一定的抑制作用,瘤重抑制率为44%;
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  相似匹配句对
     A novel tumor skin winow model in rats
     新型肿瘤皮窗模型
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     Pathological and Immunohistochemical studies on Spontaneous tumors in Nude Mice
     裸自发性肿瘤病理学及免疫组织化学研究
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     Tumor lymphangiogenesis
     肿瘤淋巴管生成
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     PARAPHARYNGEAL SPACE TUMORS
     咽旁间隙肿瘤
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     Mice Wandering around the World
     傲江湖
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  mice with tumors
The nude mice with tumors were divided into two groups: verapamil-treated group and control group.
      
Athymic mice with tumors had NK levels that tended to increase with increasing retinol doses, but these changes were not statistically significant.
      
The shortest survival of the mice with tumors was observed with C6 (all died on days 10-14 post injection), and with RG2 (all died from day 32 to day 39 following injection).
      
No predominance of sex could be pointed out among the mice with tumors.
      
Cytoros (5) and its analogues, with other ether and thioether phospholipids, appear to offer increased therapeutic benefit to mice with tumors.
      
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In the present paper, the absorption, distribution and excretion of ~3H-harringtonine in normal and tumor-bearing rats and mice are reported. After ~3H-harringtonine was injected intravenously to normal rats, blood radioactivity level decreased rapidly with two biological phases of half-life, the first one (fast) being about 3.5 minutes and the other (slow) 50 minutes. Fifteen minutes after intravenous injection of ~3H-harringtonine to normal rats, the highest level of radioactivity was present in the kidneys,...

In the present paper, the absorption, distribution and excretion of ~3H-harringtonine in normal and tumor-bearing rats and mice are reported. After ~3H-harringtonine was injected intravenously to normal rats, blood radioactivity level decreased rapidly with two biological phases of half-life, the first one (fast) being about 3.5 minutes and the other (slow) 50 minutes. Fifteen minutes after intravenous injection of ~3H-harringtonine to normal rats, the highest level of radioactivity was present in the kidneys, while appreciable radioactivity was present in the liver, bone marrow, lung, heart, gastrointestinal tract, spleen and muscle. The radioactivity in the testis, whole blood and brain was low. Two hours after injection, the drug concentration in various tissues decreased rapidly, but that of the bone marrow decreased more slowly, thus forming the highest concentration among the tissues tested. Twenty-four hours after administration of ~3H-harringtonine, only very low levels of activity were found in all tissues. In tumor-bearing mice a similar distribution pattern was observed. Twenty-four hours after intravenous injection of ~3H-harringtonine to normal rats, the total urinary excretion of radioactivity was found to be about 30.2%, while about 16.6% was present in the feces. It was also shown that approximately 14.5% of the administered radioactivity was excreted as unchanged harringtonine within 24-hour period. Biliary excretion was also an important route of excretion. Normal rats excreted 24.5% of the administered radioactivity in the bile in 24 hours, while about 17.1% was excreted as unchanged harringtonine. When ~3H-harringtonine was administered orally to normal mice, it was absorbed rapidly but incompletely.

本文报告~3H-三尖杉酯碱在正常及肿瘤鼠体内的吸收、分布和排泄。静脉注射~3H-三尖杉酯碱后,大鼠血中放射性迅速降低,快、慢两相的生物半衰期分别为3.5分钟和50分钟。给大鼠静脉注射~3H-三尖杉酯硷,注射后15分钟时,药物在各组织中的分布以肾脏为最高,肝、骨髓、肺、心脏、胃肠、脾、肌肉次之,睾丸、血及脑较低。两小时后各组织中的药物浓度均迅速下降,但骨髓的下降较慢,在所有组织中药物浓度居于首位。24小时后则在所测组织中药物浓度均降到相当低的水平。~3H-三尖杉酯碱在肿瘤小鼠体内的分布情况与正常大鼠的分布趋势大致相仿。~3H-三尖杉酯碱在静脉注射后24小时自大鼠体内排出的总放射性,在尿相当于注射剂量的30.2%,在粪相当于16.6%,其中原型药共占14.5%。此外胆汁也是一条重要排泄途径。静脉注射后24小时可自胆汁排出剂量的24.5%,其中原型药占17.1%。该硷口服给药可迅速吸收入血,但吸收不完全。

Regulation of rTFN-γand SPG on TNF-α was obeerved in normal and tumor mice by

用免疫印迹电泳方法,观察了重组鼠γ-干扰素(rIFN-γ)及抗肿瘤多糖Sizofiran(SPG)对正常和肿瘤鼠TNF-α的调节。rINF-γ和SPG均能诱导TNF的水平增加,但在正常与肿瘤鼠中表现了两个不同的特征。①TNP被调节的时程不同:肿瘤鼠TNF的增加发生在用药后早期,并迅速降至对照水平;正常鼠的TNF增加迟于肿瘤鼠,但能维持较长时间。②TNF被调节的水平不同:肿瘤鼠眼用rIFN-γ和SPG后,TNF的增加分别最高为48%和43%;正常鼠则分别可达88%和90%。如将rIFN-γ和SPG合并使用。对TNF的调节能力要优于两者的单独使用。上述结果提示正常与肿溜状态有自身的抗肿瘤免疫特征,TNF的调节在很大程度上亦依赖于给药的方式。

Abstract Rodent monoclonal

鼠源抗肿瘤单抗通常用杂交瘤技术制备。作者首次尝试以噬菌体抗体库技术替代杂交瘤方法制备抗肿瘤鼠单抗。以RT-PCR方法直接从免疫Ba1B/c小鼠脾脏淋巴细胞扩增出全套免疫球蛋白重链Fd段及轻链基因,克隆到原核表达载体并将抗体片断Fab表达于线状噬菌体表面,构建了噬菌体抗体库(1.0×10 ̄7)。以人乳腺癌细胞系Bcap37活细胞为靶抗原对噬菌体抗体库进行的4轮亲和筛选显示了噬菌体抗体的特异性富集。从第4轮筛选后选取182个克隆进行ELISA检测发现174个具有与肿瘤细胞结合活性。用12种人肿瘤细胞系及人淋巴细胞和成纤维细胞对所获克隆进行了进一步鉴定。我们所应用的方法为抗肿瘤单抗的制备提供了一条更为有效的新途径。

 
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